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7612103 |
Pleuromutilin derivatives as antimicrobials
Compounds of formula
wherein
R 1 and R 1 ′ are hydrogen or deuterium, R 2 , R 3 and R 4 are hydrogen or deuterium, R 5 is the residue of an amino acid, X is S or N-ALK,
is...
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7589232 |
Alkynyl aryl carboxamides
The present invention is related to alkynyl aryl carboxamides of Formula (I′) and use thereof for the treatment and/or prevention of an inflammatory disorder, obesity and/or metabolic disorders...
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7589089 |
Inhibitors for GlyT-1
The present invention relates to compounds of formula I
wherein
R 1 , R 2 , R 3 , R 4 , and X are as defined herein or to pharmaceutically acceptable acid addition salts thereof, with the...
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7579367 |
Aryl substituted pyridines and the use thereof
This invention relates aryl substituted pyridines of Formula I:
or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R 1 -R 4 are set in the specification. The...
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7560473 |
Amine derivative with potassium channel regulatory function, its preparation and use
The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions...
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7560456 |
Pesticidal pyridinecarboxamide derivatives
The invention relates to 3-pyridylcarboxamide derivatives of formula (I):
wherein the various symbols are as defined in the description, compositions thereof, methods for controlling pests by...
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7550489 |
Substituted pyridyoxy amides
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases...
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7528274 |
Acylthiols and component thiol compositions as anti-HIV and anti-retroviral agents
Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and...
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7514456 |
Nicotinamide derivatives useful as p38 inhibitors
Compounds of formula (I):
are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the...
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7494989 |
Pyridine compounds useful as N-type calcium channel antagonists
Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when...
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7491721 |
Antimycobacterial pharmaceutical composition
An antimycobacterial combination and composition for treating tuberculosis are described. The compounds used are...
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7476686 |
Substituted aryl thioureas and related compounds; inhibitors of viral replication
The invention provides compounds and pharmaceutically acceptable salts of Formula I
wherein the variables A 1 , A 2 , R 1 , R 2 , V, W, X, Y, and Z are defined herein. Certain compounds of...
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7476685 |
Pyridine carboxamide derivatives and their use as pesticides
The invention relates to 3-pyridylcarboxamide derivatives of the formula (I):
wherein the various symbols are as defined in the description, compositions thereof, methods for controlling pests...
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7468457 |
Ligand inhibitors of the RAR receptors, process for preparing same and therapeutic/cosmetic applications thereof
Novel biaryl compounds having the structural formula (I):
are useful in a variety of pharmaceutical applications, whether human or veterinary, and also in cosmetics.
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7390509 |
Compositions and methods for nutrition supplementation
The present invention relates to compositions comprising various vitamins and minerals and methods for using these compositions for nutritional supplementation in, for example, pregnant or...
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7365068 |
Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
The invention provides compounds and pharmaceutically acceptable salts of Formula I
wherein the variables A 1 , A 2 , R 1 , R 2 , V, W, X, Y, and Z are defined herein. Certain compounds of...
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7338667 |
Pharmaceutical formulation
The present invention concerns an extended release formulation having an accelerating erosion and/or dissolution rate of the surface of the formulation. The formulation comprises a drug having low...
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7335661 |
Fungicidal mixtures
Fungicidal mixtures, comprising
A) the triazolopyrimidine of the formula I
and B) amide compounds of the formula II
where X 1 and X 2 are halogen, nitro, cyano, alkyl, alkenyl,...
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7335384 |
Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith
The present disclosure describes a novel composition for the treatment and/or prevention of neurogenic inflammation. Such composition is also useful in the treatment and/or prevention of disease...
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7335380 |
Amlodipine free base
Amlodipine free base can be formulated into a convenient oral dosage form, especially a tablet, without excessive stickiness or tablet punch residue. The amlodipine free base can be crystalline...
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7320993 |
Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents
The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or...
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7276500 |
Substituted amides, their preparation and use
An amide of the formula I
and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the...
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7244750 |
Active substance combinations having insecticidal and acaricidal properties
The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties.
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7244749 |
Compositions and methods for lowering plasma lipoprotein(a) and risk factors of cardiovascular diseases
The present invention provides compositions and methods for lowering plasma Lp(a) levels in humans. The present invention provides compositions and methods for lowering the risk factors for...
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7235571 |
Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides
What is described are compounds of the formulae (I) and (II)
where the symbols and indices have the meanings given in the description.
These compounds are suitable for controlling animal pests.
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7235570 |
1,4-dihydropyridine and pyridine compounds as calcium channel blockers
The present invention is directed in part towards methods of modulating the function of calcium channels with pyridine- or 1,4-dihydropyridine-based compounds. In addition, the invention describes...
