Sign up


Match Document Document Title
8889720 Non-flushing niacin analogues, and methods of use thereof  
One aspect of the present invention relates to substituted pyridines and pharmaceutically acceptable salts thereof that are active against a range of mammalian maladies. Another aspect of the...
8871263 Manufacture of tablet in a die utilizing radiofrequency energy and meltable binder  
The present invention features a process for making a tablet by (i) compacting a powder blend in a die to form a tablet shape, wherein the powder blend contains a pharmaceutically active agent and...
8871738 Fused bicyclic oxazolidinone CETP inhibitor  
Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol,...
8865204 Manufacture of lozenge product with radiofrequency  
The present invention features a process for making a lozenge product including the steps of forming a powder blend containing an amorphous carbohydrate polymer into the desired shape of the...
8859603 Method for solubilizing metronidazole  
Metronidazole is solubilized in an aqueous phase, by mixing same with niacinamide and at least two glycolic cosolvents; the resulting solutions and pharmaceutical compositions comprised thereof are...
8846724 Compositions for treating obesity and insulin resistance disorders  
Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a...
8846723 Esters of O-substituted hydroxy carboxylic acids and preparations thereof  
Esters of O-substituted hydroxy carboxylic acids are provided having Formula 1, or 2, or both Formulas 1 and 2: wherein R and R1 are independently selected from the group consisting of substituted...
8821944 Polymorph compositions, methods of making, and uses thereof  
The described invention provides a biodegradable, biocompatible delivery system of flowable sustained release microparticulate composition of a substantially pure crystalline form of a bioactive...
8795630 Butyrylcholinesterase ligands as diagnostic tools and treatment for diseases of the nervous system  
Compounds useful for the early diagnosis of malignant tumors, multiple sclerosis, and especially Alzheimer's Disease and related dementias; especially compounds of Formula (I) wherein R1 is...
8796330 Inhibitors of histone deacetylase and prodrugs thereof  
The invention relates to the inhibition of histone deacetylase. The invention provides compounds, prodrugs thereof, and methods for inhibiting histone deacetylase enzymatic activity. The invention...
8790626 Method for treating hair growth disorders, such as female pattern alopecia, and compositions useful therefore  
The invention relates to formulations useful in treating hair disorders, improving the health of hair, increasing hair growth, and in increasing the niacin content of hair follicles. Nicotinic acid...
8790703 Method for producing preparations of substances poorly soluble in water  
The invention relates to a process for producing formulations of sparingly water-soluble substances, said sparingly soluble substances being present in amorphous embedded form in a copolymer, and...
8785432 Pharmaceutical compositions of amlodipine and valsartan  
A single layer pharmaceutical composition comprising active agent(s) amlodipine or a pharmaceutically acceptable salt thereof and valsartan or a pharmaceutically acceptable salt thereof wherein the...
8772230 Niacin and/or trigonelline as a muscle stimulant  
This invention relates to the use of niacin and/or trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.
8734769 1L1RL-1 as a cardiovascular disease marker and therapeutic target  
This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to...
8722669 Compounds and methods of treating ocular disorders  
A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically...
8715706 Methods and devices for delivery of pharmaceutical agents within orifices of the body  
A device for drug delivery to an orifice of a subject, comprising a shell which is elastically stressed by an active pharmaceutical ingredient, said shell containing and being substantially...
8716319 Substituted heterocyclic compounds  
The present invention relates to novel heterocyclic compounds and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments,...
8673944 Solid pharmaceutical composition comprising amlodipine and losartan with improved stability  
The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising granular forms of amlodipine and losartan which are separated from...
8673945 Solid pharmaceutical composition comprising amlodipine and losartan  
The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising amlodipine and losartan as active ingredients, and a disintegrant...
8658676 Clevidipine emulsion formulations containing antimicrobial agents  
Pharmaceutical formulations comprising clevidipine in an oil-in-water formulation that is resistant to microbial growth and stable against the formation of impurities.
8652519 Dissolution properties of drug products containing olmesartan medoxomil  
A pharmaceutical tablet containing olmesartan medoxomil and amlodipine besylate, which has improved dissolvability. Said composition contains (A) olmesartan medoxomil and (B) amlodipine besylate as...
8637080 Rupturing controlled release device comprising a subcoat  
The present invention provides a simple and improved rupturing controlled release device that is capable of providing a controlled release of active agent contained in the core first through a...
8633192 Compositions and uses thereof  
Compositions and their use in the treatment or prevention of hyperglycemia and related diseases or disorders are disclosed.
8633229 Pharmaceutical composition having dopaminergic activity  
The present invention relates to a pharmaceutical composition having dopaminergic activity and other related pharmaceutical activities comprising trigonelline or its derivative(s) and...
8618174 Synergistic combinations comprising a renin inhibitor for cardiovascular diseases  
The invention relates to a combination comprising the renin inhibitor of formula (I) or a pharmaceutically acceptable salt thereof.
8604054 Triglyceride-lowering agent and hyperinsulinism-ameliorating agent  
The present invention is directed to a triglyceride-lowering agent, exhibiting excellent triglyceride-lowering effect and a hyperinsulinemia-ameliorating agent. The triglyceride-lowering agent and...
