Matches 1 - 50 out of 494 1 2 3 4 5 6 7 8 9 10 >
Match Document Document Title
7615548 Method to inhibit ischemia and reperfusion injury  
Methods of treating or inhibiting ischemia and reperfusion injury are provided.
7608244 Hydrophilic light absorbing compositions for determination of physiological function in critically ill patients  
Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function...
7598279 Neurotherapeutic azole compounds  
Azole compounds containing carbamoyl group and pharmaceutically useful salts thereof are described. The compounds are effective anticonvulsants which are used in the treatment of disorders of the...
7582664 Acylaminothiazole derivatives, preparation method thereof and use of same in therapeutics  
The invention relates to a compound of formula (I): Wherein R 1 , R 2 , R 2′ , R 3 , R 4 and R 5 are as defined herein. The invention also relates to the use of said compound in therapeutics.
7579389 Antimicrobial acrylic polymer  
An antimicrobial additive composition is provided which economically and efficiently imparts antimicrobial characteristics to acrylic polymers, and particularly thermoformable acrylic sheets made...
7576103 Tetralin and indane derivatives and uses thereof  
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R 1 and R 2 are as defined herein. Also provided are methods for preparing, compositions...
7572816 Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders  
The present invention is directed to compounds having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic agents...
7569606 Platinum complexes with mononitrile-containing ligands  
Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming...
7560483 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof  
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
7547718 Substituted imidazoles  
This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such...
7538128 Dipeptidyl peptidase IV inhibitors, process for their preparation and compositions containing them  
The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula: wherein X, Y, a, R 1 , and R 2 are as defined herein.
7531560 Anti-cytokine heterocyclic compounds  
Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving...
7531559 Fungicidal 1,2,3 triazole derivatives  
A compound of formula (I):, where A is an ortho-substituted ring selected from a number of specified rings; R 1 is halogen, cyano, nitro, C 1-4 alkyl, C 1-4 haloalkyl, C 1-4 alkoxy or C 1-4 ...
7524875 Modified bio-related substance, process for producing the same, and intermediate  
A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having...
7524516 Corrosion inhibiting mildew remover kit  
The corrosion inhibiting mildew remover kit includes a premeasured amount of sodium perborate, a premeasured amount of a liquid inhibitor and a premeasured amount of a liquid blend. The premeasured...
7521563 Hydroxamic acid derivative and medicine containing the same as active ingredient  
A compound which inhibits the production of IL-6 and/or TNFα by inflammatory cytokines and is useful in the prevention of or treatments for diseases such as various inflammatory diseases in which...
7521464 Pyrazole compounds for treatment of neurodegenerative disorders  
The invention provides compounds of Formula I: wherein R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 8 and A are as defined. Compounds of formula I have activity inhibiting production of Aβ-peptide....
7514457 Substituted aryloxymethyl bicyclicmethyl acetamide compounds  
Compounds of the general formula (I): pharmaceutical compositions comprising a compound of general formula (I); and methods of treating disease conditions caused by overactivation of the VR1...
7511152 Estrogen receptor modulators  
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen...
7511042 Triazole compounds  
Disclosed are compounds of formula (I) Where Ar 1 , X, R 3 , R 4 , R 5 and R 6 are defined herein. The compounds of the invention inhibit production of cytokines and are thus useful for...
7507833 Therapeutic N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives  
A compound having a structure and therapeutic methods, compositions, and medicaments related thereto are disclosed herein.
7507755 Inhibitors of cathepsin s  
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
7504519 Derivatives of pyrazoline, procedure for obtaining them and use thereof as therapeutic agents  
The invention relates to derivatives of general formula (I), and to their pharmaceutically acceptable salts, their stereoisomeric forms, preferably their pure enantiomeric or diastereomeric forms...
7495111 Compounds useful as serotonin inhibitors and 5-HT1A agonists and antagonists  
3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Such compounds are useful for modulating activity of a 5-HT 1A receptor (agonizing or...
7495019 Benzoisoselenazole derivatives with anti-inflammation, antivirus and antithrombosis activity and their use  
The present invention relates to new bisbenzisoselenazolonyl derivatives of the following general formulae (I), (II) or (III) and their pharmaceutically acceptable salts. The inventive derivatives...
7494670 Composition and process for removing and preventing mildew and fungal growth  
This invention comprises a composition and the process of using the composition for removing and preventing mold, mildew, and fungal growth. The composition comprises at least one alkali metal...
7491831 PPAR active compounds  
Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
7482475 Therapeutic lactams  
Disclosed herein is a compound having a structure Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
7482472 Substituted isoindoles and their use  
The invention relates to coagulation of the blood. Disclosed are novel compounds of formula (I), a method for the production of these compounds, pharmaceutical compositions containing them, and...
7476763 Oxo-substituted cyclohexyl-1,4-diamine compounds  
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I: methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
7476747 Substituted gamma lactams as therapeutic agents  
A compound comprising or a pharmaceutically acceptable salt, prodrug, or a metabolite thereof is disclosed herein. Y, A, and B are as described herein. Methods, compositions, and medicaments...
7468437 Phenyl pyrrolidine ether tachykinin receptor antagonists  
The present invention is directed to certain phenyl pyrrolidine ether compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular...
7465811 Indoline compounds  
Sulfonylindoline compounds of formula I, wherein R1 through R4, Y and Z have defined meanings, a process for preparation of such compounds, and the use as pharmaceutically active substances,...
7465748 Amide derivative  
There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus...
7465718 Ansamycins having improved pharmacological and biological properties  
Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and...
7459471 Inclusion compound comprising cucurbituril derivatives as host molecule and pharmaceutical composition comprising the same  
The present invention provides an inclusion compound having a cucurbituril derivative of the formula 1 as a host molecule and a metal complex of the formula 2 as a guest molecule. A pharmaceutical...
7452899 Gamma-secretase inhibitors  
Compounds of Formula (I): inhibit the processing of APP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
7432291 Ether derivatives  
The present invention provides the compounds of formula (I) their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the...
7432290 Inhibitors of IMPDH enzyme  
The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions...
7411064 1-Heterocyclylalkyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands  
The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor
7408071 N-aryl pyrrolidine derivatives as beta-secretase inhibitors  
There is provided a series of substituted N-aryl pyrrolidine derivatives of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R...
7405231 Oxidized thioether derivatives  
The present invention provides the compounds of formula I their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the...
7396844 Benzamidine derivatives  
Benzamidine derivatives of the following formulae or analogs thereof, i.e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation...
7390506 Lipophilic drug compositions  
The invention is directed to biologically active lipophilic compositions comprising a biologically active covalently attached to, or encapsulated within, a lipid. Preferably, a biologically active...
7388029 Compositions and methods for treating hair loss using non-naturally occurring prostaglandins  
A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss,...
7381739 2,4-substituted indoles and methods of use  
The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R 1 , R 2 , R 3 , R 4 , p and n are those defined herein. The present...
7371769 Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites  
The present invention relates to a group of novel tetrahydropyridin-4-yl indoles with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine-D 2 receptors, to methods for...
7358265 Oxa-and thiadiazoles and their use as metalloproteinase inhibitors  
Compounds formula (IA) or (IB), wherein W represents HO(C═O)—, HONH(C═O)— or H(C═O)N(OH)—; X represents —O— or —S—; and R 1 , R 2 , and R 3 are as defined in the description...
7348333 Cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists  
There are described cycloalkyl derivatives of the formula (I) R 1 —Y-A-B-D-E-F-G (I)
7342030 Indole derivatives  
The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned...
Matches 1 - 50 out of 494 1 2 3 4 5 6 7 8 9 10 >