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7612100 |
Anthranilamides, process for the production thereof, and pest controllers containing the same
To provide a novel anthranilamide compound or its salt which is useful as a pesticide; a process for its production; and a pesticide containing such a compound as an active ingredient. An...
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7601743 |
Cyano anthranilamide insecticides
Compounds of formula (I) wherein the substituents are as defined in claim 1 , and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can...
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7582660 |
2-thio-substituted imidazole derivatives and their use in pharmaceutics
The invention relates to 2-thio-substituted imidazole derivatives of the formula I
in which the radicals R 1 , R 2 , R 3 and m are as defined in the description. The compounds according to the...
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7579355 |
Inhibitors of Akt activity
The present invention is directed to compounds which contain a substituted pyridine moeity which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to...
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7576107 |
5-substituted-alkylaminopyrazole derivatives as pesticides
The invention relates to the use for the control of pests, of a compound which is a 5-substituted-alkylaminopyrazole derivative of formula (I) or a salt thereof: wherein the various symbols are as...
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7572921 |
Substituted benzylimidazoles useful for the treatment of inflammatory diseases
The invention comprises a class of derivatives of substituted benzylimidazoles of the formula (I) and methods for making the same. These compounds are useful for the treatment of inflammatory...
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7572816 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to compounds having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic agents...
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7569593 |
Compounds and compositions as protein kinase inhibitors
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated...
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7569592 |
Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
Pyrazole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, are mGluR5 modulators useful in the treatment...
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7557102 |
Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor Xa inhibitors for the treatment of thromboses
Novel compounds of the formula (I), in which R, R 1 , R 2 and R 3 have the meanings indicated in Patent Claim 1 , are inhibitors of coagulation factor Xa and can be employed for the prophylaxis...
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7550463 |
Carbamoylpyridone derivatives having inhibitory activity against HIV integrase
An object of the present invention provides a novel compound having the anti-viral activity, particularly, the HIV integrase inhibitory activity, and a drug containing the same, particularly, an...
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7531187 |
Synergistic insecticidal composition containing chloronicotynyle and pyrethroids compounds
A synergistic insecticidal composition is formed containing a Chloronicotynyle compound and a Pyrethroids compound. The Chloronicotynyle compound is provided in an amount preferably ranging from...
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7517878 |
Heteroarylaminopyrazole derivatives useful for the treatment of diabetes
The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
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7514428 |
Pesticidal 1-aryl-3-amidoxime-pyrazole derivatives
1-Arylpyrazole-3-substituted-amidoxime derivatives of formula (Ia) or (Ib):
or salts thereof, wherein the various symbols are as defined in the description, and pesticidal compositions thereof,...
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7511042 |
Triazole compounds
Disclosed are compounds of formula (I)
Where Ar 1 , X, R 3 , R 4 , R 5 and R 6 are defined herein. The compounds of the invention inhibit production of cytokines and are thus useful for...
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7501446 |
Prenylation inhibitors and methods of their synthesis and use
The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical...
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7501445 |
Imidazolidinone compounds
This invention relates to compounds of the following formula:
in which R 1 , R 2 , A 1 , A 2 , X, Y, m, n, p, x and y are as defined herein, pharmaceutical compositions comprising the compounds...
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7501444 |
Prenylation inhibitors and methods of their synthesis and use
The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical...
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7495017 |
Phosphodiesterase 4 inhibitors
Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with...
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7485653 |
1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease
The present invention provides certain substituted 1,4-dihydropyridine compounds, including pure enantiomeric forms and pharmaceutical formulations thereof. These compounds provide for elevation of...
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7482349 |
Amino-5,5-diphenylimidazolone derivatives for the inhibition of β-secretase
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated β-amyloid...
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7479501 |
Heteroaryl-cyclic acetals
Compounds of formula (I) are described in which Het is a five or six membered heteroaromatic ring of the formula
in which one of R 1 and R 2 is optionally substituted heteroaryl and the other...
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7470715 |
Estrogen modulators
The present application is directed to a new class of isoxazoles and their use as estrogen modulators.
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7470713 |
Imidazole based kinase inhibitors
The present invention provides compounds having formula I
and their use for the treatment of cancer.
