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7608630 |
Marasmius androsaceus L.es Fr extract, piperidone derivative, and their use for the preparation of hypertensives
The present invention relates to Marasmius androsaceus L.es Fr extract, a compound of formula I, or pharmaceutically acceptable salts thereof, and to methods for their preparation, pharmaceutical...
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7605173 |
Pharmaceutical liquid composition containing pyridone derivative
A pharmaceutical liquid composition containing the Pirfenidone in a very high concentration of more or less 25% by weight can be obtained by dissolving the Pirfenidone in diethylene glycol...
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7605156 |
Methods for the use of inhibitors of cytosolic phospholipase A2
This invention provides methods for the use of substituted indole compounds of the general formula:
and pharmaceutically acceptable salt forms thereof. The invention provides methods for the...
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7589112 |
Methylene urea derivatives
The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the...
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7576239 |
Substituted amides
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases...
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7569727 |
Pesticidally active ketone and oxime derivatives
Compounds of formula
wherein A 0 , A 1 and A 2 are each independently of the others a bond or a C 1 -C 6 alkylene bridge; A 3 is a C 1 -C 6 alkylene bridge which is unsubstituted or...
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7563811 |
1,2-dihydropyridine compounds, manufacturing method thereof and use thereof
The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof...
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7560122 |
Pharmaceutical dosage form bearing pregnancy-friendly indicia
A pharmaceutical dosage form comprising at least one active ingredient and destined for administration to pregnant women. The pharmaceutical dosage form bears pregnancy-friendly indicia apt to...
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7550488 |
Application methods to rapidly alter disease and injury states using molecular transport of B6
The present invention discloses methods of application employing B5/B6 vitamins in molecular transport creams or gels to deliver B6 in a high dose to bring about therapeutic ways in human or mammal...
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7544367 |
Chemical method of making a suspension, emulsion or dispersion of pyrithione particles
A method for producing a suspension, emulsion or dispersion of de-agglomerated particles (advantageously submicron-sized particles) of pyrithione salts comprising contacting agglomerated pyrithione...
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7524874 |
Vanilloid receptor ligands and their use in treatments
Compounds having the general structure
and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster...
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7521463 |
Immunomodulatory compounds
Compounds are described which modulate the tzrosine kinase activity of p56 lck and signal transduction pathways in which this enzyme is involved. The invention also relates to compounds which have...
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7517880 |
Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
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7514564 |
Substituted amine derivatives and methods of use
Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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7476683 |
Glycinamide derivatives as raf-kinase inhibitors
The present invention relates to glycinamide derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the...
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7459468 |
Aryl sulfonic pyridoxines as antiplatelet agents
Aryl sulfonic pyridoxine compounds with antiplatelet aggregation characteristics for the treatment of cardiovascular and cardiovascular related disease, are described. The methods are directed to...
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7446117 |
Cox-2 inhibiting pyridine derivatives
Compounds of formula (I)
or pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a...
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7435729 |
Compounds and methods for modulation of estrogen receptors
Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective modulators for...
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7425570 |
Pyridoxine and pyridoxal analogues: new uses
The invention provides pyridoxal and pyridoxine analogues, pharmaceutical compositions containing pyridoxine and pyridoxal analogues, and methods of administering pharmaceutical compositions...
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7423012 |
Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors
The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts,
which compounds inhibit carboxypeptidase U and...
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7414064 |
4-(3,3-dihalo-allyloxy) phenoxy alkyl derivatives
Compounds of formula
wherein A 1 , A 2 and A 3 are each independently of the others a bond or a C 1 -C 6 alkylene bridge; A 4 is a C 1 -C 6 alkylene bridge; D is CH or N; W is, for...
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7410986 |
4-6-diphenyl pyridine derivatives as antiinflammatory agents
4-aryl pyrimidine compounds of general formula and salts thereof: wherein X is CH or N; R1 is hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, etc.; R2 is hydrogen or hydroxy; R3 is hydrogen, C1-6...
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7410984 |
Compounds
The present invention relates to novel pyridone derivatives capable of inhibiting α 4 integrin mediated cell adhesion, processes for their preparation, compositions comprising them and their use...
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7402598 |
Arylethanolamine β2-adrenoreceptor agonist compounds
The present invention relates to compounds of formula (I) as defined herein and salts or solvates thereof. Processes for preparing these compounds and pharmaceutical formulations containing them...
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7390509 |
Compositions and methods for nutrition supplementation
The present invention relates to compositions comprising various vitamins and minerals and methods for using these compositions for nutritional supplementation in, for example, pregnant or...
