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5110821 |
1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
Compounds of the formula ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms; R' is lower-alkyl or hydroxy-lower-alkyl or 1-5 carbon atoms; R 1 and R 2 are hydrogen, halogen,...
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5102897 |
3,5-ditertiarybutyl-4-hydroxyphenyl, 1,3,4-thiadiazoles and oxadiazoles linked by carbon, oxygen, and sulfur residues
The novel 3,5-ditertiarybutyl-4-hydroxyphenylthio-1,3,4-thiadiazoles and oxadiazoles and 3,5-ditertiarybutyl-4-hydroxyphenylmethanone-1,3,4-thiadiazo
les and oxadiazoles and related compounds of...
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5098918 |
1,2,3-thiadiazole compounds, compositions and method of anti-thrombotic treatment
Novel 1,2,3-thiadiazole compounds, new and old 1,2,3-thiadiazole compositions and method of anti-thrombotic treatment are systemically administered to a human or animal.
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5091398 |
Substituted 1,2,3,4-oxatriazolium-5-olates, a process for their preparation and their use
The 1,2,3,4-oxatriazolium-5-olates of the formula I ##STR1## in which R 1 denotes, for example, (C 2 to C 4 )alkyl, R 2 and R 3 denotes (C 1 to C 4 )alkyl have useful pharmacological...
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5091397 |
1-aza-bicyclico(2.2.1)heptanes
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which one of X and Y represents hydrogen and the other represents --CH 2 --Z where Z is a group ##STR2## in...
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5071841 |
Sulfur-containing heterocyclic compounds useful for the treatment of osteoporosis, and their production
The present invention provides a sulfur-containing heterocyclic compound of the formula (I) ##STR1## wherein ring A is a benzene ring which may be substituted; R is a hydrogen atom or a hydrocarbon...
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5066661 |
Agents for protecting plants against diseases
The invention relates to novel N-(cyanomethyl)-benzo-1,2,3-thiadiazole-7-carboxamides of the formula I ##STR1## in which X 1 and X 2 independently of one another are hydrogen or 1 to 3 halogen; R...
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5057526 |
Pharmaceutically active pyridinyl substituted 5,7-dihydropyrrolo-[3,2-f]benzoxazole-6-ones
Compounds of the formula I ##STR1## wherein R is a hydrogen atom or an alkyl radical, R 1 is a hydrogen atom or an alkyl, alkenyl or a cycloalkyl radical, R 2 is a hydrogen atom or an alkyl,...
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5051434 |
Insecticidally active nitro guanidine compounds
Insecticidal novel nitro compounds of the formula ##STR1## in which R 1 and R 2 are hydrogen or C 1 -4 alkyl, R 3 is --S--R 4 or ##STR2## in which R 4 is C 1 -4 alkyl, R 5 and R 6 are...
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5041456 |
Pharmaceutically useful 3-(indol-3-yl)-1,2,4-oxa- and thiadiazoles substituted in the 5-position by an amino containing group
The present invention provides a compound of formula I or a salt or prodrug thereof: ##STR1## wherein the dotted circle represents one or two double bonds in any position in the 5-membered ring; ...
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5032604 |
Class III antiarrhythmic agents
Compounds of structural formula: ##STR1## wherein R' is hydrogen or an aromatic ring system, and Q is a substituted nitrogen or a nitrogen containing heterocycle, and E is --S-- or --O--, are Class...
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5021413 |
Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them
Analgesic compounds are of the general formula (I): ##STR1## in which, R 1 and R 2 each represents hydrogen or C 1 -C 6 alkyl, or R 1 and R 2 together with the nitrogen atom to which they are...
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5006540 |
Substituted 3-aminosydnonimines, processes for their preparation and their use
Substituted 3-aminosydnonimines of the formula I ##STR1## and their pharmacologically acceptable acid addition salts, wherein R 1 denotes, for example, alkyl having 1 to 8 C atoms, R 2 denotes...
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4985450 |
Arylthiadiazolylsulfonamides and derivatives
There are described compounds of the formula ##STR1## where n is 0, 1 or 2; x and y are independently hydrogen, loweralkyl, loweralkoxy, arylloweralkyl, aryloxy, halogen, --CF 3 , --NO 2 , --OH,...
