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4696933 |
Guanidine compounds useful as histamine H2-antagonists
The invention relates to amide derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of the...
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4696930 |
N-(heteroarylalkyl)acylanilide derivatives as antiarrhythmic agents
Compounds of the formula: ##STR1## wherein R 1 is --alkylene'-13 NH 2 or --alkylene'--A'; R 2 , R 3 and R 4 are independently hydrogen or methyl; A and A' are, independently, unsubstituted or...
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4694004 |
Semicarbazide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
A compound of the formula: ##STR1## wherein R 1 is hydrogen, R 2 is hydrogen, lower alkyl, ar(lower)alkyl, lower alkenyl or aryl, R 3 is lower alkyl, ar(lower)alkyl, lower alkenyl or aryl,...
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4694012 |
Method of treating of preventing diseases using 1,4-dihydropyridines
This invention concerns a method of treatment using 1,4-dihydropyridine derivatives having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R is aryl or heteroaryl; R...
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4692455 |
Certain acyclic, alicyclic, aromatic or heterocyclic derivatives of 3-benzoylamino-2-oxo- butyl-amino-carbonyl-oxy-3-propanoic acids, esters thereof, pharmaceutical compositions containing same and their enkephalinase inhibiting properties
Compounds of the formula ##STR1## wherein Y is oxygen or sulfur are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and...
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4686231 |
Inhibition of 5-lipoxygenase products
Novel compounds, compositions and pharmaceutical a method of inhibiting the 5-lipoxygenase pathway in an animal in need thereof which comprising administering an effective, 5-lipoxygenase pathway...
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4683228 |
Guanidinopyrazolylamides, guanidimoimidazolylamides, compositions containing them, and method of using them to inhibit gastric acid secretion
A guanidine derivative of the formula I: ##STR1## in which R 1 , R 2 , R 3 , R 4 , ring X and D are a variety of radicals defined in the specification and A is a 3-8C alkylene chain which is...
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4680304 |
Feed compositions containing 2-(α-pyridyl)-Δ.sup.2 -heterocyclic compounds
Selected 2-(α-pyridyl)-Δ 2 -heterocyclic compounds are used as active ingredients in animal feed compositions and in methods for increasing the growth or feed efficiency of monogastric animals....
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4678795 |
1-pyridylmethyl-2-nitromethylene-1,3-diazacycloalkane insecticides
Novel insecticides of the formula ##STR1## in which R is a hydrogen atom or a lower alkyl group, X is a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio-group, a lower...
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4677210 |
1-arylalkoxy- and 1-arylalkylthioaryl-2-pyrazolines as anti-inflammatory or anti-allergic agents
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4670450 |
Cardiotonic thiazolones
Thiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
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4670449 |
Dihydropyridines
Dihydropyridine anti-ischaemic agents of the formula: ##STR1## and their salts where R is aryl or heteroaryl, R 1 and R 2 are each C 1 -C 4 alkyl or 2-methoxyethyl, Y is --(CH 2 ) n -- where n...
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4668799 |
Anti-hepatitis and anti-cirrhotic 1,3-dithiol-2-ylidene derivatives, and pharmaceutical compositions therefor
A 1,3-dithiol-2-ylidene derivative of the formula: ##STR1## wherein each of R and R 1 which may be the same or different, is a lower alkyl group, a lower alkenyl group, a cycloalkyl group, a lower...
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4665080 |
Imidazolyl compounds and their use as medicaments
The present invention relates to new ortho-, meta- and para-substituted imidazolylmethylstyrenes of the formula I ##STR1## and to a process for their preparation. The compounds according to the...
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4663327 |
1-heteroaryl-4-aryl-pyrazolin-5-ones
Microbicidally active novel 1-heteroaryl-4-aryl-pyrazolin-5-ones of the formula ##STR1## in which R represents hydrogen or alkyl, R 1 represents halogen, hydroxyl, optionally substituted alkyl,...
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4663341 |
Insecticidal n-aryl-3-aryl-4,5-dihydro-1h-pyrazole-1-carboxamides
This invention relates to N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds which are useful as pesticides, compositions containing those compounds, methods of controlling pests and...
