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6191151 |
Therapy for herpes neurological viral conditions utilizing 1,4-dihydropyridine calcium channel blockers
A therapy for Bells Palsy in mammals is proposed that rests on a causal hypothesis involving both endothelin and the herpes virus, particularly the herpes simplex virus for Bell's Palsy. Similarly,...
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6168806 |
Orally administrable nifedipine pellet and process for the preparation thereof
The present invention relates to a fast-release as well as a prolonged release type of nifedipine pellets and the process for the preparation thereof. The fast-release type of nifedipine pellets...
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6162802 |
Synergistic combination therapy using benazepril and amlodipine for the treatment of cardiovascular disorders and compositions therefor
A method for the treatment of a variety of cardiovascular disorders and related conditions in a mammal having at least one such disorder or condition is disclosed comprising treating the mammal...
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6162468 |
Frozen aqueous solution with nutrients method of packaging and utilizing the same
The invention encompasses a frozen composition containing an active ingredient. The active ingredients include but are not limited to a nutrient mixture and a medicine. In its preferred embodiment,...
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6159993 |
Methods and compositions for the rapid and enduring relief of inadequate myocardial function
Disclosed are methods and compositions for reducing coronary artery stenosis, restoring blood flow to infarcted myocardium, improving myocardial perfusion, reducing heart attacks or other adverse...
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6160018 |
Prophylactic composition and method for alzheimer's Disease
A method of preventing or delaying the onset of symptoms of Alzheimer's Disease includes the step of administering to a patient in need of such treatment a composition having an effective...
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6149896 |
Cosmetic and cosmeceutical compositions
Cosmetic and cosmeceutical compositions which enhance repair of damage caused to human DNA caused by excessive exposure to sunlight or to other radiation causing such damage. The active ingredients...
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6150413 |
Triaromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active triaromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or...
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6146653 |
Pharmaceutical preparation and a method for the treatment of diabetes
A method of treatment of humans suffering from diabetes which involves transplantation into the human of viable porcine islets capable of producing insulin within its host. The invention also...
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6127393 |
Antiproliferative, antiinfective, antiinflammatory, autologous immunization agent and method
An antiproliferative, antiinflammatory, antiinfective, immunization agent of a metal ion chelating agent such as picolinic acid or derivatives thereof, and methods of using the same. The agents...
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6110970 |
Nitrogen-containing oxyalkylene esters and uses thereof
This invention relates to nitrogen-containing oxyalkylene diester compositions for treating disease conditions including cancer and other proliferative diseases. The nitrogen-containing oxyalkylene...
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6100258 |
Aromatic amine compounds that antagonize the pain enhancing effects of prostaglandins
Compounds antagonistic of the pain enhancing effects of prostaglandins are disclosed. The compounds comprise an optionally-substituted A ring with a --CH(R 3 )N(R 2 )B--R 1 and --OD groups...
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6100251 |
Chromium polynicotinate compositions
Compositions comprising chromic tripicolinate or chromic polynicotinate in the form of enteric-coated tablets, capsules or microbeads, optionally in combination with nicotinic acid, picolinic acid...
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6090807 |
Use of heterocyclic compounds
The present invention relate to the use of heterocyclic compounds of the following formula: Het--A--B--Ar where Het, A, B and Ar have the meanings stated in the description. The compounds...
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6090830 |
Controlled release compositions and methods for the treatment of hyperlipidemia
Lipid lowering dosage units, to be used once a day, produce minimal side effects. They contain a combination of microspheres formulated to co-deliver a HMG-CoA reductase inhibitor component and a...
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6083963 |
Short contact treatment of photoaging with topical retinoids
The present invention relates to a method of treating photoaging using short-term contact with a topically-applied retinoid composition.
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6071939 |
Medicaments for the treatment of hypertension
A composition comprising diethyl (E)-4-[2-[(tert-butyloxycarbonyl)vinyl]phenyl-1,4-dihydro-2,
6-dimethylpyri dine-3,5-dicarboxylate (lacidipine) and 4'-[[2-n-propyl-4-methyl-6...
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6066655 |
4-phenyl-3-substituted 1,4-dihydropyridine esters
4-Phenyl-3-substituted 1,4-dihydropyridine esters are prepared by reaction of benzaldehydes with ketoesters and enamines, if appropriate with isolation of the ylidene intermediate products, or by...
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6063797 |
γ-RAR antagonist ligand or α-RAR agonist ligand as an apoptosis inhibitor
The use of a combination of an alpha RAR receptor-specific agonist ligand and a gamma RAR receptor-specific antagonist ligand to reduce the rate of apoptosis is disclosed.
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6057342 |
Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof,...
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6057344 |
Methods for treating hypertension, and angina using optically pure (-) amlodipine
Methods are disclosed utilizing the optically pure (-) isomer of amlodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse...
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6048881 |
Method of treating chronic pain associated with muscle spasms, tendonitis and sciatica
The invention is a method of treating chronic pain associated with muscle spasms, tendonitis and sciatica comprising administering to a human patient an effective amount of niacin.
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6020351 |
Carotenoid-nicotinamide-zinc compositions and methods of treatment using same
Selectively administering to humans, as a daily dosage, a combination of carotenoids, nicotinamide (or niacin or a precursor thereof) and a source of zinc, in excess of normal dietary levels, for...
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6017938 |
Short contact treatment for acne
The present invention relates to a method of treating acne using short-term contact with an acetylenic retinoid, preferably tazarotene and related compounds.
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6011054 |
Method for treating depression, obsessive compulsive disorder, and anxiety with N--acetyl serotonin
The present invention relates to a method of treatment of depression in a human being identified as having depression. This method comprises the administration of a therapeutically effective...
