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7629363 |
Diaryl substituted pyridinones
Disclosed are compounds Formula I
and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 /R 4 , and R 5 are defined herein. These compounds are useful for treating...
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7612101 |
Abnormal cannabidiols as agents for lowering intraocular pressure
The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular...
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7585883 |
Substituted pyridines and their uses
The present invention is directed to substituted pyridines, methods for their preparation and methods for their use in the treatment and/or prevention of mast cell related conditions.
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7547713 |
O-pyridinequinone derivatives, the composition containing the derivatives, the process for preparation of the derivatives and the use of the derivatives
The present invention relates to the o-pyridinequinone disubstituted derivatives, the composition containing the derivatives, the process for preparation of the derivatives and the use of the...
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7538126 |
Crystalline forms of valdecoxib
The present invention relates to novel crystalline forms of valdecoxib, to processes for their preparation and to pharmaceutical compositions containing them.
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7446117 |
Cox-2 inhibiting pyridine derivatives
Compounds of formula (I)
or pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a...
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7410985 |
Cycloalkyl derivatives of 3-hydroxy-4-pyridinones
The present invention provides an cycloalkyl derivative of 3-hydroxy-4-pyridinone which is useful for the chelation of metal ions such as iron. Its preparation and use is described. In particular,...
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7320993 |
Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents
The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or...
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7196105 |
Treatment of human multiple myeloma by curcumin
All multiple myeloma cell lines examined showed constitutively active IκB kinase (IKK), IκBα phosphorylation and constitutively active NF-κB. Curcumin, a chemopreventive agent, suppressed...
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7183278 |
Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component
Disclosed are novel compounds useful for the control of harmful organisms, harmful organism control agents using the same, and processes for producing the novel compounds. The useful novel...
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7173055 |
Pyrazolecarboxamide and pyrazolethioamide as fungicide
Novel pyraole derivatives of formula (I), wherein: X is oxygen or sufu, R 1 is C 1 –C 3 alkyl, C 1 –C 3 haloalkyl, C 1 –C 3 alkoxy-C 1 –C 3 alkyl or C 1 –C 3 haloalkoxy-C 1 –C 3 alkyl;...
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7122563 |
Derivatives of 4-demethylpenclomedine, use thereof and preparation thereof
Thiocarbonate and thiocarbamate derivatives of 4-demethylpenclomedine are provided along with pharmaceutical compositions containing them and use for treating cancer. A method for preparing the...
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7074813 |
Substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II:
...
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7067540 |
Substituted pyridinones
Disclosed are compounds Formula I
and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , and R 5 are defined herein. These compounds are useful for treating diseases...
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7049328 |
Use for deferiprone
A method of treating iron induced cardiac disease in a patient with iron overload, such as in thalassemia or the like comprising administering to the patient a therapeutically effective amount of...
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7026338 |
Pharmaceutical nitrones
Pharmaceutical nitrone comprise condensates of an N-hydroxylamine and a physiological aldehyde, providing improved delivery and absorption, enhanced stability and reduced toxicity. Preferred...
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7015237 |
Pyridine matrix metalloproteinase inhibitors
Selective MMP-13 inhibitors are pyridine derivatives of the formula
or a pharmaceutically acceptable salt thereof,
wherein:
R 1 and R 2 independently are hydrogen, halo, hydroxy, C 1 –C...
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7008950 |
Benzofurans as suppressors of neurodegeneration
A compound of the formula:
wherein R 1 and R 2 each is H or a hydrocarbon group which may be substituted, or R 1 and R 2 form a 3- to 8-membered carbo or heterocyclic ring which may be...
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6995166 |
Method and composition for supplementation of nutritional deficiencies in renal patients
The present invention relates to compositions and methods for treating the nutritional deficiencies observed in patients suffering from renal disease and associated disorders. Specifically, the...
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6974827 |
Phenyl substituted 4-hydroxy tetrahydroxypyridone
The present invention relates to novel compounds of the formula (I)
in which
W, X, Y, Z, G, A, B, Q 1 , Q 2 and D are each as defined in the description, to a plurality of processes for...
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6967211 |
Remedial agent for chronic articular rheumatism
The present invention relates to an excellent remedial agent for chronic rheumatoid arthritis, comprising an aminostilbazole derivative represented by the following formula [1] or a salt thereof as...
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6946479 |
N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones
Compounds of Formula (I)
are effective in the treatment of a microbial infection.
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6930117 |
N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
Compounds of Formula (I)
are effective in the treatment of a microbial infection.
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6900180 |
Pharmaceutical compositions for alleviating discomfort
The invention relates to products for complete nutrition of infants or diseased or elderly persons. The products are characterized by increased levels of folic acid, vitamin B6 and vitamin B12 or...
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6762178 |
Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
Hydroxamic acids having the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple...
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6756392 |
Nicotinamide derivatives useful as PDE4 inhibitors
The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The...
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6747048 |
Pyridine-based thyroid receptor ligands
Novel pyridine-based thyroid receptor ligands are provided which have the general formula I wherein: X is oxygen (—O—), sulfur (—S—), sulfoxide (—S(O)—), sulfonyl (—SO 2 —), CR 8...
