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8168598 |
Optimised formulation of tobramycin for aerosolization
The invention provides a tobramycin formulation for delivery by aerosolization in the form of additive-free, isotonic solution whose pH has been optimised to ensure adequate shelf-life at room...
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8158591 |
Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines
A 13-deoxy anthracycline and a taxane can be administered to a patient simultaneously, separately, sequentially, or consecutively to produce a therapeutic anticancer effect with reduced toxicity...
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8158152 |
Lyophilization process and products obtained thereby
A lyophilization process which comprises dissolving a material in one or more solvents for said material to form a solution; forcing said material at least partially out of solution by combining...
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8039442 |
Compounds and methods for treatment of sickle cell disease or complications associated therewith
Compounds, compositions and methods are provided for treatment of sickle cell disease or a complication associated therewith, or graft versus host disease, in an individual. More specifically, the...
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8026222 |
Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
Methods are provided for using a compound to treat, for example, endothelial dysfunction including vascular abnormalities. More specifically, methods are described for using an oligosaccharide...
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8008328 |
Methods for the treatment of diabetes-associated dyslipdemia
Methods for the treatment of insulin resistance, diabetes, and/or diabetes associated dyslipidemia by administering niacin and meloxicam are disclosed.
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8003617 |
Methods of treating diabetes mellitus
The invention provides methods of treating a diabetic subject comprising administering a glucosylceramide synthase inhibitor to the subject.
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7998943 |
Core 2 GlcNAc-T inhibitors III
A method of treating a subject in need of therapy for a condition involving detrimental activity of the enzyme core 2 GlcNAc-T is provided, comprising administration of a therapeutically effective...
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7989424 |
Glucopyranosyloxypyrazole derivatives and use thereof in medicines
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one...
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7964569 |
Glycomimetic replacements for hexoses and N-acetyl hexosamines
Compounds and methods are provided for obtaining oligosaccharide mimics. More specifically, compounds and methods are described wherein oligosaccharide mimics are obtained by incorporating or...
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7943594 |
Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans
One aspect of the present invention relates to solution-phase approaches to GPI synthesis. Another aspect of the present invention relates to key building blocks, and syntheses thereof, useful for...
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7939502 |
Optimised formulation of tobramycin for aerosolization
The invention provides a tobramycin formulation for delivery by aerosolization in the form of additive-free, isotonic solution whose pH has been optimised to ensure adequate shelf-life at room...
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7939551 |
Combination therapeutic compositions
The present invention provides pharmaceutical compositions and methods for the treatment of diabetes mellitus using combination therapy. The compositions relate to a compound of Formula I and an...
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7928079 |
Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates
The invention relates to compounds capable of releasing nitric oxide wherein the compounds comprise a saccharide and at least one nitric oxide-releasing diazeniumdiolate [N2O2] functional group,...
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7858109 |
Implant material
Form bodies, which can be rotationally-symmetrical or irregularly-shaped, consist of at least one member of the group of the antibiotic salts, gentamicin myristate, gentamicin palmitate, gentamicin...
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7807406 |
Fagopyritol synthase genes and uses thereof
The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin...
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7776832 |
Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines
A 13-deoxy anthracycline and a taxane can be administered to a patient simultaneously, separately, sequentially, or consecutively to produce a therapeutic anticancer effect with reduced toxicity...
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7763285 |
Polyacetylenic compounds
A method of treating type II diabetes with a polyacetylenic compound of the following formula: in which R1 is H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C20 cycloalkyl, C3-C20...
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7759317 |
Analgesic and anti-inflammatory compositions and methods with flavonoid glycoside-type compounds
The present invention relates to pharmaceutical compositions containing certain flavonoid glycoside-type compounds that have been shown in the present invention to be therapeutically useful,...
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7754695 |
Lipase inhibitors
The present invention provides lipase inhibitory agents comprising a gallotannin or ellagitannin component(s) isolated from teas or Tellima grandiflora as well as foods and beverages and medicines...
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7749972 |
1-substituted-7-(β-D-glycopyranosyloxy)(aza)indole compound and pharmaceutical containing the same
The present invention provides a compound having an SGLT1 and/or SGLT2 inhibitory activity which is usable as an agent for the prevention or treatment of diabetes, postprandial hyperglycemia,...
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7749488 |
Pharmaceutical foam
The present invention provides various pharmaceutically active topical delivery compositions. In particular, compositions of the present invention are present in a pressurized container comprising...
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7749971 |
Aminoglycoside treatment for lysosomal storage diseases
The present invention provides a method of treating lysosomal storage diseases such as Hurler syndrome and Batten disease in individuals in need of such treatment, comprising the step of...
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7696178 |
Optimised formulation of tobramycin for aerosolization
The invention provides a tobramycin formulation for delivery by aerosolization in the form of additive-free, isotonic solution whose pH has been optimised to ensure adequate shelf-life at room...
