|
Match
|
Document |
Document Title |
|
|
7078400 |
20-HETE synthase inhibitor
The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or...
|
|
|
7078421 |
Substituted phenylacetic acids
Substituted phenylacetic acids, phenylethanols and related compounds are provided that are useful in treating or controlling a number of diseases associated with glucose metabolism, lipid...
|
|
|
7045532 |
ACE-2 modulating compounds and methods of use thereof
ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include...
|
|
|
7045535 |
Compounds useful for inhibiting paramyxovirus neuraminidase
Certain cyclic compounds are presented as well as their use for inhibiting paramyxovirus neuraminidase. The compounds are represented by the following formulas:
|
|
|
7041687 |
Indazole compounds useful as protein kinase inhibitors
The present invention provides compounds of formula I:
or a pharmaceutically acceptable derivative thereof, wherein R 1 , R 2 , V 1 , V 2 , and V 3 are as described in the specification. These...
|
|
|
7030119 |
Method for treating chronic pain using MEK inhibitors
The invention features a method for treating chronic pain using a compound of formula (I).
|
|
|
7030140 |
Substituted benzimidazole antiviral agents
The present invention concerns antiviral compounds, their compositions, and use in the treatment of viral infections. More particularly, the invention provides benzimidazole derivatives for the...
|
|
|
7019003 |
Peptide deformylase inhibitors
Novel PDF inhibitors and novel methods for their use are provided.
|
|
|
7008903 |
Pesticide
The present invention provides a composition comprising synergistic amounts of a compound of the formula (I)
wherein X, E, R, A and Z are as defined herein, and at least one fungicidal active...
|
|
|
6995154 |
Heterocyclic topoisomerase poisons
The invention provides compounds of formula I:
wherein R 1 to R 5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds,...
|
|
|
6984633 |
Method to treat cardiofibrosis with a combination therapy of an angiotensin II antagonist and epoxymexrenone
A therapeutic method is described for treating cardiofibrosis or cardiac hypertrophy using a combination therapy comprising a therapeutically-effective amount of an angiotensin II receptor...
|
|
|
6974801 |
Inhibitors and methods of use thereof
New triterpenoid derivatives with various substituents at the C-17 position of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) were synthesized. Among them,...
|
|
|
6967196 |
Sulfonamide compounds and uses thereof
In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the...
|
|
|
6962936 |
Triazole-derived kinase inhibitors and uses thereof
Described herein are compounds that are useful as protein kinase inhibitors having the formula:
where Ht, R 2 , T, and m are as described in the specification. The compounds are useful...
|
|
|
6949556 |
Acylated 1,2,3,4-tetrahydronaphthyl amines and their use as pharmaceutical agents
The present invention relates to compounds of general formula (I),
wherein R 1 -R 4 have the meanings given in the specification, A is CH2, CHOH or CH—(C 1 -C 3 -alkyl), B and C are...
|
|
|
6946468 |
3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
The present invention relates to inhibitors of ras farnesylation of the Formula I
wherein:
R 1 is for example H and further values as defined in the specification; R 2 is for example...
|
|
|
6936596 |
Adenosine derivatives and use thereof
2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent...
|
|
|
6908732 |
Compounds and methods for regulating cell differentiation
The present invention makes available methods and reagents for inhibiting cell growth or promoting cell differentiation comprising contacting the cell with a differeguline in a sufficient amount to...
|
|
|
6903125 |
Tetrahydro-2H-thiopyran-4-carboxamide derivative
A pharmaceutical drug, particularly a novel compound useful for the prophylaxis or therapeutic treatment of various diseases involving infections with viruses of the Herpesviridae family,...
|
|
|
6900218 |
Pyruvate derivatives
Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation....
|
|
|
6897208 |
Benzimidazoles
The invention is directed to physiologically active compounds of the general formula (Ix)
and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts...
|
|
|
6894063 |
Substituted urea neuropeptide Y Y5 Receptor antagonists
A novel class of compounds such as antagonists of the neuropeptide Y Y5 receptor, methods of making such compounds, pharmaceutical compositions containing one or more such compounds, methods of...
|
|
|
6884811 |
Antifungal composition
An antifungal composition comprising 3-iodo-2-propynyl butylcarbamate, 4,5-dichloro-2-octyl-isothiazolin-3-one and methyl 2-benzimidazolylcarbamate is useful as industrial antifungal composition,...
|
|
|
6881745 |
Pharmaceutical compositions for poorly soluble drugs
The present invention provides a pharmaceutical composition of a practically insoluble drug, wherein the composition may be administered with food or without food. The composition may be in the...
|
|
|
6875439 |
Formulation containing amphipathic weak base and/or amphipathic cation and multiple drug resistance inhibitor
Methods are provided relating to the enhanced cytoplasmic accumulation of amphipathic weakly basic or amphipathic cationic molecules in prokaryotes and eukaryotes under conditions of high...
