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7300948 Alkynyl compounds as non nucleoside reverse transcriptase inhibitors  
Inhibitors of HIV reverse transcriptase which are useful for the treatment of HIV infection. Exemplars of the invention are compounds of the formula wherein the substituents are as defined in...
7250428 Cetylpyridinium salt of an anti-inflammatory agent and pharmaceutical compositions containing it  
Cetylpyridinium salt of diclofenac.
7235576 Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors  
This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
7189383 Radioactively labelled amino acid analogues, their preparation and use  
The present invention relates to Halogenated amino acid analogues for use in diagnosis, which compounds have the general formula (I) wherein: R is (C 1 –C 6 ) alkyl optionally substituted with...
7141590 Pharmaceutical uses and synthesis of nicotinanilide-N-oxides  
Disclosed are nicotinanilide-N-oxide compounds, methods for their production, pharmaceutical compositions which include these compounds, and methods for their use in various therapies.
7064139 Method for treating retroviral infections  
Compositions and methods of treating a retroviral infection in an afflicted host and/or inhibiting replication of a retrovirus involve administering a therapeutically effective amount of the...
7015239 Fungicide for plants  
A fungicidal composition and method of treating plant diseases using a compound of formula
6984645 Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein  
Compounds that are dual aP2/k-FABP inhibitors are provided having the formula wherein A, B, X, Y, R 1 , R 2 and R 3 are as described herein. A method is also provided for treating diabetes...
6953811 N-substituted tetrahydropyridines and their use as pesticides  
A description is given of compounds of the formula in which R 1 and R 2 independently of one another are halogen, C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halo-C 1 -C 6 alkoxy,...
6939885 Aryl sulfonamides  
Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9....
6903118 Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides  
The invention relates to new piperazinyl-substituted pyridylalkane, alkene, and alkine acid amides substituted with saturated or one or several-fold unsaturated hydrocarbon residue in the...
6878730 Quaternary ammonium compounds  
The invention features quaternary ammonium compounds of formula I, described herein, and their use in treating asthma, chronic obstructive pulmonary disorder, allergic rhinitis, and infectious...
6864276 Active substance combinations having insecticidal and acaricidal properties  
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G are each as...
6864269 Concentrated, non-foaming solution of quarternary ammonium compounds and methods of use  
A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an...
6858623 Compounds useful as reversible inhibitors of cysteine proteases  
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , Het and X are defined herein. The...
6815458 Azacyclic compounds  
Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a...
6784194 Therapeutic use of a thienylcyclohexylamine derivative  
A method of inhibiting effects of exogenous neurotoxic or neurotoxinic products in warm-blooded animals comprising administering to warm-blooded animals before exposure to said products an...
6756393 Azacyclic compounds  
Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a...
6727237 Inhibitors of bacterial NAD synthetase  
The present invention provides methods of synthesizing and screening inhibitors of bacterial NAD synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections...
6726894 Transport vehicles for macromolecules  
The invention relates to new compounds with the general formula I for use as a tool to introduce macromolecules into cells. The invention further relates to compositions for introducing...
6706741 Acetylcholinesterase inhibitors containing 1-benzyl-pyridinium salts  
The present invention provides an excellent acetylcholinesterase inhibitor. That is, it provides an acetylcholinesterase inhibitor comprising a 1-benzylpyridinium salt represented by the following...
6686358 Bicyclic amino-pyrazinone compounds  
A compound of formula (I): wherein: R 1 represents hydrogen, or linear or branched (C 1 -C 6 )alkyl optionally substituted by one or more identical or different groups selected from aryl,...
6677361 Topical formulations for the transdermal delivery of niacin and methods of treating hyperlipidemia  
Niacin and niacin prodrugs are topically administered as suitable formulations to device for impoving the lipid profiles of subjects, preferably humans.
6664280 Antivesicant compounds and methods of making and using thereof  
As disclosed herein, the present invention provides a compound having the structural formula wherein R 1 , R 2 , R 3 , and R 4 are each independently H, or a methyl, halo, trifluoromethyl,...
6649633 Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes  
This application is directed to compounds useful as inhibitors at PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
6638946 Substituted pyridine or piperidine compounds  
The invention relates to a compound of formula (I): wherein: A represents pyridine, pyridinium or piperidine R 1 , R 2 , R 3 and R 4 are as defined in the description R 5 represents hydrogen,...
6638940 Tetrahydropyridines as pesticides  
Compounds of formula are described, wherein R 1 and R 2 are for example, independently of each other, halogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, halogen-C 1 -C 6 -alkyl, halogen-C 3 -C 6...
