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9040068 Control of bed bugs  
A method of combating bed bugs and/or other insects in a locus containing or susceptible to presence of same, in which a DMSO-containing formulation is applied to the locus. Various pesticidal...
9040563 Dual inhibitors of farnesyltransferase and geranylgeranyltransferase I  
Many GTPases such as Ras, Ral and Rho require post-translational farnestylation or geranylgeranylation for mediating malignant transformation. Dual farnesyltransferase (FT) (FTI) and...
9034904 Forms of dexlansoprazole and processes for the preparation thereof  
Provided is dexlansoprazole propylene glycolate hydrate. Polymorphic forms thereof are also provided. The dexlansoprazole propylene glycolate hydrate maybe such that the propylene glycol component...
9029365 Arthropodicidal anthranilamides  
This invention provides a composition comprising a first compound selected from Formula 1, an N-oxide or an agriculturally suitable salt thereof; and a second compound selected from...
9029352 Process for the preparation of C-FMS kinase inhibitors  
The present invention is directed to a process for the preparation of heterocyclic derivatives of formula I wherein J, X, Z, and R2 are as defined herein. Such compounds are useful as protein...
9029399 17α-hydroxylase/C17,20-lyase inhibitors  
The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5 and R6 are as defined herein. The compounds of the present...
9018233 Diaminoaryl derivatives substituted by carbamate and pesticidal composition containing same  
The invention relates to diaminoaryl derivatives substituted by carbamate, salts thereof and a pesticidal composition containing the same, which exhibit superior pest control effects against...
9018235 Insecticide compositions  
Insecticide compositions which comprise one or not less than two kinds of compounds being selected from a compound represented by the formula [I]: or a salt thereof, and a neonicotinoid compound...
9012479 Pyrazolylaminopyridines as inhibitors of FAK  
The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the...
9012478 Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto  
Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions...
8999956 N-[(het)arylalkyl)] pyrazole(thio)carboxamides and their heterosubstituted analogues  
The present invention relates to fungicidal N-[(het)arylalkyl)]pyrazolecarboxamide or thiocarboxamide and their heterosubstituted analogs, their process of preparation and intermediate compounds...
8999971 Methods for increasing the stabilization of hypoxia inducible factor-1 alpha  
Disclosed herein are methods for controlling the activity of hypoxia-inducible transcription factor 1-alpha (HIF-1α) and diseases, conditions, or syndromes related thereto, inter alia, Peripheral...
8993480 Active ingredient combinations with insecticidal properties  
Agrochemical compositions comprising at least one active compound from the class of the anthranilamides and at least one further active compound selected from the group consisting of insecticides,...
8980629 Compounds that modulate intracellular calcium  
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of...
8980896 Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles  
The present invention provides formulations which may comprise macrocyclic lactones and at least one spirodioxepinoindole derivative or a spirooxepinoindole derivative for combating parasites in...
8975285 P38 MAP kinase inhibitors  
There are provided inter alia compounds of formula (I) wherein R1, Ar, L, X, R3 and Q are as defined in the specification for use in therapy, especially in the treatment of inflammatory diseases.
8975284 Co-solvent compositions and methods for improved delivery of dantrolene therapeutic agents  
The present invention provides for methods of using tert-butyl alcohol (TBA) co-solvent systems in the formulation and production of a pharmaceutical agent with low solubility. The present...
8975282 Substituted pyrazolone compounds and methods of use  
The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in...
8969246 Pesticidal mixtures  
Pesticidal mixtures comprising, as active components, 1) an anthranilamid compound of the formula I wherein the variables are defined according to the description, and 2) at least one fungicidal...
8969352 Substituted 2-azabicycles and their use as orexin receptor modulators  
The present invention is directed to compounds of Formula I: wherein X is N or CR1; Y is N or CR2; R1 is H, alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl, isoxazole, oxadiazolyl, or pyrazolyl; R2...
8969392 Pesticide composition comprising propamocarb-fosetylate and an insecticidally active substance  
The present invention relates to a pesticide composition intended for protecting plants, crops or seeds against phyto-pathogenic fungi or damaging insects, and the corresponding methods of...
8969388 Substituted pyrazolone compounds and methods of use  
The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in...
8969338 Ethynyl derivatives  
The present invention relates to ethynyl derivatives of formula I wherein U, V, Y, R1, R2, R2′, R3, R3′ and R8 are described herein. It has been found that the compounds of general formula I are...
8962623 Aminopyrazine compounds  
A compound of formula (I): wherein all symbols have the same meanings as defined in the specification; a salt thereof, a solvate thereof, an N-oxide thereof, or a prodrug thereof, has an Itk...
