Matches 201 - 250 out of 300 < 1 2 3 4 5 6 >
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5036084 Certain 1-(3-pyridyl)-2-phenoxy-alkanones having anti-microbial activity  
Pyridinyl derivatives of formula I ##STR1## wherein R 1 to R 5 are each independently hydrogen, halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkoxy, cyano, C...
5017608 Hydrocinnamic acid derivatives  
Hydrocinnamic acid derivatives of the formula ##STR1## wherein one or two of the symbols R 1 to R 4 are halogen or methoxy and the others are hydrogen; R 5 is hydrogen or phenyl; R 6 is a...
5013744 Acetylenes disubstituted with a pyridinyl group and a substituted phenyl group having retinoid like activity  
Retinold like activity is exhibited by compounds of the formula ##STR1## where R 1 -R 3 independently are hydrogen, lower alkyl, cycloalkyl or lower alkenyl, A and B independently are hydrogen,...
5010087 Tricyclic compounds and TXA.sub.2 antagonistic compositions thereof  
Novel tricyclic compounds having a TXA 2 -antagonizing activity represented by formula (I): ##STR1## which strongly antagonize an action of thromboxane A 2 and are expected to have preventive and...
4990507 N-containing heterocyclic compounds, and composition comprising the same  
The invention relates to a pharmaceutical composition as a therapeutic agent for ischemic disease comprising a compound of the formula ##STR1## wherein R 1 is carbamoyl substituted with morpholino...
4988713 2-selenomethyl-1,4-dihydropyridines having calcium-antagonistic properties and pharmaceutical compositions containing them  
Compounds of formula I ##STR1## wherein R 1 is a cyano, nitro, acetyl, benzoyl or alkoxycarbonyl group; R 2 is an optionally substituted phenyl or heteroaryl group; R 3 is an...
4973597 Anticonvulsant agents  
This invention provides certain pyridinecarboxamide derivatives, their pharmaceutical formulations, and their use as anticonvulsant agents.
4966902 Heterocyclic neophane analogs, processes for their preparation and their use as pest-combating agents  
Compounds of the formula (I) and their stereoisomers ##STR1## wherein A, B, C' and D independently of one another denote CH or N, in which at least one of the symbols A, B, C' or D must correspond...
4961939 Deodorized water-in-oil emulsion containing fish oil  
The present invention is directed to water-in-oil and oil-in-water emulsions containing fish oil which are stabilized by enzyme systems which prevents or retards against the deleterious formation...
4960798 Methods for the treatment of angina  
Acetylene compounds of the formula (I): ##STR1## wherein Y, R 1 , R 2 R 3 , and R 4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The...
4952595 Heterocyclic amide derivatives  
Novel heterocyclic amide derivatives of the formula ##STR1## in which R 1 represents alkyl, or represents alkenyl which has more than 2 carbon atoms and is optionally substituted by halogen, or...
4931458 Heterocyclic rodenticidal compounds, compositions containing the compounds, and methods of use  
Heterocyclic compounds of the formula ##STR1## wherein X is --CHCH--; R 1 is the group Ar--R 2 or --CHCH--C(CH 3 )CH--R 21 ; Ar is phenyl, pyridyl, furyl or thienyl; R 2 is --CO 2 R 3...
4920136 Substituted pyridylethanolamine livestock production promoters  
For promoting livestock production, the novel substituted pyridylethanolamines of the formula ##STR1## in which R 1 represents CN, --COOR 8 or --CONR 9 R 10 , R 2 represents optionally...
4898889 Methods for the treatment of hypertension  
Acetylene compounds of the formula (I): ##STR1## wherein Y, R 1 , R 2 , R 3 , and R 4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The...
4889865 10-aryl-1,8-dihydroxy-9- anthrones and their esters  
Mono, di and tri-esters of 1,8-dihydroxy-10-phenyl-9-anthrone or -9-anthranol have the formula ##STR1## wherein p is 0 or 1, (a) when p=0, t=1 and R 2 represents hydrogen or --COR 3 , (b)...
4883815 Hydrocinnamic acid derivatives  
Hydrocinnamic acid derivatives of the formula ##STR1## wherein one or two of the symbols R 1 to R 4 are halogen or methoxy and the others are hydrogen; R 5 is hydrogen or phenyl; R 6 is a...
4882146 Preventing ADP-ribosylation of G-proteins in a living subject  
Nicotinamide and its analogues (but not nicotinic acid) are effective in preventing or reversing the effects of microbial toxins, e.g. pertussis toxin, which ADP-ribosylate G-proteins.