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4981864 |
Method for inhibition of erythrocyte aggregation using anellated tricyclic compounds
The present invention is concerned with the use of compounds of the general formula: ##STR1## wherein R 1 is a phenyl radical of the general formula: ##STR2## or R 1 is a 5 or 6 membered...
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4968691 |
Heterocyclo-substituted azabicyclo muscannic agonists
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which X represents a group ##STR2## in which p represents an integer of 2 to 4; r represents an integer of 1 or...
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4956375 |
N-indanyl carboxamide derivative and agricultural/horticultural fungicide containing the derivative as active ingredient
Disclosed herein is an N-indanyl carboxamide derivative as a novel compound, represented by the following general formula (I): ##STR1## wherein A represents a group of the formula, ##STR2##...
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4954518 |
4H-1-benzopyran-4-one derivative or its salt, process for producing the same and pharmaceutical composition comprising the same as active ingredient
This invention relates to a 4H-1-benzopyran-4-one derivative represented by the formula: ##STR1## or a salt thereof, a process for producing the same and a pharmaceutical composition comprising the...
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4952587 |
Physiologically active 1,2,4,-oxa- and thiadiazoles
The present invention provides a compound of formula I or a salt or prodrug thereof: ##STR1## wherein the dotted circle represents one or two double bonds in any position in the 5-membered ring; ...
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4952580 |
Pesticidal polyhaloalkene derivatives
Polyhaloalkene compounds of the formula: ##STR1## wherein X is sulfur, oxygen, or nitrogen, Y 1 and Y 2 are fluorine, Z is hydrogen or the same as Y 1 and Y 2 , and n is 1-4; provided that: ...
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4943307 |
Plant-protective pesticidal composition
The invention relates to a plant-protective solution containing 2.5 to 40 % by weight of one or more water-insoluble plant-protective ingredient(s) 20 to 71.5 % by weight of dimethylformamide...
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4943584 |
(p-Phenoxyphenoxy)-methyl-five-membered hetaryls
Novel (p-phenoxyphenoxy)-methyl-five-membered heeroaromatic radicals of the formula ##STR1## where the substituents have the following meanings: R 1 , R 2 , R 3 hydrogen, halogen, C 1 -C 8 ...
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4933356 |
Diflunisal potentiation of acetazolamide in the control of intraocular pressure
The invention relates to an improved therapy to control intraocular pressure (IOP). More specifically, the present invention relates to an improved treatment of glaucoma patients to control ocular...
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4904660 |
Histidine derivatives as superior renin inhibitors
Novel compounds of the following formula (I) and their salts: A compound of the formula (I) ##STR1## These compounds are expected to be useful for renin inhibitors. Thus, the compounds are useful...
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4863945 |
Pyrrolobenzimidazoles and pharmaceutical compositions containing them
Pyrrolobenzimidazoles of the formula: ##STR1## are useful for treatment of heart and circulatory diseases. R 1 is substituted phenyl; or optionally substituted naphthyl or a five- or six-membered...
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4861788 |
Antibacterial 1-normon-2-yl-heterocyclic compounds
Compounds of formula (I): ##STR1## wherein ##STR2## is a 5-membered heterocyclic group having a 6-Ď€electron system, the five ring atoms being either (a) one carbon atom and four atoms selected...
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4855310 |
Thiadiazole compounds as antagonists of SRS-A
Novel heterocyclic compounds shown by the general formula ##STR1## or the pharmaceutically acceptable salts thereof useful as medicament in particular as antagonist of slow reacting substance of...
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4851406 |
Heterocyclic-substituted indoles and pharmaceutical compositions containing them
The present invention provides indole derivatives of the general formula: ##STR1## wherein R 1 is a hydrogen atom or an alkyl, alkenyl, cycloalkyl, cycloalkenyl, carboxyl, cyano, alkylcarbonyl,...
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4845106 |
Heterocyclic thiazole compounds
Novel insecticides of the formula ##STR1## in which n is 0 or 1, X is S, O, ##STR2## Y is N or ##STR3## Z is a 5- or 6-membered nitrogen-containing heterocyclic ring, and R to R 9 variously...
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4831032 |
Cardiotonic benzimidazoles
The present invention provides benzimidazoles of the general formula: ##STR1## wherein R 1 , X, A, and R 2 are as defined in the specification. The present invention also provides processes for...
