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7375122 |
Compounds useful as pesticides
Compounds useful to control pests are provided.
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7361668 |
Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors
The invention concerns quinuclidine derivatives of formula I or II wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals. The compounds of the...
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7354933 |
Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
The present invention relates to a cyclic urea compound of formula I:
as defined herein. The invention is also directed to the process for its preparation, pharmaceutical composition comprising...
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7354938 |
Pyrazole compounds and uses related thereto
Substituted pyrazoles are provided that are useful for the treatment of, for example, diabetes, obesity and metabolic syndrome.
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7329670 |
Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
The compounds are aryl and heteroaryl substituted heterocyclic ureas of the formula A—NH—C(O)—NH—B where A is the aryl or hetaryl substituted heterocyclic group and B is an aryl or...
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7326728 |
Modulators of glucocorticoid receptor, AP-1, and/or NF-κβ activity and use thereof
Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes,...
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7326724 |
Salts of omeprazole and esomeprazole I
The present invention relates to new salts of omeprazole and esomeprazole respectively, i.e. salts of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]su
lfinyl]-1H-benzimidazole and the...
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7312235 |
Benzamide inhibitors of factor Xa
Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or...
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7312204 |
Insecticides
The present invention relates to insecticidal mixtures of chloronicotinyl insecticides of the formula (I)
in which
R 1 represents C 1 -C 5 -alkyl, R 2 represents hydrogen or C 1 -C 5 -alkyl...
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7309710 |
Crystals
Obtaining the crystal of 4,6-dimethyl-4′-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]
nicotinanilide having excellent activity of inhibiting Ca 2+ release-activated Ca 2+ channel and suppressing...
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7309711 |
Fungicidal agent combinations
The invention relates to novel fungicidallly active compound combinations of 2′-cyano-3,4-dichloroisothiazole-5-carboxanilide of the formula
and the active compounds listed in the disclosure.
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7304066 |
Pyridyl cyanoguanidine compounds
Compounds according to formula (I)
wherein R1 represents hydrogen, halogen or one or more straight or branched, saturated or unsaturated C 1-6 hydrocarbon radical, optionally substituted with...
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7291642 |
Bradykinin-B1 antagonists, process for their preparation and their use as medicaments
The present invention provides bradykinin-B1 antagonists of the formula
in which A, Ar, G, Q, R 1 and R 4 are as defined in claim 1, their enantiomers, their diastereomers, their mixtures and...
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7288559 |
Carboxamide spirohydantoin CGRP receptor antagonists
The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache,...
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7288541 |
Propylcarbamate derivatives as inhibitors of serine and cysteine proteases
The present invention includes ketone derivatives (I) and (II), which are useful as cathepsin K inhibitors. The described invention also includes methods of making such ketone derivatives as well...
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7288554 |
Ortho-substituted aryl amides for controlling invertebrate pests
Disclosed are compounds of Formula I, their N-oxides and agriculturally suitable salts (I) wherein J is a phenyl ring, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered...
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7285554 |
Pyrazole derivative
Drugs, in particular, pyrazole derivatives represented by the following general formula (I) which have a calcium release-activated calcium channel inhibitory effect and medicinal compositions, in...
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7279476 |
Pyrazole-derived kinase inhibitors and uses thereof
Described herein are compounds that are useful as protein kinase inhibitors having the formula:
where B, R 1 , n, R 3 , Q, and R 4 are described in the specification. The compounds are useful...
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7279470 |
Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The...
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7276525 |
Osteogenesis-promotion enhancer and method of screening the same
It is an object of the present invention to provide an excellent enhancer for an osteogenesis accelerator that can enhance the activity of BMP as an osteogenesis accelerator. Another object of the...
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7273882 |
Aminoacetamide acyl guanidines as β-secretase inhibitors
There is provided a series of substituted acyl guanidines of Formula (Ik)
or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 2 , R 3 , R 4 , R 5 , R 25 , R 26 and R 27...
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7253187 |
Heterocyclic inhibitors of ERK2 and uses thereof
Described herein are compounds that are useful as protein kinase inhibitors having the formula:
wherein Z 1 and Z 2 are each independently nitrogen or CH and Ring A, T m R 1 , QR 2 , U n R 3...
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7253191 |
2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry
The invention relates to 2-thio-substituted imidazole derivatives of the formula I
in which the radicals R 1 , R 2 , R 3 and R 4 are as defined in the description. The compounds according to...
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7253170 |
Pyrazole-amine compounds useful as kinase inhibitors
The present invention provides pyrazole derived compounds of formula (I)
useful for treating p38 kinase-associated conditions, where W, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and m are as...
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7247647 |
Cyano anthranilamide insecticides
This invention provides compounds of Formula 1, N-oxides and suitable salts thereof
wherein
R 1 is Me, Cl, Br or F; R 2 is F, Cl, Br, C 1 -C 4 haloalkyl or C 1 -C 4 haloalkoxy; R 3 ...
