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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7494989 |
Pyridine compounds useful as N-type calcium channel antagonists
Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when...
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7482026 |
Compositions and methods directed towards sore muscles and joints
Chemical formulations and methods for reducing muscle and joint soreness are disclosed. A representative chemical formulation includes compounds such as a selenium-compound, chondroitin sulfate,...
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7470718 |
Method for treating a demyelinating condition
Methods for treating a demyelinating condition in a subject in need of treatment are provided. In some aspects the methods encompass administering to the subject an amount of a Ca 2+ -channel...
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7442714 |
Amlodipine gentisate and a method of its preparation
The present invention relates to an acid salt of amlodipine gentisate and a method of its preparation. More particularly, the present invention relates to a crystalline acid salt of amlodipine...
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7425319 |
Method for enhancing protective cellular responses to genotoxic stress in skin
The present invention is directed to methods of using pro-NAD agents capable of enhancing the dermal and epidermal skin cell NAD content. These pro-NAD agents may be administered topically, orally,...
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7419655 |
Skin care products
The invention provides compositions and methods for conditioning the skin and reversing the effects of aging on the skin.
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7381434 |
Methods and compositions of Areca catechu
This invention comprises methods and compositions of Areca catechu . Methods of the present invention comprise extracting plant material of Areca catechu so that compositions having...
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7381427 |
Seborrheic keratosis treatment
The subject of the present invention is seborrheic keratosis removal and prevention utilizing safe dependable effective biocompatible treatments with no scarring, bleeding, burning, freezing,...
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7348317 |
Aqueous compositions containing metronidazole
An aqueous solution of metronidazole in which the concentration of metronidazole is higher than 0.75%. The solution contains a combination of solubility-enhancing agents, one of which is a...
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7335380 |
Amlodipine free base
Amlodipine free base can be formulated into a convenient oral dosage form, especially a tablet, without excessive stickiness or tablet punch residue. The amlodipine free base can be crystalline...
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7332152 |
Cosmetic composition
A cosmetic composition is provided comprising vitamin B 6 , vitamin B 3 and an organic acid. The components of the composition interact synergistically to enhance skin lightening.
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7320993 |
Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents
The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or...
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7291352 |
Methods and compositions for oral delivery of Areca and mate' or theobromine
The present invention comprises methods and compositions comprising Areca extract compositions and compositions comprising extracts of Ilex paraguariensis or theobromine. Methods of the...
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7279492 |
S-(−)-amlodipine nicotinate and process for the preparation thereof
The present invention provides a novel salt of S-(−)-amlodipine, i.e., a nicotinic acid salt of S-(−)-amlodipine, a process for preparing the same, and a pharmaceutical composition comprising...
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7273856 |
Linear basic compounds having NK-2 antagonist activity and formulations thereof
Described herein are compounds of formula (I) useful as antagonists of tachykinins in general, and in particular of neurokinin A; and the pharmaceutical formulations comprising the compounds of...
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7247645 |
Dihydropyridine derivatives
Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula:
analogs thereof and pharmaceutically...
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7244749 |
Compositions and methods for lowering plasma lipoprotein(a) and risk factors of cardiovascular diseases
The present invention provides compositions and methods for lowering plasma Lp(a) levels in humans. The present invention provides compositions and methods for lowering the risk factors for...
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7241456 |
Formulations for topical delivery of bioactive substances and methods for their use
The invention relates to topical delivery of bioactive agents. More particularly, the invention relates to anhydrous formulations for percutaneous absorption. The invention provides formulations...
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7235570 |
1,4-dihydropyridine and pyridine compounds as calcium channel blockers
The present invention is directed in part towards methods of modulating the function of calcium channels with pyridine- or 1,4-dihydropyridine-based compounds. In addition, the invention describes...
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7229999 |
Pyridine-3-carboxamide derivatives as CB1 inverse agonists
The present invention relates to compounds of the formula
wherein X and R 1 to R 8 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds...
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7226937 |
Methods for modulating phototoxicity
The invention relates to methods for modulating photodamage via the use of collagen derived molecules which either enhance or inhibit damage caused by ultraviolet light.
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7202278 |
4-fluoro-N-indan-2-yl benzamide and its use as a pharmaceutical
A method of stimulating the expression of endothelial NO-synthase in a mammal, which method comprises administering a physiologically active amount of 4-fluoro-N-indan- 2-yl benzamide according to...
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7199140 |
Vinyl phenyl derivatives as GLK activators
The invention relates to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein A, R 1 , R 2 , R 3 , n and m are described in the specification, useful in the treatment of
...
