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7300948 |
Alkynyl compounds as non nucleoside reverse transcriptase inhibitors
Inhibitors of HIV reverse transcriptase which are useful for the treatment of HIV infection. Exemplars of the invention are compounds of the formula
wherein the substituents are as defined in...
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7250428 |
Cetylpyridinium salt of an anti-inflammatory agent and pharmaceutical compositions containing it
Cetylpyridinium salt of diclofenac.
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7235576 |
Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
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7189383 |
Radioactively labelled amino acid analogues, their preparation and use
The present invention relates to Halogenated amino acid analogues for use in diagnosis, which compounds have the general formula (I) wherein: R is (C 1 –C 6 ) alkyl optionally substituted with...
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7141590 |
Pharmaceutical uses and synthesis of nicotinanilide-N-oxides
Disclosed are nicotinanilide-N-oxide compounds, methods for their production, pharmaceutical compositions which include these compounds, and methods for their use in various therapies.
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7064139 |
Method for treating retroviral infections
Compositions and methods of treating a retroviral infection in an afflicted host and/or inhibiting replication of a retrovirus involve administering a therapeutically effective amount of the...
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7015239 |
Fungicide for plants
A fungicidal composition and method of treating plant diseases using a compound of formula
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6984645 |
Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
Compounds that are dual aP2/k-FABP inhibitors are provided having the formula
wherein A, B, X, Y, R 1 , R 2 and R 3 are as described herein. A method is also provided for treating diabetes...
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6953811 |
N-substituted tetrahydropyridines and their use as pesticides
A description is given of compounds of the formula
in which
R 1 and R 2 independently of one another are halogen, C 1 -C 6 alkyl, halo-C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halo-C 1 -C 6 alkoxy,...
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6939885 |
Aryl sulfonamides
Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9....
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6903118 |
Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
The invention relates to new piperazinyl-substituted pyridylalkane, alkene, and alkine acid amides substituted with saturated or one or several-fold unsaturated hydrocarbon residue in the...
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6878730 |
Quaternary ammonium compounds
The invention features quaternary ammonium compounds of formula I, described herein, and their use in treating asthma, chronic obstructive pulmonary disorder, allergic rhinitis, and infectious...
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6864276 |
Active substance combinations having insecticidal and acaricidal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G are each as...
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6864269 |
Concentrated, non-foaming solution of quarternary ammonium compounds and methods of use
A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an...
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6858623 |
Compounds useful as reversible inhibitors of cysteine proteases
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , Het and X are defined herein. The...
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6815458 |
Azacyclic compounds
Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a...
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6784194 |
Therapeutic use of a thienylcyclohexylamine derivative
A method of inhibiting effects of exogenous neurotoxic or neurotoxinic products in warm-blooded animals comprising administering to warm-blooded animals before exposure to said products an...
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6756393 |
Azacyclic compounds
Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a...
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6727237 |
Inhibitors of bacterial NAD synthetase
The present invention provides methods of synthesizing and screening inhibitors of bacterial NAD synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections...
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6726894 |
Transport vehicles for macromolecules
The invention relates to new compounds with the general formula I for use as a tool to introduce macromolecules into cells. The invention further relates to compositions for introducing...
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6706741 |
Acetylcholinesterase inhibitors containing 1-benzyl-pyridinium salts
The present invention provides an excellent acetylcholinesterase inhibitor. That is, it provides an acetylcholinesterase inhibitor comprising a 1-benzylpyridinium salt represented by the following...
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6686358 |
Bicyclic amino-pyrazinone compounds
A compound of formula (I): wherein: R 1 represents hydrogen, or linear or branched (C 1 -C 6 )alkyl optionally substituted by one or more identical or different groups selected from aryl,...
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6677361 |
Topical formulations for the transdermal delivery of niacin and methods of treating hyperlipidemia
Niacin and niacin prodrugs are topically administered as suitable formulations to device for impoving the lipid profiles of subjects, preferably humans.
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6664280 |
Antivesicant compounds and methods of making and using thereof
As disclosed herein, the present invention provides a compound having the structural formula wherein R 1 , R 2 , R 3 , and R 4 are each independently H, or a methyl, halo, trifluoromethyl,...
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6649633 |
Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes
This application is directed to compounds useful as inhibitors at PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
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6638946 |
Substituted pyridine or piperidine compounds
The invention relates to a compound of formula (I): wherein: A represents pyridine, pyridinium or piperidine R 1 , R 2 , R 3 and R 4 are as defined in the description R 5 represents hydrogen,...
