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7381739 |
2,4-substituted indoles and methods of use
The present invention provides a compound of the formula:
a pharmaceutically acceptable salt or a prodrug thereof, where R 1 , R 2 , R 3 , R 4 , p and n are those defined herein. The present...
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7371769 |
Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
The present invention relates to a group of novel tetrahydropyridin-4-yl indoles with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine-D 2 receptors, to methods for...
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7358265 |
Oxa-and thiadiazoles and their use as metalloproteinase inhibitors
Compounds formula (IA) or (IB), wherein W represents HO(C═O)—, HONH(C═O)— or H(C═O)N(OH)—; X represents —O— or —S—; and R 1 , R 2 , and R 3 are as defined in the description...
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7348333 |
Cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists
There are described cycloalkyl derivatives of the formula (I)
R 1 —Y-A-B-D-E-F-G (I)
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7342030 |
Indole derivatives
The present invention relates to the compounds of formula I:
their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned...
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7326726 |
Biaryl substituted triazoles as sodium channel blockers
Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical...
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7323480 |
Substituted triazoles as modulators of PPAR and methods of their preparation
The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention...
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7320994 |
Triazole derivatives as tachykinin receptor antagonists
This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of...
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7312219 |
Heteroaromatic inhibitors of fructose 1,6-bisphosphatase
Novel FBPase inhibitors of the formula I and X
are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.
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7309721 |
Aminoalkylphosphonates and related compounds as Edg receptor agonists
The present invention encompasses compounds or Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and...
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7291634 |
α-amino-N-hydroxy-acetamide derivatives
The invention relates to α-amino-N-hydroxy-acetamide derivatives of formula I,
wherein R is di-lower alkyl amino, 1,2,3-triazol-1-yl, 1,2,3-triazol-2-yl or 1,2,4-triazol-4-yl, m represents an...
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7282511 |
Isatine derivatives with neurotrophic activity
The present invention relates to novel isatin derivatives, pharmaceutical compositions comprising the isatin derivatives of the invention, methods of preparing the isatin derivatives of the...
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7276514 |
Pyrroloquinoline quinone drugs for treatment of cardiac injury and methods of use thereof
The invention includes composition comprising substantially purified pyrroloquinoline quinone, that are useful in methods for the treatment and prevention of cardiac injury caused by hypoxia or...
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7276518 |
Substituted cyclohexane-1,4-diamine compounds
Substituted cyclohexane-1,4-diamine compounds, methods for production thereof, pharmaceutical compositions comprising these compounds and methods of treatment using these compounds.
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7271185 |
Optically active azole derivative and process for producing the same
A method for producing an optically active 2-phenyl-2,3,-dihydroxypropyl azole derivative, which is a useful compound in various fields. An optically active α-hydroxycarboxylic acid derivative...
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7268154 |
Substituted triazole compounds
The present invention relates to compounds of formula (I)
wherein
R 1 , R 2 and R 3 are as defined in the specification and to pharmaceutically suitable acid addition salts thereof. The...
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7262215 |
N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors
This invention relates to N-carbacycle monosubstituted indolocarbazole compounds. Furthermore, this invention relates to medicaments comprising N-carbacycle monosubstituted indolocarbazoles...
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7259179 |
Kinase inhibitors
A compound of the general formula:
or pharmaceutically acceptable salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating protein kinase-associated...
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7253200 |
Imidazole compounds
Imidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H 4 receptor expression, and in treating conditions such as inflammation, H 4 ...
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7247640 |
Medicament for treatment of bone marrow suppression, for treatment of infectious diseases and for increasing the number of leukocytes
A medicament for prophylaxis or treatment of bone marrow suppression, for treatment of infectious diseases and for increasing the number of leukocytes, which comprise as an active ingredient a...
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7238719 |
Process for producing 1,2,3-Triazole compounds
Disclosed is a process for efficiently producing a compound represented by formula (I):
wherein R 1 represents aryl, amino, alkyl, or alkoxy; R 2 represents a protective group of the...
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7232840 |
Agents for combating plant pests
The present invention relates to compositions for controlling plant pests containing the compound of formula (I)
in a mixture with fungicidally active compounds, except for...
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7232811 |
Furosemide modulators of HM74
Host cells expressing HM74 were used to obtain furosemide-like molecules with agonist activity having the following structure formula:
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7226938 |
Heterocyclic compounds
Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H 4 receptor, including allergic rhinitis.
