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6352985 |
Benzimidazole compounds
A benzimidazole compound represented by the formula (I): wherein R 3 is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl...
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6344485 |
Method for treating glaucoma
Methods of using prostaglandin agonists for the reduction of intraocular pressure, and accordingly glaucoma.
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6339100 |
Methods for inhibiting mastocytosis
A method of preventing or treating in a subject mastocytosis which comprises administering to the subject a therapeutically effective amount of a compound having the structure: or a...
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6319949 |
Pesticidal sprays
A method for preventing fungal diseases in crops which comprises the steps of: (a) applying to a crop an aqueous or a non-aqueous spray composition which includes a pesticide and a spray adjuvant...
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6306848 |
Method of modifying wrinkles using guanidine derivatives
The invention relates to wrinkling modifiers and anti-aging cosmetic compositions which each comprise a guanidine derivative represented by the following general formula (1): ##STR1## wherein...
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6294559 |
Antiproliferative agents associated with peroxisome proliferator activated receptors gamma1 and gamma2
This invention is directed to compounds and ligands that bind to peroxisome proliferator activated receptors (PPAR) γ1 and γ2 and which function as antiproliferative, antiviral and antitumour...
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6248769 |
Phenyl-triazole compounds for PDE-IV inhibition
Novel compounds which are effective PDE IV inhibitors are disclosed. These compounds have the general structure of: ##STR1## where R 1 , R 2 , R 3 , R 4 , X 1 , X 2 and Z are described herein. The...
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6248159 |
Wood preservative
A wood protecting agent, particularly for the protection of wood against dry-wood-destroying insects is provided. The wood protecting agent comprises a wood preservative carrier and the combination...
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6245734 |
Physiologically active polyoxypeptin and deoxypolyoxypeptin and anticancer drugs containing the same
As novel substances having an activity of inducing an apoptosis even on the apoptosis-resistant cancer cells, there are obtained polyoxypeptin and deoxypolyoxypeptin represented by the following...
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6239175 |
Carbamoyloxy derivatives of mutiline and their use as antibacterials
Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R 1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is...
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6239151 |
Compounds as inhibitor of tumor necrosis factor alpha release
The invention provides hydrazine derivatives of the formula ##STR1## wherein R 1 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R 2 is an...
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6239137 |
Salts of aminoimidazole carboxamide and 5 amino or substituted amino 1,2,3-triazole, induce apoptosis, inhibit DNA synthesis and control cyclooxygenase activity
Compositions and methods are described for the induction of apoptosis inhibition of DNA synthesis, and/or inhibiting COX-2 activity using an effective amount of salts of aminoimidazole carboxamide,...
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6225329 |
Modulators of protein tyrosine phosphatases (PTPases)
The present invention provides novel compounds of Formula 1, compositions containing these compounds, methods of their use, and methods of their manufacture, where such compounds are...
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6218373 |
Formulations containing hyaluronic acid
A method of treating a disease of condition administering topically to the skin or exposed tissue of a human, a dosage amount of a pharmaceutical composition, said dosage comprising a...
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6187800 |
Method for the prevention and treatment of mastitis
A method for treating or preventing mastitis in mammals is disclosed. The method contemplates the intramammary injection or dipping the teat with micrococcin antibiotics, preferably micrococcin P1...
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6184241 |
Aspartic protease inhibitors
The present invention is directed to aspartic protease inhibitors, in particular to HIV protease, renin, pepsin and cathepsin D inhibitors. Inhibitors of the present invention have a 3 to...
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6180133 |
Antioxidant composition for topical/transdermal prevention and treatment of wrinkles
An anti-wrinkle skin treating composition comprises a pressure sensitive matrix patch having dissolved in the adhesive a mixture of antioxidants in the form of a Vitamins C ester and Vitamin E....
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6166028 |
Diaminopuridine-containing thiourea inhibitors of herpes viruses
Compounds of the formula ##STR1## are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus,...
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6156775 |
Use of fluorinated triazoles in treating affective and attention disorders
The present invention relates to the use of fluorinated triazoles in treating affective disorders.
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6150371 |
Method for preventing and for treating autoimmune disease
A method for preventing or treating autoimmune diseases (excluding type I diabetes) by administering an insulin resistance improving substance as an active ingredient.
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6143757 |
Chemical compounds
Compounds of the general structural formula ##STR1## and use of the compounds and salts and solvates thereof, as therapeutic agents.
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6143776 |
Tosylproline analogs as thymidylate synthase inhibitors
Tosylproline analogs of formula I, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are thymidylate synthase inhibitors; and are useful...
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6130212 |
Use of novel organoselenium compounds as pro-oxidizing agents, their methods of preparation and pharmaceutical compositions and application thereof
Compounds represented by the following formula I: ##STR1## in which: R 1 to R 5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is...
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6123954 |
Apparatus and method for inhibiting microbial growth in an aqueous medium
A method of inhibiting microbial growth in wash water contained in a photoprocessing system. The method comprises placing in the wash water an apparatus comprising a pump with an attached permeable...
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6123756 |
Wood-protecting agent
The invention concerns a wood-protecting agent, particularly for the protection of wood against dry-wood destroying insects, which comprises a wood preservative carrier and (I) the combination of...
