|
Match
|
Document |
Document Title |
|
|
7622589 |
Substituted sulfonylaminoarylmethyl cyclopropanecarboxamide as VR1 receptor antagonists
This invention provides a compound of the formula (I):
wherein, variables A, B, D, E, and R 1 to R 11 are as defined in the specification.
|
|
|
7622486 |
Pyridine compounds, process for their preparation and compositions containing them
The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a...
|
|
|
7615568 |
Antithrombotic ethers
This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions...
|
|
|
7598276 |
Pharmaceutical salts and polymorphs of a factor Xa inhibitor
The present invention provides for salts comprising a compound of Formula I and an acid that has activity against mammalian factor Xa. The present invention is also directed to methods of making...
|
|
|
7598231 |
Tricyclic compound, compositions, and methods
The present invention is directed to compounds of Formula I:
or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the...
|
|
|
7595332 |
Amides that inhibit vanilloid receptor subtype 1 (VR1)
The present invention relates to compounds of formula (I)
that are novel VR1 antagonists useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity.
|
|
|
7595321 |
Compounds having selective inhibiting effect at GSK3
The present invention relates to new compounds of formula (I) wherein Z is N; Y is CONR 5 , NR 5 CO, SO 2 NR 5 , NR 5 SO 2 , CH 2 NR 5 , NR 5 , NR 5 CONR 5 , CH 2 CO, CO, O or CH 2 O; X is CH or N;...
|
|
|
7582680 |
Methods and compositions for treating mammalian spinal cord injuries
Methods of treating an injured vertebrate spinal cord are described. In one aspect of the invention, a method of treating an injured vertebrate spinal cord includes contacting the spinal cord with...
|
|
|
7576098 |
Heterocyclic compounds as inhibitors of factor VIIa
The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable...
|
|
|
7572817 |
2,5-disubstituted 3-mercaptopentanoic acid
The present invention concerns compounds of formula (I), and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus...
|
|
|
7563811 |
1,2-dihydropyridine compounds, manufacturing method thereof and use thereof
The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof...
|
|
|
7553858 |
Combination of flupirtine and tramadol
The subject of the present invention is to provide a combination of two centrally acting analgesics, flupirtine and tramadol, or their respective pharmaceutically acceptable salts for the treament...
|
|
|
7550481 |
Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of Alzheimer's disease
The present invention is directed to phenylamide and pyridylamide derivative compounds of which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which...
|
|
|
7547714 |
Tricyclic compounds, compositions, and methods
The present invention is directed to compounds of Formula I:
or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the...
|
|
|
7528159 |
5-aryl pyridines as 11-beta inhibitors for the treatment of diabetes
Compounds of formula (I):
as well as pharmaceutically acceptable salts and esters thereof used in the form of pharmaceutical compositions.
|
|
|
7514564 |
Substituted amine derivatives and methods of use
Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
|
|
|
7511066 |
Antithrombotic aromatic ethers
This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions...
|
|
|
7504422 |
Polyamine compounds
This invention relates to methods for treating retinopathy and repairing tissue damage. The methods include administering to a subject in need thereof an effective amount of one or more compounds...
|
|
|
7501541 |
Malonamides as orexin antagonists
The present invention relates to compounds of formula I
wherein
Ar 1 , Ar 2 , R, R 1 , R 2 , R 3 and n are as defined herein or to pharmaceutically suitable acid addition salts, optically...
|
|
|
7485654 |
Corneal perception recovery drug containing amide compound
The amide compound of the formula (I) [each symbol is as defined in the description] has a promoting action on neuritogenesis of trigeminal nerve cells, and the compound is useful as a corneal...
|
|
|
7482341 |
Pyridines
Compounds of formula
as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 6 have the significance given in claim 1 can be used in the form of pharmaceutical...
|
|
|
7468382 |
Pyridine derivatives useful as inhibitors of PKC-theta
Disclosed are novel compounds of formula (I):
wherein R 1 , R 2 and R 3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of...
|
|
|
7462634 |
N-(pyridin-2-yl)-sulfonamide derivatives
The present invention relates to novel compounds, to pharmaceutical compositions comprising the compounds described herein, their pharmaceutically acceptable salts, hydrates and solvates, as well...
|
|
|
7459468 |
Aryl sulfonic pyridoxines as antiplatelet agents
Aryl sulfonic pyridoxine compounds with antiplatelet aggregation characteristics for the treatment of cardiovascular and cardiovascular related disease, are described. The methods are directed to...
|
|
|
7446117 |
Cox-2 inhibiting pyridine derivatives
Compounds of formula (I)
or pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a...
|
|
|
7442839 |
Phenethanolamine derivative for the treatment of respiratory diseases
The present invention relates to novel compounds of formula (I),
to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular...
