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7037914 |
Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient
A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I)
(wherein all symbols are as defined in the specification), a non-toxic acid...
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7030119 |
Method for treating chronic pain using MEK inhibitors
The invention features a method for treating chronic pain using a compound of formula (I).
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7012085 |
1,3 disubstituted pyrrolidines as α-2-adrenoceptor antagonists
The invention provides compounds of formula (I) wherein R 0 , R 1 , R 2 and A are as defined in the description, and the preparation thereof. The compounds of formula (I) have high affinity as α...
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6982264 |
Substituted alcohols useful in treatment of Alzheimer's disease
The invention relates to substituted alcohol compounds of the formula (I):
wherein X, R 1 , R 2 , R 3 , R N , R 20 and R C are defined herein. The compounds are useful in the treatment or...
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6916813 |
(1-phenyl-2-heteoaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase
Compounds having the formula (I), and pharmaceutically acceptable salts thereof,
are useful for modulating mitochondrial F 1 F 0 ATPase activity and treating ischemic conditions including...
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6872737 |
Heterocyclic inhibitors of glycogen synthase kinase GSK-3
Compounds of general formula (I):
where A, E, G, X, Y and the bond - - - take various meanings are of use in the preparation of a pharmaceutical formulation, for example in the treatment of a...
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6852739 |
Methods using proton pump inhibitors and nitric oxide donors
The present invention describes novel nitrosated and/or nitrosylated proton pump inhibitor compounds, and novel compositions comprising at least one proton pump inhibitor compound that is...
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6852744 |
Pyrrolidine derivatives and their use as chymase inhibitor
Novel pyrrolidine derivatives, being useful as chymase inhibitor or intermediate for synthesis of the active compounds, which has the formula (I): wherein R 1 is cycloalkyl, substituted or...
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6852745 |
Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
Novel biphenyl sulfonamide compounds which are combined angiotensin and endothelin receptor antagonists are claimed along with methods of using such compounds in the treatment of conditions such as...
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6846839 |
Methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis
The present invention relates to methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis. More specifically, this invention relates to methods for...
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6844342 |
Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides...
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6818662 |
Pharmaceutical composition
The present invention provides a pharmaceutical composition comprising N-(3-chloro-4-morpholin-4-yl)phenyl-N′-hydroxyimidoformami
dine and sulfobutyl ether β-cyclodextrin or a salt thereof,...
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6809091 |
Substances capable of inducing apoptosis
A method for the manufacture of a substance having an apoptosis-inducing ability characterized in including a step of subjecting at least one compound selected from the following (a), (b), (c) and...
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6767918 |
N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions...
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6746684 |
Microencapsulated solid pesticides
A microcapsule characterized by comprising a solid pesticide as a core material coated with a wall material which is a resin formed by polycondensation of a sparingly water-soluble...
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6743817 |
Substituted fused pyrroleimines and pyrazoleimines
Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R 1 and R 2 are defined herein. These compounds are highly selective agonists,...
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6713498 |
Method for treating glaucoma VI
Provided, among things, is a method of decreasing intraocular pressure in an animal, including a human, comprising administering an intraocular pressure decreasing amount of a compound of the...
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6699904 |
PPAR agonists
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and...
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6686383 |
Prophylactic or therapeutic drug for renal diseases
This invention relates to methods for the prophylaxis or treatment of diabetic nephropathy comprising, administering as an active ingredient, a compound, or salt thereof, of formula (I) wherein...
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6664277 |
Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use
The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical...
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6632817 |
Fluoromethoximino compounds
The invention relates to novel fluoromethoximino compounds, to a process for their preparation and to their use as pesticides, and also to novel intermediates and to a plurality of processes for...
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6620767 |
Pesticidal n-heteroaryl alpha-alkoximino-carboxamides
The invention relates to compounds of the general formula wherein R 1 is hydrogen, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkyl or unsubstituted or mono- to penta-substituted...
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6552052 |
Pyrrolo&lsqb 2,1-c&rsqb &lsqb 1,2,4&rsqb thiadiazoles and Pyrollo&lsqb 2,1-c&rsqb &lsqb 1,12,4&rsqb oxadiazoles useful as nitric oxide synthase inhibitors
Pyrrolo[2,1-c][1,2,4]thiadiazole or pyrollo[2,1-c][1,2,4]oxadiazoles having the formula: or pharmaceutically acceptable salts thereof, useful as nitric oxide synthase inhibitors wherein each...
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6541483 |
Acridone-derived compounds useful as antineoplastic and antiretroviral agents
The present invention relates to several novel acridone-derived compounds of of formula (I) or (II). These compounds are potent anti-viral agents, useful in the treatment of viral diseases, such as...
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6521650 |
Amines as pharmaceutical agents
Novel gamma aminobutyric acids of formula (I) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders,...
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6521649 |
Agricultural and horticultural disease controller and a method for controlling the diseases
A method for using a compound represented by the general formula: (wherein R 1 and R 2 are the substituents, respectively, defined in the specification) for agricultural and horticultural...
