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5728699 |
Benzylsulfide derivative, process for its production and pesticide
The present invention presents a benzylsulfide derivative of the formula (I) or its salt: ##STR1## wherein R 1 is a C 1 -6 alkyl group, a C 1 -6 haloalkyl group, a C 2 -4 alkenyl group, a cyano...
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5723502 |
Topical spin trap composition and method
A composition and method for ameliorating a cellular dysfunction of a tissue such as the cosmetic treatment of hair loss and stimulation of hair growth are disclosed. The method comprises...
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5723499 |
Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(i): ##STR2## and are...
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5723475 |
Arylpiperidine and arylpiperazine derivatives and medicament containing the same
The compound of the formula (I) or its salt or a medicament containing the same ##STR1## wherein, A and B represent a carbonyl group or sulfonyl group, m and p are different and represent 0 or 1, ...
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5723459 |
Biologically active acylated amino acid derivatives
The present invention relates to novel compounds which possess a broad range of useful biological activities. These compounds can maintain, increase, or restore sensitivity of cells to therapeutic...
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5719169 |
Substituted benzoylguanidines, their use as a medicament or diagnostic, and medicament containing them
The invention relates to benzoylguanidines of the formula I: ##STR1## to pharmaceutically acceptable salts of these compounds and to a process for preparing compounds of the formula I, which...
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5719168 |
Acetamide derivatives and their use as feeding behaviour modifiers
The present invention relates to compounds of formula (I) wherein R 1 is selected from H and 3-chloro; R 2 is selected from a phenyl group and a pyridyl group; R 3 and R 4 are selected...
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5716973 |
Anti-viral compounds
This invention relates to novel difluoro statone analogs, to the processes and intermediates useful for their preparation and to their use as anti-vital agents.
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5716971 |
Pyridine derivatives, their production and use
Pyridine derivatives of the formula ##STR1## wherein the ring A stands for an optionally further substituted benzene ring; the ring B stands for an optionally substituted pyridine ring; Q stands...
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5714518 |
HIV protease inhibitors and methods of making the same
HIV protease inhibitors, obtainable by chemical synthesis, block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well...
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5714506 |
Selective β.sub.3 agonists for the treatment of diabetes and obesity
Compounds of formula ##STR1## are selective β 3 adrenergic receptor agonists with very little β 1 and β 2 adrenergic receptor activity and as such the compounds are capable of increasing...
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5712295 |
Agonists and antagonists of the nicotinic acetylcholine receptors of insects to control endoparasites
Use of agonists and antagonists of the nicotinergic acetylcholine receptors of insects for combating endoparasites is disclosed.
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5710166 |
N-acyl beta amino acid derivatives useful as platelet aggregation inhibitors
Novel N-Acyl Beta Amino Acid derivatives of the formula ##STR1## are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using...
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5710160 |
Diphenyl pyridyl ethane derivatives as PDE IV inhibitors
The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the...
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5707640 |
Poisonous baits for controlling soil-inhabiting pests
A poisonous bait for controlling soil-inhabiting pests comprising an active compound for controlling a soil-inhabiting pest and, as excipient, an artificial culture medium for mushrooms or the...
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5703095 |
Use of N-arylmethylene, ethylenediaminetriacetates, N-arymethylene iminodiacetates or N,N'-diarylmethylene ethylenediamineacetates against oxidative stress
N-arylmethylene ethylenediaminetriacetate, N-arylmethylene iminodiacetate or N,N'-diarylmethylene ethylenediaminediacetate type compounds and their use in combatting oxidative stress, and...
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5700460 |
Methods of attracting and combatting insects
A method for attracting and controlling insects comprising offering to said insects for ingestion an effective amount of a compound of the formula: ##STR1## wherein the structural variables are as...
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5700817 |
Cyclic lipid derivatives as potent PAF antagonists
The present invention describes novel cyclic diol derivatives represented by formula I and II: ##STR1## in which Y represents O, S, SO, SO 2 , (CH 2 ) m wherein m is zero or an integer of 1 to 5,...
