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9012443 Bicyclic aryl and heteroaryl sodium channel inhibitors  
The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are...
9011910 Implantable tizanidine compositions and methods of treatment thereof  
A method of treating the symptoms of spasticity comprises implanting a reservoir-based drug delivery composition into a subject to systemically deliver a therapeutically effective amount of...
8980837 Inhibitors of IAP  
The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′,...
8980298 Implantable tizanidine compositions and methods of treatment thereof  
A method of treating the symptoms of spasticity comprises implanting a reservoir-based drug delivery composition into a subject to systemically deliver a therapeutically effective amount of...
8933107 Pesticide thiazolyloxy substituted phenylamidine derivatives  
The present invention relates to aryloxy substituted phenylamidine derivatives of formula (I) wherein the substituents are as in the description, their process of preparation, their use as...
8883830 Topical therapy for the treatment of migraines, muscle sprains, muscle spasms, spasticity and related conditions  
The invention is directed to topical formulations and methods of treating a migraines and/or cluster headaches, muscle sprains, muscle spasms, spasticity, tension headaches, tension related...
8877748 Heterocyclic fused anthraquinone derivatives, manufacturing method and pharmaceutical composition using thereof  
A heterocyclic fused anthraquinone derivative, which is represented by a formula (I): wherein R1 is a substituent being one selected from a group consisting of hydrogen, halogens, aminoalkyl...
8859592 Insecticidal compounds  
A compound of formula (I): wherein A1, A2, A3, A4, A5, G1, R1, R2, R3 and R4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and...
8846727 Haloalkyl heteroaryl benzamide compounds  
A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.
8841335 Pharmaceutical composition for inhibiting apoptosis of neuron or neurodegeneration  
Provided is a pharmaceutical composition for inhibiting apoptosis of neurons or neurodegeneration. The pharmaceutical composition effectively prevents or treats diseases related to apoptosis of...
8828908 Herbicidally active bicyclic 1,3-dione compounds  
Bicyclic dione compounds of formula (I), and derivatives thereof, which are suitable for use as herbicides.
8716320 Antibacteriall heterocyclic ureas  
The present invention provides novel heterocyclic urea compounds having useful antibacterial activity, pharmaceutical compositions comprising one or more of these compounds, methods of making the...
8664249 Tetrasubstituted benzenes  
Tetrasubstituted benzenes that act as modulators of gamma secretase and their use in the treatment of one or more symptoms of treating neurodegenerative disorders, e.g., Alzheimer's disease, are...
8592486 Compounds for inflammation and immune-related uses  
The invention relates to compounds of structural formulas (I), (VII) and (XI): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein X1, X2, X3, Y, Z, L, R1, R2,...
8580799 Fungicide hydroximoyl-heterocycles derivatives  
The present invention relates to hydroximoyl-heterocycle derivatives of formula (I) wherein T represents a substituted or non-substituted heterocyclyl group, Q represents a carbo or heterocyclic...
8524749 Controlled release compositions of tizanidine  
The present invention relates to a novel controlled release formulations of tizanidine. The invention also provides methods of using novel controlled release formulations of tizanidine to treat a...
8450351 N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase  
The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as pharmaceutical compositions thereof and methods of use thereof...
8410150 Inhibitors of carnitine palmitoyltransferase and treating cancer  
A CPT inhibitor compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof: or a pharmaceutically acceptable salt thereof. A pharmaceutical composition...
8383139 Thiadiazolyloxyphenylamidines and use thereof as fungicides  
The present invention relates to thiadiazolyloxyphenylamidines of the general formula (I), to a process for the preparation thereof, to the use of the amidines according to the invention in...
8334316 Substituted organosulfur compounds and methods of using thereof  
The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative...
8299102 Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals  
The present invention relates to heteroarylcyclopropanecarboxamides of the formula I, in which Het, X, Ra, Rb, Rc, Rd, R1, R2 and R3 have the meanings indicated in the claims, which modulate the...
8288371 Ortho pyrrolidine, benzyl-substituted heterocycle CCR1 antagonists for autoimmune diseases and inflammation  
Compounds of the formula are disclosed. The compounds are CCR1 antagonists which are useful for the treatment and prevention of inflammatory and autoimmune diseases. Other embodiments are also...
8288403 Heterocyclic gamma secretase modulators  
The invention relates to methods for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct...
