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6319944 |
Aryl amidines, compositions containing such compounds and methods of use
Compounds represented by formula I: ##STR1## or a pharmaceutically acceptable salt or hydrate thereof, are disclosed. Pharmaceutical compositions and methods of treatment are also included.
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6313154 |
Bis-thiadiazole derivatives or salts thereof and agrohorticultural disease controller and method for using the same
A bis-thiadiazole derivative represented by general formula (I): ##STR1## wherein R 1 and R 2 represent H, C 1 -C 8 alkyl, halo C 1 -C 4 alkyl, unsubstituted or substituted phenyl, 5- or...
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6297261 |
Substituted phenyl derivatives, their preparation and use
A compound having the formula (I) or a pharmaceutically acceptable salt thereof where the variables are defined in the specification are useful in the treatment of sickle-cell anemia. ##STR1##
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6288092 |
Triaryl compounds
(4-oxy-3-(aryl)phenyl)pyridine compounds, in free or acid addition salt form, are useful as pharmaceuticals for treatment and prophylaxis of inflammation, particularly inflammatory or obstructive...
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6232331 |
Benzofuroxan derivatives, their therapeutic uses and pharmaceutical compositions
The invention discloses use of a compound of the benzofuroxan series for treatment of cardiovascular disorders represented by the general formula (I) ##STR1## and pharmaceutically acceptable salts...
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6211210 |
Diphenyl-1,2,3-thiadiazol-3-oxides, compositions and methods of use
The invention encompasses compounds of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic...
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6211209 |
Method of inhibiting connective tissue degradation
The present invention provides a method of inhibiting connective tissue degradation that comprises administering to a patient having a condition in which connective tissue is degraded a...
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6174883 |
3-substituted-2-oxindoles derivatives
This invention relates to novel 3-substituted-2-oxindole derivatives of the formula ##STR1## and the phamaceutically-accepted salts thereof which are inhibitors of prostaglandin H 2 synthase,...
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6159938 |
Serine protease inhibitors comprising α-keto heterocycles
Provided are methods of inhibiting the activity of a serine protease using protease inhibitors that include an alpha-keto heterocycle in their structure. The methods are useful in the treatment of...
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6150374 |
Substituted cycloalkenes, process of preparing them and method of using them as pesticides
The invention relates to novel substituted cycloalkenes of the formula (I), ##STR1## to a plurality of processes for their preparation, and to novel intermediates and a plurality of processes for...
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6124333 |
Metalloproteinase inhibitors
Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are...
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6100252 |
Heterocyclic compounds and their use as angiotensin antagonists
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6096769 |
Fungicidal co-formulation
The invention relates a concentrated liquid fungicidal composition comprising a fungicidally acceptable carrier and/or surface active agent and (a) at least one compound of formula I, ##STR1## (b)...
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6093738 |
Proton pump inhibitors
Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H + /K + -ATPase. The compounds...
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6066662 |
Hydroxylamine derivatives and their use as metalloproteinase inhibiting agents
The invention provides hydroxylamine derivatives of formula (I) wherein A, R 1 , R 2 and R 3 have the significance given in the description, which are matrix metalloproteinase inhibitors and...
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6013644 |
Spiro-substituted azacycles as modulators of chemokine receptor activity
The present invention is directed spiro-substituted azacycles of formula I: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , k, l and m are defined herein) which are useful as modulators of chemokine...
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6011033 |
Phenylene derivatives
This invention relates to a phenylene derivative represented by the following formula (1) or a salt thereof and also to a medicine containing it as an effective ingredient. ##STR1## wherein R 1 ...
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6008219 |
Bicyclic amine derivatives and their use as anti-psychotic agents
This invention relates to compounds of formula (I) ##STR1## which are useful as modulators of D 3 receptors, in particular as antipsychotic agents.
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6001829 |
Fluoropropenyl oxadiazoles and the use thereof as pest control agents
The present invention relates to novel fluoropropenyl heterocycles of the formula (I) found CF 2 CX--CH 2 -Het (1), in which Het, X and R are each as defined in...
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5998379 |
Serine protease inhibitors-proline analogs
The present invention relates to certain substituted oxadiazole, thiadiazole, and triazole peptoids that are useful as inhibitors of serine proteases, in particular human neutrophil elastase....
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5990137 |
Method of inhibiting NADPH oxidase
The instant methods employs pharmaceutical compositions comprising aromatic azines; and imines, of the Formula 1 to selectively inhibit inflammation by preventing the oxidating burst from...
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5981556 |
1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
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5972937 |
Heterocyclic compounds possessing 5HT.sub.2C receptor antagonist activity
The invention relates to heterocyclic families of compounds having pharmacological activity, in particular possessing 5HT 2C receptor antagonist activity processes for their preparation, to...
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5958958 |
1,2,4-oxa diazolino and 1,24-oxa diazolidion heterocycles as useful nitric oxide synthase inhibitors
1,2,4-oxa-diazolino and 1,2,4-oxa-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
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5942528 |
Acylated 5-amino-1,2,4-thiadiazoles as pesticides and fungicides
The present invention relates to novel acylated 5-amino-1,2,4-thiadiazoles of the formula (I) ##STR1## in which R 1 , R 2 , R 3 and Y each have the meanings stated in the description, a process...
