Matches 401 - 450 out of 497 < 1 2 3 4 5 6 7 8 9 10 >
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4925860 Stable pharmaceutical composition of 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester  
Described is a stable pharmaceutical composition of 3-(hydroxymethyl-5,5-diphenylhydantoin disodium phosphate ester, the prodrug of 5,5-diphenylhydantoin (phenytoin) a commonly used drug for the...
4923885 5-amino-1-(4-naphthoylbenzyl)-1,2,3-triazole-4-carboxamides and analogs as antiproliferative agents  
Novel 5-Amino-1-(4-Naphthoylbenzyl)-1,2,3-triazole-4-carboxamides and analogs are disclosed as having antiproliferative activities useful in the treatment and control of psoriasis, inflammatory...
4904681 D-cycloserine and its prodrugs as cognitive enhancers  
The compound D-4-amino-3-isoxazolidone, its pharmaceutically-acceptable salts and its prodrug compounds are described as having cognitive-enhancing activity.
4898889 Methods for the treatment of hypertension  
Acetylene compounds of the formula (I): ##STR1## wherein Y, R 1 , R 2 , R 3 , and R 4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The...
4886803 Benzimidazole derivatives  
Compounds are described of formula (I) ##STR1## wherein R 1 is a hydrogen atom, an alkyl group, an alkoxy group, a dialkylamino group or a halogen atom; n is 1 to 4; R 2 is a hydrogen atom, an...
4880805 Use of alkylenediamine derivatives for the treatment of blood flow disturbances and pharmaceutical compositions containing them  
The present invention is concerned with the use of compounds of the general formula: ##STR1## wherein A is an optionally substituted phenyl or heteroaromatic radical, R 6 and R 7 are hydrogen or...
4863940 N-acetonyl-substituted amides and phytopathogenic fungicidal use thereof  
Certain N-acetonyl-substituted-amides of the formula: ##STR1## wherein A is a heterocycle, a phenylalkyl, a phenylalkoxy, naphthyl, cycloalkyl, alkoxyalkyl, alkyl, haloalkyl or alkenyl group; X, Y...
4853381 Ethanolamine compounds  
The invention provides compounds of the general formula (I) ##STR1## wherein Ar represents a phenyl group optionally substituted by one or more substituents selected from halogen atoms, or the...
4845090 Nitroxyl compound and diagnostic media based thereon useful for enhancing NMR imaging  
Diagnostic media suitable for NMR diagnoses contain compounds of Formula I ##STR1## wherein is a single bond or a double bond, X is the grouping --(CH 2 ) n -- or, if is a single bond, also...
4835167 Tricyclic benzotriazoles, processes for the preparation thereof and pharmaceutical compositions containing them  
The present invention provides new tricyclic benzotriazoles of the general formula: ##STR1## wherein Z is a hydrogen atom or an acyl radical, Y is an oxygen or sulphur atom or two hydrogen atoms...
4831032 Cardiotonic benzimidazoles  
The present invention provides benzimidazoles of the general formula: ##STR1## wherein R 1 , X, A, and R 2 are as defined in the specification. The present invention also provides processes for...
4829074 Azolyl substituted aralkyl compounds and pesticidal use thereof  
Compounds of the formula: ##STR1## The compounds are useful as pesticides, particularly insecticides.
4826847 Beta-blocking oxindole derivatives  
The present invention provides oxindole derivatives of the formula: ##STR1## wherein the various substituents are defined hereinbelow. The above compounds display nitrate-like as well as...
4820721 1-aryl-5-(2-oxo-1-pyrrolidinyl)-1,2,3-triazolines as novel anticonvulsants  
Anticonvulsant compounds are of the formula: ##STR1## wherein R 1 is 2-oxo-1-pyrrolidinyl, and R 2 is hydrogen or p-chloro. They are prepared by the reaction of a phenyl azide with...
4816471 Substituted heterocyclic benzamides, methods of preparing them and their application as anti-emetics  
There are provided substituted heterocyclic benzamides and derivatives thof which exhibit strong anti-emetic properties.
4801594 Aromatase inhibitors  
This invention provides azole derivatives, their pharmaceutical formulations, and their use in methods of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals.