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6518289 |
1-substituted-1-aminomethyl-cycloalkane derivatives (&equals gabapentin analogues), their preparation and their use in the treatment of neurological disorders
Novel amines of formulas (1), (1C), (1F), (1G) and (1H) or a pharmaceutical acceptable salt thereof wherein n is an integer of from 0 to 2; m is an integer of from 0 to 3; R is sulfonamide, amide,...
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6503934 |
Substituted thiadiazolesulfonamides
Compounds of the formula (I): are suitable for the preparation of pharmaceuticals for prophylaxis and treatment of all those diseases where an increased concentration of interleukin-1β...
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6486185 |
3-heteroarylidene-2-indolinone protein kinase inhibitors
The present invention relates to novel 3-heteroarylidene-2-indolinone compounds and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are...
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6469004 |
Benzoheterocycles and their uses as MEK inhibitors
The invention provides compounds having formula (I), wherein W is OH, or derivatives of the carboxylic acid, and Q is a heterocyclo-condensed ortho-phenylene residue. These compounds are useful as...
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6469032 |
3-(4′-bromobenzylindenyl)-2-indolinone and analogues thereof for the treatment of disease
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
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6469036 |
Peptidyl heterocyclic ketones useful as tryptase inhibitors
The present invention relates to a series of peptidyl heterocyclic ketones which are inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment...
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6468977 |
Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes
Novel 1,2,4-thiadiazole compounds are provided, which are effective as inhibitors of cysteine activity-dependent enzymes and in particular of cysteine proteases. The compounds are useful in...
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6469059 |
Fungicidal composition and method for disease control of paddy-rice plants
A fungicidal composition for paddy-rice plants has as active ingredients N-(1-cyano-1,2-dimethylpropyl)-2-(2,4-dichlorophenoxy)propan
amide in combination with one or more compounds selected from...
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6426355 |
Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group
Compounds having the formula: wherein R 1 -R 5 , X and G are described herein and which are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus,...
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6420395 |
Azacyclooctane and heptane derivatives, their preparation and use in therapy
The present invention discloses compounds of formula (1) or (2), any of its enantiomers or any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein n is 0, or 1; R is hydrogen,...
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6410574 |
Fungicidal composition and method for using the same
The present invention relates to a fungicidal composition obtained by mixing a 1,2,3-thiadiazole derivative of general formula (I) useful as a plant disease controller with at least one fungicide...
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6410575 |
Viral treatment
A pharmaceutical composition that inhibits or slows the growth of viruses in animals, particularly in mammals, is disclosed. This same composition is can be used to treat viral infections,...
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6403621 |
Method for protecting plants
A method of protecting plants against attack by nematodes which comprises applying an effective amount to the plants, to parts of the plants and/or to the locus of the plants a compound having...
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6403622 |
Phenylacetic acid heterocyclyl amides having an insecticidal effect
Novel phenylacetic acid heterocyclyl amides of the formula in which R 1 , R 2 , R 3 , R 4 , A, X and n are as defined in the description, a process for preparing these novel compounds and their...
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6380243 |
Aminopyridine-containing thiourea inhibitors of herpes viruses
Compounds of the formula wherein A is heteroaryl; R 9 -R 12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon...
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6358942 |
Phenyloxazolidinones having a c-c bond 4-8 membered heterocyclic rings
A compound of Formula (I): or pharmaceutical acceptable salts thereof wherein X is NR 1 ; R 1 is H, C 1-6 alkyl optionally substituted with one or more OH, CN, or halo, or R 1 is —(CH 2 ) h...
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6348480 |
Pharmaceutical compound comprising a pyrazole derivative and methods of using the same for the treatment of calcium release-activated calcium channel associated diseases
The present invention is directed to drugs, in particular, pyrazole derivatives represented by the following general formula (I) which have a calcium release-activated calcium channel inhibitory...
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6348032 |
Method of inhibiting neoplastic cells with benzimidazole derivatives
A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to benzimidazole derivatives.
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6344469 |
Fungicide mixtures
Fungicidal mixture comprises a) a carbamate of the formula I, in which X is CH or N, n is 0, 1 or 2 and R is halogen, C 1 -C 4 -alkyl and C 1 -C 4 -haloalkyl, it being possible for the radicals...
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6340697 |
Oxime derivatives and agricultural chemicals containing the same
Various oxime derivatives are provided, which do not cause any chemical damage to plants and which exhibit sufficient effectiveness against various plant diseases. The oxime derivatives are...
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6339100 |
Methods for inhibiting mastocytosis
A method of preventing or treating in a subject mastocytosis which comprises administering to the subject a therapeutically effective amount of a compound having the structure: or a...
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6339101 |
N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
This invention relates to novel compositions and uses of a N-linked sulfonamide of an N-heterocylic carboxylic acid or isostere thereof for treating a vision disorder or improving vision or...
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6337341 |
1,2,3-Thiadiazole derivatives or salts thereof and agrohorticultural disease controller
A 1,2,3-thiadiazole derivative represented by general formula (I) or a salt thereof: wherein R 1 is H, (halo) C 1 -C 4 alkyl, 5- or 6-membered heterocycle containing 1 to 3 same or different...
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6335355 |
Crop protection products
Plant-protecting mixtures of active ingredients having a synergistically increased action, wherein component I is a compound having a plant-immunizing action of the formula I in which Z is CN,...
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