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6638940 |
Tetrahydropyridines as pesticides
Compounds of formula are described, wherein R 1 and R 2 are for example, independently of each other, halogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, halogen-C 1 -C 6 -alkyl, halogen-C 3 -C 6...
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6624178 |
Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof
The invention discloses novel compounds of the pyridinium series useful for the management of diabetes and aging-related vascular complications, including kidney disease, nerve damage,...
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6608094 |
Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof
Novel compounds of the pyridinium series useful for the management of diabetes and aging-related vascular and neurovascular complications, including kidney disease, nerve damage, atherosclerosis,...
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6586452 |
C1 to C4 side chain modified nodulisporic acid analogs
The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.
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6495567 |
Triaryl methane compounds and their use in the treatment of diarrhea and scours
A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours...
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6469034 |
Cyclohexenyl-ethyl-thiourea compounds for inhibiting HIV reverse transcriptase
Novel CycloHexenyl-Ethyl-Thiourea (CHET) compounds as inhibitors of reverse transcriptase and effective agents for the treatment of HIV infection, including mutant, drug-sensitive, drug-resistant,...
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6465521 |
Composition for desorbing bacteria
The invention provides a composition for desorbing bacteria from solid surfaces and from living tissues, which is in the form of a two-phase preparation, and which upon shaking forms a temporary...
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6455555 |
Anti-HIV infection agents and method for treating HIV infection
The present invention relates to agents for anti-HIV infection, which contain, as an active ingredient, at least one photosensitizing dye selected from the group consisting of the compounds of the...
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6455554 |
Oxopyridinyl pharmaceutical compositions and methods for use
Pharmaceutical compositions incorporate aryl substituted olefinic amine compounds. Representative compounds are (2S)-(4E)-N-methyl-5-[3-(5-isopropoxy-1-oxopyridin)yl)]-4-pe
nten-2-amine,...
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6451824 |
Sulfonylaminocarboxylic acids
Compounds of formula (I) are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading...
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6440934 |
Angiogenically effective unit dose of FGF-2 and method of use
The present invention has multiple aspects. In particular, in one aspect, the present invention is directed to a unit dose composition comprising 0.2 μg/kg to 48 μg/kg of an FGF-2 of SEQ ID NO:...
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6423698 |
Combination therapy for the prophylaxis and/or treatment of benign prostatic hyperplasia
A combination therapy for the prophylaxis and/or treatment of benign prostatic hyperplasia in susceptible warm-blooded animals which comprises administering a combination of two or more compounds...
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6391899 |
Compounds and compositions for treating tissue ischemia
There is disclosed a genus of compounds and pharmaceutical compositions that are protective for mitigating damage associated with tissue ischemia, particularly stroke (CNS ischemia), and ischemia...
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6387934 |
2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives
2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases or disorders whose course involves increased...
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6331564 |
Use of triaryl methane compounds for inhibiting unwanted cellular proliferation associated with inflammatory disease
The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell...
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6323220 |
Substituted pyridine or piperidine compounds
The invention relates to a compound of formula (I): ##STR1## wherein: A represents pyridine, pyridinium or piperidine R 1 , R 2 , R 3 and R 4 are as defined in the description R 5 ...
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6277360 |
Washing composition
The invention provides a washing composition for washing a surface to deposit thereon a solid active agent, the washing composition comprising an emulsion of silicone droplets, the silicone...
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6184228 |
Anti-sickling agents: selection methods and effective compounds
The present invention is directed to a method for selecting compounds for use in treating sickle cell disease in a patient. The method comprises the steps of selecting a first set of HbS ligands...
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6172117 |
Biocidal preservatives
Biocidal preservatives for use especially in preventing rotting and deterioration of wood include quaternary ammonium compounds which preferably have a fatty aliphatic substituent on the quaternary...
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6162446 |
In-situ generation of zinc pyrithione in personal care compositions
Disclosed is a personal care composition comprising: (a) water or an alcohol, (b) at least one dispersant or surfactant, and (c) as an antimicrobial or preservative additive, particles of an...
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6090807 |
Use of heterocyclic compounds
The present invention relate to the use of heterocyclic compounds of the following formula: Het--A--B--Ar where Het, A, B and Ar have the meanings stated in the description. The compounds...
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6060454 |
Compositions, apparatus and methods for facilitating surgical procedures
Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and...
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6028103 |
Triaryl methane compounds and analogues thereof useful for the treatment or prevention of sickle cell disease or diseases characterized by abnormal cell proliferation
The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell...
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6022551 |
Antimicrobial composition
A rapidly acting antimicrobial alcohol-containing composition and method of using the composition to disinfect surfaces, such as the hands is disclosed.
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