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5919809 |
3-substituted-2-oxindole derivatives
This invention relates to novel 3-substituted-2-oxindole derivatives of the formula ##STR1## and the pharmaceutically-acceptable salts thereof which are inhibitors of prostaglandin H 2 synthase,...
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5905077 |
Inhibitors of HIV protease useful for the treatment of AIDS
The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection and/or AIDS.
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5891909 |
Amidinohydrazones as protease inhibitors
Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R 1 -R 4 , R 6 -R 9 , Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or...
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5888941 |
Carbozamides with antifungal activity
Compounds of general formula I and their salts and solvates are antifungal agents and as such are useful in the treatment of various fungal infections. Pharmaceutical compositions including these...
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5861380 |
Serine protease inhibitors-keto and di-keto containing ring systems
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of...
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5824677 |
Substituted amino alcohol compounds
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty....
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5814629 |
Microbicides
The invention relates to novel microbicidal and plant-immunising compounds of formula I ##STR1## wherein: X is hydrogen, halogen, C 1 -C 4 alkyl, SR 8 , N(R 9 )R 10 , CH 2 OH, CHO or COOR 8 ; ...
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5792783 |
3-heteroaryl-2-indolinone compounds for the treatment of disease
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
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RE35811 |
Insecticidally active nitro guanidine compounds
Insecticidal novel nitro compounds of the formula ##STR1## in which R 1 and R 2 are hydrogen or C 1 -4 alkyl, R 3 is --S--R 4 or ##STR2## in which R 4 is C 1 -4 alkyl, R 5 and R 6 are...
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5750538 |
Method of treating hypercholesterolemia and related disorders
The present invention relates to a novel method for treating a mammal suffering from hypercholesterolemia and related disorders.
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5750551 |
Treatment for viral diseases
An angiotensin II antagonist compound is administered to mammals with viral disease. This administration ameliorates virus-associated cell injuries, producing therapeutic effects in viral diseases....
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5736561 |
Vascular hypertrophy suppressor
This invention relates to a method for the prophylaxis or treatment of vascular hypertropy in a mammal by administering a pharmaceutically effective amount of a compound represented by the formula...
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5731335 |
(1-Heteroazolyl-1-heterocycane derivatives and their use as neuroprotective agents
This invention provides heterocyclic compounds of formula (I) that are potentially useful in the treatment of neuropsychiatric disorders associated with progressive processes leading to neuronal...
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5728737 |
N-alkoxy-amidine derivatives
The present invention relates to novel N-alkoxy-arnidine derivatives of the formula (I), to a process for their preparation and to their use as pesticides. In addition, the invention also relates...
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5726195 |
Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents
Certain novel aminoacyl adenylate mimics are described. An exemplary compound of this invention is S-(R*,R*)!-3,6-anhydro-1,2-dideoxy-1- 5- 4- (5-nitro-2-thienyl)ethynyl!ph...
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5719170 |
Substituted cyclohexanol esters, their use for treating diseases, and pharmaceutical preparations
Cyclohexanol esters of the formula I ##STR1## are described in which the radicals have the given meaning. The compounds are pharmacologically active and may therefore be used as pharmaceuticals, in...
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5688809 |
5-heteroarylindole derivatives
The present invention relates to compounds of the formula ##STR1## The present invention also relates to intermediates for the preparation of compounds of the formula I, pharmaceutical compositions...
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5679670 |
Sulfonamides useful as carbonic anhydrase inhibitors
Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration...
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5677302 |
Thiadiazole compounds useful as proton pump inhibitors
Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H + /K + -ATPase. The compounds...
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5677318 |
Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents
The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic...
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5665744 |
6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenzn [cd] indoles
6-Thiadiazole-4-1-amino-1,2,2a,3,4,5-hexahydrobenz[c-d]indol
es are provided which are useful in modifying the function of serotonin in mammals.
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5646172 |
Method of inducing antiandrogenic activity using imidazolidines substituted with a heterocycle
Novel imidazoles of the formula ##STR1## wherein the substituents are as defined in the disclosure and their non-toxic, pharmaceutically acceptable addition salts with acids and bases having...
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5631253 |
Fungicidal propenoic acid derivatives
Compounds having the formula (I): ##STR1## and stereoisomers thereof, wherein A is hydrogen, halo, hydroxy, C 1 -4 alkyl, C 1 -4 alkoxy, C 1 -4 haloalkyl, C 1 -4 haloalkoxy, C 1 -4 alkylcarbonyl, C...
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5607956 |
1-heteroazolyl-1-heterocyclyl alkane derivatives and their use and their use as neuroprotective agents
The present invention relates to novel heterocyclic compounds having the general formula (1) ##STR1## geometric and optical isomers and racemates thereof where such isomers exist, as well as...
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5604224 |
Substituted heterocyclylisoquinolinium salts and compositions and methods of use thereof
Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries...
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