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5698565 |
Use of phenoxy-pyridine derivatives
A method of treating or preventing illnesses caused by a disorder of the dopamine system. The method comprises administering to a host requiring such treatment or prevention an effective amount of...
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5693659 |
Substituted oxime derivatives and processes for their preparation
Compounds of general formula (1) are described: ##STR1## wherein W-- is (1) C(Y)-- where Y is a halogen atom, or an alkyl or --XR a group where X is --O--, --S(O) m -- where m is zero or...
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5691366 |
Nitro compounds, process for preparation thereof and use thereof
A new nitro compound of the formula: ##STR1## wherein R 1 and R 2 are each lower alkyl or lower alkoxy(lower)-alkyl, or ##STR2## is cyclized to form ##STR3## X is --O--, --S-- or --NH--, m is an...
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5688819 |
Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH...
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5681820 |
Guanidinoalkyl glycine β-amino acids useful for inhibiting tumor metastasis
This invention herein relates to a method of treating a condition mediated by inhibition of α v β 3 integrins and a method of inhibiting tumor metastasis by administering a therapeutically...
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5672597 |
Acetamide derivative
An acetamide derivative having the general formula (I): ##STR1## or a pharmacologically acceptable salt thereof; a synthetic intermediate of the above-mentioned acetamide derivative; a treating...
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5672609 |
Pyridine compounds, intermediates compositions and methods of use
The present invention is directed to compounds of Formula I: ##STR1## wherein: n is 2 or 3; R is dimethylamino, diethylamino, 1-piperidinyl, 1-pyrrolidinyl, 4-morpholinyl, or...
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5672615 |
Arylsulfonamido-substituted hydrodxamic acids
Disclosed are the compounds of formula I ##STR1## wherein R and R 1 together with the chain to which they are attached or R 1 and R 2 together with the carbon atom to which they are attached...
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5670528 |
Thioamides and their use as crop protection agents
Thioamides of the formula I ##STR1## where A, B, R' are hydrogen, cyano, alkyl, alkoxy or halogen, X is CHCH 3 or N--OCH 3 , R 1 , R 2 - are hydrogen or alkyl, Y is a group...
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5668146 |
Symmetrical bis-heteroarylmethoxyphenyliminoxyalkyl carboxylates as inhibitors of leukotriene biosynthesis
Compounds having the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein W and Y at each occurrence are the same and W is selected from the group consisting of optionally...
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5665756 |
Aminoalkyloximes useful in the treatment of depression and obsessive compulsive disorders
Novel aminoalkyloximes of the formula ##STR1## wherein: a. X is hydrogen, loweralkyl, loweralkoxy, halogen, trifluoromethyl, or a group of the formula ##STR2## wherein Y is hydrogen or loweralkyl,...
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5658908 |
Opioid diarylmethylpiperazines and piperdines
Diarylmethylpiperazine compounds having utility as receptor-binding species, e.g., for mediating analgesia, and for combatting drug addiction, alcohol addiction, and drug overdose. The compounds...
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5658919 |
Aqueous pharmaceutical suspension and process for preparation thereof
The present invention relates to an aqueous pharmaceutical suspension composition containing suspended acetaminophen and at least one additional pharmaceutical active, a suspension system...
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5658904 |
1,2-ethanediol derivative and salt thereof and cerebral function-improving agent comprising the same
This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral...
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5656636 |
Pyridine compounds for treating leukotriene-related diseases
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5652252 |
Benzocycloheptenes
The subject of the invention is compounds of general formula: ##STR1## in which: X represents O or CHR, R 1 , R 2 , R 3 and R 4 , which are identical or different, represent a hydrogen atom or...
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5652250 |
N-substituted β-aryl- and β-heteroaryl-α-cyanoacrylamide derivatives and process for their preparation
The present invention relates to new compounds of formula ##STR1## wherein A is a bicyclic ring chosen from naphthalene, tetrahydronaphthalene, quinoline, isoquinoline and indole. B is a R 2 ...
