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6562846 |
Bisarylimidazolyl fatty acid amide hydrolase inhibitors
The present invention relates to bisarylimidazolyl derivatives and pharmaceutical compositions comprising said compounds inhibiting fatty acid amide hydrolase and useful for the treatment of pain,...
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6548520 |
Substituted imidazoles having anti-cancer and cytokine inhibitory activity
The present invention is related to novel 2-alkyl substituted imidazoles of formula (I) useful for the treatment of CSBP kinase mediated diseases.
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6548519 |
Pyridoxine and pyridoxal analogues: novel uses
The invention provides pyridoxal and pyridoxine analogues, pharmaceutical compositions containing pyridoxine and pyridoxal analogues, and methods of administering pharmaceutical compositions...
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6534503 |
Melanocortin receptor-3 ligands to treat sexual dysfunction
Methods for treating sexual dysfunction, such as erectile dysfunction or sexual arousal disorder, with a compound having the generic formula X 1 —X 2 -(D)Phe-Arg-(D)Trp-X 3 . A particularly...
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6531492 |
Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents
The present invention relates to compounds of the formula wherein R 2 , R 3 , R 6 and A are defined as in the specification, to pharmaceutical compositions containing them and to their...
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6531478 |
Amino pyrazole derivatives useful for the treatment of obesity and other disorders
Amino pyrazole derivatives of the formula: which are ligands for the neuropeptide Y, subtype 5 receptor and pharmaceutical compositions containing an amino pyrazole derivative as the active...
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6524603 |
Process and composition for the antiparasitic treatment of the surroundings of animals
A pesticidal composition and anti-parasitic treatment using the same, wherein the composition includes, in a combined pesticidally effective amount (a) carbaryl and (b) a compound having the...
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6525076 |
Selective factor Xa inhibitors
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating...
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6518257 |
1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof
To provide a composition having a steroid C 17,20 -lyase inhibitory activity and useful as an agent for the prophylaxis or treatment of prostatism and tumors such as breast cancer. A compound...
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6517871 |
Bioenhanced formulations comprising eprosartan in oral solid dosage form
This invention relates to bioenhanced formulations comprising eprosartan or eprosartan mesylate in the amorphous form, a process for its production, compositions containing the compound and methods...
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6518287 |
Substituted imidazoles as dual histamine H1 and H3 agonists or antagonists
The present invention discloses novel substituted imidazole compounds which have either or dual histamine-H 1 and H 3 receptor antagonist activity as well as methods for preparing such compounds....
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6514952 |
Hydantoin derivatives as inhibitors of leucocyte adhesion and as VLA-4 antagonists
Compounds of the formula I in which B, D, E, R, W, Y, Z, b, c, d, e, f, g and have the meanings indicated in the claims, are inhibitors of the adhesion and migration of leucocytes and/or...
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6514993 |
Serotonin 5-HT1A and dopamin D2 receptor ligands
The present invention relates to a novel series of 4-phenylpiperazines, 4-phenylpiperidines and 4-phenyl-1,2,3,6-tetrahydropyridines compounds of general formula (I) wherein A is alkylene,...
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6514966 |
Compounds for the treatment of obesity
NPY antagonists, methods of using such NPY antagonists and pharmaceutical compositions containing such NPY antagonists. The NPY antagonists are useful for the treatment of NPY mediated...
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6511981 |
Compositions and treatment for diabetic complications
This invention is directed to methods, pharmaceutical compositions and kits comprising an aldose reductase inhibitor (ARI), a prodrug thereof or a pharmaceutically acceptable salt of said ARI or...
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6511998 |
Pyrazole carboxamides useful for the treatment of obesity and other disorders
Pyrazole carboxamide derivatives of the formula: which are ligands for the neuropeptide Y, subtype 5 receptor, and pharmaceutical compositions containing a pyrazole carboxamide derivative as the...
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6511997 |
Aminopyrazole derivatives
Aminopyrazole derivatives represented by formula (I), or salts thereof, wherein X 1 and X 2 are each a hydrogen atom or a halogen atom, or X 1 and X 2 may be united together to form a lower...
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6509361 |
1,5-Diaryl substituted pyrazoles as p38 kinase inhibitors
The present invention contemplates 1,5-diaryl-substituted pyrazole compounds that, inter alia, inhibit the activity of p38 MAP kinase. Also contemplated by the invention are processes for the...
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6506779 |
Acetylene derivatives as anti-inflammatory/analgesic agents
The present invention relates to compounds of the formula wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X and Y are defined as in the specification, to pharmaceutical compositions containing them...
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6498172 |
Prostaglandin agonists and their use to treat bone disorders
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
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6495551 |
Substituted phenyloxazolidinones and their use as antibiotics
The invention concerns compounds of formula (I), wherein, for example, R 1 is of the formula —NHC(═O)R a wherein R a is (1-4C)alkyl; R 2 and R 3 are independently hydrogen or fluoro; R...
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6495550 |
Pyridine-substituted benzanilides as potassium ion channel openers
The present invention provides a genus of pyridine-substituted benzanilides that are useful as openers of potassium ion channels. The compounds of the invention are of use in both therapeutic and...
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6492397 |
N-arylheteroarylalkyl imidazol-2-one compounds for treatment of arteriosclerosis
A class of N-arylheteroarylalkyl imidazol-2-one compounds is described for use in treatment of arteriosclerosis. Compounds of particular interest are angiotensin II antagonists of Formula I: ...
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6472397 |
Nitrogen-containing heterocyclic compounds having antiplatelet aggregation effect and medicinal use thereof
The compounds represented by the formula (I), and pharmacologically acceptable salts and solvates thereof are disclosed. The compound is hydrolyzed in organisms into a compound represented by the...
