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4510151 |
Pyridinylimidazole pharmaceutical composition
A pharmaceutical composition containing a therapeutically effective amount of a pyridinylimidazole 4- or 5-substituted carboxylic acid and esters thereof is provided to treat cardiovascular ailment.
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4508719 |
Hydroxyimino and alkoxyimino derivatives of 1,4-dihydropyridine and anti-hypertensive compositions
Compounds of formula I: ##STR1## are described in which R 1 is a linear or branched alkyl radical containing between 1 and 5 carbon atoms, the alkyl radical being unsubstituted or substituted by...
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4505920 |
Certain N-substituted-4-aryl-3,5-pyridine dicarboxylates and their antihypertensive use
Unsaturated heterocyclic dihydropyridine of the formula ##STR1## wherein R 3 and R 4 together with the N to which they are attached form an unsaturated heterocyclic group, have been found to...
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4505918 |
4-[2-Pyridinylthio(oxy or amino)methyl]-1H-imidazoles and derivatives
4-[2-Pyridinylthio(oxy or amino)methyl]-1H-imidazoles and derivatives and acid addition salts thereof are selective central-adrenergic receptor agonists and thereby useful as antihypertensives.
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4503061 |
Substituted phenyl-pyridinones as cardiotonic agents
Certain 2(1H)-pyridinones are cardiotonic agents. Methods for their preparation and use are disclosed.
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4503065 |
Antiinflammatory 4,5-diaryl 1-2-halo imidazoles
Novel 4,5-diaryl-2-halo imidazoles, for example, 2-bromo-4,5-bis-(4-chorophenyl)imidazole, and their acid addition salts are useful for treating inflammation in mammals. Some of the compounds are...
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4500527 |
Antihypertensive 4[(3-alkylamino-2-hydroxypropyl)-oxyiminomethyl phenyl]-1,4-dihydropyridines
Unsaturated heterocyclic dihydropyridines of the formula: ##STR1## wherein the substituents defined herein have been found to have useful antihypertensive activity.
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4499097 |
2-(Pyridyl)imidazolyl ketones
This disclosure describes novel substituted 2-(pyridyl)imidazol-4-yl ketones and derivatives thereof which possess activity as hypotensive agents.
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4497821 |
Medicaments having antihypoxic and ischaemia-protective activity
A method of controlling damage to the central nervous system of a patient which comprises administering to such patient a central nervous system-controlling effective amount of a pyridine...
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4496564 |
Amide derivatives
The invention relates to amide derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of the...
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4486443 |
Hydantoin derivatives and pharmaceutical use
Hydantoins of formula (I) ##STR1## have biological properties related to those of naturally occurring prostaglandins and may be used in medicine, for example in the treatment of thrombosis.
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4472422 |
Antihypertensive 4,5-diaryl-α-polyfluoro-alkyl-1H-imidazole-2-methanamines
4,5-Diaryl-α-polyfluoroalkyl-1H-imidazole-2-methanamines are useful in the treatment of hypertension.
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4465685 |
Antiinflammatory pyrazole thioureas
Compounds of formula (I) ##STR1## inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid oxygenation and are useful in medicine as, e.g., anti-inflammatory and...
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4465681 |
Bis-(aminoalkoxy)-phenyl, pyridyl ketones, and use as immunological agents
Pyridine derivatives of the formula: ##STR1## or pharmaceutically acceptable acid addition salts thereof, wherein R 1 , R 2 , R 3 and R 4 are the same or different and each represents hydrogen...
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4463005 |
Bicyclic guanidines
The invention relates to bicyclic derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of...
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4450165 |
Dihydropyridine compounds
A dihydropyridine compound of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein Het is 5- or 6-membered aromatic heteroaryl, R 1 and R 2 are each lower...
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4447431 |
Tri-substituted imidazole derivatives, pharmaceutical preparations containing them, and their use
The invention relates to novel tri-substituted imidazole derivatives, especially compounds of the general formula I ##STR1## in which R 1 and R 2 represent, independently of each other,...
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4435396 |
Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor
Heretofore unavailable 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles; a novel process therefor, also advantageous for the preparation of known antiulcer...
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4407808 |
2-Heterocyclic alkylamino-3-nitropyrroles
3-Nitro-2-substituted aminopyrroles are histamine H 2 -receptor antagonists. The 2- position substituent is a fully-unsaturated heterocyclyl alkyl group preferably with alkyl group interrupted by...
