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7622138 |
Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same
The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing...
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7618651 |
Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same
The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing...
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7605136 |
Effector conjugates, methods for their preparation and their pharmaceutical use
Conjugates of epothilones and epothilone derivatives (as effectors) with suitable saccharides or saccharide derivatives (as recognition units) are described. Their production is carried out by the...
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7572774 |
Methods for treating glutamate cytotoxicity with beta-naphthoquinone compounds
The present invention relates to the use of beta-naphthoquinone derivatives, and salts thereof, for the prevention and/or the treatment of glutamate cytotoxicity. It further relates to the use of...
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7566699 |
Fused heterocyclic derivative, medicinal composition containing the same, and medicinal use thereof
The present invention provides fused heterocyclic derivatives represented by the general formula:
wherein R 1 represents H, halogen, OH, etc.; R 2 represents H, halogen or an alkyl group; R 3...
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7541342 |
Use of PKC-activating compounds as cardioprotectants and as apoptosis-inducing anti-tumor agents
Compounds for the inducing apoptosis in cancer cells are described. The described compounds induce the translocation of protein kinase C-δ to the mitochondria and the phosphorylation of...
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7531521 |
Formulation for use in the prevention and treatment of carbohydrate induced diseases and conditions
The present invention provides a novel method for inhibiting sugar-induced weight gain resulting from fructose and glucose driven lipogenesis. The method for inhibiting sugar-induced weight gain is...
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7374747 |
Pharmaceutical foam
The present invention provides various pharmaceutically active topical delivery compositions. In particular, compositions of the present invention are present in a pressurized contained comprising...
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7371733 |
Anti bacterial compounds
The invention relates to novel paranmycin compounds that have activity against gram positive and gram negative bacteria, preferably bacteria that are resistant to other antibiotics. Paranmycins are...
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7345024 |
Pharmaceutical preparation, method for its production as well as its use
The invention relates to hardly soluble antiphlogistic salts and antiphlogistic-antibiotic pharmaceutical preparations and their use. The hardly water soluble antiphlogistic antibiotics salts have...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7294618 |
Glucopyranosyloxypyrazole derivatives and medicinal use thereof
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula:
wherein R 1 , R 2 and R 3 represent a hydrogen atom or a halogen atom; R 4 represents...
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7244712 |
Aminoglycoside antibiotics and methods of using same
The present invention relates to aminoglycoside compounds having antibiotic activity. Moreover, the present invention relates to L-aminoglycoside compounds and diastereomers thereof which posses...
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7241746 |
Method and composition for treating periodontal disease
The present invention is directed to a pharmaceutical composition comprising a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. A suitable antibiotic is...
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7232805 |
Cobalamin conjugates for anti-tumor therapy
The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker...
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7220727 |
Aminoglycosides as antibiotics
The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminogylcosides are useful to treat or prevent infectious diseases (e.g.,...
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7189702 |
Glucopyranosyloxypyrazole derivatives and medicinal use thereof
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula:
wherein one of Q and T represents a group represented by the general formula:
while...
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7182954 |
Prebiotic oligosaccharides via alternansucrase acceptor reactions
Oligosaccharides produced by an alternansucrase enzyme catalyzed reaction of sucrose with an acceptor oligosaccharide are effective as prebiotics for controlling enteric bacterial pathogens....
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7153877 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7144867 |
Anticancer glycoside compounds
The present invention relates to new classes of anti-cancer compounds. In particular, the present invention provides glycoside compounds as anti-cancer agent, alone, or in combination with other...
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7119110 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7087579 |
Glucopyranosyloxypyrazole derivatives and medicinal use thereof
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula:
wherein one of Q and T represents a group represented by the general formula:
while...
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7084123 |
Glucopyranosyloxypyrazole derivatives and use thereof in medicines
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula:
wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug:...
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7053060 |
Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
The present invention relates to glucopyranosyloxybenzylbenzene derivatives represented by the general formula:
wherein R 1 represents a hydrogen atom, a hydroxy group, a substituted or...
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6987094 |
Optimized formulation of tobramycin for aerosolization
The invention provides a tobramycin formulation for delivery by aerosolization in the form of additive-free, isotonic solution whose pH has been optimised to ensure adequate shelf-life at room...
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6900182 |
Inositolphosphoglycan and ribose for treatment of ischaemia-reperfusion injury
Compositions comprising inositolphosphoglycans (IPGs) and ribose are disclosed, and their use in the prevention or treatment of ischaemic-reperfusion injury. This treatment increases the energy...
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6872706 |
Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same
The present invention relates to glucopyranosyloxybenzylbenzene derivatives represented by the general formula:
wherein P represents a group forming a prodrug; and R represents a lower alkyl...
