Patents in Class 514/357

Matches 1 - 50 out of 1071

Match	Document	Document Title
1	7615230	Method for decreasing sebum production The present invention is directed to the topical application of the malonamide ACAT inhibitors described by Formula I. Other aspects of the invention are directed to topical formulations of these...
2	7592358	Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds Alkyne compounds having MCH-receptor antagonistic activity, which are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly...
3	7572819	Compounds which potentiate glutamate receptor and uses thereof in medicine Compounds of formula (I) or a pharmaceutically acceptable salt, solvate or prodrug thereof, are disclosed: wherein R 1 is C 1-6 alkyl, haloC 1-6 alkyl, C 2-6 alkenyl, amino, monoC 1-4...
4	7572818	2-pyridylethylbenzamide derivative Compound of general formula (I) in which p is an integer equal to 1, 2, 3 or 4; q is an integer equal to 1, 2, 3, 4 or 5; each substituent X is chosen, independently of the others, as being...
5	7566738	Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use Acyloxyalkyl carbamate prodrugs of 3-aminopropylsulfinic acid and analogs thereof, pharmaceutical compositions of 3-aminopropylsulfinic acid and analogs thereof, methods of making prodrugs of...
6	RE40861	Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine...
7	7560474	Derivatives of pyridilethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, process for their preparation and pharmaceutical compositions containing them The novel derivatives of pyridilethanol (phenylethyl) amines of formula I are described wherein n is an integer from 1 to 4, R 1 is a hydrogen atom, hydroxyl group or lower C 1-6 alkoxy group...
8	7560122	Pharmaceutical dosage form bearing pregnancy-friendly indicia A pharmaceutical dosage form comprising at least one active ingredient and destined for administration to pregnant women. The pharmaceutical dosage form bears pregnancy-friendly indicia apt to...
9	7557132	Compounds useful as pesticides Compounds useful to control pests are provided.
10	7550497	Phosphoramide derivatives New phosphoramide derivatives of formula (I) and the salts and solvates thereof, wherein the meanings of the various substituents are as disclosed in the description. Said compounds are useful as...
11	7550490	Benzamide derivatives as histone deacetylase inhibitors with potent differentiation and anti-proliferation activity The present invention is related to the preparation and pharmaceutical use of novel benzamide derivatives as defined in the specification of formula (I) as histone deacetylase inhibitors (HDACI),...
12	7547731	Formamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
13	7547716	Sulfonamide derivatives A medicament for enhancing an effect of a cancer therapy based on a mode of action of DNA injury, which comprises as an active ingredient a compound represented by the general formula (I) or a...
14	7547701	Haloalkyl containing compounds as cysteine protease inhibitors The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these...
15	7547444	Methods for controlling fungi and bacteria The present invention includes compounds of pyridinium salts and methods of their use for agricultural purposes. The present invention also relates to methods of controlling fungi and/or bacteria.
16	7538127	Medicinal compounds A compound of formula (I) or a salt, solvate, or physiologically functional derivative thereof, wherein: m is an integer of from 2 to 8; n is an integer of from 2 to 5; with the proviso that m+n is...
17	7531695	Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders The present invention is directed to compounds having the structure (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic...
18	7531538	α- and β-Amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
19	7528170	Sulfonamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
20	7521461	Benzoic acid derivatives as modulators of PPAR alpha and gamma A compound of formula (I) wherein R 1 represents aryl optionally substituted by a heterocyclic group or a heterocyclic group optionally substituted by aryl wherein each aryl or heterocyclic group...
21	7521062	Thiosemicarbazones as anti-virals and immunopotentiators The present invention is directed to novel immune potentiators, novel vaccine adjuvants, novel compounds and pharmaceutical compositions, novel methods for treating viral infections, including HCV,...
22	7517880	Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
23	7517535	Non-systemic control of parasites Use of agonists and antagonists of the nicotinergic acetylcholine receptors of insects for the non-systemic control of parasitic insects, such as fleas, lice and flies, on humans and on animals.
24	7501541	Malonamides as orexin antagonists The present invention relates to compounds of formula I wherein Ar 1 , Ar 2 , R, R 1 , R 2 , R 3 and n are as defined herein or to pharmaceutically suitable acid addition salts, optically...