4880816 Brain-specific delivery of dopamine utilizing dihydropyridine/pyridinium salt-type redox carriers  
A brain-specific dopaminergic response is elicited in a patient in need of such treatment, e.g., a patient afflicted with Parkinson's disease of hyperprolactinemia, by administering thereto a...
4874773 3-Aminocarbonyl-1,4-dihydropyridine-5-carboxylic acid compounds, and pharmaceutical composition containing the same  
Novel 3-aminocarbonyl-1,4-dihydropyridine-5-carboxylic acid compounds of the formula: ##STR1## wherein R 1 is H, C 1 -5 alkyl, C 2 -5 alkenyl, C 3 .5 alkynyl, C 3 -8 cycloalkyl, R 2 is C 1 -10...
4871752 Use of aryloxycarboxylic acid derivatives against dermatological diseases  
The use of aryloxycarboxylic acid derivatives for the production of a medicament against dermatological diseases especially for combatting ulcus cruris, striae distense atrophicae, cellulitis,...
4870090 Therapeutic agent for the treatment of disorders associated with cerebral ischemia  
An agent for the treatment of disorders associated with cerebral ischemia which comprises N-(2-hydroxyethyl) nicotinamide nitrate as an active ingredient.
4868180 Vitamin-containing granules and production thereof  
A vitamin-containing granule comprising one or more compounds selected from the group consisting of vitamin B 6 , vitamin B 2 , nicotinamide and a pantothenic acid salt, and a binding agent, said...
4859663 Multiply substituted pyridine 1-oxide compounds which are useful in treating brain disorders  
Multiply substituted pyridine 1-oxides of the formula I ##STR1## in which R 1 and R 2 are, in each case, identical or different and represent alkyl having 1 to 6 carbon atoms, R 3 denotes...
4859665 Antihypertensive combination products containing a dihydropyridine and a pyridazodiazepine  
Compositions for treating hypertension comprising an effective amount of a dihydropyridine of the formula ##STR1## in which X is 1 or 2 identical or different substituents from the group consisting...
4840959 Pyridinecarboxamide derivatives and their use as fungicide  
Disclosed are novel pyridinecarboxamide derivatives represented by the general formula: ##STR1## wherein X represents a halogen atom, methyl group or trifluoromethyl group, R represents a lower...
4839353 Anti-ulcer substituted pyridine derivatives  
A substituted pyridine derivative represented by the general formula ##STR1## wherein R 1 represents a phenyl or naphthyl group which may optionally be substituted by a substituent selected from...
4832954 Nicorandil containing external preparations  
The transdermal penetration of N-(2-hydroxyethyl) nicotinamide nitrate useful for the treatment of angina pectoris is improved by the use of a mixed solvent comprising an alcohol of 2 to 7 carbon...
4831030 Diphenylpyridine compounds, processes for the preparation thereof and composition comprising the same  
The invention relates to compounds for treatment of hypertension, and cardiovascular and cerebrovascular diseases, which compounds are of the formula: ##STR1## wherein R 1 is...
4826531 Pyridine derivatives and their uses as fungicides and insecticides  
Acrylic acid derivatives having the formula (I): ##STR1## and stereoisomers thereof, wherein W is R 1 O 2 C--CCH--ZR 2 , R 1 and R 2 are alkyl or fluoroalkyl groups, and Z is oxygen or...
4822808 Method for production of stable nicorandil preparation  
A method for producing a stable preparation containing nicorandil, a saturated higher aliphatic acid or a saturated higher alcohol which is solid at ordinary temperatures, and optionally, an...
4818766 Novel phenoxyaliphatylphenyleneoxyalkyl esters and amides  
The invention relates to novel 1,4-dihydropyridine-3-carboxylic acid phenoxyaliphatylphenyleneoxyalkyl esters of the formula ##STR1## in which Ac represents an acyl group, X represents oxy or...
4792564 Method of treatment and prevention of cerebral vasospasms  
A method is disclosed for preventing or treating cerebral vasospasms such as those which usually follow subarachnoid hemorrhage. The method comprises administering to the animal a safe and...
4791122 Circulation active novel 5-aryldihydropyridines  
5-Aryl-1,4-dihydropyridines of the formula ##STR1## in which R represents cycloalkyl, heteroaryl or aryl which is optionally substituted by at least one substituent independently selected...
