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7241812 |
Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
The present invention relates to compounds which modulate the activity of the S1P1 receptor, the use of these compounds for treating conditions associated with signaling through the S1P1 receptor,...
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7241758 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological...
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7238718 |
Method for treating myolytic disease and method for screening antimyolytic agent
An object of the present invention is to provide a method which is able to prevent or improve the progress of myolytic diseases such as muscular dystrophy. Such an object is able to be solved by a...
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7232817 |
α- and β-amino acid hydroxyethlamino sulfonyl urea derivatives useful as retroviral protease inhibitors
α- and β-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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7230018 |
Substituted propane-1,3-diamine derivatives and the pharmaceutical use thereof
Substituted propane-1,3-diamine derivatives, methods for producing such derivatives, and medicaments and pharmaceutical compositions containing such derivatives useful for the treatment or...
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7226935 |
Hypoglycemic agent
A zinc(II) complex which is lowly toxic, has high insulin-like activity, and is effectively usable as a hypoglycemic agent for the prevention or treatment of diabetes; a hypoglycemic agent...
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7220761 |
Compounds and methods for controlling fungi, bacteria and insects
The present invention includes compounds of pyridinium salts and methods of their use for industrial uses. The present invention also relates to methods of controlling fungi and/or bacteria. The...
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7220781 |
Meta-benzamidine derivatives as serine protease inhibitors
Compounds of formula I
in which R 1 , R 2 , R 3 , each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted or...
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7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
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7214714 |
20-hydroxyeicosatetraenoic acid production inhibitors
A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof
[wherein R 1 represents a substituted morpholino group, a substituted...
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7214678 |
Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain
According to the invention there is provided a compound the formula I;
wherein A, X, B, R 1 , R 2 , R 3 and R 4 are as defined in the specification.
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7208506 |
Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents
The present invention relates to compounds of formula I
wherein R 1 , R 2 and R 3 are defined herein, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and...
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7202261 |
Calcilytic compounds
The present invention features calcilytic compounds. “Calcilytic compounds” refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to...
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7199141 |
Drugs for chronic pains
Nitro-oxyderivative compounds or salts thereof having the following general formula (I): A—(B) b0 —(C) c0 —NO 2 wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1,...
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7173049 |
Fungicidal compositions
1) Fungicidal compositions comprising:
a) at least one pyridylmethylbenzamide derivative of formula (I):
in which the various radicals are as defined in the description,...
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7169750 |
Methods to mobilize progenitor/stem cells
Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the...
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7166590 |
Amino acid derivatives
A compound of the formula (I):
[wherein R 1 is (substituted) alkyl, alkoxy, phenyl, hetero ring etc.; A is bond, CO, SO 2 ; R 2 is H, (substituted) alkyl etc.; D is alkylene etc.; E is COO,...
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7166593 |
Glucocorticoid receptor modulators
The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonist and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor....
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7163951 |
N-biarylmethyl aminocycloalkanecarboxamide derivatives
N-Biarylmethylaminocycloalkanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated...
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7157477 |
Aliphatic amino-substituted demethoxylated hypocrellins and their synthesis
The invention involves a methods and compositions for use in photodynamic therapy. Novel perylenequinone derivatives, conjugates comprising perylenequinone derivatives and a binding agent, and...
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7153876 |
Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation, and their use
Compounds of formula I,
in which R 1 , R 2 , A, and B having the definitions set forth in the claims, are valuable pharmacologically active compounds, which exhibit a strong antithrombotic...
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7144881 |
Arylcyclopropylcarboxylic amides as potassium channel openers
The present invention provides novel arylcyclopropylcarboxylic amides and related derivatives having the general Formula I
wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined...
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7129246 |
N-adamantlmethyl derivatives and intermediates as pharmaceutical compositions and processes for their preparation
The invention provides compounds of general formula (I) in which m, A, R 1 and Ar have the meanings defined in the specification; a process for, and intermediates used in, their preparation;...
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7129252 |
Six membered amino-amide derivatives an angiogenisis inhibitors
The present invention relates to six membered amino-amide derivatives, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment...