|
|
|
6872736 |
Non-aqueous emulsifiable concentrate formulation
The invention relates to a non-aqueous, emulsifiable concentrate (EC) formulation for crop protection active compounds which comprises
(a1) 50 to 300 g/L of at least one azole derivative having a...
|
|
|
6867229 |
Antiparasitic composition for the treatment and protection of pets
Composition which is useful in particular for the treatment and protection of domestic animals which are infested with parasites or are likely to be infested with them, these compositions...
|
|
|
6864254 |
Inhibitor for 20-hete-yielding enzyme
An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is...
|
|
|
6861431 |
Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same
Methods of modulating the activity of multidrug transporters are disclosed. The methods of modulating the activity of multidrug transporters use compounds that selectively increase or decrease the...
|
|
|
6861441 |
Use of EP4 receptor ligands in the treatment of neuropathic pain and colon cancer
The present invention relates to the use of an EP4 receptor ligand in the manufacture of a medicament for use in the treatment of neuropathic pain, colon cancer, migraine, and for increasing the...
|
|
|
6858607 |
7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I:
or pharmaceutically acceptable salts or prodrugs thereof, wherein:
...
|
|
|
6849648 |
Phenylene alkyne matrix metalloproteinase inhibitors
A compound of Formula I
or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G 1 , G 2 , and B are as defined in the application, are selective inhibitors of...
|
|
|
6846807 |
Colorectal neoplasia prophylaxis
Development of colorectal neoplasia in a patient subject or predisposed to colorectal neoplasia is reduced by the steps of (a) determining a patient is subject or predisposed to colorectal...
|
|
|
6846839 |
Methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis
The present invention relates to methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis. More specifically, this invention relates to methods for...
|
|
|
6841563 |
Aryloxy propanolamines for improving livestock production
Disclosed is a compound represented by structural formula (I): R1 is a substituted or unsubstituted aryl group. R2 and R3 are independently —H, a C1-C4 straight chained or branched alkyl group....
|
|
|
6815459 |
Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
The present invention provides novel seleno compounds containing nitrone moiety, a process for preparing the same, the use of the novel compounds as therapeutics for treating and/or preventing...
|
|
|
6812239 |
Method of identification of inhibitors of PDE1C and methods of treatment of diabetes
The present invention provides a method of identifying novel agents that increase glucose dependent insulin secretion in pancreatic islet cells as well as methods of treating diabetes using the...
|
|
|
6797721 |
Phorboxazole derivatives for treating cancer
Synthetic Phorboxazole A and derivatives thereof for the treatment of cancer, including inhibition of cancer cell growth, induction of apoptosis, and inhibition of metastises.
|
|
|
6780881 |
Freeze-dried pantoprazole preparation and pantoprazole injection
Lyophilized pantoprazole preparations which are obtainable by freeze-drying of an aqueous solution of pantoprazole, ethylenediamine tetraacetic acid and/or a suitable salt thereof, and sodium...
|
|
|
6777418 |
Retinoid compounds (I)
The current invention provide novel retinoid compounds and methods for their synthesis, methods of treating or preventing emphysema, cancer and dermatological disorders and pharmaceutical...
|
|
|
6767918 |
N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions...
|
|
|
6762197 |
Difluoromethyltriazolone compounds, use of the same and intermediates for the production thereof
A triazolone compound of the formula [I]: wherein; R 1 represents optionally substituted phenyl or the like, T represents m-phenylene optionally substituted by methyl or the like; and a...
|
|
|
6759408 |
Combination regimens using progesterone receptor modulators
This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general...
|
|
|
6743817 |
Substituted fused pyrroleimines and pyrazoleimines
Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R 1 and R 2 are defined herein. These compounds are highly selective agonists,...
|
|
|
6740669 |
Crystal modification of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and its use as antiepileptic
The invention relates to the novel modification A or A′ of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide of the formula its use and pharmaceutical preparations comprising...
|
|
|
6730312 |
Pesticidal composition for seed treatment
The present invention provides an at least quaternary composition for controlling insects or representatives of the order Acarina and microorganisms, which composition comprises: (A) an...
|
|
|
6726937 |
Antifungal composition
The present invention provides use of a composition containing 2-n-octyl-4-isothiazolin-3-one and N-n-butyl-1,2-benzisothiazolin-3-one for providing antifungal efficacy to a wood preservative...
|
|
|
6716841 |
Nitrogen containing heterobicycles as factor Xa inhibitors
This invention relates generally to nitrogen containing heterobicycles of formulas A and B: which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical...
|
|
|
6716413 |
Indole compounds as tissue-specific exogenous optical agents
Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function...
|
|
|
6706715 |
Urea derivatives with antiproteolytic activity
The present invention relates to compounds of the formula I, in which R 1 , R 2 , R 4 , R 5 , D 1 , D 2 , X 1 , X 2 , X 3 , A and B have the meanings indicated in the claims. The compounds of...
|