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4659723 |
Substituted azolylalkyl pyridinyl ethers
Novel substituted azolylalkyl pyridinyl ethers of the formula ##STR1## in which Az represents 1,2,4-triazolyl or imidazolyl, B represents the keto or the CH(OH) group, Y represents halogen,...
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4659720 |
5-amino or substituted amino imidazoles useful to treat coccidiosis
5-Amino or substituted amino imidazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling cecal and or intestinal coccidiosis when administered in minor...
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4657908 |
Carbonyl derivatives
The invention relates to carbonyl derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention where is provided a guanidine derivative of...
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4647557 |
Novel heterocyclic derivatives bearing an amino radical, processes for their production and the pharmaceutical compositions containing them
This invention relates to novel heterocyclic derivatives bearing an amino group and to processes for making said compounds. More particularly this invention provides novel heterocyclic compounds...
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4642311 |
β-adrenergic blocking imidazolylphenoxy propanolamines
Substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and...
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4636518 |
Imidazole derivatives and pharmaceutical compositions
Compounds of the general formula: ##STR1## and acid addition salts thereof; in which Ar and Ar 1 which may be the same or different, each represent an aromatic radical which may be substituted one...
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4636519 |
Ketene S,S-acetal derivative, a process for manufacturing thereof and a method for curing mycosis by administering it
A novel ketene S,S-acetal derivative which is useful as an antimycotic agent and an agricultural chemical of fungicidal, plant growth regulating or insecticidal properties represented by the...
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4634711 |
Pyridylalkyl imidazole-2-thiols
Potent dopamine-β-hydroxylase inhibitors having the formula: ##STR1## which are useful to inhibit dopamine-β-hydroxylase activity, pharmaceutical compositions including these inhibitors, and...
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4634716 |
Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
Compounds of the formula: ##STR1## where R 3 is ##STR2## where n is 1-3 and the R a 's and R b 's are independently hydrogen or loweralkyl; and pharmaceutically acceptable salts thereof; are...
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4624958 |
Antiprotozoal 1,4-di(p-amidinophenyl)imidazoles
Diamidines of the formula ##STR1## wherein X is a propylene, isobutylene, guanidine, pyrrole, tetrazole, imidazole or substituted imidazole group; and...
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4622330 |
Antiprotozoal 3-amino or substituted amino pyrazoles
Novel 3-amino or substituted amino pyrazoles are disclosed as having antiprotozoal and antiparasitic activity in particular anticoccidial activity and are useful for controlling cecal and or...
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4621092 |
Substituted proline compounds, composition and method of use
Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of...
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4616002 |
Dihydro pyridine compounds, compositions and use
Compounds of the formula I ##STR1## in which n represents 1, 2 or 3, Ar represents a carbocyclic or heterocyclic aryl radical, Ac represents the acyl radical of an acid, Z represents a radical --OR...
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4608382 |
2-(Sulphinyl and sulfonyl)-4(5)-phenyl-5(4)-(3'-pyridyl)-imidazols
Novel substituted 2-mercaptoimidazoles of the formula ##STR1## in which at least one of the radicals R 1 and R 2 is a substituted or unsubstituted heteroaryl group and the other is a substituted...
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4605661 |
Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
This invention provides a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals by administering certain imidazole derivatives. Pharmaceutical...
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4604402 |
Hydroxy substituted ureido amino and imino acids
Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of...
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4593028 |
5-hetero aryl-substituted-2-pyridones useful as cardiotonic agents for treatment of congestive heart failure
Cardiotonic 5-heteroaryl-substituted-2-pyridone compounds, pharamaceutical compositions, and a method for the treatment of congestive heart failure.
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4579857 |
Anti-inflammatory 1-mercaptoalkyl-substituted-2-imidazolidinone derivatives, composition, and method of use therefor
1-Mercaptoalkyl-substituted-2-imidazolidinones having anti-inflammatory activity are disclosed. Methods for their preparation and use are described.
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4572913 |
Use of 3-(arylmethyleneamino)-1-aryl-2-pyrazolines in the prophylaxis and treatment of inflammation, pain, pyresis, and asthma
Compounds of formula (I) ##STR1## inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid oxygenation and are useful in medicine as, e.g., anti-inflammatory and...