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6469040 |
Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing and treating neoplasia. In particular, the invention describes the method of preventing and...
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6465493 |
Triarylimidazoles
Compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein R 1 , R 2 and R 3 are various substituent groups; and one of X 1 and X 2 is N or CR′, and the other is NR′...
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6465492 |
Heterocyclic compounds
A heterocyclic compound has the following formula (I) wherein Y represents a substituted or unsubstituted ethylene group or a trimethylene group, W represents the group —SO 2 R 1 , X...
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6462063 |
C-proteinase inhibitors
The present invention relates to a novel class of N,N′-di substituted hydantoin hydroxamates capable of inhibiting C-proteinase, and to their use to regulate, modulate and/or inhibit abnormal...
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6462069 |
Compounds, pharmaceutical compositions, and methods for inhibiting protein kinases
Amino-pyrazole compounds that modulate and/or inhibit the activity of protein kinases. These compounds and pharmaceutical compositions containing them are capable of mediating and/or inhibiting the...
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6458744 |
Pesticidal compounds and compositions
The invention relates to 4-thiomethylpyrazole compounds of formula (I): wherein R 1 , R 2 , Q and n are as defined in the description, and to their use as pesticides.
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6458813 |
Substituted pyridine compounds and methods of use
Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain...
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6458789 |
2-aminopyridine derivatives and combinatorial libraries thereof
The present invention relates to novel 2-aminopyridine derivative compounds of the following formula: wherein R 1 to R 5 have the meanings provided herein. The invention further relates to...
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6455550 |
N-alkanoylphenylalanine derivatives
Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms...
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6444690 |
Insecticidal compositions
The present invention relates to insecticidal mixtures of chloronicotinyl insecticides of the formula (I) in which R 1 represents C 1 -C 5 -alkyl, R 2 represents hydrogen or C 1 -C 5 -alkyl or...
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6436962 |
Arylhydantoin derivatives and uses thereof
Arylhydantoin derivatives and their pharmaceutically acceptable salts are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described....
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6432988 |
2-arylalkylthio -imidazoles, 2-arylalkenyl -thio -imidazoles and 2-arylalkinyl -thio -imidazoles as anti -inflammatory substances and substances inhibiting the release of cytokine
The invention relates to 4-heteroaryl-5-phenylimidazole derivatives having 2-arylalkylthio, 2-arylalkenylthio and 2-arylalkynylthio substitution, of the general formula I: in which Ar is a...
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6426341 |
Treatment for diabetic complications
This invention is directed to methods, pharmaceutical compositions and kits comprising an aldose reductase inhibitor (ARI), a prodrug thereof or a pharmaceutically acceptable salt of said ARI or...
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6423712 |
2,4-Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them
The present invention relates to imidazolidine compounds of the formula I, The compounds of the formula I are valuable pharmaceutical active compounds, which are suitable, for example, for the...
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6420384 |
Proton pump inhibitors
Compounds and methods of treating or preventing bone disorders including osteoporosis, rheumatoid arthritis, and metastatic bone disease are provided. The inventive compounds comprise a bone...
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6416752 |
Termite bait composition and method
An improved termite bait composition comprises a powdered cellulosic attractant having a particle size in the range of approximately 1 to 100 micrometers and a termite killing agent. Also disclosed...
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6417204 |
Pyridoxine AMD pyridoxal analogues: cardiovascular therapeutics
The invention provides pyridoxal and pyridoxine analogues, pharmaceutical compositions containing pyridoxine and pyridoxal analogues, and methods of administering pharmaceutical compositions...
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6410533 |
Antibacterial compounds
The present invention provides compounds having useful antibacterial activity and pharmaceutical compositions comprising one or more of these compounds. The invention further relates to a method of...
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6403630 |
Treating cancers associated with overexpression of HER-2/neu
Cancers associated with overexpression of HER-2/neu are treated with a selective inhibitor of cyclooxygenase-2 as the sole treating agent or said inhibitor in combination regimen with HERCEPTIN®...
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6403656 |
Use of ppar-&ggr activators in dermatology
The invention concerns the use of at least one activator of receptors of the PPAR-γ type for preparing a pharmaceutical composition for treating skin disorders related to an anomaly of the...
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6399606 |
Neuroprotective agents and methods related thereto
Neuroprotective agents are disclosed having the following structure: wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. Such compounds have utility in the treatment of conditions...
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6387898 |
Treatment for CNS injuries
This invention relates to a novel use of imidazole compounds in the treatment of CNS injuries.
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6384061 |
Hydantoin compounds and methods related thereto
The present invention relates to novel hydantoin compounds represented by formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an anti-cancer agent,...
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6376519 |
1-(4-sulfamylaryl)-3-substituted-5-aryl-2-pyrazolines and inhibitors of cyclooxygenase-2
Compounds of the formula wherein: X is selected from the group consisting of trihalomethyl, C 1 -C 6 alkyl, and a group of formula II: wherein: R 3 and R 4 are independently selected from...
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6372765 |
Parasiticidal formulations that can be applied dermally
The present invention relates to formulations for the dermal control of parasitic insects of animals, having the following composition agonists or antagonists of the nicotinergic acetylcholine...
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6362192 |
2-(Pyrazolyloxy) -pyridin-3-ylacetic acid derivatives, agents containing the same and use thereof against noxious fungi and animal parasites
Compounds of the formula I and salts thereof, in which the substituents and the index n have the following meanings: Q is —C(═CHCH 3 )—COOCH 3 , —C(═CHOCH 3 )—COOCH 3 , —C(═NOCH...
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