|
|
|
7439268 |
Compositions containing prodrugs of florfenicol and methods of use
The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one...
|
|
|
7435743 |
Pyridine derivatives
Pyrimidine compounds of general formula:
wherein —R 1 represents
in which R 11 is hydrogen, C 1-6 alkyl, halogen, hydroxy, C 1-12 alkoxy, nitro, amino, C 1-6 alkylsulfonylamino, C...
|
|
|
7423012 |
Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors
The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts,
which compounds inhibit carboxypeptidase U and...
|
|
|
7414064 |
4-(3,3-dihalo-allyloxy) phenoxy alkyl derivatives
Compounds of formula
wherein A 1 , A 2 and A 3 are each independently of the others a bond or a C 1 -C 6 alkylene bridge; A 4 is a C 1 -C 6 alkylene bridge; D is CH or N; W is, for...
|
|
|
7410986 |
4-6-diphenyl pyridine derivatives as antiinflammatory agents
4-aryl pyrimidine compounds of general formula and salts thereof: wherein X is CH or N; R1 is hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, etc.; R2 is hydrogen or hydroxy; R3 is hydrogen, C1-6...
|
|
|
7399776 |
Polyamine compounds for treating chemokine receptor mediated diseases
This invention relates to a method for treating inflammatory diseases or immune diseases, developmental or degenerative diseases, or tissue injuries. The method includes administering to a subject...
|
|
|
7399775 |
β-amyloid protein production/secretion inhibitor
Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1):
and capable of...
|
|
|
7393868 |
AMPA receptor potentiators
The present invention relates to AMPA receptor potentiators of Formula I:
formulations comprising them, methods for their use, and intermediates useful for their preparation.
|
|
|
7388022 |
Polysubstituted 1,1-pyridylaminocyclopropanamine compounds
A compound selected from those of formula (I):
wherein:
n represents an integer from 1 to 6 inclusive, R 1 and R 2 represent a hydrogen atom, a (C 1 -C 6 )alkyl group or an aryl-(C 1 -C 6...
|
|
|
7388021 |
Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y 1 receptor. The invention also provides for various...
|
|
|
7375121 |
Chemical compounds
The present invention concerns compounds of formula (I), and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts,
which compounds inhibit carboxypeptidase U and...
|
|
|
7326725 |
Fungicidal composition based on at least one pyridylmethylbenzamide derivatives and at least on dithiocarbamate derivative
1) Fungicidal compositions comprising: a) at least one pyridylmethylbenzamide derivative of formula (I), in which the various radicals are as defined in the description, and b) at least one...
|
|
|
7323474 |
Pyridine derivatives inhibiting angiogenesis and/or VEGF receptor tyrosine kinase
The invention relates to pyridine derivatives of formula (I)
wherein the substituents and symbols are defined as indicated in the description, processes for the preparation thereof, their usage...
|
|
|
7320993 |
Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents
The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or...
|
|
|
7320985 |
Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid
A method for stabilizing an arylcarboxylic acid, which comprises adding a heterocyclic base to the arylcarboxylic acid or a pharmacologically acceptable salt thereof, a stabilizer thereof and an...
|
|
|
7317024 |
Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
The invention relates to a class of novel non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity...
|
|
|
7312236 |
Substituted (4-aminocyclohexen-1-yl)phenyl and (4-aminocyclohexen-1-yl)pyridinyl compounds as 5-HT1F agonists
The present invention relates to compounds of formula I:
or a pharmaceutically acceptable acid addition salt thereof, where;
X is —C(R 4 )═ or —N═; Ar is phenyl, substituted...
|
|
|
7312235 |
Benzamide inhibitors of factor Xa
Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or...
|
|
|
7309713 |
Use of the non-opiate analgesic drug flupirtine for the treatment of overactive bladder and associated diseases including urge incontinence, urinary flow problems as a result of prostate hyperplasia and irritable bowel syndrome
The present invention is directed to the prevention, reversal and medical treatment of lower urinary tract dysfunction including bladder instability and other related diseases as described below...
|
|
|
7294642 |
1,3-Diamino-2-hydroxypropane pro-drug derivatives
The present invention relates to compounds of formula (AA) (I) and (X):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the...
|
|
|
7285565 |
Benzamides and related inhibitors of factor Xa
Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or...
|
|
|
7268147 |
Compounds useful for the treatment of diseases
The invention relates to compounds of formula (1)
and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
|
|
|
7268135 |
Biaryl sulfonamides and methods for using same
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
|
|
|
7265136 |
Substituted stilbene compounds with vascular damaging activity
A compound for use in inducing necrosis in vascular tissue of a tumor in an animal. The compound contains a first moiety which is a cis-stilbene moiety and a second moiety which is an inhibitor of...
|