8252820 1-orthofluorophenyl substituted 1,2,5-thiazolidinedione derivatives as PTP-as inhibitors  
Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the...
8236811 Therapeutic use for treating of leukemia  
The disclosure relates to methods of treating leukaemia, in particular myeloid leukaemia, comprising administering the compound...
8217064 Tetrasubstituted benzenes  
Tetrasubstituted benzenes that act as modulators of gamma secretase and their use in the treatment of one or more symptoms of treating neurodegenerative disorders, e.g., Alzheimer's disease, are...
8119667 Carbonates of fenicol antibiotics  
Novel fenicol compounds having useful properties as antibiotic prodrugs, are provided, together with methods of making and using these new compounds.
8119666 1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (PTPase)  
Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the...
8088802 N-phenylarylsulfonamide compound, pharmaceutical composition comprising the compound as active ingredient, synthetic intermediate for the compound and process for its preparation  
An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl,...
8084448 Organic compounds  
Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the...
8084452 Substituted enaminocarbonyl compounds used as insecticides  
The present application relates to novel substituted enaminocarbonyl compounds, to processes for their preparation and to their use for controlling animal pests, especially arthropods, in...
8044053 Sulfonamide substituted pyrazoline compounds, their preparation and use as CB1 modulators  
The present invention relates to substituted pyrazoline compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the...
8003675 3,4-dihalogenoisothiazole derivative, and agricultural or horticultural plant disease-controlling agent  
A 3,4-dihalogenoisothiazole derivative represented by the general formula [I] (wherein R1 is a halogen atom; A is an oxygen atom or a sulfur atom; and R is a C1-C6 alkyl group, a C2-C5 alkenyl...
7939528 Heterocycle compounds  
The present invention relates to novel compounds which are antagonist or inverse agonists at an opioid receptor. Such compounds are useful in the treatment of obesity and related diseases and/or...
7928031 Catalyst comprising indium salt and organic ionic liquid and process for friedel-crafts reactions  
Disclosed is a catalyst composition based on an indium salt and an organic ionic liquid, a process for making the catalyst composition, and uses thereof. The catalyst composition is particularly...
7858642 Substituted hydroxyethylamine aspartyl protease inhibitors  
The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a...
7820702 Sulfonylpyrrolidine modulators of androgen receptor function and method  
Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2, R3, R4, R4a,...
7781436 Indol-3-y-carbonyl-piperidin and piperazin-derivatives  
The present invention relates to indol-3-yl-carbonyl-piperidin and piperazin derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the residues R1 to R3...
7781466 Preparation for the fungicidal and algicidal finish of alkaline coating compositions  
The invention relates to a preservative comprising at least one isothiazolone, at least one quaternary ammonium compound, and at least one stabilizer selected from the group of sulphite salts,...
7772285 Benzophenone derivatives or salts thereof  
A benzophenone derivative represented by the following formula: wherein R1 represents, for example, an optionally substituted heterocyclic group, or a substituted phenyl group; Z represents, for...
7772260 Imidazo[2,1-b]-1,3,4-thiadiazole sulfonamides  
This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous...
7741349 Imidazo[2, 1-b]-1,3,4-thiadiazole sulfonamides  
This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous...
7714003 Imidazo[2,1-b ]-1,3,4-thiadiazole sulfonamides  
This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous...
7700633 Organic compounds  
Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the...
7700635 Imidazo[2,1-b]-1,3,4-thiadiazole sulfonamides  
This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous...
7666885 Enzyme inhibitors  
Compounds of general formula (I): where A, E, G, X, Y and the bond - - - take various meanings are of use in the preparation of a pharmaceutical formulation, for example in the treatment of a...
7645781 N-aryl-2-oxazolidinone-5-carboxamides and their derivatives  
The present invention provides antibacterial agents having the formulae I, II, and III described herein.
7632851 Benzo[1,2,5]oxadiazoles and benzol[1,2,5]thiadiazoles useful as histopathological staining agents, imaging agents and biomarkers  
The present invention relates to novel benzo[1,2,5]oxadiazoles and benzo[1,2,5]thiadiazoles of formula (I) wherein X is O or S, R1 is 5-(2-fluoro-ethylamino)-thiazol-2-yl,...
7528173 Plasma carboxypeptidase B inhibitors  
Compounds of the following formula (I), for example: (1), wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical compositions...
7459473 N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres  
This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including...

Matches 1 - 50 out of 293 1 2 3 4 5 6 >