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7687472 |
Methods and compositions for treating hyperglycemic, hyperlipidemic, or hyperinsulinemic disorders
Methods of treating hyperglycemic, hyperlipidemic, and hyperinsulinemic disorders are provided. Compositions for treating such disorders are also provided. The compositions can include hexose and...
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7655633 |
Nitrogen-containing heterocyclic derivatives, medicinal compositions containing the same and medicinal use thereof
The present invention provides nitrogen-containing heterocyclic derivatives represented by the general formula: wherein X1 represents N or CR1; X2 represents N or CR2; X3 represents N or CR3; X4...
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7635685 |
Bifunctional antibiotics for targeting rRNA and resistance-causing enzymes and for inhibition of anthrax lethal factor
A novel group of aminoglycosides which share some structural features of currently available aminoglycosides with regard to the backbone, while also having significant structural differences, is...
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7622138 |
Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same
The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing...
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7605136 |
Effector conjugates, methods for their preparation and their pharmaceutical use
Conjugates of epothilones and epothilone derivatives (as effectors) with suitable saccharides or saccharide derivatives (as recognition units) are described. Their production is carried out by the...
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7572774 |
Methods for treating glutamate cytotoxicity with beta-naphthoquinone compounds
The present invention relates to the use of beta-naphthoquinone derivatives, and salts thereof, for the prevention and/or the treatment of glutamate cytotoxicity. It further relates to the use of...
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7566699 |
Fused heterocyclic derivative, medicinal composition containing the same, and medicinal use thereof
The present invention provides fused heterocyclic derivatives represented by the general formula: wherein R1 represents H, halogen, OH, etc.; R2 represents H, halogen or an alkyl group; R3 and R4...
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7541342 |
Use of PKC-activating compounds as cardioprotectants and as apoptosis-inducing anti-tumor agents
Compounds for the inducing apoptosis in cancer cells are described. The described compounds induce the translocation of protein kinase C-δ to the mitochondria and the phosphorylation of ...
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7531521 |
Formulation for use in the prevention and treatment of carbohydrate induced diseases and conditions
The present invention provides a novel method for inhibiting sugar-induced weight gain resulting from fructose and glucose driven lipogenesis. The method for inhibiting sugar-induced weight gain is...
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7371733 |
Anti bacterial compounds
The invention relates to novel paranmycin compounds that have activity against gram positive and gram negative bacteria, preferably bacteria that are resistant to other antibiotics. Paranmycins are...
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7345024 |
Pharmaceutical preparation, method for its production as well as its use
The invention relates to hardly soluble antiphlogistic salts and antiphlogistic-antibiotic pharmaceutical preparations and their use. The hardly water soluble antiphlogistic antibiotics salts have...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7294618 |
Glucopyranosyloxypyrazole derivatives and medicinal use thereof
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R1, R2 and R3 represent a hydrogen atom or a halogen atom; R4 represents a lower...
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7244712 |
Aminoglycoside antibiotics and methods of using same
The present invention relates to aminoglycoside compounds having antibiotic activity. Moreover, the present invention relates to L-aminoglycoside compounds and diastereomers thereof which posses...
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7241746 |
Method and composition for treating periodontal disease
The present invention is directed to a pharmaceutical composition comprising a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. A suitable antibiotic is...
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7232805 |
Cobalamin conjugates for anti-tumor therapy
The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker...
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7220727 |
Aminoglycosides as antibiotics
The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminogylcosides are useful to treat or prevent infectious diseases (e.g.,...
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7189702 |
Glucopyranosyloxypyrazole derivatives and medicinal use thereof
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein one of Q and T represents a group represented by the general formula: while the...
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7182954 |
Prebiotic oligosaccharides via alternansucrase acceptor reactions
Oligosaccharides produced by an alternansucrase enzyme catalyzed reaction of sucrose with an acceptor oligosaccharide are effective as prebiotics for controlling enteric bacterial pathogens....
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such...
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7153877 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7144867 |
Anticancer glycoside compounds
The present invention relates to new classes of anti-cancer compounds. In particular, the present invention provides glycoside compounds as anti-cancer agent, alone, or in combination with other...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7084123 |
Glucopyranosyloxypyrazole derivatives and use thereof in medicines
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug: one...
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6987094 |
Optimized formulation of tobramycin for aerosolization
The invention provides a tobramycin formulation for delivery by aerosolization in the form of additive-free, isotonic solution whose pH has been optimised to ensure adequate shelf-life at room...
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6900182 |
Inositolphosphoglycan and ribose for treatment of ischaemia-reperfusion injury
Compositions comprising inositolphosphoglycans (IPGs) and ribose are disclosed, and their use in the prevention or treatment of ischaemic-reperfusion injury. This treatment increases the energy...
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