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8962661 Fungicidal composition and method for controlling plant diseases  
To provide a fungicidal composition having stable and high fungicidal effects against cultivated crops infected with plant diseases resulting from plant diseases. A fungicidal composition...
8946234 Halogen-substituted compounds  
The invention relates to compounds of the general formula (I), in which the radicals A1, A2, A3, A4, Lm, Q, R1, T and U have the meaning given in the description and to the use of the compounds...
8940773 Prolyl hydroxylase inhibitors and methods of use  
The present disclosure relates to HIF-1α prolyl hydroxylase inhibitors, compositions which comprise the HIF-1α prolyl hydroxylase inhibitors described herein and to methods for controlling, inter...
8937088 Ureas for the treatment and prevention of cancer  
A compound of Formula (I), salts thereof, prodrugs thereof, metabolites thereof, pharmaceutical compositions containing such a compound, and use of such compound and compositions to treat diseases...
8921403 Combinations of imazalil and hydroxypyridones  
The present invention relates to combinations of imazalil, or a salt thereof, and hydroxypyridones which provide an improved biocidal effect. More particularly, the present invention relates to...
8865742 Intermediate compounds and processes for the preparation of quinoline derivatives such as Laquinimod sodium  
The present invention relates to processes for the preparation of quinoline-3-carboxamide derivatives, such as sodium 5-chloro-3-(ethylphenylcarbamoyl)-1-methyl-2-oxo-1,2-dihydro quinolin-4-olate...
8865748 Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer  
Disclosed herein is {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]-amino}ace tic acid and the ester and amide prodrugs thereof, that can stabilize hypoxia inducible factor-2 alpha (HIF-2α) and...
8841330 Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors  
This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
8802720 Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals  
The present invention relates to compounds of the formula I, wherein A, Y, Z, R3 to R6, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active...
8791102 Acetanilide sphingosine-1-phosphate receptor antagonists  
This disclosure relates to sphingosine-1-phosphate (S1P) receptor antagonists, compositions comprising the S1P receptor antagonists and methods for using and processes for making the S1P receptor...
8778977 Pyridinonyl PDK1 inhibitors  
The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.
8765793 Compositions with skin benefit compounds and chelator stabilized cationic ammonium compounds  
Stabilized cationic ammonium compounds are described. The compounds are stabilized with pyridine-based chelators and/or heteroketo-based chelators that impede the generation of nitrogen comprising...
8754121 Use of deoxyelephantopin (DET) and analogues thereof for treatment of melanoma  
Methods for treating melanoma in a subject in need thereof are disclosed. The method comprises administering to the subject a composition comprising a therapeutically effective amount of...
8754109 Pirfenidone therapy and inducers of cytochrome P450  
The present invention relates to methods involving avoiding adverse drug interactions with pirfenidone and CYP inducers, such as smoking.
8747891 Ceramide anionic liposome compositions  
Described herein are pharmaceutical compositions according to aspects of the present invention which include one or more hydrophilic antineoplastic chemotherapeutics, such as vinca alkyloid...
8741936 Method of modulating stress-activated protein kinase system  
Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38...
8716283 Type III secretion inhibitors, analogs and uses thereof  
The invention, in some aspects, relates to compounds and compositions useful for inhibiting Type III secretion systems in pathogenic bacteria, such as Yersinia Pestis. In some aspects, the...
8680124 Treatment of cancers with acquired resistance to kit inhibitors  
The present invention provides compositions and uses thereof for treating cancers which have acquired resistance to a KIT inhibitor by administering effective amounts of DAST...
8669254 Pyridine, pyridazine, pyrimidine or pyrazine carboxamides as HDL-cholesterol raising agents  
The present invention relates to compounds of the formula wherein A1 to A3 and R1 to R9 are defined in the description, and to pharmaceutically acceptable salts thereof, their manufacture,...
8664248 Derivatives of pyridoxine for inhibiting HIV integrase  
The present invention relates to methods of treating hepatitis C infection, HIV infection, AIDS, or AIDS-related complex, or inhibiting HIV replication by administering a compound of Formula I...
8648099 3-pyridine carboxylic acid hydrazides  
The present invention relates to compounds of formula I, wherein R1 to R5 are defined in the description and claims, and to pharmaceutically acceptable salts thereof. The present invention relates...
8648098 Pirfenidone therapy and inducers of cytochrome P450  
The present invention relates to methods involving avoiding adverse drug interactions with pirfenidone and CYP inducers, such as smoking.
8637553 Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions  
A compound of Formula (I): salts thereof, prodrugs thereof, metabolites thereof, pharmaceutical compositions containing such a compound, and use of such compound and compositions to treat diseases...
8637554 Methods for treating thyroid cancer  
The invention provides methods for enhancing iodine absorption in a thyroid in a subject and treating thyroid cancer by administering to the subject a composition which includes a multi-kinase...
