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7625916 |
Medicinal composition
A medicinal composition which comprises an insulin resistance-improving drug and vitamin B 1 or derivative thereof. In this medicinal composition, the side effects of the insulin...
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7605145 |
Micronutrient formulations for treatment of diabetes mellitus
Formulations for minimizing damage to at least one of cells, organs and systems within the body of a subject afflicted with Diabetes Mellitus. The invention additionally encompasses methods for...
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7598241 |
Carboxamide derivatives and their use as factor Xa inhibitors
Novel compounds of the formula (I) in which R 1 , D, X, W, Y and T have the meaning indicated in Patent Claim (1), e.g. (II), are inhibitors of coagulation factor Xa and can be employed for the...
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7589112 |
Methylene urea derivatives
The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the...
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7585883 |
Substituted pyridines and their uses
The present invention is directed to substituted pyridines, methods for their preparation and methods for their use in the treatment and/or prevention of mast cell related conditions.
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7550463 |
Carbamoylpyridone derivatives having inhibitory activity against HIV integrase
An object of the present invention provides a novel compound having the anti-viral activity, particularly, the HIV integrase inhibitory activity, and a drug containing the same, particularly, an...
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7514455 |
Inhibitors against complex II of electron transport system
An electron transport system complex II inhibitor comprising 2-pyridinol derivative represented by the general formula [I]
wherein R is alkyl or alkenyl optionally having substituent containing...
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7511124 |
Compositions comprising phosphatidylethanolamine-binding peptides linked to anti-viral agents
Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for...
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7449451 |
Use of multiple antioxidant micronutrients as systemic biological radioprotective agents against potential ionizing radiation risks
Disclosed herein is a method for protecting humans in need of such protection from physical damage caused by ionizing radiation comprising administering to said humans on a defined basis prior to...
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7446117 |
Cox-2 inhibiting pyridine derivatives
Compounds of formula (I)
or pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a...
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7417059 |
Substituted aromatic-ring compounds, process for producing the same and use
The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production,...
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7407974 |
Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
The present invention provides compounds of Formula (I):
wherein A, B, C, G, and W 1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are...
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7402599 |
Protein structures and protein fibres
This invention relates to protein fibre formation and in particular to methods of producing protein fibres to form a protein structure comprising a plurality of first polypeptide units arranged in...
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7399774 |
6-substituted nicotinamide derivatives as opioid receptor antagonists
A compound of the formula (I) or a pharmaceutically acceptable salt, enantiomer, racemate, diastereomers or mixtures thereof, or a solvate thereof, formulations and methods of use thereof, as...
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7399755 |
Formulations comprising multiple dietary and endogenously made antioxidants and B-vitamins and use of same
The invention is directed to formulations comprised of multiple dietary and endogenously made antioxidants and B-vitamins and the use of these formulations in preventing and treating coronary...
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7354941 |
Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of PDE4 isozymes
Compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructive...
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7320993 |
Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents
The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or...
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7279290 |
ATM kinase compositions and methods
The present invention provides methods for detecting activation of ATM kinase, DNA damage, and DNA damaging agents. Further provided are antibodies which specifically recognize the phosphorylation...
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7273878 |
Difluoroalkene derivative, pest control agent containing the same, and intermediate therefor
A difluoroalkene derivative which is sufficiently effective in controlling various pests even when used in a small dose and is highly safe for crops, natural enemies to the pests, and animals; and...
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7271181 |
Inhibitors of p38
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods...
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7238717 |
CCR9 inhibitors and methods of use thereof
The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates...
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7230017 |
Dihydropyridinone derivatives
The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases,...
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7183278 |
Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component
Disclosed are novel compounds useful for the control of harmful organisms, harmful organism control agents using the same, and processes for producing the novel compounds. The useful novel...
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7153870 |
Nicotinamide derivatives useful as PDE4 inhibitors
This invention relates to nicotinamide derivatives of general formula (I):
in which R 1 , R 2 and R 3 have the meanings defined herein, and to processes for the preparation of, intermediates...
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7151112 |
Pharmaceutical uses and synthesis of nicotinamides
This invention is directed to methods of using a compound of the formula
and pharmaceutically acceptable salts thereof, wherein n, X, R 1 and R 2 are disclosed herein, for treating...
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7141586 |
Nicotinamide derivatives useful as PDE4 inhibitors
This invention relates to nicotinamide derivatives of formula (I) and to processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions containing, and the...
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7125880 |
Corticotropin releasing factor antagonists
Corticotropin-releasing factor (CRF) antagonists having the formulae
wherein the dashed lines, A, B, Y, Z, G, R 3 , R 4 , R 5 , R 6 , R 16 and R 17 are as defined in the application, and...
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7115563 |
Composition and its therapeutic use
A composition having a variety of therapeutic and cosmetic uses comprises:
(i) a vitamin; (ii) a metal salt that provides metal ions in vivo; and (iii) insulin or a growth hormone.
...