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7229999 |
Pyridine-3-carboxamide derivatives as CB1 inverse agonists
The present invention relates to compounds of the formula
wherein X and R 1 to R 8 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds...
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7223774 |
Benzamide 2-hydroxy-3-diaminoalkanes
The present invention relates to compounds of formula (I):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme...
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7208508 |
Use of bradycardiac substances in the treatment of myocardial diseases associated with hypertrophy and novel medicament combinations
The present invention relates to the new use of bradycardiac substances such as a Ca ++ channel blocker, beta-receptor blocker or i f channel blocker, the i f channel blockers being preferred,...
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7199136 |
1,4-dihydro-1,4-diphenylpyridine derivatives
The invention relates to novel 1,4-dihydro-1,4-diphenylpyridine derivatives of formula (I)
wherein the variable groups are as defined in the text and claims. Processes for their preparation,...
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7195773 |
Pesticidal composition
A pesticidal composition comprising a pesticidally effective amount of at least one of a pyridic compound of the formula (I) or it salt and at least one of other pesticides: wherein Y is a...
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7173055 |
Pyrazolecarboxamide and pyrazolethioamide as fungicide
Novel pyraole derivatives of formula (I), wherein: X is oxygen or sufu, R 1 is C 1 –C 3 alkyl, C 1 –C 3 haloalkyl, C 1 –C 3 alkoxy-C 1 –C 3 alkyl or C 1 –C 3 haloalkoxy-C 1 –C 3 alkyl;...
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7160907 |
Pleuromutilin derivatives
Pleuromutilin compounds of the formula:
are of use in anti-bacterial therapy.
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7153869 |
Substituted amino acids as erythropoietin mimetics
This invention relates to a series of substitituted amino acids of Formula I
pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the...
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7148233 |
Treatment of cardiovascular and related pathologies
Methods for treating cardiovascular and related diseases such as hypertrophy are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate,...
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7144892 |
Treatment of cardiovascular and related pathologies
Methods for treating cardiovascular and related diseases such as myocardial infarction are described. The methods are directed to concurrently administering a compound such as...
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7125898 |
Nicotinamide derivatives useful as p38 inhibitors.
Compounds of formula (I):
are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the...
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7125871 |
Excitatory amino acid receptor modulators
Compounds of the formula (I) in which R 1 , R 2 and X 1 have the meanings given in the specification, modulate metabotropic glutamate receptor function and are useful in treating disorders of the...
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7109243 |
Inhibitors of cathepsin S
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
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7109221 |
Fungicidal mixtures based on amide compounds and morpholine or piperidine derivatives
Fungicidal mixtures comprise as active components
a) an amide compound of the formula I
A-CO—NR 1 R 2 I
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7071219 |
Mono-acylated o-phenylendiamines derivatives
Mono-acylated o-phenylendiamines derivatives of formula A
wherein Ar, R 1 , and R 2 are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of...
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7064124 |
NF-κB inhibitor containing substituted benzoic acid derivative as active ingredient
A NF-κB inhibitor represented by the following formula (I) is provided:
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7034045 |
Monofluoroalkyl derivatives
The present invention provides certain monofluoroalkyl derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions,...
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7026339 |
Inhibitors of HCV NS5B polymerase
The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present...
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6979468 |
Oral composition and method for the treatment of inflammatory cutaneous disorders
A method and composition for the treatment of acne vulgaris, acne rosacea, and other inflammatory skin conditions comprises the oral administration of a composition comprising a dose of...
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6972297 |
2-Hydroxy-mutilin carbamate derivatives for antibacterial use
2-(S)-hydroxymutilin carbamate derivatives of formula (I), in which R 1 is a 5- or 6-membered optionally substituted heteroaryl group; and R 2 is vinyl or ethyl, are useful in the treatment of...
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6919087 |
Pharmaceutical compositions comprising amlodipine maleate
An amlodipine maleate pharmaceutical composition is provided with good stability when formulated with a pH within the range of 5.5 to 7, when measured as a 20 wt % aqueous slurry. The stability can...
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RE38761 |
Styryl compounds which inhibit EGF receptor protein tyrosine kinase
A method of inhibiting cell proliferation in a patient suffering from such disorder comprising administering to said patient an effective amount of a composition comprising, in admixture with a...
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6903118 |
Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
The invention relates to new piperazinyl-substituted pyridylalkane, alkene, and alkine acid amides substituted with saturated or one or several-fold unsaturated hydrocarbon residue in the...
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6863904 |
Compositions and methods for prophylactic and therapeutic supplementation of nutrition in subjects
The present invention relates to compositions without added iron and methods for prophylactic nutritional supplementation and therapeutic nutritional supplementation. Specifically, the method...
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