8957094 Therapeutic agent or prophylactic agent for fibromyalgia  
A therapeutic agent or prophylactic agent has an analgesic effect on both nociceptive pain and neuropathic pain and is effective in treatment of fibromyalgia. The agent includes as an effective...
8952026 PRMT1 inhibitors and uses thereof  
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting PRMT1...
8952042 FXR (NR1H4) binding and activity modulating compounds  
The present invention relates to compounds of formula (1): where R, A, Q and Z are defined herein, or an enantiomer, diastereomer, tautomer, solvate, prodrug or pharmaceutical acceptable salt...
8952018 Pharmaceutical combination of MEK inhibitor and B-Raf inhibitors  
A novel combination comprising the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimet hyl;...
8946234 Halogen-substituted compounds  
The invention relates to compounds of the general formula (I), in which the radicals A1, A2, A3, A4, Lm, Q, R1, T and U have the meaning given in the description and to the use of the compounds...
8946250 3,4-diarylpyrazoles as protein kinase inhibitors  
3,4-diarylpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions...
8946236 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents  
The present invention relates to new insecticides of the formula (I) in which R1, R2, R3, R4, R5, R6, A, Q and n can have the definitions stated in the description, to a number of processes for...
8946231 P2X3, receptor antagonists for treatment of pain  
The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or...
8946267 Therapeutic agent or prophylactic agent for neuropathic pain  
A therapeutic agent or a prophylactic agent for neuropathic pain provides a synergistically-enhanced analgesic effect at a dose at which a calcium channel α2δ ligand does not produce any side...
8946266 Substituted triazole and imidazole derivatives as gamma secretase modulators  
The present invention is concerned with novel substituted triazole and imidazole derivatives of Formula (I) wherein R1, R2, A1, A2, A3, A4, X, and Het1 have the meaning defined in the claims. The...
8940777 Pest controlling composition and method of controlling pest  
A pest controlling composition comprising tolclofos-methyl and a neonicotinoid compound represented by the formula (1) as active ingredients.
8937055 Heterocyclic ring compound having muscle cell or adipocyte differentiation regulating action  
The present invention provides a compound having a muscle cell or adipocyte differentiation regulating action, useful for the prophylaxis or treatment of diseases such as diabetes, obesity,...
8937083 Pesticidal compositions and processes related thereto  
This document discloses molecules having the following formula (“Formula One”): and processes related thereto.
8937089 Synergistic mixtures of anthranilamide invertebrate pest control agents  
Disclosed are mixtures and compositions for controlling invertebrate pests relating to combinations comprising (a)...
8927581 Fungicidal N-(2-pyridylpropyl) carboxamide derivatives and their oxa, aza and thia analogues  
The present invention relates to fungicide N-(2-pyridylpropyl)carboxamide derivative and its oxa, aza and thia analogs of formula (I), their process of preparation and intermediate compound for...
8921400 Arthropodicidal anthranilamides  
This invention provides a composition comprising a biologically effective amount of a compound of Formula 1, an N-oxide or an agriculturally suitable salt thereof wherein R1, R2, R3, R4a, R4b and...
8921402 Substituted pyrazoles as estrogen receptor ligands  
The invention provides a compound of formula (I) wherein G is a pyrazole ring as defined in the specification and R4, R5, R6 and R7 are as defined in the specification; or a pharmaceutically...
8921401 Pyrazole compounds, compositions and methods for treatment of degenerative diseases and disorders  
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
8916592 Malononitrile compounds  
Compounds of formula I wherein X is O or S(═O)n; n is 0, 1 or 2; R1 is optionally substituted alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, halocycloalkyl,...
8916555 3,5-diaminopyrazole kinase inhibitors  
Provided herein are 3,5-diaminopyrazoles, for example, compounds of Formula IA, that are useful for modulating regulated-in-COPD kinase activity, and pharmaceutical compositions thereof. Also...
8912184 Therapeutic and diagnostic methods  
The invention relates to methods of treating diseases, particularly cancers, that respond favorably to the inhibition of Nicotinamide phosphoribosyltransferase (Nampt); it also relates to...
8906943 Synthetic compounds and methods to decrease nicotine self-administration  
Methods and small molecule compounds for smoking and CNS disease harm reduction are provided. One example of a class of compounds that may be used is represented by the compound having the...
8906941 Carboxamide compounds and their use as calpain inhibitors  
The present invention relates to novel carboxamide compounds and their use as a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The...
8906904 Alkoxy pyrazoles as soluble guanylate cyclase activators  
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6 and R7 are as defined herein. The invention also relates to...
8901121 Metalloenzyme inhibitor compounds  
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
8901153 Pesticidal compositions and processes related thereto  
This document discloses molecules having the following formula (“Formula One”): and processes related thereto.