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7220763 |
Indole-type derivatives as inhibitors of p38 kinase
The invention is directed to methods to inhibit p38-α kinase using compounds comprising a phenyl or thienyl coupled through a piperidine or piperazine nucleus to an indole residue wherein the...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7208504 |
Bicyclic inhibitors of hormone sensitive lipase
Benzotriazoles of formula I
in which R1 to R8 have the abovementioned meanings and process for their preparation are described. The compounds show an inhibitory effect on hormone-sensitive lipase.
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7198796 |
Antifungal parenteral products
Parenteral pharmaceutical formulations containing an echinocandin antifungal compound and an aqueous solvent are provided, wherein the formulation includes ethanol, for example about 20% w/v...
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7186738 |
Antibacterial oxalidinones
Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereo Formula (I): wherein N-HeT is for example triazolyl; Q is for example phenyl or pyridyl,...
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7179804 |
Tachykinin receptor antagonists
The present invention relates to selective NK-1 receptor antagonists of Formula (I); or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of...
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7179794 |
Multivalent macrolide antibiotics
Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial...
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7179826 |
Compositions useful as inhibitors of protein kinases
The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
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7176164 |
1,3-selenazolin derivatives and process for preparing the same
A process for preparing novel 1,3-selanazolin derivatives represented by chemical formula 1 at high yield. This process includes a step of reacting a selenourea and an α-haloacyl halide in a...
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7160905 |
Hydroxyethylene compounds with Asp2 inhibitory activity
The present invention relates to novel hydroxyethylene compounds having Asp2 (β-secretase. BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them...
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7160908 |
Dynamic anticancer platinum compounds
A series of dynamic platinum compounds for cancer treatment are described. The compounds may become active and inactive reversibly.
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7157421 |
Piracetam and piracetam analog conjugate and a pharmaceutical composition for treatment of neuronal disorders
A compound of the formula
where R 1 is H, C 1 –C 4 alkyl and OH; R 2 in is H, C 1 –C 4 alkyl and OH; R 3 is H and C 1 –C 4 alkyl; R 4 is H and C 1 –C 4 alkyl; n is an integer...
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7157482 |
Antibacterial 1,3-oxazolidin-2-one derivatives
Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereof, wherein: N—HET is for example triazolyl substituted with R 1 ; R 1 is for example...
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7151104 |
Pyrazolopyridines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7138394 |
Vehicle for topical delivery of anti-inflammatory compounds
A vehicle for topical delivery which contains a liquid eutectic mixture of hydrophobic compounds.
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7132409 |
Adenosine derivatives and use thereof
2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent...
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7129256 |
Antiparkinsonism drugs
A compound represented by the formula:
wherein A is thiazolyl or the like, X is a bond or the like, m is an integer of 0 to 4, Y is optionally substituted alkyl or the like, Z is a substituent...
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7128896 |
Pathological tissue detection and treatment employing targeted benzoindole optical agents
Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor...
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7125568 |
Lipophilic drug compositions
The invention is directed to biologically active lipophilic compositions comprising a biologically active covalently attached to, or encapsulated within, a lipid. Preferably, a biologically active...
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7125893 |
6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula I
in which R 1a , R 1b , R 2a , R 3a , R 3b , R 4 , R 5 , R 6 , R 7 , A, Y, D, E, G, Y and Z...
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7119075 |
Use of herbal agents for potentiation of bioefficacy of anti infectives
The present invention relates to the use of bioenhancers to decrease the resistance of microbial strains to anti-infective such an antibiotics and antifungals by potentiating the activities of...
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7115577 |
Colorectal neoplasia prophylaxis
Development of colorectal neoplasia in a patient subject or predisposed to colorectal neoplasia is reduced by the steps of (a) determining a patient is subject or predisposed to colorectal...
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7112599 |
Oxazole compounds for the treatment of neurodegenerative disorders
The present invention relates to compounds of the Formula
wherein R 3 , R 5 , R 6 , R 7 , and Z, and other variables enumerated under one or more of R 3 , R 5 , R 6 , R 7 , and Z, are as...
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7109243 |
Inhibitors of cathepsin S
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
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7109189 |
Mitochondrially targeted antioxidants
The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to a glutathione peroxidase mimetic. These compounds can be used to...
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7105548 |
Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5
Triazole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl which are metabotropic glutamate...
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