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7635708 |
Methods and pharmaceutical compositions for inhibiting tumor cell growth
The present invention is based on the finding that activation of PPARγ plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that...
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7582664 |
Acylaminothiazole derivatives, preparation method thereof and use of same in therapeutics
The invention relates to a compound of formula (I):
Wherein R 1 , R 2 , R 2′ , R 3 , R 4 and R 5 are as defined herein. The invention also relates to the use of said compound in therapeutics.
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7528133 |
Use of thiazolidinediones derivatives for preventing uterine contractions in premature labour or lactation
The present invention provides methods of preventing or reducing oxytocin-mediated action by using a thiazolidinedione, such as troglitazone, or thiazolidinedione-like compounds. These methods...
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7498327 |
Indolylalkylamine metabolites as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
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7459473 |
N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres
This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including...
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7411064 |
1-Heterocyclylalkyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor
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7388029 |
Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss,...
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7361687 |
Arylsulphonamide derivatives and methods of preparing
The present invention relates to novel arylsulphonamide compounds, defined by formula I and the description, as well as their method of preparation and their therapeutic use
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7348017 |
Dithiazole compounds, matrix metalloprotease inhibitors and external preparations for the skin
A dithiazole compound or a salt thereof is disclosed. The compound inhibits matrix metalloprotease (MMPs) activity and can be used in pharmaceutical and cosmetic compositions for the treatment of...
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7259179 |
Kinase inhibitors
A compound of the general formula:
or pharmaceutically acceptable salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating protein kinase-associated...
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7223780 |
Triazole-derivatives as blood clotting enzyme factor Xa inhibitors
The present invention is directed to the compound of formula I which is useful for inhibiting the activity of blood clotting enzyme Factor Xa. The present invention is also directed to compositions...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7192940 |
Ether compounds
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias,...
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7129256 |
Antiparkinsonism drugs
A compound represented by the formula:
wherein A is thiazolyl or the like, X is a bond or the like, m is an integer of 0 to 4, Y is optionally substituted alkyl or the like, Z is a substituent...
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7129257 |
Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
Pyrazolo[3,4-e]benzoxazoles and analogues thereof for lowering intraocular pressure and treating glaucoma are disclosed.
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7105556 |
Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
Compounds are provided which have the structure
wherein Q is C or N, X 1 is C or N, and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, A, m, n, X 2 , X 3 and X 4 are as defined herein, which...
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7087621 |
Benzo- and azabenzodithiazole compounds
The present invention provides compounds of formula I
or a pharmaceutically acceptable salt, solvate, prodrug or isomer thereof and compounds of the formula
or a...
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6951878 |
Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases (PTPases)
The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein...
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6936624 |
Agents for preserving technical materials against insects
The use of the compounds of the formula (I)
as agents for preserving technical materials against insects.
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6927215 |
Heterocyclic fluoroalkenyl thioethers and the use thereof as pesticides (I)
The present invention relates to novel heterocyclic fluoroalkenyl thioethers of the formula (I)
in which
X represents hydrogen, halogen or alkyl, m represents integers from 2 to 10, n...
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6841536 |
Prodrugs and conjugates of thiol- and selenol-containing compounds and methods of use thereof
Disclosed is a prodrug of the formula:
where A is a sulfur or a selenium, and R is derived from a mono- di- or oligo- saccharide.
Also disclosed is a prodrug of the formula:
where A is...
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6838439 |
Heterocytes as inhibitors of leucocyte adhesion and as VLA-4 antagonists
The present invention relates to compounds of the formula I
which are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 which belongs to...
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6803379 |
PHARMACOLOGICAL AGENTS AND METHODS OF TREATMENT THAT INACTIVATE PATHOGENIC PROKARYOTIC AND EUKARYOTIC CELLS AND VIRUSES BY ATTACKING HIGHLY CONSERVED DOMAINS IN STRUCTURAL METALLOPROTEIN AND METALLOENZYME TARGETS
The invention relates to the treatment of viral, bacterial, parasitic, proliferative diseases, neurodegenerative diseases, inflammatory diseases, immunological diseases, transplanted organ...
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6780881 |
Freeze-dried pantoprazole preparation and pantoprazole injection
Lyophilized pantoprazole preparations which are obtainable by freeze-drying of an aqueous solution of pantoprazole, ethylenediamine tetraacetic acid and/or a suitable salt thereof, and sodium...
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6777405 |
Detection and treatment of duplex polynucleotide damage
Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions...
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6743817 |
Substituted fused pyrroleimines and pyrazoleimines
Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R 1 and R 2 are defined herein. These compounds are highly selective agonists,...
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6689372 |
Microbicidal active substances
The use of oxathiazolones of formula is described R 1 is phenyl unsubstituted or substituted by one or more C 1 -C 5 alkyl, hydroxyl, halogen substituents or by a 1,3,4-oxathiazol-2-one...
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6669926 |
Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients
Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function...