8574619 Reducing cholesterol levels with combined use of quercetin and statin  
A method of reducing the cholesterol level of a subject by administering to that subject quercetin, vitamin C, vitamin B3, and statin.
8557865 Methods for treating osteoarthritis  
A method and composition for treating osteoarthritis with ion-channel regulators is disclosed. The ion-channel regulators are used alone or in combination with other osteoarthritis treatment...
8507548 Method for treating addiction using quercetin-containing compositions  
This invention relates to a method of treating addiction using a composition containing quercetin. Preferably, it also contains vitamin B3, and vitamin C.
8492413 Pharmaceutical combination of 5-fluorouracil and derivate of 1,4-dihydropyridine and its use in the treatment of cancer  
New compounds of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ester type having general formula I wherein R is a lower alkyl group, which is methyl or ethyl R1 and R2 is sodium...
8481570 1-methylnicotinaide derivatives and formulations of treatment of lipoprotein abnormalities  
The present invention is directed to nicotinamide derivatives, and their use in treating lipoprotein abnormalities, alone or in combination with a statin.
8440638 Compositions and methods for modulating calcium flux, glucose homeostasis and apoptosis  
Compositions and methods are disclosed which are effective for modulating glucose homeostasis, calcium ion flux and cell death in target cells.
8426451 Oral solid preparation and method of manufacturing the same  
An oral solid preparation including a base compound and a powdery or granular additive colored with a colorant and a method of manufacturing an oral solid preparation including the steps of:...
8389552 (S)-6-(2-(4-(cyclobutylsulfonyl)-1H-imidazol-1-yl)-3-cyclopentylpropanamido)nicotinic acid useful as a glucokinase activator  
The present invention provides Formula (1A) compounds that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by...
8389574 Method useful for the prevention of type 2 diabetes and its complications in pre-diabetic patients with insulin resistance  
The present invention relates to the use of acetyl L-carnitine in combination with an anti hypertensive drug, and a statin, for the preparation of a medicament for the prevention or delay of onset...
8377971 Non-flushing niacin analogues, and methods of use thereof  
One aspect of the present invention relates to substituted pyridines and pharmaceutically acceptable salts thereof that are active against a range of mammalian maladies. Another aspect of the...
8343533 Manufacture of lozenge product with radiofrequency  
The present invention features a process for making a lozenge product including the steps of forming a powder blend containing an amorphous carbohydrate polymer into the desired shape of the...
8329746 Method for treating osteoarthritis  
A method and composition for treating osteoarthritis with ion-channel regulators is disclosed. The ion-channel regulators are used alone or in combination with other osteoarthritis treatment...
8309535 Compositions and methods to treat recurrent medical conditions  
The invention describes methods and compositions for alleviating recurrent medical afflictions for which anxiety may cause or exacerbate the affliction. A subject suffering from the affliction is...
8293721 CETP inhibitors derived from benzoxazole arylamides  
Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are potent CETP inhibitors, and are useful for raising HDL-cholesterol, reducing...
8263574 Topical formulations for the treatment of depression with S adenosyl methionine  
Disclosed herein are topical formulations for treating depression with S adenosyl methionine (SAM-e) The topical formulations contain at least 35% wt/wt of SAM-e partially dissolved in aqueous and...
8236346 Method for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (-)-nilvadipine enantiomer  
The present invention provides methods for reducing Aβ deposition, Aβ neurotoxicity and microgliosis in an animal or human afflicted with a cerebral amyloidogenic disease, such as Alzheimer's d...
8236347 Pharmaceutical compositions for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis  
The present invention provides methods for reducing Aβ deposition, Aβ neurotoxicity and microgliosis in an animal or human afflicted with a cerebral amyloidogenic disease, such as Alzheimer's d...
8221799 Multiple antioxidant optimal health/veterans ultimate complete formulations  
The invention is directed to a method for administering antioxidant micronutrient formulations comprising multiple dietary and endogenous antioxidants, B-vitamins, vitamin D and minerals at...
8217062 Topical composition comprising a dihydropyridine calcium antagonist  
A topical composition comprising a dihydropyridine calcium antagonist, a stiffening agent and a release modifier. The stiffening agent comprises a fatty alcohol, a fatty acid sorbitane ester, or a...
8211947 Composition and method for treating and preventing musculoskeletal and connective tissue disorders  
The present invention relates to a pharmaceutical composition and method for treating and preventing musculoskeletal and connective tissue diseases of unknown etiology, such as different forms of...
8211922 1-methylnicotinamide derivatives and formulations for treatment of lipoprotein abnormalities  
The present invention is directed to nicotinamide derivatives, and their use in treating lipoprotein abnormalities, alone or in combination with a statin.
8183295 Pharmaceutical composition comprising a renin inhibitor, a calcium channel blocker and a diuretic  
The invention relates to a pharmaceutical composition comprising (i) a renin inhibitor, (ii) a calcium channel blocker (CCB), and a diuretic and to a method of using such composition for the...
8143241 DNA damage repair inhibitors for treatment of cancer  
The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and...