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7232836 |
Arthropodicidal anthranilamides
This invention provides compounds of Formula 1, their N-oxides and agriculturally suitable salts
wherein
R 1 , R 2 , R 3 , R 4a , R 4b and R 5 are as defined in the disclosure.
...
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7226940 |
Substituted heterocycles for the treatment of diabetes and other diseases
The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes,...
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RE39681 |
1-(4-sulfamyaryl)-3-substituted-5-aryl-2-pyrazolines and inhibitors of cyclooxygenase-2
Compounds of the formula
wherein:
X is selected from the group consisting of trihalomethyl, C 1 -C 6 alkyl, and a group of formula II:
wherein:
R 3 and R 4 are...
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7223777 |
Compounds for the management of aging-related and diabetic vascular complications, process for their preparation, therapeutic and cosmetic uses thereof
The invention discloses a new clause of a five membered heterocylic ring compounds of general formula I
and its pharmaceutically or cosmetically acceptable salts, wherein R1, R2, R3, R4, R5, A,...
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RE39634 |
Bisarylimidazoly fatty acid amide hydrolase inhibitors
The present invention relates to bisarylimidazolyl derivatives and pharmaceutical compositions comprising said compounds inhibiting fatty acid amide hydrolase and useful for the treatment of pain,...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7214678 |
Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain
According to the invention there is provided a compound the formula I;
wherein A, X, B, R 1 , R 2 , R 3 and R 4 are as defined in the specification.
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7214693 |
Heterocyclic selective androgen receptor modulators and methods of use thereof
This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the...
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7199137 |
Imidazole derivatives as Raf kinase inhibitors
Novel compounds (I) and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and...
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7199138 |
Substituted anthranilamides for controlling invertebrate pests
This invention provides compounds of Formula I, N-oxides and salts thereof
wherein A, B, R 1 through R 5 , R 7 through R 9 , X and Y are as defined in the disclosure.
Also disclosed are...
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7192967 |
Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents
The invention relates to new pyridylalkane, alkene, and alkine carboxamides substituted with an imide with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid...
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7192954 |
Monocyclic anilide spirohydantoin CGRP receptor antagonists
The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache,...
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7186727 |
Pyridyl-substituted spiro-hydantoin compounds and use thereof
A class of substituted spiro-hydantoin compounds (II) having the formula:
its pharmaceutically acceptable salts, enantiomers, solvates, or prodrugs thereof, wherein R 16 is a substituted...
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7186734 |
Aryl imidazoles and related compounds as C5a receptor modulators
The invention provides Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formula
where the variables are defined herein.
Such compounds are ligands of C5a...
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7186277 |
Composition for dyeing keratin fibres, comprising a cationic para-phenylenediamine derivative substituted with a diazacyclohexane or diazacycloheptane ring
In one embodiment, the disclosure relates to a composition for dyeing keratin fibres, for example, human keratin fibres such as the hair, comprising at least one para-phenylenediamine derivative...
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7183296 |
Anti-HIV pyrazole derivatives
The present invention comprises novel and known pyrazole derivatives having anti-HIV activity, a process for their manufacture, pharmaceutical compositions and the use of such compounds in...
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7179823 |
5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity
A compound of formula (I) F wherein R 1 represents a hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; x represents a bond, an oxygen atom, a sulfur...
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7179822 |
Hetero biaryl derivatives as matrix metalloproteinase inhibitors
This invention provides compounds defined by Formula I
and pharmaceutically acceptable salts thereof,
and pharmaceutical compositions comprising a compound of Formula I, or a pharmaceutically...
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7179824 |
Arthropodicidal anthranilamides
This invention pertains to a compound of Formula I, its N-oxide or an agriculturally suitable salt of the compound (Formula I) wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined in the...
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7173044 |
Imidazoline derivatives having CB1-antagonistic activity
The present invention relates to 1,2,4-tri-substituted imidazoline derivatives, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said...
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7169799 |
Process for producing crystal
The present invention relates to a production method of a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl
]sulfinyl]benzimidazole·n′H 2 O (wherein n′ is about 0 to...
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7169798 |
Inhibitors of c-Jun N terminal kinases (JNK) and other protein kinases
The present invention provides compounds of formula I:
where R 1 is H, CONH 2 , T( n )-R, or T( n )-Ar 2 , n may be zero or one, and G, XYZ, and Q are as described below. These compounds are...
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7157476 |
Aminofurazan compounds useful as protein kinase inhibitors
The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
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7157475 |
Diamide invertebrate pest control agents
Compounds of Formula (I), and their N-oxides and suitable slats, are disclosed which are useful as invertebrate pest control agents, wherein A and B are independently O or S; E is C or N; J is a...
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7153874 |
Imidazole derivatives
The present invention provides 4-[1-Aryl-imidazol-4-ylethynyl]-2-alkyl-pyridine and 1-heteroaryl-imidazol-4-ylethynyl]-2-alkyl-pyridine derivatives and pharmaceutically acceptable salts thereof for...
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