8629166 5-cycloalkyl- or 5-heterocyclyl-nicotinamides  
The present invention relates to compounds of the formula wherein R1 to R4 are defined in the description, and to pharmaceutically acceptable salts thereof, their manufacture, pharmaceutical...
8609701 Pirfenidone treatment for patients with atypical liver function  
Methods are provided for administering pirfenidone to a patient that has exhibited abnormal biomarkers of liver function in response to pirfenidone administration. The methods include...
8598210 Prolyl hydroxylase inhibitors and methods of use  
The present disclosure relates to HIF-1α prolyl hydroxylase inhibitors, compositions which comprise the HIF-1α prolyl hydroxylase inhibitors described herein and to methods for controlling, inter...
8592462 Pirfenidone treatment for patients with atypical liver function  
Methods are provided for administering pirfenidone to a patient that has exhibited abnormal biomarkers of liver function in response to pirfenidone administration. The methods include...
8575202 Chelator stabilized cationic ammonium compounds and compositions comprising the same  
Stabilized cationic ammonium compounds are described. The compounds are stabilized with pyridine-based chelators and/or heteroketo-based chelators that impede the generation of nitrogen comprising...
8492412 Gel containing pirfenidone  
The invention relates to a gel composition containing pirfenidone, which is advantageous over other cutaneously administered pharmaceutical forms known in the prior art and which can be used in...
8470858 Agave syrup extract having anticancer activity  
The present invention comprises an agave syrup stored for at least eight weeks, having phytochemicals preferably selected from the group comprising flavonoids, polycosanols and sapogenins, which...
8470854 Lactam-containing compounds and derivatives thereof as factor XA inhibitors  
The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4 I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a...
8450347 Composition for relieving discomfort  
The invention relates to a method of controlling feelings of pain in infants or diseased or elderly persons using a complete nutrition or a nutritional supplement. The method comprises...
8420674 Method of providing pirfenidone therapy to a patient  
The invention relates to methods for decreasing adverse events associated with pirfenidone (5-methyl-1-phenyl-2-(1H)-pyridone) therapy. The invention discloses an optimized dose escalation scheme...
8410082 Fluorinated diaryl urea derivatives  
This invention relates to novel diaryl urea compounds, their derivatives, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this...
8389570 Hydroxamates as therapeutic agents  
The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore...
8367666 3-carbamoyl-2-pyridone derivatives  
The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I): wherein R1, R2, R3, R4, and G are defined as herein, a...
8349832 Compounds and compositions for treating cancer  
The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of...
8338457 Selective ablation of pain-sensing neurons by administration of a vanilloid receptor agonist  
The present invention provides methods and kits for the selective ablation of pain-sensing neurons. The methods comprise administration of a vanilloid receptor agonist to a ganglion in an amount...
8334307 Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating proliferative diseases  
Provided herein are hydroxypyridone derivatives, for example, a compound of Formula I, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating,...
8324255 Chelator stabilized cationic ammonium compounds and compositions comprising the same  
Stabilized cationic ammonium compounds are described. The compounds are stabilized with pyridine-based chelators and/or heteroketo-based chelators that impede the generation of nitrogen comprising...
8318780 Methods of administering pirfenidone therapy  
The present invention relates to methods involving avoiding adverse drug interactions with fluvoxamine and pirfenidone or other moderate to strong inhibitors of CYP enzymes.
8309608 Use of eNOS transcription enhancers in the cell therapy of ischemic heart diseases  
The present invention relates to the use of compounds which enhance the transcription of endothelial nitric oxide synthase (eNOS) for treating stem and progenitor cells in the cell therapy of...
8273774 Phenoxypyridinylamide compounds  
The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment...
8263574 Topical formulations for the treatment of depression with S adenosyl methionine  
Disclosed herein are topical formulations for treating depression with S adenosyl methionine (SAM-e) The topical formulations contain at least 35% wt/wt of SAM-e partially dissolved in aqueous and...
8252773 Combination therapy with organic arsenicals  
The invention provides a combination therapy wherein one or more other therapeutic agents are administered with an organic arsenical, preferably SGLU-1 or a pharmaceutically acceptable salt...
8236827 Compounds  
A compound for use in the treatment of proliferative disorders, such as cancer, having the following formula: wherein: R1, R2 and R3 are independently H or lower alkyl;R4, R5, R6, R7 and R8 are...
8236280 Polyamides for nucleic acid delivery  
A new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications, including a gene transfer vector that has comparable efficiency to a viral vector without...
8236798 Carboxamide compounds and their use as calpain inhibitors  
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine...
8227491 5-(3,4-dichloro-phenyl)-N-(2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide and salts thereof  
The present invention relates to a compound of formula I, in all its isomeric forms and pharmaceutically acceptable salts thereof, their manufacture, pharmaceutical compositions containing them...

Matches 1 - 50 out of 304 1 2 3 4 5 6 7 >