4786647 Method for eliciting anxiolysis  
The invention provides a method for relieving anxiety in a mammal using a compound of the formula ##STR1## wherein R is Benzyl or cyclohexyl, or a non-toxic pharmaceutically acceptable salt...
4769381 Nicorandil-containing preparation for injection  
A non-liquid type preparation for injection that has improved stability contains N-(2-hydroxyethyl)-nicotinamide nitrate ester (generally known as nicorandil) and an inorganic or organic acid...
4767757 Acyloxythiophene-carboxamide fungicides, compositions and use  
Novel fungicidally active acyloxythiophene-carboxamides of the formula ##STR1##
4758599 Clear, hydroalcoholic aftershave lotion which moisturizes, conditions, and prevents irritation  
A clear, hydroalcoholic solution that contains sodium lactate to moisturize, quaternium 26 to condition, contains chamomile as an anti-irritant with niacinamide to refresh the skin. This product...
4751294 Sucralose co-crystallized with a nitrogenous base  
Sucralose (4-chloro-4-deoxy-α-D-galactopyranosyl 1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside) is thermally stabilized by co-crystallization with a nitrogenous base, for example niacinamide or...
4734406 3-pyridylmethylnaphthyl derivatives and composition containing them useful to inhibit thromboxane synthetase  
Compounds of the formula I ##STR1## in which R 1 , R 2 , R 3 and Y have the indicated meanings, their physiologically tolerated acid addition salts, and a process for the preparation of these...
4732898 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders  
The present invention are 2-(2-aryl-2-oxo-alkylidene) analogs of 1,2,3,4-tetrahydropyridine-3,5-pyridinecarboxylic acids and particularly esters thereof having valuable calcium antagonist and...
4727079 Brain-specific dopaminergic activity involving dihydropyridine carboxamides, dihydroquinoline and isoquinoline carboxamides  
A brain-specific dopaminergic response is elicited in a patient in need of such treatment, e.g., a patient afflicted with Parkinson's disease of hyperprolactinemia, by administering thereto a...
4725609 Method of promoting healing  
This invention pertains to the topical use of nicotinamide to promote, angiogenesis, reepithelialization and wound healing. Formulations and vehicles for administering nicotinamide are also within...
4675328 Phenyl-pyridinium salts and use thereof in inhibiting intestinal resorption  
Polycyclic salts of the formula A-XN+CH 2 --(Y) n --(CH 2 ) p --(Z) q --L--(T) r --M I wherein A - is the anion of a strong organic or inorganic acid; XN + is pyridinium,...
4659722 Bactericidal N-(2,2,2 trichloroethyl)pyridinecarboxamides  
Disclosed is the compound of the formula: ##STR1## wherein X is oxygen, sulfur or ##STR2## R 1 is 3-pyridyl or 4-pyridyl, R 2 is C 1 .about.C 12 -alkyl; C 3 - or C 4 -alkenyl; C 5 - or C 6 ...
4657917 Platelet aggregation inhibitory agents  
A pharmaceutical composition in unit dosage form suitable for administration to an animal in need thereof comprising a pharmaceutically acceptable carrier and an amount sufficient to inhibit blood...
4621093 Vaso-dilating and coronary active 4-nitrophenyl-tetrahydropyridines  
4-(Nitrophenyl)-1,2,3,4-tetrahydropyridines of the formula ##STR1## in which R 1 and R 2 are identical or different and each represent hydrogen, phenyl or a straight-chain or branched alkyl...
4616002 Dihydro pyridine compounds, compositions and use  
Compounds of the formula I ##STR1## in which n represents 1, 2 or 3, Ar represents a carbocyclic or heterocyclic aryl radical, Ac represents the acyl radical of an acid, Z represents a radical --OR...
4596813 Pyridylcarbonyl and thiocarbonyl derivatives useful as fungicides  
The substituted heteroaryl compounds of this invention are good fungicides. In particular, they possess especially good activity against Bean Powdery Mildew, and other plant fungal diseases.
4591594 Thromboxane synthase inhibitors as antiobesity agents  
The present disclosure relates to the use of thromboxane synthase inhibitors as antiobesity agents and insulin lowering agents. Such compounds fall into a variety of classes among which are...
4590200 Naphthalene thromboxane synthetase inhibitors  
A novel series of carboxy-substituted naphthalenes and carboxy-substituted benzo-fused heterocycles, such as carboxy-substituted derivatives of indole, benzofuran and benzothiophene, has been...
Matches 201 - 250 out of 300 < 1 2 3 4 5 6 >