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7468381 |
Control of arthropods in animals
A method of controlling parasites in or on an animal comprising administering to the animal a parasiticidally effective, substantially non-emetic 1-arylpyrazole.
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7456201 |
Pharmaceutically active compounds and methods of use
The invention provides substituted pyrazole compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are...
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7452885 |
Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation
The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I
The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and...
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7452874 |
Thrombopoietin mimetics
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating...
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7452873 |
Inhibitors of GSK-3 and uses thereof
The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions...
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7449484 |
Compounds
The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred...
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7445791 |
Synergistic insecticidal composition containing Chloronicotynyle and Organosphosphorus compounds
A synergistic insecticidal composition is prepared by combining a Chloronicotynyle compound and an Organophosphorus (OP) compound. The preferred synergistically effective amount of the...
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7442713 |
2-thio-substituted imidazole derivatives and their use in pharmaceutics
The invention relates to 2-thio-substituted imidazole derivatives of the formula I
in which the radicals R 1 , R 2 , R 3 , R 4 and p are as defined in the description. The compounds according...
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7442702 |
Prostaglandin agonists
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
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7432254 |
Method for treating glaucoma IC
Provided is a method of treating or ameliorating or preventing glaucoma, decreasing intraocular pressure or improving or amemliorting ocular accommodation in an animal, including a human comprising...
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7429593 |
Utilities of amide compounds
Compounds having an activity to enhance the expression of apoAI are provided, which are used as medicaments. Compounds of formula (I):
in which ring A and Ar 1 are independently a monocyclic...
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7425570 |
Pyridoxine and pyridoxal analogues: new uses
The invention provides pyridoxal and pyridoxine analogues, pharmaceutical compositions containing pyridoxine and pyridoxal analogues, and methods of administering pharmaceutical compositions...
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7425569 |
1H-pyrazoles useful in therapy
Compounds of formula (I),
or a pharmaceutically acceptable derivative thereof, wherein R 1 and R 3 independently represent H, C 1-6 alkyl, C 3-8 cycloalkyl, or halogen; R 2 represents C 1-6...
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7417047 |
Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for β-secretase modulation
The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I
The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and...
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7417041 |
Imidazopyrimidines as transforming growth factor (TGF) inhibitors
Novel fused heteroaromatic compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described....
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7414066 |
Amide compounds and medications containing the same technical field
The present invention provides to a novel compound having an ACAT inhibiting activity. The present invention relates to compounds represented by formula (I)
wherein
represents an...
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7414061 |
Aryl-isoxazol-4-yl-imidazole derivatives
The present invention is concerned with aryl-isoxazol-4-yl-imidazole derivatives of formula I:
wherein
R 1 to R 6 are as defined in the specification and pharmaceutically acceptable acid...
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7414060 |
Pyridine-2-carboxyamide derivatives
The invention relates to compounds of formula I:
wherein R 1 to R 3 are as defined in the specification, to processes for their preparation, to pharmaceutical compositions containing them,...
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7414055 |
Inhibitors of Akt activity
The present invention is directed to compounds which contain a substituted pyridine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to...
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7407972 |
Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
The present invention provides compounds of Formula (I):
wherein A, B, C, G, and W 1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are...
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7388018 |
4-Piridinylmethylsulphonamide derivatives as fungicidal plant protein agents
Sulfonamides of the formula I
where the substituents are as follows:
R 1 is hydrogen, alkyl, alkoxy, alkenyl or alkynyl; and R 2 , R 3 , R 4 , R 5 are hydrogen, halogen, alkyl, alkoxy or...
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7375122 |
Compounds useful as pesticides
Compounds useful to control pests are provided.
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7361668 |
Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors
The invention concerns quinuclidine derivatives of formula I or II wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the...
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7354938 |
Pyrazole compounds and uses related thereto
Substituted pyrazoles are provided that are useful for the treatment of, for example, diabetes, obesity and metabolic syndrome.
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7354933 |
Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
The present invention relates to a cyclic urea compound of formula I:
as defined herein. The invention is also directed to the process for its preparation, pharmaceutical composition comprising...
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7329670 |
Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
The compounds are aryl and heteroaryl substituted heterocyclic ureas of the formula A—NH—C(O)—NH—B where A is the aryl or hetaryl substituted heterocyclic group and B is an aryl or...
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