6624178 Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof  
The invention discloses novel compounds of the pyridinium series useful for the management of diabetes and aging-related vascular complications, including kidney disease, nerve damage,...
6608094 Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof  
Novel compounds of the pyridinium series useful for the management of diabetes and aging-related vascular and neurovascular complications, including kidney disease, nerve damage, atherosclerosis,...
6586452 C1 to C4 side chain modified nodulisporic acid analogs  
The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.
6495567 Triaryl methane compounds and their use in the treatment of diarrhea and scours  
A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours...
6469034 Cyclohexenyl-ethyl-thiourea compounds for inhibiting HIV reverse transcriptase  
Novel CycloHexenyl-Ethyl-Thiourea (CHET) compounds as inhibitors of reverse transcriptase and effective agents for the treatment of HIV infection, including mutant, drug-sensitive, drug-resistant,...
6465521 Composition for desorbing bacteria  
The invention provides a composition for desorbing bacteria from solid surfaces and from living tissues, which is in the form of a two-phase preparation, and which upon shaking forms a temporary...
6455555 Anti-HIV infection agents and method for treating HIV infection  
The present invention relates to agents for anti-HIV infection, which contain, as an active ingredient, at least one photosensitizing dye selected from the group consisting of the compounds of the...
6455554 Oxopyridinyl pharmaceutical compositions and methods for use  
Pharmaceutical compositions incorporate aryl substituted olefinic amine compounds. Representative compounds are (2S)-(4E)-N-methyl-5-[3-(5-isopropoxy-1-oxopyridin)yl)]-4-pe nten-2-amine,...
6451824 Sulfonylaminocarboxylic acids  
Compounds of formula (I) are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading...
6440934 Angiogenically effective unit dose of FGF-2 and method of use  
The present invention has multiple aspects. In particular, in one aspect, the present invention is directed to a unit dose composition comprising 0.2 μg/kg to 48 μg/kg of an FGF-2 of SEQ ID NO:...
6423698 Combination therapy for the prophylaxis and/or treatment of benign prostatic hyperplasia  
A combination therapy for the prophylaxis and/or treatment of benign prostatic hyperplasia in susceptible warm-blooded animals which comprises administering a combination of two or more compounds...
6391899 Compounds and compositions for treating tissue ischemia  
There is disclosed a genus of compounds and pharmaceutical compositions that are protective for mitigating damage associated with tissue ischemia, particularly stroke (CNS ischemia), and ischemia...
6387934 2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives  
2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases or disorders whose course involves increased...
6331564 Use of triaryl methane compounds for inhibiting unwanted cellular proliferation associated with inflammatory disease  
The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell...
6323220 Substituted pyridine or piperidine compounds  
The invention relates to a compound of formula (I): ##STR1## wherein: A represents pyridine, pyridinium or piperidine R 1 , R 2 , R 3 and R 4 are as defined in the description R 5 ...
6277360 Washing composition  
The invention provides a washing composition for washing a surface to deposit thereon a solid active agent, the washing composition comprising an emulsion of silicone droplets, the silicone...
6184228 Anti-sickling agents: selection methods and effective compounds  
The present invention is directed to a method for selecting compounds for use in treating sickle cell disease in a patient. The method comprises the steps of selecting a first set of HbS ligands...
6172117 Biocidal preservatives  
Biocidal preservatives for use especially in preventing rotting and deterioration of wood include quaternary ammonium compounds which preferably have a fatty aliphatic substituent on the quaternary...
6162446 In-situ generation of zinc pyrithione in personal care compositions  
Disclosed is a personal care composition comprising: (a) water or an alcohol, (b) at least one dispersant or surfactant, and (c) as an antimicrobial or preservative additive, particles of an...
6090807 Use of heterocyclic compounds  
The present invention relate to the use of heterocyclic compounds of the following formula: Het--A--B--Ar where Het, A, B and Ar have the meanings stated in the description. The compounds...
6060454 Compositions, apparatus and methods for facilitating surgical procedures  
Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and...
6028103 Triaryl methane compounds and analogues thereof useful for the treatment or prevention of sickle cell disease or diseases characterized by abnormal cell proliferation  
The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell...
6022551 Antimicrobial composition  
A rapidly acting antimicrobial alcohol-containing composition and method of using the composition to disinfect surfaces, such as the hands is disclosed.
Matches 1 - 50 out of 190 1 2 3 4 >