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4803211 |
Thiadizazole compounds as antagonists of SRS-A
This invention relates to novel heterocyclic compounds structurally characterized by containing a specific heterocyclic group and by the presence of --CH 2 --S-- directly bound to the specific...
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4795755 |
Heterocyclic derivatives
This invention relates to heterocyclic derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative...
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4782083 |
3,4-dihydro-2H-1-benzopyrans useful as anti-hypertensive agents
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: one of R 1 and R 2 is hydrogen or C 1 -4 alkyl and the other is C 1 -4 alkyl or R 1 and R 2 together...
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4767775 |
Substituted pyrazolin-5-ones, composition containing them, and method of combating fungi or bacteria
Microbicidal substituted pyrazolin-5-ones of the formula ##STR1## in which R 1 and R 2 independently of one another each represent hydrogen, alkyl, alkenyl, alkinyl, cyanoalkyl, hydroxyalkyl,...
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4758578 |
Arylthiadiazolylsulfonamides, pharmaceutical compositions and use
There are described compounds of the formula ##STR1## where n is 0, 1 or 2; X and Y are independently hydrogen, loweralkyl, loweralkoxy, arylloweralkyl, aryloxy, halogen, --CF 3 , --NO 2 , --OH,...
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4753957 |
Substituted 2,4-imidazolidinediones and fungicidal compositions
This invention relates to substituted 2,4-imidazolidinediones, their method of preparation and use as broad spectrum systemic fungicides effective in controlling phytopathogenic fungi such as...
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4731364 |
Dihydrobenzo(B)thiophenes and pharmaceutical compositions thereof useful as antifungals
2-Alkyl-, 2-alkenyl- and 2-alkynyl-2,3-dihydro-2-(1H-azolyl(C 1 -C 2 )alkyl)benzo[b]thiophenes especially 2-alkyl-, 2-alkenyl- and...
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4721712 |
1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also on the carboxamide nitrogen atom, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO)...
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4714707 |
Aryl substituted heterocycles for treating gastrointestinal motility dysfunction
Aryl substituted diazaheterocyclic amines and their use in the treatment of gastrointestinal motility dysfunctions.
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4713393 |
Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents
Phenylalkyl-2,3-dihydrobenzofurans and analogs were prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a...
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4696939 |
Benzothiadiazole compounds for treating hypertension
Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.
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4695567 |
Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases
The present invention provided pyrrolobenzimidazoles or tautomer thereof, of the general formula: ##STR1## wherein R 1 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 3 -C 7 cycloalkyl; ...
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4692457 |
Acaricides
The invention provides the acaricidal thiadiazoles of the formula: ##STR1## (where: R 1 and R 2 , which may be the same or different, are each hydrogen, optionally-substituted alkyl of 1 to 10...
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4689335 |
Heterocyclic guanidines for treating gastrointestinal motility dysfunction
A method for treating gastrointestinal motility dysfunctions using phenylheterocyclic guanidines and novel heterocyclic guanidine compounds.
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4683228 |
Guanidinopyrazolylamides, guanidimoimidazolylamides, compositions containing them, and method of using them to inhibit gastric acid secretion
A guanidine derivative of the formula I: ##STR1## in which R 1 , R 2 , R 3 , R 4 , ring X and D are a variety of radicals defined in the specification and A is a 3-8C alkylene chain which is...
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4636505 |
Amide derivatives
Acylanilides of the formula ##STR1## wherein R 1 and R 2 , the same or different, each is cyano, carbamoyl, nitro, halogeno, perfluoroalkyl or other defined substituents; R 3 is hydrogen or...
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4571406 |
Anti-hypertensive chromans and chromenes
Compounds of formula (I): ##STR1## wherein: either one of R 1 and R 2 is hydrogen and the other is selected from the class of C 1 -6 alkylcarbonyl, C 1 -6 alkoxycarbonyl, C 1 -6 alkylcarbonyloxy,...
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4569942 |
N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also further substituted on the carboxamide nitrogen by an alkyl, cycloalkyl, phenyl or substituted...
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4563476 |
Substituted 5-hydroxy-2,3-dihydrobenzofurans and analogs thereof useful as anti-inflammatory agents
Substituted 5-hydroxy-2,3-dihydrobenzofuran and analogs such as the substituted 6-hydroxy-2,3-dihydrobenzopyrans were prepared from an appropriately substituted...
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4556672 |
3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
Certain new 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and...
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