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7629365 |
Heterocyclic compounds
3-Chloro-6-(hydroxymethyl)-2-methyl-5-[4-({4-[(trifluorometh
yl)oxy]phenyl}oxy)phenyl]-4(1H)-pyridinone, having the following formula:
is described along with its pharmaceutically acceptable...
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7625949 |
Methods for treating retroviral infections
The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R 1 -R 5 , R 11c ...
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7507769 |
Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen
The present invention provides methods for treating and preventing benign breast disease by administering 4-hydroxy tamoxifen to a patient. When percutaneously administered to a patient's breasts,...
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7504421 |
Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use
The invention relates to compounds of general formula (I), a method for the production thereof and the use thereof as pharmacologically effective substances for a broad medical indication spectrum....
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7485653 |
1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease
The present invention provides certain substituted 1,4-dihydropyridine compounds, including pure enantiomeric forms and pharmaceutical formulations thereof. These compounds provide for elevation of...
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7446117 |
Cox-2 inhibiting pyridine derivatives
Compounds of formula (I)
or pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a...
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7435743 |
Pyridine derivatives
Pyrimidine compounds of general formula:
wherein —R 1 represents
in which R 11 is hydrogen, C 1-6 alkyl, halogen, hydroxy, C 1-12 alkoxy, nitro, amino, C 1-6 alkylsulfonylamino, C...
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7414055 |
Inhibitors of Akt activity
The present invention is directed to compounds which contain a substituted pyridine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to...
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7410986 |
4-6-diphenyl pyridine derivatives as antiinflammatory agents
4-aryl pyrimidine compounds of general formula and salts thereof: wherein X is CH or N; R1 is hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, etc.; R2 is hydrogen or hydroxy; R3 is hydrogen, C1-6...
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7320993 |
Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents
The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or...
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7276528 |
Compounds for the inhibition of nitric oxide synthase
There are provided novel compounds of formula (I)
wherein A, R 1 , R 3 , R 4 , R 5 , T, U, V, W, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof;...
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7262209 |
Carbonyloxy-cyanomethyl compounds as antiparasitic agents
The invention relates to compounds of the general formula
wherein Ar 1 , Ar 2 , R 4 , R 5 , R 6 , R 7 , R 8 , W, X, a and b have the significances given in the specification, and optionally the...
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7148243 |
Antivirals
Compounds of the formula I:
wherein
R x is cyano or bromo; R 1 is halo; R 2 is C 1 14 C 3 alkyl,
and pharmaceutically acceptable salts and prodrugs thereof have activity as antiretrovirals.
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7135487 |
Sulphonamide derivatives
The present invention relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
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7135486 |
Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof
This application relates to compounds of formula (I),
wherein R 1 , R 2 , R 3 , and R 4 are defined as recited in the claims, or a tautomer, salt, hydrate, or alkoxide thereof. A process...
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7129255 |
Substituted 2-carba-3,5-dicyano-4-aryl-6-aminopyridines and the use of the same as selective ligands of the adenosine receptor
This application relates to compounds of the formula
wherein the groups R 1 –R 6 are as defined in the specification and claims, and to a pharmaceutical composition containing the same, and...
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7125880 |
Corticotropin releasing factor antagonists
Corticotropin-releasing factor (CRF) antagonists having the formulae
wherein the dashed lines, A, B, Y, Z, G, R 3 , R 4 , R 5 , R 6 , R 16 and R 17 are as defined in the application, and...
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7119109 |
Heteroarylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase
There are provided novel compounds of formula (I)
wherein R 1 , R 2 , R 3 , T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof; together with...
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7109218 |
Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same
Compounds of the formula (I)
a process for their preparation and their use as medicaments are described.
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7041670 |
Florfenicol-type antibiotics
The present invention relates to novel florfenicol compounds having the chemical structure:
wherein the compounds are useful for the treatment and/or prevention of bacterial infections in a...
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7037927 |
Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor
The present invention relates to compounds of formula (I)
that are novel VR1 antagonists useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity.
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7015237 |
Pyridine matrix metalloproteinase inhibitors
Selective MMP-13 inhibitors are pyridine derivatives of the formula
or a pharmaceutically acceptable salt thereof,
wherein:
R 1 and R 2 independently are hydrogen, halo, hydroxy, C 1 –C...
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6949556 |
Acylated 1,2,3,4-tetrahydronaphthyl amines and their use as pharmaceutical agents
The present invention relates to compounds of general formula (I),
wherein R 1 -R 4 have the meanings given in the specification, A is CH2, CHOH or CH—(C 1 -C 3 -alkyl), B and C are...
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6946479 |
N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones
Compounds of Formula (I)
are effective in the treatment of a microbial infection.
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6930117 |
N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
Compounds of Formula (I)
are effective in the treatment of a microbial infection.
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6911451 |
Phenylalanine derivatives
Phenylalanine derivatives of formula (1) are described:
wherein
L 1 is a linker atom or group; X 1 is a group selected from —N(R 3 )CO—, —N(R 3 )SO 2 —, —N(R 3 )C(O)O— or —N(R...