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6833362 |
Method and composition for the accelerated in vivo removal of ethanol
A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or...
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6825173 |
Preparation of fagopyritols and uses therefor
The present invention describes isolated Fagopyritol A1, isolated Fagopyritol A3, and isolated Fagopyritol B3. Compositions which include two or more of Fagopyritol A1, Fagopyritol A2, Fagopyritol...
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6821959 |
Antibiotic-natural polysaccharide polymer adducts
Antibiotic-natural polysaccharides polymer adducts based on non-covalent and non-ionic bonds, with an improved profile of activity compared with the corresponding antibiotic.
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6818625 |
Method for increasing survival rate of cells in animal cell culture under hypoxia condition
The present invention relates to a method for increasing survival rate of cells in animal cell culture under hypoxia condition by adding antibiotics to the culture media. The method of present...
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6753319 |
D-mannose contraceptives
The present invention concerns the use of D-Mannose to prevent or inhibit uniting of sperm and egg in the conception process. The administration of D-Mannose to a female such that the environment...
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6716822 |
Therapeutic agent for ischemia which inhibits apoptosis under ischemic condition
The present invention relates to a therapeutic agent for ischemia which inhibits apoptosis under ischemic condition. The therapeutic agent of the present invention comprises antibacterial agents of...
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6699841 |
Method of preparing physiologically acceptable aqueous solutions, and solutions thus obtained
A physiologically acceptable aqueous solution, and water-soluble compositions suitable for obtaining it, comprising a first physiologically acceptable compound of an acidic nature and a second...
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6677309 |
Anti-cancer drug aldehyde conjugate drugs with enhanced cytotoxicity compounds, compositions and methods
Monomeric and dimeric anti-cancer drug aldehyde conjugate compounds and pharmaceutically acceptable salts thereof. Specifically, monomeric and dimeric aldehyde conjugates of 1-2,...
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6649594 |
Compositions for metabolic protection and repair of lips
An effective barrier function for the lips is restored and maintained by the topical administration of various formulations, including mixtures of ceramides and essential and nonessential free...
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6630135 |
Use of sustained release antibiotic compositions in ophthalmic surgical procedures
An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painful and potentially traumatic injections of...
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6583118 |
Chondroprotective agents
A chondroprotective agent comprising a flavonoid compound of the general formula (I): wherein R 1 to R 9 are, independently, a hydrogen atom, hydroxyl group, or methoxyl group and X is a...
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6538027 |
Compositions comprising ratite oil or active fractions thereof and methods of using these composition as insect repellents
This invention provides compositions for repelling insects, particularly biting insects, such as mosquitoes, ticks, and biting flies comprising ratite oil, active fractions of ratite oil obtained...
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6492342 |
Hygromycin A prodrugs
This invention relates to compounds of the formula and to pharmaceutically acceptable salts and solvates thereof, wherein a, b, X, Y, Z, R 1 , R 2 , and R 3 are as defined herein. The compounds...
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6475993 |
Treatment of hereditary diseases with gentamicin
This invention relates to a method of treating an inherited disease due to a point mutation producing a stop codon by administering an effective dose of an aminoglycoside antibiotic or a derivative...
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6461331 |
Device and method for infusion of small molecule insulin mimetic materials
A medication delivery device for delivering a small molecule insulin mimetic material to a body of an individual includes a housing, a reservoir and a controller. The housing contains a driving...
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6407064 |
Aminoalcohol derivative and medicament comprising the same
An aminoalcohol derivative which is a ceramide analogue, and a medicament, especially an agent for treating neuronal diseases and an agent for protecting brain, comprising the same.
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6399580 |
Methods and compositions for stimulating tissue growth and epithelial moisturization
The invention herein encompasses methods effective to stimulate epithelial cell proliferation and/or enhance epithelial moisturization and lubrication in a mammalian subject utilizing a composition...
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6379882 |
Method for selecting compounds for treating ischemia-related cellular damage
A method of screening for and treating subjects with a therapeutically effective amount of a compound that is effective in reducing cellular damage related to an ischemic condition, such as stroke...
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6352978 |
Pharmaceutical compositions containing tobramycin and xanthan gum
Topically administrable aqueous solution compositions containing tobramycin and xanthan gum are disclosed. The solution compositions contain a buffering agent and a pH-adjusting agent in an amount...
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6265385 |
Topoisomerase II poison and bis-dioxopiperazine derivative combination therapy
The present invention relates to a method for selectively killing tumor or metastatic cells within a defined compartment of the organism of a large mammal, in particular a human, said method...
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6168799 |
β-D-glucan topical composition
A topical composition for healing treatment of burns and wounds and scarring therefrom has as the active ingredient cereal-derived (1-3) (1-4) β-D-glucan at about 0.5-15 w/w percent. The...
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