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4405628 |
4-Pyridylimidazolones and method of use
This invention relates to aroylimidazole-2-ones and their acid and base addition salts as well as their use as cardiotonics in the treatment of cardiac failure.
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4391827 |
3-(2-Hydroxy-4-(substituted)phenyl)-cycloalkanone and cycloalkanol analgesic agents and intermediates therefor
Cycloalkanones, cycloalkanols and unsaturated analogs thereof, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have...
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4389403 |
1-Aroyl-2-phenylamino-2-imidazolines, drugs containing these compounds, and use thereof
1-Aroyl-2-phenylamino-2-imidazolines of the general formula ##STR1## where R 1 and R 2 are identical or different and each is chlorine, bromine, fluorine, methyl, ethyl, methoxy, trifluoromethyl...
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4380547 |
Dihydropyridine compounds which are substituted in the 4-position by imidazolyl or thiazolyl and their medicinal use
The invention relates to dihydropyridine compounds of formula (I) as defined in the specification, containing a hetero-ring substituent in the 4-position. Also included in the invention are...
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4379158 |
Antisecretory imidazole amidine compounds, composition and method of use
Novel heterocyclic compounds shown by the formula ##STR1## wherein Het represents a 5-membered or 6-membered heterocyclic group which may have substituent(s); Z represents a sulfur atom or oxygen...
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4379147 |
Substituted 2-(anilinomethyl)-2-imidazoline derivatives, compositions containing these derivatives, and the use thereof for combating pests
Compounds of the formula ##STR1## wherein R 1 and R 2 independently of one another are each a chlorine atom or the methyl group, Y is the group ##STR2## or --CHN--R 5 , in which R 3 is methyl...
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4374839 |
Pharmacologically active 1,3-bis[(2-heterocyclyl-methyl-thio)ethyl)ethyl)guanidino]alkane derivatives
The compounds are C 2 -C 8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N', N"-disubstituted guanidino), N-(N'-substituted...
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4372964 |
Antiinflammatory 4,5-diaryl-1H-imidazole-2-methanols
Antiinflammatory 4,5-diaryl-1H-imidazole-2-methanols, such as 4,5-bis(4-fluorophenyl)-α,α-di(trifluoromethyl)-1H-imidazo
le-2 -methanol are useful in treatment of arthritis.
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4367236 |
Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives
4-Alkanoylimidazol-2-ones of the following general structure which are useful as cardiotonics in the treatment of cardiac failure ##STR1## wherein Q and T are each an oxygen atom or a divalent...
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4366160 |
Imidazole derivatives
Imidazole derivatives of the formula ##STR1## wherein R 1 , R 2 and R 3 , independently, are hydrogen, halogen, trifluoromethyl, nitro, lower alkyl or lower alkylthio; one of R 4 and R 5 is...
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4350696 |
Imidazole derivatives, process for their preparation and pharmaceutical compositions thereof
Compounds of the general formula: ##STR1## wherein X is a group of the formula: ##STR2## m is 2 or 3; n is an integer of from 1 to 4; and R is a 5-membered heterocyclic group containing as...
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4348404 |
Antiinflammatory 4,5-diaryl-α-polyfluoroalkyl-1H-imidazole-2-methanamines
Antiinflammatory 4,5-diaryl-α-polyfluoroalkyl-1H-imidazole-2-methanamines such as 4,5-bis(4-methoxyphenyl)-α,α-di(trifluoromethyl)-1H-imidaz
ole- 2-methanamine, are useful in treatment of...
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4347251 |
Novel 3-substituted amino-1-substituted heteroaryl-2-pyrazolines
This disclosure describes novel 3-substituted amino-1-substituted heteroaryl-2-pyrazolines and their C 4 and C 5 analogs, effective as agents that ameliorate inflammation, analgesic agents,...
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4336257 |
Novel 2-pyridylbenzimidazole compounds
Novel alkylsubstituted 2-pyridylimidazoles, halosubstituted-2-pyridylbenzimidazoles, and 2-pyridylimidazopyridines are disclosed. The compounds have pharmaceutical utility as xanthine oxidase...
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4330545 |
Heterocyclic imidazolyl vinyl ethers and use of same as fungicides or bactericides
Aryl-imidazol-1-yl vinyl ethers and their acid addition salts are disclosed, wherein the imidazolyl vinyl ether has the formula: ##STR1## Ar in the formula represents a substituted or unsubstituted...