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6864267 |
Calcilytic compounds
Novel calcilytic compounds and methods of using them are provided.
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6835743 |
Pesticidal pyrazoles and derivatives
Process for the protection of a building that has already been built or is going to be built, whereby an effective amount of an insecticidally active compound is spread around or under the said...
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6794397 |
Substituted nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted nicotinamides and analogs thereof, represented by Formula V: or a pharmaceutically acceptable salt or prodrug thereof, wherein: Ar′ and Ar are...
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6794377 |
Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparation comprising them
Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic...
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6762197 |
Difluoromethyltriazolone compounds, use of the same and intermediates for the production thereof
A triazolone compound of the formula [I]: wherein; R 1 represents optionally substituted phenyl or the like, T represents m-phenylene optionally substituted by methyl or the like; and a...
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6750232 |
2-aminopyridine compounds and use thereof as drugs
A class of substituted compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (II), wherein R 1 is...
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6673789 |
2-pyridinylguanidine urokinase inhibitors
Compounds of formula (I): or a pharmaceutically acceptable salt thereof, or solvate of either entity, wherein R 4 is a guanidinyl moiety and the other substituents are as defined in the text,...
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6653331 |
Targeted drug delivery using sulfonamide derivatives
The present invention relates to Glutathione S-transferase (GST)/Reduced Glutathione (GSH) as a means for the in-vivo release of a drug that has been conjugated to specific electrophilic moieties...
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6642215 |
Method of modulating NF-kB activity
A method of modulating the level of activated, NF-κB in cells by contacting cells with a cyanoguanidine compound of general formula I wherein n is 0, 1 or 2; each R independently represents...
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6583161 |
Benzenesulfonamides and benzamides as therapeutic agents
The invention provides compounds, compositions and methods relating to novel aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as...
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6566378 |
Pesticidal compositions and pesticidal methods
A pesticidal composition comprising 3,5-dichloro-1-(3, 3-dichloro-2-propenyloxy)-4-[3-(5-trifluoromethylpyridin-2-y
loxy)propoxy]benzene and at least one compound selected from the group consisting...
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6566375 |
Elevation of HDL cholesterol by 4-&lsqb (aminothioxomethyl)-hydrazono&rsqb -N-(substituted)-4-arylbutanamides
Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the “good” cholesterol and as such may be useful for treating diseases such as atherosclerosis. These...
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6521617 |
Treatment of apoptotic cell death
New methods are provided for treating against apoptotic cell death, including apoptotic cardiac and neuronal cells. Therapies of the invention include administration of a mitochondrial oxidizer...
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6515000 |
Fungicidal mixtures based on amide compounds
Fungicidal mixtures, comprising A) an amide compound of the formula I in which R 1 , R 2 are identical or different and are halogen, nitro, cyano, C 1 -C 8 -alkyl, C 2 -C 8 -alkenyl, C 2 -C 8...
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6486183 |
Antivirals
Compounds of formula (I): wherein R x is cyano or bromo; R 1 is halo; R 2 is C 1 -C 3 alkyl, and pharmaceutically acceptable salts and prodrugs thereof have activity as antiretrovirals.
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6479520 |
Method of treating a patient having precancerous lesions with phenyl pyridinone derivatives
Derivatives of phenyl pyridinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.
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6465494 |
Methods for treatment of cystic fibrosis
Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of cystic fibrosis.
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6444675 |
4-alkyl and 4-cycloalkyl derivatives of dihydropyridine NPY antagonists
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of 4-alkyl and cycloalkyl derivatives of dihydropyridines of Formula I. As antagonists of NPY-induced...
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6436962 |
Arylhydantoin derivatives and uses thereof
Arylhydantoin derivatives and their pharmaceutically acceptable salts are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described....
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6251925 |
Therapeutic biaryl derivatives
The present invention relates to therapeutic biaryl derivatives of formula (I), and pharmaceutically acceptable derivatives thereof ##STR1## wherein R 1 is a phenyl, naphthyl, pyridyl, thiazolyl,...
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6248759 |
Method for treatment of light-injured retinal degeneration disease
A method for treatment of light-injured retinal degeneration disease comprising, administering an effective amount of a dihydropyridine calcium antagonist other than nimodipine is provided. The...
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6166032 |
Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use
A method for controlling tobacco use and alleviating withdrawal symptoms due to the cessation of tobacco use comprising administering to a human desiring to control tobacco use and/or suffering...
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6150397 |
5-aroylnaphthalene derivatives as anti-inflammatory agents
The present invention relates to certain 5-aroylnaphthalene derivatives of formula (I): ##STR1## that are inhibitors of prostaglandin G/H synthase, pharmaceutical compositions containing them,...
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6107298 |
Methods for prevention and treatment of Tourette's syndrome and schizophrenia
Patients susceptible to or suffering from Tourette's syndrome or schizophrenia are treated by administering an effective amount of an aryl substituted aliphatic compound, an aryl substituted...
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