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7375112 |
Compounds and methods for regulating triglyceride levels
The present invention provides a method of administering vitamin B6 related compounds for treatment of hypertriglyceridemia. Vitamin B6 related compounds include pyridoxal,...
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7368479 |
Alpha-sulfonylamino-acetonitriles
The invention relates to α-sulfonylamino-acetonitrile derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein Ar 1 , and Ar 2 ...
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7368435 |
Topical endoparasiticide and ectoparasiticide formulations
A topical formulation having significant parasiticidal activity effective against endoparasites and/or ectoparasites such as heartworms, mites, fleas, ticks, flies is provided, which can be safe to...
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7354940 |
2,5-dioxoimidazolidin-4-yl acetamines and analogues as inhibitors of metalloproteinase mmp12
The invention provides compounds of formula (I) in which L, X, Y, Z 1 , Z 2 , R 1 , R 2 , R 3 and G 2 have the meanings defined in the specification; processes for their preparation;...
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7348344 |
Polysubstituted 1,1-pyridyloxycyclopropanamine compounds
A compound selected from those of formula (I):
wherein:
n represents an integer from 1 to 6 inclusive, R 1 and R 2 represent a hydrogen atom, a (C 1 -C 6 )alkyl group or an aryl-(C 1...
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7345092 |
High concentration topical insecticides containing pyrethroids
A topical insecticide preparation is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The topical insecticide contains a...
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7335672 |
Vanilloid receptor ligands and their use in treatments
Substituted pyridines and pyrimidines and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache,...
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7335384 |
Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith
The present disclosure describes a novel composition for the treatment and/or prevention of neurogenic inflammation. Such composition is also useful in the treatment and/or prevention of disease...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7307092 |
Compounds Capable of Activating Cholinergic Receptors
Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)-4-penten-2-amine,...
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7304044 |
Lowering blood glucose, urea, cholesterol, triglycerides and normalizing homocysteine levels by dietary addition of selected essential amino acids and three vitamins
Administration of a dietary supplement consisting of L-Tryptophan (80 mgs), L-Methionine (90 mgs), L-Valine (103 mgs), L-Lysine Monohydrochloride (128 mgs), Vitamin B-12 (0.5 mg), Vitamin B-6 (10...
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RE39916 |
Compounds that modulate PPAR activity and methods for their preparation
This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the...
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7271181 |
Inhibitors of p38
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods...
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7262209 |
Carbonyloxy-cyanomethyl compounds as antiparasitic agents
The invention relates to compounds of the general formula
wherein Ar 1 , Ar 2 , R 4 , R 5 , R 6 , R 7 , R 8 , W, X, a and b have the significances given in the specification, and optionally the...
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7256186 |
Gamma secretase inhibitors
This invention discloses novel gamma secretase inhibitors of the formula:
wherein:
R 1 is a substituted aryl or substituted heteroaryl group; R 2 is an R 1 group, alkyl, —XC(O)Y,...
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7255882 |
Enkephalinase inhibitor and GABA precursor loading as anti-anxiety compositions
Benzodiazepine withdrawal induced anxiety is treated by administration of an enkephalinase inhibitor, and a gamma-aminobutyric acid (“GABA”) precursor, or an endorphin or enkephalin releaser....
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7253178 |
Carboxylic acids
The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the...
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7241782 |
Polymorph V of torasemide
The invention relates to a novel polymorph V of torasemide, to a process for its preparation, to its use as a raw material for the preparation of crystalline modifications I and III of torasemide,...
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7241454 |
Pesticidal formulations
Aqueous pesticidal suspensions comprise: (a) 5 to 40% w/v of (i) a pesticide having a melting point in the range of from 50 to 120° C. and a solubility in water of not more than 0.2% w/v or (ii) a...
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7232837 |
Stereoisomers with high affinity for adrenergic receptors
The present invention provides stereoscopically-pure diastereomers of Formula I:
In a preferred embodiment, the stereoisomers of the present invention are of Formula II, depicted below:
R 2 ,...
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7230003 |
Aromatic prodrugs of propofol, compositions and uses thereof
Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof...
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7226937 |
Methods for modulating phototoxicity
The invention relates to methods for modulating photodamage via the use of collagen derived molecules which either enhance or inhibit damage caused by ultraviolet light.
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7214693 |
Heterocyclic selective androgen receptor modulators and methods of use thereof
This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the...
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7208507 |
Pyridines and uses thereof
The invention relates to pyridines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor cells.
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