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4567189 |
Imidazole derivatives used in antithrombotic method
Compounds of the general formula: ##STR1## and acid addition salts thereof; in which Ar and Ar 1 which may be the same or different, each represent an aromatic radical which may be substituted...
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4564621 |
α-Aryl-α-pyridylalkanoic acid derivatives, process for preparation thereof and pharmaceutical composition comprising the same
New α-aryl-α-pyridylalkanoic acid derivatives of the formula: ##STR1## wherein R 1 is cyano or carbamoyl, R 2 is hydrogen or halogen, R 3 is hydrogen or lower alkyl, one of R 4 and R...
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4563446 |
Thromboxane synthetase inhibiting 3-(1-alkenyl) pyridines
Novel compounds of the formula: ##STR1## wherein R 2 is an aromatic or heterocyclic group, which may optionally be substituted, R 2 is a methyl group, a hydroxymethyl group, a nitroxymethyl...
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4563473 |
Compositions and method for inhibition of sebum synthesis
Novel sebum synthesis inhibiting compositions comprising a sebum inhibiting effective amount of at least one compound selected from the group consisting of compounds of the formula ##STR1## wherein...
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4560690 |
2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
2,4-Disubstituted thiazole compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof wherein X is NH and Y is CH or N, or X is S and Y is CH; R 1 is...
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4556665 |
Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones
Novel imidazolonecarbonylarylimidazoles of the formula: ##STR1## are described having cardiovascular properties, especially as cardiotonic agents in the treatment of congestive heart failure....
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4555519 |
Thromboxane synthetase enzyme inhibiting N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]pyridinecarboxamides
This invention concerns novel N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]pyridinecarboxamides which are useful as inhibitors of thromboxane synthetase and/or as hypotensive agents in...
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4554286 |
Antifungal 1-triazolyl-2-aryl-3-(5-trifluoromethylimidazol-1-yl)propan-2-ol derivatives
1-Triazolyl-2-aryl-3-(5-trifluoromethylimidazol-1-yl)propan-
2-ol derivatives useful in the treatment of fungal infections in humans, animals and plants, and their preparation.
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4550119 |
2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones
2,4-Dihydro-5-[(substiuted)phenyl]-4,4-disubstituted-3H-pyra
zol-3-one compounds as cardiotonic and antihypertensive agents, pharmaceutical compositions and methods of treating diseases with such...
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4547512 |
2-(Imidazolyl alkylamino)-3-carboxy(or hydroxy)-pyridines
This invention relates to 2-amino-3-hydroxy, and 3-carboxy pyridine derivatives, in which the amino group is substituted by a methylthioethyl, butyl or oxypropyl group bearing a terminal...
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4542141 |
Compound having vasodilating, antiaggregating and hypocholesterolemic activities, process for the preparation thereof and pharmaceutical compositions therefrom
The compound having formula (I) ##STR1## is obtained by reacting 1,2-diphenyl-4-[2-phenylsulfinyl)-ethyl]-4-hydroxymethyl-pyr
azolidine-3,5- dione (hydroxymethylsulfinpyrazone) with nicotinic acid,...
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4532250 |
5-Heteroarylimidazol-2-ones having cardiotonic activity
Described are compounds of the formula ##STR1## wherein R is heteroaryl and R 1 is hydrogen or loweralkyl, or a pharmaceutically acceptable salt thereof. The compounds exhibit cardiotonic activity.
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4526895 |
3-Pyridyl-5-alkoxy-pyrazole derivatives and pharmaceutical composition for use as a cardiotonic medication
The invention relates to new 3-pyridyl-5-alkoxy-pyrazole derivatives of the following formula: ##STR1## wherein R 1 represents a 4-pyridyl, 3-pyridyl or 2-pyridyl group which is unsubstituted or...
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4525360 |
Anti-psychotic phenylindene derivatives and acid addition salts thereof
The present invention relates to novel phenylindene derivatives having interesting pharmacodynamic properties which make them useful as psychopharmacologicals in the treatment especially of...
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4515798 |
Benzoylparabanic acids
Novel substituted 1-pyridyloxyphenyl-3-benzoylparabanic acids of the formula ##STR1## wherein R 1 is hydrogen, halogen or C 1 -C 4 alkyl, R 2 and R 3 , each independently of the other, are...
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