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4317831 |
Antimicrobial derivatives of 3-(1H-imidazol-1-yl)-2-propen-1-ones
Compounds are provided having the structure ##STR1## wherein R 1 is lower alkyl; phenyl-lower alkyl; phenyl; substituted phenyl wherein the phenyl group bears one or two halogen, hydroxy, lower...
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4317825 |
Antitumor and immunosuppressive 4-carbamoyl imidazolium-5-olate derivatives
There are provided compounds of the formula: ##STR1## wherein R is a heteroaroyl group containing a nitrogen, sulfur or oxygen atom which may be substituted with a lower alkyl group, an aralkyl...
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4308277 |
2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same
Compounds of the formula ##STR1## in which R 1 and R 2 independently of one another are substituted or unsubstituted aryl or hetero-aryl groups, R 3 is hydrogen or lower alkyl and R 4 is a...
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4302464 |
Imidazolylpyridine therapeutic agents
A series of 2-substituted-4-(4-imidazolyl)pyridines and the pharmaceutically acceptable acid addition salts thereof as histamine H 2 -receptor inhibitors for controlling gastric acidity.
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4281005 |
Novel 2-pyridylimidazole compounds
Novel alkylsubstituted 2-pyridylimidazoles, halosubstituted-2-pyridylbenzimidazoles, and 2-pyridylimidazopyridines are disclosed. The compounds have pharmaceutical utility as xanthine oxidase...
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4273776 |
Antibacterial and antifungal derivatives of 3-(1H-imidazol-1-yl)-2-propen-1-ones
Compounds are provided having the structure ##STR1## wherein R 1 is lower alkyl; phenyl-lower alkyl; phenyl; substituted phenyl wherein the phenyl group bears one or two halogen, hydroxy, lower...
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4271169 |
N-Heterocyclic alkyl-N'-pyridyl alkylthioureas, ureas and guanidines
The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. A compound of this invention is...
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4269844 |
Alkoxypyridyl N-cyano or N-carbamoylguanidino alkanes, compositions containing same and uses thereof
The compounds are C 2 -C 8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted...
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4251535 |
Antiinflammatory 4,5-diaryl-2-nitroimidazoles
Antiinflammatory 4,5-diaryl-2-nitroimidazoles, such as 4,5-bis(4-fluorophenyl)-2-nitroimidazole, useful for treating arthritis and related diseases.
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4234594 |
Pyrazolyl amino imidazolines as antihypertensive agents
Described is a method of treating hypertensive by administering to mammalian patients compounds of the formula ##STR1## wherein R 1 and R 2 are hydrogen, loweralkyl, lowercycloalkyl, aralkyl,...
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4233306 |
1-Iminomethylene-substituted 2-(phenoxy-alkyl)-2-imidoazoline derivatives
Compounds of the formula I ##STR1## wherein R 1 and R 2 are each chlorine or methyl, R 3 is hydrogen or C 1 -C 4 -alkyl and R 4 is cyano or a group of the formula A or B. ##STR2## and their...
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4230713 |
Heterocyclic tetrahydro-1-alkyl-4-oxo-1H-imidazol-2-ylidene urea and phenyl esters of tetrahydro-1-alkyl-4-oxo-1H-imidazol-2-ylidene carbamic acid compounds
Heterocyclic tetrahydro-1-alkyl-4-oxo-1H-imidazol-2-ylidene urea and compounds which are useful as anxiolytic agents in living animals and also some of which act to block acid secretions.
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4230714 |
Imidazole therapeutic agents
A series of 2-(imidazol-1-ylmethyl)pyridines and 2-(imidazol-1-ylmethyl)quinolines has been prepared, including their pharmaceutically acceptable acid addition salts. These particular compounds are...
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4218460 |
Nitroimidazoles
Nitroimidazolylvinylthiadiazoles, their production, and formulations containing same for use as chemotherapeutics in the treatment of microbial infections in humans and animals, especially of...
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4218457 |
2-Substituted 5-hydroxy-1H-imidazole-4-carboxamide derivatives and use
Compounds of the formula, ##STR1## wherein R is C 2 -C 17 alkyl group, C 3 -C 7 cycloalkyl group, 1-adamantyl group, pyridyl group, pyridine N-oxide, diphenylmethyl group, benzyl group which...
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4212869 |
Substituted 1-pyridinyloxy-1-(imidazolyl)-2-butanone compounds and their use as fungicides
Substituted 1-pyridinyloxy-1-(triazolyl or imidazolyl)-2-butanone compounds which correspond to the formula: ##STR1## wherein each X independently represents halogen, methyl, trichloromethyl,...
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