4795755 Heterocyclic derivatives  
This invention relates to heterocyclic derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative...
4789680 Aralkyltriazole compounds  
1-phenyl-lower alkyl-1H-1,2,3-triazole compounds of the formula ##STR1## in which Ph represents phenyl substituted by up to and including 3 substituents selected from lower alkyl, halogen and...
4789686 Process for the preparation of an aqueous solution of the sodium salt of methionine  
A concentrated aqueous solution of the sodium salt of methionine, which is practically free from inorganic salts, is produced from the medium resulting from the hydrolysis of...
4780317 Sustained release antimicrobial agents and method of fouling control using the same  
A sustained release antimicrobial agent comprises a clathrate compound composed of a water-soluble microbicide and at least one of the compounds shown at (I) to (V) below: (I)...
4778815 Method of inhibiting cataracts by topical application of a 2-substituted 1,2-benzisoselenazol-3(2H)-one  
A method of inhibiting cataract formation occasioned by the oxidative cross-linking of proteinaceous material in the lens fiber of the eye of a mammal comprising the topical administration of an...
4778814 Method of treating ocular allergy by topical application of a 2-substituted-1,2-benzisoselenazol-3(2H)-one  
A method of treating an ocular allergy in a mammal comprising the topical application of an effective anaphylactic inhibiting amount of a compound of the formula: ##STR1## wherein R is phenyl or...
4774252 Benzisoselenazolonyl derivatives and processes for the treatment of rheumatic disease  
The present invention relates to new benzisoselenazolonyl derivatives of the general formula (I) ##STR1## and processes for the treatment of rheumatic diseases.
4772587 Dipeptide derivative of fatty acid  
A novel compound that exhibits inhibitory activity against prolyl endopeptidase and a method for chemical synthesis of said compound, as well as its use as a prolyl endopeptidase inhibitor and an...
4769383 Dioxonaphthotriazoles having antiallergic activity  
A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein R 1 is a hydrogen atom or a C 1 -6 alkyl group, R 2 , R 3 and R 4 are the same or different and are...
4765985 Devices and methods for treating memory impairment  
A device for the transdermal administration of a drug for the treatment of memory impairment comprising: (a) a drug impermeable backing layer; (b) a drug permeable rate controlling membrane...
4759923 Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives  
It has been found that certain derivatives of poly(diallylmethylamine) are therapeutically effective serum cholesterol lowering agents.
4752611 Anticoccidial 1,2,3-trazole compounds  
There are disclosed certain 1,2,3-triazole compounds with a substituted benzyl group at the 1-position, an amido group at the 4-position and a aminomethylene amino group at the 5-position. The...
4740516 Substituted t-butanol fungicidal agents  
A method of combating plant pathogenic fungi which comprises administering to such fungi or to a habitat thereof a plant pathogenic fungicidally effective amount of a substituted tert.-butanol...
4734427 Fungicidal phenylsulphonyl imidazoles  
The phenylsulphonylazoles of the formula ##STR1## in which R 1 represents alkyl, m represents the number 1 or 2, n represents the number 0 or 1, and R 2 represents a radical of the...
4713393 Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents  
Phenylalkyl-2,3-dihydrobenzofurans and analogs were prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a...
4711902 Medicament formulation  
A medicament formulation of intravenous injection comprising a medicinally active compound, a lipid phase, an emulsifier and water, the lipid phase being present in up to about 30% by weight, the...
4701207 Phenyl (phenoxy or phenylthio) azolomethanes  
Disclosed are aryl(aryloxy or arylthio) azolomethanes, their preparation and their pesticidal and plant growth regulation uses.
4696922 5-azolylacetoxymilbemycins as ecto- and endoparasites  
The present invention relates to milbemycin derivatives of the formula I ##STR1## wherein X is hydrogen or β-halogen, R is methyl, ethyl, isopropyl or sec-butyl and Az is a 5 membered heterocyclic...
4695567 Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases  
The present invention provided pyrrolobenzimidazoles or tautomer thereof, of the general formula: ##STR1## wherein R 1 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 3 -C 7 cycloalkyl; ...
