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7423067 |
Diphenyl cyclopentyl amides as cannabinoid-1 receptor inverse agonists
Novel compounds of structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases...
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7423012 |
Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors
The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts,
which compounds inhibit carboxypeptidase U and...
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7420000 |
Amino phosphonate and amino bis-phosphonate derivatives
Aminophosphonate and amino bisphosphonate compounds and methods for their preparation are provided. Also provided are pharmaceutical and agricultural compositions containing the compounds. The...
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7419967 |
Sulfonamide inhibitors of aspartyl protease
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
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7417060 |
Aminoalcohol derivatives
The present invention relates to a compound formula[I]:
wherein
X is bond, —CH 2 —, —O— or —NH—, R 1 and R 12 are each independently hydrogen, halogen, lower alkyl, etc., R 2 ...
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7417059 |
Substituted aromatic-ring compounds, process for producing the same and use
The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production,...
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7414064 |
4-(3,3-dihalo-allyloxy) phenoxy alkyl derivatives
Compounds of formula
wherein A 1 , A 2 and A 3 are each independently of the others a bond or a C 1 -C 6 alkylene bridge; A 4 is a C 1 -C 6 alkylene bridge; D is CH or N; W is, for...
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7407989 |
Compounds useful for modulating abnormal cell proliferation
There is described compounds of Formula I, and salts, solvates and hydrates thereof:
wherein: R 1 , R 2 and R 3 are each independently selected from OH, C 1-6 alkyl, OC 1-6 alkyl, OC(O)C 1-6...
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7407959 |
Cathepsin cysteine protease inhibitors
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for...
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7405230 |
Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs
PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I:
wherein R 1 , R 2 , R 3 and R 4 ...
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7399765 |
Substituted diazabicycloalkane derivatives
Compounds of formula (I)
Z-Ar 1 —Ar 2 (I)
wherein Z is a diazabicyclic...
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7388023 |
Amino acids with affinity for the α2δ-protein
Certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of...
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7378446 |
Compound having anti-HCV activity and process for producing the same
The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its...
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7378448 |
Diphenylether amide derivatives as opioid receptor antagonists
A compound of the formula (I) wherein the variables X 1 , X 2 , B, D, R 1 to R 7 including R 3′ , p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer,...
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7378437 |
Drugs for diabetes
Use for the diabetes treatment of compounds or salts thereof, having the following general formula (I): A-(B) b0 —(C) c0 —NO 2 wherein A contains the radical of a drug having an...
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7375122 |
Compounds useful as pesticides
Compounds useful to control pests are provided.
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7375119 |
Amide type carboxamide derivative
The present invention provides an amide-type carboxamide derivative of the formula [1]:
wherein X is a group of the formula: —N═ or the formula: —CH═; R 1 is a halogen atom, a lower...
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7371768 |
Pyrazol derivatives, pest control agent comprising the same as active ingredient, and process for producing the same
The present invention relates to pest control agent having systemic activity and a high safety along with a wide insecticidal spectrum and excellent insecticidal activity, which are...
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7365068 |
Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
The invention provides compounds and pharmaceutically acceptable salts of Formula I
wherein the variables A 1 , A 2 , R 1 , R 2 , V, W, X, Y, and Z are defined herein. Certain compounds of...
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7365070 |
Modulators of melanocortin receptor
This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic...
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7365085 |
Compounds and methods
Disclosed is a compound having the formula:
pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are...
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7361674 |
7, 8 and 9-substituted tetracycline compounds
7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are...
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7354943 |
Statine derivatives for the treatment of Alzheimer's disease
The present invention relates to compounds of formula (I):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme...
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7354942 |
Benzylether and benzylamino beta-secretase inhibitors for the treatment of Alzheimer's disease
The present invention is directed to benzylether and benzylamino derivative compounds of formula (I)
which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of...
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7338950 |
Amide compounds as ion channel ligands and uses thereof
Compounds are disclosed that have a formula represented by the following:
The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a...
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7332512 |
Halogenated nitrobutadienes for controlling animal pests
The present invention relates to novel halonitrobutadienes, to processes for their preparation and to their use for controlling animal pests.
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7329679 |
1,2 Diarylbenzimidazoles and their pharmaceutical use
Benzimidazoles of general formula I
and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a...
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7326725 |
Fungicidal composition based on at least one pyridylmethylbenzamide derivatives and at least on dithiocarbamate derivative
1) Fungicidal compositions comprising: a) at least one pyridylmethylbenzamide derivative of formula (I), in which the various radicals are as defined in the description, and b) at least one...
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7326696 |
Amino-methyl substituted tetracycline compounds
Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
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7320993 |
Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents
The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or...
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7317028 |
Cell differentiation inducer
The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore,...
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RE39991 |
Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
A compound having the following formula:
wherein R 3 and M are defined herein, and processes therewith.
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7300948 |
Alkynyl compounds as non nucleoside reverse transcriptase inhibitors
Inhibitors of HIV reverse transcriptase which are useful for the treatment of HIV infection. Exemplars of the invention are compounds of the formula
wherein the substituents are as defined in...
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7294639 |
Biaromatic ligand activators of PPARγ receptors
Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPARγ receptor, such biaromatic ligand having the structural formula (I):
and are well suited,...
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7291631 |
CXCR4 chemokine receptor binding compounds
The present invention relates to compounds that bind to chemokine receptors, and having the formula
wherein each A, X, Y, R 1 , R 2 and R 3 are substituents. The present invention also...
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7291596 |
Pharmaceutical composition for thrombin peptide derivatives
Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical...
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7288555 |
Fungicidal composition based on a pyridylmethylbenzamide derivative and a valinamide derivative
Fungicidal compositions comprising:
a) at least one pyridylmethylbenzamide derivative of formula (I), in which the various radicals are as defined in the description, and b) at least one...
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7279478 |
Cathepsin cysteine protease inhibitors
This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating...
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7279470 |
Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The...
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7271184 |
Acyclic and cyclic guanidine- and acetamidine derivatives, their preparation and their use as pesticides, esp. as parasiticides
Novel pesticides of formula (I)
wherein the substituents, R, R 1 , R 2 , R 2′ , T, U, X and Y are as defined in claim 1 , are described. Also described are compositions suitable for use as...
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7268152 |
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
Compounds of Formula (IA) and Formula (IB)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate, or salt...
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7268147 |
Compounds useful for the treatment of diseases
The invention relates to compounds of formula (1)
and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
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7268135 |
Biaryl sulfonamides and methods for using same
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
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7268153 |
N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment...
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7262209 |
Carbonyloxy-cyanomethyl compounds as antiparasitic agents
The invention relates to compounds of the general formula
wherein Ar 1 , Ar 2 , R 4 , R 5 , R 6 , R 7 , R 8 , W, X, a and b have the significances given in the specification, and optionally the...
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7259157 |
N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
Compounds represented by Formula (I):
or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
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7256204 |
Amine compounds, their production and use
A compound of the formula:
wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or...
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7253194 |
Compounds and inhibitors of phospholipases
The present invention relates generally to amino acid derivatives and to methods of making the same. In particular, the invention relates to compounds bearing a stereochemical identity, that is,...
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7250412 |
PH sensitive prodrugs of 2,6-Diisopropylphenol
The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby...
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7244751 |
Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity
The present invention is related to the preparation and pharmaceutical use of novel benzamide derivatives as defined in the specification of formula (I) as histone deacetylase inhibitors (HDACI),...
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