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7101875 |
Methods for treating arthritic disorders
This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula:
and pharmaceutically acceptable salt forms...
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7074813 |
Substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II:
...
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7060260 |
Water-soluble silk proteins in compositions for skin care, hair care or hair coloring
Skin care, hair care and hair coloring compositions comprising a water-soluble silk protein as an active ingredient are described. The water-soluble silk protein deposits onto the skin or the...
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7060717 |
Nicotinamide derivatives useful as PDE4 inhibitors
The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The...
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7056934 |
Nicotinamide derivatives useful as PDE4 inhibitors
This invention relates to nicotinamide derivatives of general formula (I):
in which R 1 , R 2 and R 3 have the meanings defined herein, and to processes for the preparation of, intermediates...
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7056932 |
Heterocyclyl substituted 1-alkoxy acetic acid amides
The invention is concerned with novel heterocyclyl substituted 1-alkoxy acetic acid derivatives of formula (I)
wherein R 1 to R 6 and A are as defined in the description and in the claims, as...
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7045537 |
Protein structures and protein fibres
This invention relates to protein fiber formation and in particular to methods of producing protein fibers to form a protein structure comprising a plurality of first polypeptide units arranged in...
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7015237 |
Pyridine matrix metalloproteinase inhibitors
Selective MMP-13 inhibitors are pyridine derivatives of the formula
or a pharmaceutically acceptable salt thereof,
wherein:
R 1 and R 2 independently are hydrogen, halo, hydroxy, C 1 –C...
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7015216 |
Heteroaryl-β-alanine derivatives as alpha 4 integrin inhibitors
Disclosed are a series of heteroaryl-β-alanine derivatives, compositions containing them, processes for their preparation and their use in medicine.
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7008950 |
Benzofurans as suppressors of neurodegeneration
A compound of the formula:
wherein R 1 and R 2 each is H or a hydrocarbon group which may be substituted, or R 1 and R 2 form a 3- to 8-membered carbo or heterocyclic ring which may be...
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6992095 |
Stilbene compounds comprising an adamantyl group, compositions and methods thereof
The invention relates to novel stilbene compounds having the general formula (I):
as well as to pharmaceutical compositions for use in human or veterinary medicine, including dermatological,...
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6992094 |
Diarylselenide compounds and their use in human or veterinary medicine and in cosmetics
The invention concerns novel diarylselenide compounds corresponding to the general formula (I) and the use thereof in pharmaceutical compositions in human or veterinary medicine (in the treatment...
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6989396 |
Tropane alkaloid multidrug resistance inhibitors from Erythroxylum pervillei and use of the same
Compounds and methods of modulating the activity of P-glycoproteins are disclosed. The method utilizes compounds derived from Erythroxylum pervillei. The compounds overcome multidrug resistance...
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6967211 |
Remedial agent for chronic articular rheumatism
The present invention relates to an excellent remedial agent for chronic rheumatoid arthritis, comprising an aminostilbazole derivative represented by the following formula [1] or a salt thereof as...
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6949556 |
Acylated 1,2,3,4-tetrahydronaphthyl amines and their use as pharmaceutical agents
The present invention relates to compounds of general formula (I),
wherein R 1 -R 4 have the meanings given in the specification, A is CH2, CHOH or CH—(C 1 -C 3 -alkyl), B and C are...
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6919087 |
Pharmaceutical compositions comprising amlodipine maleate
An amlodipine maleate pharmaceutical composition is provided with good stability when formulated with a pH within the range of 5.5 to 7, when measured as a 20 wt % aqueous slurry. The stability can...
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6911451 |
Phenylalanine derivatives
Phenylalanine derivatives of formula (1) are described:
wherein
L 1 is a linker atom or group; X 1 is a group selected from —N(R 3 )CO—, —N(R 3 )SO 2 —, —N(R 3 )C(O)O— or —N(R...
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6881742 |
Benzyl amidoxime derivatives, intermediate products and method for their production and use as fungicides
Novel benzamidoxime derivatives, processes and intermediates for their preparation and their use as fungicides are described. In the context of the present invention, benzamidoxime derivatives are...
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6881756 |
Method for treating skin disorders
The present invention relates to a method for reducing inflammation in the skin and/or treating inflammatory skin disorders, pain, or pruritis by topically applying a composition comprising totarol...
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6878704 |
Heterocyclic mutilin esters and their use as antibacterials
Pleuromutilin compounds of the formula:
are of use in anti-bacterial therapy.
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6875440 |
Method for controlling termite
Termites can be controlled by applying an effective amount of N-[2-chloro-3,5-bis(trifluoromethyl)phenyl]-N′-(2,6-difluo
robenzoyl)urea supported on cellulose.
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6872716 |
Antipsychotic sulfonamide-heterocycles, and methods of use thereof
One aspect of the present invention relates to heterocyclic compounds comprising a sulfonamide moiety. A second aspect of the present invention relates to the use of the heterocyclic compounds...
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