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5650174 |
Composition for peroral therapy of cognition impairment and a process thereof
A solid composition for peroral therapy of cognition impairment is formulated to stabilize the acid labile drug, CI-979 HCl, by layering a mixture of thereof with a binder on mini-sugar spheres,...
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5648369 |
Aminoalkylpyridine compounds which are useful as anitconvulsant drugs, excitatory amino acid inhibitors and NMDA sigma receptor antagonists
Pharmaceutical compositions comprise as the active ingredient potent orally active, nonneurotoxic anticonvulsant compounds that are excitatory amino acid and NMDA/sigma receptor antagonists and...
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5646167 |
Arylsulfonamido-substituted hydroxamix acids
Disclosed are compounds of formula I ##STR1## wherein R, R 1 , R 2 and Ar have meanings as defined; pharmaceutically acceptable prodrug derivatives and pharmaceutically acceptable salts thereof;...
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5643960 |
Method of delaying onset of alzheimer's disease symptoms
The present invention relates, in general, to a method of preventing or delaying the onset of Alzheimer's disease and related neurodegenerative disorders. The method involves the administration to...
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5639789 |
Butadiene derivatives and process for using the same
Novel butadiene derivatives of the formula [I]: ##STR1## wherein Ring A is tri-lower alkoxyphenyl, R 1 and R 2 combine each other to form a group of the formula: ##STR2## or one of R 1 and R 2 ...
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5631253 |
Fungicidal propenoic acid derivatives
Compounds having the formula (I): ##STR1## and stereoisomers thereof, wherein A is hydrogen, halo, hydroxy, C 1 -4 alkyl, C 1 -4 alkoxy, C 1 -4 haloalkyl, C 1 -4 haloalkoxy, C 1 -4 alkylcarbonyl, C...
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5624943 |
Pyridine compounds which are useful as leukotriene-B.sub.4 -antagonists
The invention relates to new pyridine derivatives of general formula I which have useful properties, e.g., as leukotriene-B 4 -antagonists. Pharmaceutical compositions containing these compounds...
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5622723 |
Procedure for encapsulating chlorpheniramine
An improvement in the process of coacervation of chlorpheniramine maleate is provided whereby a predetermined amount of chlorpheniramine maleate charged to the process is maintained in the...
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5616336 |
Method of combatting insect eggs and ovicidal compositions
A method of protecting a crop by killing eggs of insects, or insects at the egg stage, the insects being detrimental to the crop, said method comprising applying to a locus where the eggs of...
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5614550 |
Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses
Compounds of formula (I) are provided: ##STR1## wherein: R 1 represents an alkyl group; or a group of formula (II), (III), (IV) or (V): ##STR2## and wherein the groups R 2 , R 3 , R 4 and R 5 ...
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5614539 |
Urea compounds which are useful as platelet aggregation inhibitors
Novel urea derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
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5612358 |
Pyridine compouds which have useful insecticidal activity
An insecticidal compound of the formula ##STR1## wherein A completes a 5 or 6 membered aromatic ring selected from the group pyridyl, pyridyl substituted with C 1 -5 alkyl, C 1 -5 haloalkyl, C 1 -5...
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5607978 |
Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives, substituted in the 1-position with halo, methyl, hydroxyl, nitro, amino, amido, azido, oxime,...
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5605916 |
Arylalkyl-amines having anticonvulsant and neuroprotective properties
There is provided a method of treatment of neurological disorders, such as epilepsy, stroke and cerebral ischaemia, which comprises the administration of a compound of Formula I: ##STR1## wherein,...
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5605902 |
5-HT.sub.2 receptor antagonist compositions useful in treating venous conditions
Methods of employing compositions containing 5-hydroxytryptamine-2 (5-HT 2 ) receptor antagonists for the treatment of such venous conditions as varicose veins, venous insufficiency and wounds are...
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