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8791142 Oxazole pyridine derivatives useful as S1P1 receptor agonists  
The present invention provides oxadiazole pyridine derivatives of Formula (I), their use as medicaments and their use for treating multiple sclerosis and other diseases.
8791100 Aryl benzylamine compounds  
The present invention relates to substituted aryl-benzylamine compounds, to processes for their production, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
8791091 Aryl dihydropyridinone and piperidinone MGAT2 inhibitors  
The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are...
8785440 Bruton's tyrosine kinase inhibitors  
The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
8785442 Compound as antagonist of lysophosphatidic acid receptor, composition, and use thereof  
The present invention relates to a compound as antagonist of LPA receptor, and a pharmaceutical composition comprising the same. The present invention also relates to the use of the compound and...
8778940 Chemical inducers of neurogenesis  
The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in...
8778974 Trisubstituted 1,2,4 triazoles  
The present invention relates to 1-aryl-3-aniline-5-alkyl-1,2,4-triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical...
8771665 Inhibitors of hepatitis C virus polymerase  
The present invention provides, among other things, compounds represented by the general Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, R1A, R1B, R2, and R3 are as defined...
8765739 Azetidine compound and pharmaceutical use thereof  
Compounds of formula [I]: wherein each symbol is as defined in the description, or a pharmaceutically acceptable salts or solvates thereof.
8754227 Metalloenzyme inhibitor compounds  
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
8754053 Isoxazoline derivatives as insecticides  
The present invention relates to compounds formula (I), wherein P is P1, P2, heterocyclyl or heterocyclyl substituted by one to five Z; and wherein A1, A2, A3, A4, G1, R1, R2, R3, R4, R5, R6, R17,...
8748627 Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome  
The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes,...
8748461 Metalloenzyme inhibitor compounds  
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
8748340 Pesticidal compositions and processes related thereto  
This document discloses pesticidal compostions comprising molecules having the following formulas: and processes related thereto.
8748412 Phenylalanine derivatives and their use as non-peptide GLP-1 receptor modulators  
Provided herein are non-peptide GLP-1 receptor modulator compounds, for example, of Formula I, pharmaceutical compositions comprising such compounds, and processes of preparation thereof. Also...
8748470 Methods for treating ovarian cancer by inhibiting fatty acid binding proteins  
The present invention concerns methods and compositions for the inhibition or reduction of the primary tumor and metastasis by inhibition of fatty acid binding proteins.
8742119 Pyruvate kinase M2 modulators, therapeutic compositions and related methods of use  
Compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
8742118 Methods for preparing intermediates of perampanel  
Methods for the synthesis of 2-alkoxy-5-(pyridin-2-yl)pyridine of formula I or salts thereof are provided.
8735398 Hepatitis C virus inhibitors  
The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus...
8735362 Insecticidal compounds based on isoxazoline derivatives  
The present invention relates to compounds of formula (I): Wherein A1, A2, A3, A4, G1, L, Y1, Y2, Y3, Y4, R1, R2, R3 and R4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the...
8735432 N-(Heteroaryl)-1-heteroarylalky1-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof  
The invention concerns compounds of general formula (I), wherein n, X1, X2, X3, X4, Y and W are as defined herein. The invention also concerns a method for preparing said compounds and their...
8735399 Selective subtype alpha 2 adrenergic agents and methods for use thereof  
The invention provides oxazolidine and thiazolidine derivatives that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein are useful in treating a...
8729271 Glycine transporter inhibiting substances  
The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the...
8729107 Pyridines for treating injured mammalian nerve tissue  
Embodiments of the present disclosure provide a novel pyridine, pharmaceutical compositions comprising such pyridine, and the use of such compositions in treating injured mammalian nerve tissue,...
8729103 Silent desensitizers of neuronal nAChR and methods of use thereof  
One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of...
8729104 Diphenyl substituted alkanes as flap inhibitors  
The instant invention provides compounds of formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of formula I are useful as anti-atherosclerotic, anti-asthmatic,...
8729105 Heteroarylmethyl amides  
The present invention relates to compounds of the formula wherein A1, A2, A3 and R1 to R8 are defined in the description, and to pharmaceutically acceptable salts thereof, their manufacture,...
8710084 Tetrazolyl oxime derivative, salt thereof, and plant disease control agent  
The present invention provide a tetrazolyl oxime derivative represented by formula (1) (in formula (1), X represents a halogen atom or the like, n1 represents an integer of 0 to 5, A represents a...
8710083 Pyridylphenyl compounds for inflammation and immune-related uses  
The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein Y, L, X1, X2, Z, R3, R4, and n are defined...
8710055 Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors  
The present invention encompasses compounds of general formula (I) wherein the groups R2 to R4, A, X and m are defined as in claim 1, which are suitable for the treatment of diseases characterised...
8697715 Serine/threonine kinase inhibitors  
Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory...
8697732 Pyridine derivatives  
The invention relates to novel pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
8697704 Hepatitis C virus inhibitors  
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...
8697733 Pyridine derivatives as sphingosine 1-phosphate (S1P) receptor modulators  
The present invention relates to novel pyridine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of...
8691821 Oxazolidinones as modulators of mGluR5  
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, agonists and partial...
8673941 Oxazole derivatives useful as inhibitors of FAAH  
The present invention is directed to certain oxazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical...
8673911 Inhibitors of histone deacetylase  
This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates,...
8658659 Substituted oxazole derivatives and their use as tyrosine kinase inhibitors  
The present invention relates to novel compounds selected from substituted oxazole derivatives of formula (I) that selectively modulate, regulate, and/or inhibit signal transduction mediated by...
8658675 Pyridin-4-yl derivatives  
The invention relates to pyridine derivatives of Formula (I), wherein A, R1, R2, R3, and R4 are as described in the description, their preparation and their use as pharmaceutically active...
8658661 Oxadiazole inhibitors of leukotriene production  
The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical...
8653062 Compounds as receptor modulators with therapeutic utility  
The present invention relates to novel cyclic amine and cycloalkyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as...
8648081 Parasiticidal dihydroisoxazole compounds  
Provided are dihydroisoxazole compounds I useful for controlling parasites both in animals and agriculture. Further provided are methods for controlling parasite infestations of an animal by...
8637559 Oxazole compound and pharmaceutical composition  
The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: wherein R1 is an aryl group which may have one or more substituents; R2 is an aryl group or a...
8633222 Arylvinylazacycloalkane compounds and methods of preparation and use thereof  
Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare...
8633134 Substituted amidine compounds for combating animal pests  
The invention relates to substituted amidine compounds of formula (I), to the enantiomers, diastereomers and salts thereof and to compositions comprising such compounds. The invention also relates...
8629165 Methods for treating cognitive disorders  
Disclosed herein are methods of treating a patient suffering a cognitive disorder.
8623875 Isoxazoline insecticides  
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A is a 6-membered aromatic ring containing carbon atoms and 0-3 nitrogen atoms...
8618137 Fungicidal heterocyclic compounds  
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein R1, R2, R3, R4, R5, A, W, X, G, Z, J and n are as defined in the...
8618112 Crystalline forms of an inhibitor of 11-β-hydroxysteroid dehydrogenase type 1  
Novel crystalline salts of 3-[4-(3-ethanesulfonyl-propyl)-bicyclo[2.2.2]oct-1-yl]-4-met hyl-5-(2-trifluoromethyl-phenyl)-4H-1,2,4-triazole are potent inhibitors of 11β-hydroxysteroid dehydrogenase ...
8618139 Oxadiazole derivatives as sphingosine 1-phosphate (S1P) receptor modulators  
The present invention relates to novel oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of...