4683228 Guanidinopyrazolylamides, guanidimoimidazolylamides, compositions containing them, and method of using them to inhibit gastric acid secretion  
A guanidine derivative of the formula I: ##STR1## in which R 1 , R 2 , R 3 , R 4 , ring X and D are a variety of radicals defined in the specification and A is a 3-8C alkylene chain which is...
4663335 Trans-(+)-2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]a c  
The trans(+)-2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidiny l)cyclohexyl]a cetamide enantiomer, and salts thereof, have been found to be useful as Central Nervous System anti-seizure drugs, at...
4654374 Chemical disinfectant and sterilant  
The invention is an improved disinfectant and sterilant in a chemical form. The disinfectant and sterilant formulation is based upon glutaraldehyde which must be in acidic form. The normal pH range...
4644021 Sustained release antimicrobial agents and methods of fouling control using the same  
Sustained release antimicrobial agents comprising a clathrate compound composed of a water-soluble antimicrobial agent, and 1,1,6,6-tetraphenyl-2,4-hexadiyne-1,6-diol or...
4642309 Indolin-2-one derivatives preparation thereof and intermediates for the preparation thereof  
The present invention provides indolin-2-one derivatives of the general formula: ##STR1## wherein R 1 is a C 1 -C 6 alkyl radical or a radical of the general formula: ##STR2## in which A is a...
4636505 Amide derivatives  
Acylanilides of the formula ##STR1## wherein R 1 and R 2 , the same or different, each is cyano, carbamoyl, nitro, halogeno, perfluoroalkyl or other defined substituents; R 3 is hydrogen or...
4610994 1,2,3-triazole anticonvulsant drugs  
Anticonvulsant compositions comprise as the active ingredient a compound selected from the group consisting of those of the formulae: ##STR1## wherein R 1 is phenyl, 4-pyridyl, 3-pyridyl, or...
4609666 Aromatase inhibiting derivatives of α,α-bis(4-halophenyl)methyltetrazoles and triazoles  
This invention provides certain azole derivatives, their pharmaceutical formulations, and a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals.
4607043 Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-carboxylic acids and derivatives as cognition activators  
Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-alkanoic acids, base addition salts, esters, and amides are useful as agents for the reversal of amnesia. Pharmaceutical compositions containing said...
4599348 1-azolyl-substituted oxime ether fungicides  
Combating fungi with novel 1-azolyl-substituted oxime ethers of the formula ##STR1## in which R is alkyl, alkoxyalkyl, alkenyl, alkinyl or cycloalkyl; or aralkyl, phenoxyalkyl or phenyl optionally...
4581367 1-phenyl-2-(heterocyclyl-alkyl-amino)-ethanols  
Compounds of the formula wherein Het is a heterocycle; n is an integer from 1 to 4, inclusive, preferably 2 or 3; R 1 is H or acyl; R 2 is H, R 1 O, --NHSO 2 R 7 , --NHCOR 8 ,...
4578388 Unsymmetrical guanidino, thioureido, isothioureido and nitromethyleneamino derivatives  
The compounds are C 2 -C 8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino). N-(N'-substituted...
4563455 Antiulcer fused imidazole compounds  
New fused imidazole compounds of the formula: ##STR1## wherein A is lower alkylene, R 1 is hydrogen, lower alkyl, lower alkoxy or halogen, R 2 is hydrogen, lower alkyl, cyclo(lower)alkyl,...
4560688 Tricyclic antihistamines  
Antihistamines of the formula ##STR1## wherein ##STR2## is a 5 or 6 membered ring which is phenyl or heterocyclic; ##STR3## is a six membered ring which is 2,3, or 4 pyridyl or is phenyl or...
4560694 Fungicidal alkylene(cycloalkylene)-bis-heterocyclyl-biguanides  
Alkylene(cycloalkylene)-bis-heterocyclyl-biguanides of the formula ##STR1## in which A and B each independently is a nitrogen-containing heterocyclic radical which is linked via a nitrogen atom, ...
Matches 401 - 450 out of 497 < 1 2 3 4 5 6 7 8 9 10 >