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6004988 |
Carboxylic acid derivatives, their preparation and their use
Carboxylic acid derivatives of the formula I ##STR1## here R 1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the...
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6004987 |
Use of ligands which are specific for RXR receptors
The present invention relates to the use of at least one ligand which is specific for RXR receptors, in the preparation of a pharmaceutical composition to be administered systemically and intended...
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6001836 |
Dihydropyridine NPY antagonists: cyanoguanidine derivatives
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of cyanoguanidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of...
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5998448 |
Combined preparations with vascular effect containing dihydropyridines acetylsalicylic acid nitroesters and vitamins
The invention relates to new combinations of dihydropyridines of the general formula (I) ##STR1## in which R 1 to R 5 have the meaning indicated in the description, for the prevention and...
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5985860 |
System for transdermal delivery of pain relieving substances
Compositions for pain relieving non-steroidal anti-inflammatory drugs and/or medicaments such as ibuprofen, methotrexate, capsaicin, diphenhydramine, aspirin, methyl-nicotinate and other...
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5981555 |
Compositions, kits and methods for administration of antilipemic drugs
The present invention concerns composition, kits and methods for reducing the flushing effect (cutaneous erythema) of an antilipemic drug, for treating hyperlipemia, for improving the effectiveness...
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5962482 |
Method of reducing cellulite in mamalian skin
The present invention relates to a method for combating cellulite or reducing localized fatty excesses which comprises administering to a person having cellulite or localized fatty excesses a body...
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5955482 |
Use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters as medicaments
The present invention relates to the use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters, some of which are known, of the general formula (I) ##STR1## in which A and R 1 -R 3 have the meaning...
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5948799 |
Method for improving morbidity and/or mortality
This invention relates to a method for reducing morbidity and/or mortality in a mammal with congestive heart failure due to non-ischemic etiology comprising administering amlodipine or a...
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5948443 |
Acetylsalicylic acid and micronutrient supplementation for nutritional losses and coronary heart disease
The present invention pertains generally to the field of Public Health, including the prevention and treatment of coronary heart disease which is currently the first cause of death in the American...
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5942526 |
5-acyl-1,4-dihydropyridines
The present invention relates to the new use of 1-alkyl-3,5-diacyl-1,4-dihydropyridines which are known in some cases, of the general formula (I) ##STR1## in which R 1 to R 4 have the meaning...
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5929122 |
Combination preparation containing tramadol and a calcium channel antagonist
A pharmaceutical combination preparation, particularly for the treatment of pain, which contains a combination of the pain killer tramadol with at least one calcium channel antagonist, and a method...
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5916906 |
Compositions comprising nicotinylalanine and an inhibitor of glycine conjugation or vitamin B6
This invention relates to compositions comprising nicotinylalanine (NAL) and/or related analogues, and an inhibitor of glycine conjugation, either synthetic or naturally occurring. Vitamin B6 may...
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5905086 |
Remedy for anxiety neurosis
N-(2-Hydroxyethyl)nicotinamide nitrate or its salt prevents or ameliorates anxiety neurosis or panic disorder, or the following anxiety. This compound or its salt has few side effects and exhibits...
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5905075 |
Chromium nicotinate compositions and uses thereof
Compositions comprising chromic tripicolinate or chromic polynicotinate in combination with nicotinic acid, picolinic acid or both nicotinic acid and picolinic acid. The compositions may further...
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5902609 |
Composition for the control of wound scar production
This invention pertains to a composition for controlling wound scar production containing a calcium antagonist and a protein synthesis inhibitor. The method can be used to minimize wound scars,...
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5900425 |
Pharmaceutical preparations having controlled release of active compound and processes for their preparation
The invention relates to pharmaceutical preparations having controlled release of active compound and to processes for their preparation, in particular for poorly soluble active compounds having...
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5900239 |
Hair growth stimulating composition containing trigonelline or trigonellic acid and ginseng
A strengthening agent for living creatures for the care of the skin and horny structures, in particular nails, hooves and claws, and for the stimulating and/or revitalizing of the growth of...
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5891845 |
Drug delivery systems utilizing liquid crystal structures
Vitamin E TPGS/drug compositions and methods are provided which obviate the need for surfactants or non-evaporated co-solvents because the active drug component is dissolved directly into Vitamin E...
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5886012 |
Method of treatment for disease associated with excessive PHF using combination therapy involving exogenous calcium and calcium channel blockers
Hypotensive mammals are treated to lower mean blood pressure by administering synergistic amounts of a calcium blocking agent together with a calcium supplement.
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5871776 |
Controlled-release nifedipine
A nifedipine formulation for oral administration is described that provides controlled, constant release of the pharmaceutical for about twenty four hours after a short delay following oral...
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5856346 |
Short-acting dihydropyridines
Compounds of the general formula ##STR1## wherein R 1 and R 2 are independently selected from the group consisting of hydrogen, chloro, bromo, nitro, cyano, trifluoromethyl, and R 3 and R 4 are...
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5856328 |
Circulatory disorder improving agent
A circulatory disorder improving agent comprising, as an active ingredient, a dihydropyridine derivative of the formula (I) ##STR1## or an acid addition salt thereof. Said circulatory disorder...
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5837725 |
Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors
Bridged bicyclic aromatic compounds are provided having the structure ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are as defined herein. The novel compounds are useful for modulating gene...
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5834496 |
Methods for treating hypertension using optically pure S(-) felodipine
Methods and compositions are disclosed utilizing the optically pure S(-) isomer of felodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant...
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