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6579893 |
Use of troglitazone and related compounds for the treatment of cancer
The present invention is directed toward the use of the drug Troglitazone and related thiazolidinedione compounds in the treatment of the climacteric and cancer. This use is based on the novel...
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6576632 |
Biaryl compounds useful as anticancer agents
The present invention relates to compounds of formula I and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 10 , R 11 , b, m, n, p...
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6537989 |
Azadioxacycloalkene derivatives, methods for the production thereof and their use as fungicides and pest control agents
The present invention relates to azadioxacycloalkenes of the formula I in which the substituents R 1 to R 5 and X, the index n and the bridge member W have the following meanings: R 1 is C 1...
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6531496 |
O-aryl dithiazole dioxides
The invention relates to new O-aryldithiazole dioxides, to two processes for their preparation, and to their use as pesticides in crop protection and in the protection of materials.
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6521650 |
Amines as pharmaceutical agents
Novel gamma aminobutyric acids of formula (I) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders,...
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6518289 |
1-substituted-1-aminomethyl-cycloalkane derivatives (&equals gabapentin analogues), their preparation and their use in the treatment of neurological disorders
Novel amines of formulas (1), (1C), (1F), (1G) and (1H) or a pharmaceutical acceptable salt thereof wherein n is an integer of from 0 to 2; m is an integer of from 0 to 3; R is sulfonamide, amide,...
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6451790 |
Azadioxacycloalkenes and their use for combating harmful fungi and animal pests
Compounds of formula I wherein W is optionally substituted alkylene; Y is N or CR a ; R a is hydrogen, halogen or alkyl; R 1 n represents hydrogen or 1 to 4 substituents; R 2 is hydrogen,...
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6410574 |
Fungicidal composition and method for using the same
The present invention relates to a fungicidal composition obtained by mixing a 1,2,3-thiadiazole derivative of general formula (I) useful as a plant disease controller with at least one fungicide...
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6384056 |
Heterocyclic thioesters or ketones for vision and memory disorders
This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using heterocyclic...
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6358942 |
Phenyloxazolidinones having a c-c bond 4-8 membered heterocyclic rings
A compound of Formula (I): or pharmaceutical acceptable salts thereof wherein X is NR 1 ; R 1 is H, C 1-6 alkyl optionally substituted with one or more OH, CN, or halo, or R 1 is —(CH 2 ) h...
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6339101 |
N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
This invention relates to novel compositions and uses of a N-linked sulfonamide of an N-heterocylic carboxylic acid or isostere thereof for treating a vision disorder or improving vision or...
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6335036 |
Granular pharmaceutical preparation of ebselen
A granular pharmaceutical preparation prepared by granulating finely powdered Ebselen(2-phenyl-1,2-benzisoselenazol-3(2H)-one) using a hydrophilic polymer, and an aqueous suspension thereof. The...
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6326387 |
Methods and compositions for stimulating neurite growth
The present invention relates to methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compositions comprise a neurotrophic amount of a compound which...
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6316476 |
Heterocyclic compounds with antibacterial and antimycotic properties
The invention is drawn to novel antibiotics, XENORXIDES of formula shown below, wherein R 1 , R 2 =hydrogen, substituted or unsubstituted alkyl, cycloalkyl, acyl, aryl, aralkyl, or heterocyclyl...
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6313164 |
Dithiolin derivatives, their preparation and their therapeutic effect
Compounds of the formula (I): ##STR1## wherein one of m and n is 0, and the other is 0, 1 or 2; k is 0 or 1 to 12; R 1 is hydrogen, a substituent which is an aryl or a heterocyclic, or an...
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6291533 |
Dietary supplements for each specific blood type
Dietary supplement compositions designed to be responsive to specific blood types, and thus most beneficial for people with specific antigenic blood types.
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6288092 |
Triaryl compounds
(4-oxy-3-(aryl)phenyl)pyridine compounds, in free or acid addition salt form, are useful as pharmaceuticals for treatment and prophylaxis of inflammation, particularly inflammatory or obstructive...
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6225330 |
Selective NPY (Y5) antagonists (tricyclics)
This invention is directed to tricyclic compounds which are selective antagonists for NPY (Y5) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective...
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6207690 |
Troglitazone compounds for treating climacteric and cancer
The present invention is directed toward the use of the drug Troglitazone and related thiazolidinedione compounds in the treatment of the climacteric and cancer. This use is based on the novel...
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6200997 |
Heterocyclyl-substituted phenyl compounds, processes and intermediates for their preparation and their use for controlling harmful fungi and animal pests
The present invention relates to heterocyclyl-substituted phenyl compounds of the formula I, ##STR1## where the substituents have the following meanings: Y is halogen, C 1 -C 4 -alkyl, C 1 -C...
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6197799 |
Dithiazoldioxides and the use thereof as microbicides
The invention relates to novel dithiazole dioxides, to processes for their preparation and to their use in crop protection and in the protection of materials.
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6136829 |
Oxathiadiazole derivatives usful as iNOS inhibitors
1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
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