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7125880 |
Corticotropin releasing factor antagonists
Corticotropin-releasing factor (CRF) antagonists having the formulae
wherein the dashed lines, A, B, Y, Z, G, R 3 , R 4 , R 5 , R 6 , R 16 and R 17 are as defined in the application, and...
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7122564 |
Biaromatic ligand activators of PPARγ receptors
Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPARγ receptor, such biaromatic ligand having the structural formula (I):
and are well suited,...
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7122547 |
Anthranilic acid amides and the use thereof as medicaments
The invention relates to anthranilic acid amides and the use thereof as medicaments for the treatment of diseases that are triggered by persistent angiogenesis, in addition to intermediate products...
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7115605 |
Peptide deformylase inhibitors
PDF inhibitors and novel methods for their use are provided.
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7115632 |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds
A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a...
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7109203 |
Sulfonamide derivatives
Sulfonamide derivitives of the formula I wherein R 1 -R 6 are as defined in the description, processes for their production, their use as pharmaceuticals, particularly for use in the treatment or...
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7105549 |
Aryl substituted pyridines and the use thereof
This invention relates aryl substituted pyridines of Formula I:
or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R 1 –R 4 are set in the specification. The...
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7101900 |
Benzyl amidoxime derivatives, intermediate products and method for their production and use as fungicides
Novel benzamidoxime derivatives, processes and intermediates for their preparation and their use as fungicides are described. In the context of the present invention, benzamidoxime derivatives are...
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7101875 |
Methods for treating arthritic disorders
This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula:
and pharmaceutically acceptable salt forms...
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7098226 |
TNF-α production inhibitors
A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the...
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7091224 |
Anthranilic acid amides and their use as VEGF receptor tyrosine kinase inhibitors
The invention relates to anthranilic acid amide derivatives of formula (I), wherein R 1 represents H or lower alkyl, R 2 represents H or lower alkyl, R 3 represents perfluoro lower alkyl, and X...
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7087625 |
Phosphodiesterase 4 inhibitors
PDE4 inhibition is achieved by novel nitroxide compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formulas I–III:
wherein A, B, D,...
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7081468 |
Ortho-substituted anthranilic acid amides and their use as medicaments
Ortho-substituted anthranilic acid amides and use thereof as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described.
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7078400 |
20-HETE synthase inhibitor
The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or...
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7071175 |
Pyridine mercapto carboxylic acids as carboxypeptidase U inhibitors
The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts,
which compounds inhibit carboxypeptidase U and...
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7071188 |
Composition and method for improving plant growth
The present invention relates to plant-protecting active ingredient mixtures having synergistically enhanced action and to a method of improving the growth of plants, comprising applying to the...
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7067543 |
Anthranilic acid amides and pharmaceutical use thereof
The invention relates to anthranilic acid amide derivatives of formula (I), wherein Ar is represented by the subformula (I a ), wherein R a represents H or lower alkyl, and R 1 represents H or...
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7060715 |
Substituted pyridines as selective cyclooxygenase-2 inhibitors
The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic...
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7053078 |
Serine protease inhibitors
Compounds of formula (I)
in which R 2 , X, Y, Cy, L and Lp(D) n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment...
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7049330 |
Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
This invention relates to compounds which have activity as 5-HT 1A agonists and antagonists which may be useful for the treatment of anxiety, depression, cognitive deficits, and prostate cancer,...
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7049317 |
CCR-3 receptor antagonists
The invention provides compounds of Formula (I):
wherein R 1 –R 4 have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions...
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7045532 |
ACE-2 modulating compounds and methods of use thereof
ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include...
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7037927 |
Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor
The present invention relates to compounds of formula (I)
that are novel VR1 antagonists useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity.
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7034045 |
Monofluoroalkyl derivatives
The present invention provides certain monofluoroalkyl derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions,...
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7034044 |
Conjugated aromatic compounds with a pyridine substituent
The present invention relates to compounds of formulae
The compounds of the present invention are NMDA (N-methyl-D-aspartate)-receptor subtype blockers and are used in the treatment of diseases...
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7015216 |
Heteroaryl-β-alanine derivatives as alpha 4 integrin inhibitors
Disclosed are a series of heteroaryl-β-alanine derivatives, compositions containing them, processes for their preparation and their use in medicine.
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