25	7498358	Human ADAM-10 inhibitors The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological...
26	7495001	Benzannelated derivatives, their manufacture and use as pharmaceutical agents There are presented compounds of the formula wherein R 6 and R 7 is R 4 and R 5 or R 5 and R 6 together with the carbon atoms to which they are attached, form a ring as...
27	7491739	TNF-α production inhibitors A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the...
28	7488848	Alpha ketoamide compounds as cysteine protease inhibitors The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these...
29	7482491	Amino alcohol derivative, addition salt thereof, and immunosuppressant An amino alcohol derivative represented by the following general formula (1) (for example, (±)-2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2- methylpentane-1-ol) exhibits strong...
30	7482369	Anthranilic acid amides and their use as VEGF receptor tyrosine kinase inhibitors The invention relates to anthranilic acid amide derivatives of formula I, wherein R 1 represents H or lower alkyl, R 2 represents H or lower alkyl, R 3 represents perfluoro lower alkyl,...
31	7479491	Azanthranylalkyl and -cycloalkyl amides and their use as VEGF receptor inhibitors The invention relates to substituted anthranylalkyl and -cycloalkyl amides of general formula (I) and to their use as medicaments for treating diseases caused by persistent angiogenesis.
32	7476763	Oxo-substituted cyclohexyl-1,4-diamine compounds Novel cyclohexyl-1,4-diamine compounds corresponding to formula I: methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
33	7476683	Glycinamide derivatives as raf-kinase inhibitors The present invention relates to glycinamide derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the...
34	7468383	Proteasome inhibitors and methods of using the same The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and...
35	7465748	Amide derivative There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus...
36	7459470	N-oxide anthranylamide derivatives and their use as medicaments Substituted N-oxidanthranilamide derivatives, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described. The compounds...
37	7459468	Aryl sulfonic pyridoxines as antiplatelet agents Aryl sulfonic pyridoxine compounds with antiplatelet aggregation characteristics for the treatment of cardiovascular and cardiovascular related disease, are described. The methods are directed to...
38	7456179	Methods of treating ischemic related conditions The present invention relates to methods of treating ischemia-related conditions by administering to a patient in need of such methods certain thiosemicarbazone compounds. Preferred embodiments of...
39	7435729	Compounds and methods for modulation of estrogen receptors Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective modulators for...
40	7429604	Six-membered heterocycles useful as serine protease inhibitors The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, X 1 , X 2 , X 3 , X 4 ,...
41	7429593	Utilities of amide compounds Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments. Compounds of formula (I): in which ring A and Ar 1 are independently a monocyclic...
42	7429592	Cyanoanthranilamide derivatives and the use thereof as medicaments Substituted cyanoanthranilamide derivatives, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described. The compounds...
43	7423170	Anticancer agents based on regulation of protein prenylation Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is...
44	7423067	Diphenyl cyclopentyl amides as cannabinoid-1 receptor inverse agonists Novel compounds of structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases...
45	7423012	Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and...
46	7420000	Amino phosphonate and amino bis-phosphonate derivatives Aminophosphonate and amino bisphosphonate compounds and methods for their preparation are provided. Also provided are pharmaceutical and agricultural compositions containing the compounds. The...
47	7419967	Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
48	7417060	Aminoalcohol derivatives The present invention relates to a compound formula[I]: wherein X is bond, —CH 2 —, —O— or —NH—, R 1 and R 12 are each independently hydrogen, halogen, lower alkyl, etc., R 2 ...
49	7417059	Substituted aromatic-ring compounds, process for producing the same and use The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production,...
50	7414064	4-(3,3-dihalo-allyloxy) phenoxy alkyl derivatives Compounds of formula wherein A 1 , A 2 and A 3 are each independently of the others a bond or a C 1 -C 6 alkylene bridge; A 4 is a C 1 -C 6 alkylene bridge; D is CH or N; W is, for...

Matches 1 - 50 out of 1071

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