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6740668 |
Methods for inhibiting diabetic complications
The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation,...
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6734143 |
2-methoxyimino-2(pyridinyloxymethyl)phenyl acetamides useful as fungicides
The present invention provides 2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamides according to formula (I) as well as their use as fungicidal compounds.
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6713492 |
N-acyloxylated cycloalkyl compounds, composition containing the same and methods of use therefor
Drugs or reagents containing as the active ingredient N-acyloxylated cycloalkyl compounds represented by general formula (I): wherein A is optionally substituted C 4 or C 5 cycloalkyl which...
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6656958 |
Substituted pyridine compounds useful for controlling chemical synaptic transmission
The present invention is directed to a series of substituted pyridine compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical...
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6642260 |
Nitric oxide donors and pharmaceutical compositions containing them
The present invention provides a compound containing at least one sulfhydryl group and at least one NO donor group, wherein said compound contains one or more protected sulfhydryl groups linked to...
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6589967 |
Oxime O-ether compounds and fungicides for agricultural and horticultural use
The present invention relates to novel oxime O-ether compounds represented by a general formula [I]; wherein R 1 represents C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkoxy, etc., m represents an...
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6569875 |
Fungicide mixtures based on pyridin carboxamides and benzimidazoles or the precursors thereof
Fungicidal mixtures comprise as active components a) an amide compound of the formula I A—CO—NR 1 R 2 I in which A is an aryl group or an aromatic or nonaromatic, 5- or 6-membered...
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6559170 |
Pyridine derivatives having fungicidal activity and processes to produce and use same
Compounds of formula (One) wherein A 1 , A 2 , A 3 , and A 4 independently H, halogen, or methyl; E is —N═ or —CH═; G is O═ or S═; J is —O—, —NH— or —NT 1 — wherein T 1 is...
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6515000 |
Fungicidal mixtures based on amide compounds
Fungicidal mixtures, comprising A) an amide compound of the formula I in which R 1 , R 2 are identical or different and are halogen, nitro, cyano, C 1 -C 8 -alkyl, C 2 -C 8 -alkenyl, C 2 -C 8...
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6509379 |
Phenylacetic acid derivatives, process and intermediate products for their preparation, and their use as fungicides and pesticides
Phenylacetic acid derivatives of the formula I where the variables are as disclosed herein, their salts, processes and intermediates for their preparation, and their use for controlling harmful...
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6503948 |
Method for prevention or treatment of acute allograft rejection and a pharmaceutical composition therefor
A method for treating an organ donor prior to harvesting organ to reduce graft rejection in a recipient. An amount effective to reduce graft rejection of at least one compound selected from the...
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6495580 |
Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with...
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6495571 |
Pyridine compounds, use and preparation thereof
New pyridine compounds are provided along with their method of preparation. The compounds are useful as intermediates in preparing new anticancer agents. A few of the pyridine compounds are also...
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6436969 |
Dialysis solutions and methods
The present invention provides improved dialysis compositions and methods for dialysis comprising utilizing the disclosed AGE inhibitors, together with methods to reduce dialysis-related...
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6436934 |
Fungicide mixtures based on amide compounds and morpholine or piperidine derivatives
Fungicidal mixtures comprise as active components a) an amide compound of the formula I A—CO—NR 1 R 2 I in which A, R 1 and R 2 are as defined in the description, and b) dimethomorph or...
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6432989 |
Use of CRF antagonists to treat circadian rhythm disorders
A corticotropin releasing factor (CRF) antagonist is administered to treat disorders that can be treated by altering circadian rhythm.
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6432990 |
2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamides with polyether derivatives on the pyridine ring
The present invention provides novel 2-methoxyimino-2-(pyridinyloxymethyl)phenyl acetamide compounds with polyether substituents on the pyridine ring, their use as fungicidal compounds, and their...
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6376518 |
Acyl derivatives of 4-demethylpenclomedine, use thereof and preparation thereof
Acyl derivatives of 4-demethylpenclomedine are provided along with pharmaceutical compositions containing them and use for treating cancer. A method for preparing the derivatives is also provided.
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6372748 |
Fungicide mixtures based on pyridine amides and fenarimol
Fungicidal mixtures comprise as active components a) an amide compound of the formula I A—CO—NR 1 R 2 I in which A is an aryl group or an aromatic or non-aromatic, 5- or 6-membered...
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6369083 |
2-methoxyimino-2 (pyrinyloxymethyl) phenyl acetamides with polyether derivatives on the pyridine ring
The present invention provides novel 2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamide compounds with polyether substituents on the pyridine ring, their use as fungicidal compounds, and their...
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6300346 |
Indenyl hydroxamic acids, (hydroxy) ureas and urethanes for treating patients with precancerous lesions
Indenyl hydroxamic acids, (hydroxy) ureas and urethanes are useful in the treatment of precancerous lesions and neoplasms.
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6235761 |
Compound, composition and method for treating cancer
Substantially pure 3,5-dichloro-2-nethoxy-4-hydroxy-6-(trichloromethyl)pyridine
or 4-demethylpenclomedine (formula I), acid addition salts thereof, pharmaceutical compositions containing the...
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6221886 |
Thio acid derived monocyclic N-heterocyclics as anticoagulants
This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to...
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