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6121299 |
Modulating inflammation with cytochrome P-450 activators and inhibitors
This invention relates to methods of modulating inflammation in mammals. Inflammation is modulated by regulating the cytochrome P-450 pathway. Inflammation is reduced by treating the subject with...
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6121298 |
Antibacterial and mildewproofing organopolysiloxane composition
An antibacterial and mildewproofing organopolysiloxane composition comprising (A) an organopolysiloxane such as polydimethylsiloxane terminated with silanol groups or polydimethylsiloxane...
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6107316 |
Method for treating protozoal infections
A method for treating protozoal infections is described. The method employs N-acetonylbenzamide compounds provided in an effective amount to inhibit the growth of protozoans. The compounds are...
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6103700 |
Fluoro labelled anthracyclinone and anthracycline derivatives
Compounds of formula (A), wherein R 1 , R 2 , R 3 , Y and Z are organic substituents, are useful in the diagnosis of amyloidosis; some of the compounds of formula (A) are novel. Processes for their...
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6103131 |
Methods for controlling biofouling using sulfamic acids
The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one sulfamic acid or...
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6093714 |
Tricyclic benzazepine compounds
Tricyclic benzazepine compounds represented by the following formula (I) and pharmacologically acceptable salts thereof are disclosed. These compounds have antiallergic activity and are useful for...
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6093735 |
Selective β-3 adrenergic agonists
The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective β3 adrenergic...
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6083965 |
N-aryl-1,2,3-triazole compounds for pharmaceutical and veterinary application
Compounds of formula (I): ##STR1## wherein the substituents are as defined herein, are antiparasitic agents.
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6080770 |
Modulators of molecules with phosphotyrosine recognition units
The present invention relates to novel organic compounds, to methods for their preparation, to compositions containing them, to their use for treatment of human and animal disorders, to their use...
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6077861 |
Diphenyl triazoles as potassium channel modulators
Novel compounds of Formula 1 are useful to treat disorders responsive to openers of the large conductance calcium-activated potassium channels: ##STR1## wherein "Het" is one of a select group of...
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6066662 |
Hydroxylamine derivatives and their use as metalloproteinase inhibiting agents
The invention provides hydroxylamine derivatives of formula (I) wherein A, R 1 , R 2 and R 3 have the significance given in the description, which are matrix metalloproteinase inhibitors and...
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6063734 |
Etylene derivatives and pesticides containing said derivatives
Ethylene derivatives of formula (I): ##STR1## where Q is an unsubstituted or substituted phenyl or heterocyclic group, especially a 4-thiazolyl, 1- or 3-pyrazolyl, 1,3-oxazol-4-yl, phenyl or...
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6057346 |
Inhibition of retroviral LTR promoters by calcium response modifiers
A class of calcium-response modification compounds is disclosed which inhibits the activation of retroviral LTR promoters, including the HIV-LTR. This class of compounds are used to delay or...
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6054471 |
Use of fluorinated triazoles in treating neuropathic pain
The present invention relates to the use of fluorinated triazoles in treating neuropathic pain.
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6051573 |
Treatment of GLC1A glaucoma with non-steroidal glucocorticoid antagonists
Compositions of non-steroidal glucocorticoid antagonists for treating GLC1A glaucoma and methods for their use are disclosed.
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6043261 |
Pyrrolodino imidines useful as nitric oxide synthase inhibitors
The current invention discloses useful pyrrolodino imidine derivatives useful as nitric oxide synthase inhibitors.
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6030984 |
Pyridone compounds useful in treating Alzheimer's disease
The invention is concerned with the use of bi- and tricyclic pyridone compounds of the formula where A, R 1 , R 3 , R 4 , and R 7 are described herein and of their pharmaceutically acceptable...
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6017900 |
Topical composition containing hyaluronic acid and nsaids
A pharmaceutical composition comprising a plurality of effective non-toxic dosage amounts of a composition for topical administration to the site of pathology or trauma of skin or exposed tissue of...
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6015808 |
Synthesis of pharmaceutical compositions with lactams and β-lactams/oxo thia azabicyclo compounds
Pharmaceutical compositions with heretofore unknown and enhanced physical, chemical, and biological properties are prepared by combining known biologically active parent compounds with oxo thia...
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6013643 |
Mildew resistant organopolysiloxane compositions
A mildew resistant organopolysiloxane composition is provided, including (A) an organopolysiloxane having silanol groups or alkoxyl groups, (B) a hydrolyzable silane, and (C) a triazolyl...
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6008219 |
Bicyclic amine derivatives and their use as anti-psychotic agents
This invention relates to compounds of formula (I) ##STR1## which are useful as modulators of D 3 receptors, in particular as antipsychotic agents.
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5977154 |
Selective β3 adrenergic agonist
The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective β3 adrenergic...
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5968920 |
Compounds having a benzisoselen-azoline and -azine structure, method for preparing same and therapeutic uses thereof
The invention concerns novel benzisoselen-azoline and -azine derivatives. These novel derivatives have the following general formula (II): ##STR1## where: R 1 to R 8 and R 10 have various...
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5965565 |
Piperidines promote release of growth hormone
The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R 1 , R 1a , R...
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5962484 |
Photoprotective/cosmetic compositions comprising substituted polyorganosiloxanes/polyorganosilanes
Topically applicable sunscreen/cosmetic compositions well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar...
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