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7169805 |
Captopril derivatives
Captopril nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment or prophylaxis of cardiovascular, inflammatory...
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7153877 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7148245 |
Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them
Compounds of formula (I):
in which:
Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, R 2 and R 3 ...
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7148239 |
Method of enhancing cellular production of molecular chaperon, hydroxylamine derivatives useful for enhancing the chaperon production and the preparation thereof
A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed...
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7138146 |
Acrochordon alleviation
The subject of the present invention is acrochordon removal and prevention utilizing safe dependable effective biocompatable treatments with no scarring, bleeding, twisting, yanking, choking,...
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7119110 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7115638 |
Amide derivative of amlodipine
A derivative of amlodipine having the following formula is useful as a pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension
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7115563 |
Composition and its therapeutic use
A composition having a variety of therapeutic and cosmetic uses comprises:
(i) a vitamin; (ii) a metal salt that provides metal ions in vivo; and (iii) insulin or a growth hormone.
...
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7109206 |
Methods and compositions for the rapid and enduring relief of inadequate myocardial function
Disclosed are methods and compositions for reducing coronary artery stenosis, restoring blood flow to infarcted myocardium, improving myocardial perfusion, reducing heart attacks or other adverse...
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7101909 |
Calcium channel drugs and uses
Novel multibinding compounds are disclosed. The compounds of this invention comprise 2–10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a...
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7101868 |
Substituted arylamine derivatives and methods of use
Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7078048 |
Method and compositions for treating rosacea
Rosacea is treated with a composition comprising an antimicrobial and at least one of an anti-inflammatory and a non-retinoid inhibitor of at least one of NF-κβ, AP-1, MMPs, adhesion molecules,...
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7049308 |
C-nitroso compounds and use thereof
A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (from 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon,...
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7041286 |
Composition for mitigating a pernicious thrombotic event
A composition. The composition comprises aspirin, magnesium, and nattokinase, and either niacin or nitroglycerine. The composition has a structural form of: a chewable form, a dissolvable form, a...
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7015238 |
Crystalline organic acid salt of amlodipine
A novel crystalline organic acid salt of amlodipine having improved physiochemical properties, a preparation method thereof and a pharmaceutical composition comprising the same are provided.
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7012086 |
Treatment of retrovirus induced derangements with niacin compounds
Chronic infection with retroviruses, such as HIV, induce a number of metabolic derangements. The present invention relates to a method for treating retrovirus-infected subjects with niacin...
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7008950 |
Benzofurans as suppressors of neurodegeneration
A compound of the formula:
wherein R 1 and R 2 each is H or a hydrocarbon group which may be substituted, or R 1 and R 2 form a 3- to 8-membered carbo or heterocyclic ring which may be...
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6998411 |
2-Methylheptylisonicotinate and process for production thereof
The present invention relates to a novel antifungal antibacterial compound 2-methylheptylisonicotinate of formula 1 below obtained from natural sources and to a process for the isolation thereof.
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6995179 |
Dihydropyridine derivative
Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel....
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6995148 |
Adenosine cyclic ketals: novel adenosine analogues for pharmacotherapy
The present invention relates to novel compounds that are novel adenosine receptor analogues. Specifically, the compounds of the present invention preferably function as both adenosine receptor...
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6992095 |
Stilbene compounds comprising an adamantyl group, compositions and methods thereof
The invention relates to novel stilbene compounds having the general formula (I):
as well as to pharmaceutical compositions for use in human or veterinary medicine, including dermatological,...
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6969533 |
Beverage and additive for inflamed tissue
The invention is a beverage involving an ingestible fluid and a dosage amount of an ingestible composition for treating an inflammatory tissue in a mammal, involving the inflammatory tissue...
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6964782 |
Stable hydrogen peroxide compositions, products and methods of use
Disclosed are several preferred embodiments of hydrogen peroxide which are packaged with ease of use and extended shelf-life in mind. The embodiments include foam, mist, gel, and disposable...
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6936625 |
Amlodipine camsylate and method for preparing thereof
Amlodipine camsylate of the present invention is a crystalline salt of amlodipine suitable for pharmaceutical formulation, which is prepared by using low toxic camphor sulfonic acid to meet...
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6924299 |
Methods and compositions useful in enhancing oxygen delivery to cells
The invention discloses compositions and methods which are useful in improving delivery of oxygen to cells. The compositions require at least one derivative of a compound. The derivatives are...
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