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8697715 Serine/threonine kinase inhibitors  
Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory...
8697732 Pyridine derivatives  
The invention relates to novel pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
8697704 Hepatitis C virus inhibitors  
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...
8697733 Pyridine derivatives as sphingosine 1-phosphate (S1P) receptor modulators  
The present invention relates to novel pyridine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of...
8691821 Oxazolidinones as modulators of mGluR5  
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, agonists and partial...
8686155 Aurora kinase modulators and method of use  
The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4, R6, R7 and R8 are defined herein, which are capable of modulating...
8680269 Pesticidal compositions  
The present invention concerns novel heteroaryl-N-aryl thiosemicarbazones and their use in pest control, as insecticides and acaπcides This invention also includes preparation of the pesticide ...
8673941 Oxazole derivatives useful as inhibitors of FAAH  
The present invention is directed to certain oxazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical...
8673911 Inhibitors of histone deacetylase  
This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates,...
8674109 Pesticidal compositions  
The present invention concerns novel heteroaryl-N-aryl carbamates and their use in pest control, as insecticides and acaricides This invention also includes preparation of the pesticide...
8658659 Substituted oxazole derivatives and their use as tyrosine kinase inhibitors  
The present invention relates to novel compounds selected from substituted oxazole derivatives of formula (I) that selectively modulate, regulate, and/or inhibit signal transduction mediated by...
8658675 Pyridin-4-yl derivatives  
The invention relates to pyridine derivatives of Formula (I), wherein A, R1, R2, R3, and R4 are as described in the description, their preparation and their use as pharmaceutically active...
8658661 Oxadiazole inhibitors of leukotriene production  
The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical...
8653062 Compounds as receptor modulators with therapeutic utility  
The present invention relates to novel cyclic amine and cycloalkyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as...
8648081 Parasiticidal dihydroisoxazole compounds  
Provided are dihydroisoxazole compounds I useful for controlling parasites both in animals and agriculture. Further provided are methods for controlling parasite infestations of an animal by...
8637559 Oxazole compound and pharmaceutical composition  
The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: wherein R1 is an aryl group which may have one or more substituents; R2 is an aryl group or a...
8633222 Arylvinylazacycloalkane compounds and methods of preparation and use thereof  
Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare...
8633134 Substituted amidine compounds for combating animal pests  
The invention relates to substituted amidine compounds of formula (I), to the enantiomers, diastereomers and salts thereof and to compositions comprising such compounds. The invention also relates...
8629165 Methods for treating cognitive disorders  
Disclosed herein are methods of treating a patient suffering a cognitive disorder.
8623875 Isoxazoline insecticides  
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A is a 6-membered aromatic ring containing carbon atoms and 0-3 nitrogen atoms...
8618137 Fungicidal heterocyclic compounds  
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein R1, R2, R3, R4, R5, A, W, X, G, Z, J and n are as defined in the...
8618112 Crystalline forms of an inhibitor of 11-β-hydroxysteroid dehydrogenase type 1  
Novel crystalline salts of 3-[4-(3-ethanesulfonyl-propyl)-bicyclo[2.2.2]oct-1-yl]-4-met hyl-5-(2-trifluoromethyl-phenyl)-4H-1,2,4-triazole are potent inhibitors of 11β-hydroxysteroid dehydrogenase ...
8618139 Oxadiazole derivatives as sphingosine 1-phosphate (S1P) receptor modulators  
The present invention relates to novel oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of...
8614217 Fungicide hydroximoyl-tetrazole derivatives  
The present invention relates to hydroximoyl-tetrazole derivatives of formula (I), their process of preparation, their use as fungicide active agents, particularly in the form of fungicide...
8614233 Cinnamoyl inhibitors of transglutaminase  
A compound of Formula, (I) or Formula: (II).
8604062 Process for the preparation of isoxazolyl-methoxy nicotinic acids  
The present invention relates to a process for the preparation of a compound of formula (I) wherein R1 and R2 are as defined herein, which is useful as an intermediate in the preparation of active...
8604061 2-aminooxazolines as TAAR1 ligands  
The invention relates to compounds of formula I wherein X, Y, R1, R2, and n are as defined hereinor to a pharmaceutically suitable acid addition salt thereof. The invention also relates to...
8598170 Dual-acting oxazole antihypertensive agents  
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These...
8592461 Plant disease control agent  
The present invention provides a plant disease control agent containing at least one of tetrazoyloxime dirivatives and salts thereof, and at least one selected from the group consisting of fosetyl,...
8592418 5-aryl isoxazolines for controlling pests  
The present invention relates to new isoxazoline compounds of formula wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and optionally the...
8592464 Nitric oxide furoxan derivative compounds endowed with antitumoral activity  
The present invention relates to nitric oxide furoxan derivative compounds which showed to be active in the treatment of tumors. In addition, they may be used as adjuvants in cancer immunotherapy.
8592460 Amino-pyridine derivatives as S1P1 /EDG1 receptor agonists  
The invention relates to novel amino-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
8580824 Pyridin-4-yl derivatives as immunomodulating agents  
The invention relates to pyridine derivatives of Formula (I) wherein A, R1, R2, R3, R4, R5, and R6 are as described in the description, their preparation and their use as pharmaceutically active...
8580825 Oxadiazole inhibitors of leukotriene production  
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical...
8580799 Fungicide hydroximoyl-heterocycles derivatives  
The present invention relates to hydroximoyl-heterocycle derivatives of formula (I) wherein T represents a substituted or non-substituted heterocyclyl group, Q represents a carbo or heterocyclic...
8575200 Pyridin-2-yl derivatives as immunomodulating agents  
The invention relates to pyridine derivatives of Formula (I) wherein A, R1, R2, R3, R4, R5, R6 and R7 are as described in the description, their preparation and their use as pharmaceutically active...
8575197 Pyrolinone derivative and pharmaceutical composition comprising the same  
The present invention provides a novel P2X3 and/or P2X2/3 receptor antagonist. A compound represented by the formula (I): wherein Z1 is optionally protected hydroxy, etc.; Z2 is —C(═O)—, etc.;...
8575201 Oxadiazole inhibitors of leukotriene production  
The present invention relates to compounds of formula (I) and (IA): and pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical...
8557849 Fungicide hydroximoyl-tetrazole derivatives  
The present invention relates to hydroximoyl-tetrazole derivatives of formula (I), their process of preparation, preparation intermediate compounds, their use as fungicide active agents,...
8557850 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Plant disease control agent
 
The present invention provides a plant disease control agent containing at least one of tetrazoyloxime dirivatives and salts thereof, and at least one selected from the group consisting of fosetyl,...
8546374 Amino-tetrazoles analogues and methods of use  
A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions...
8536203 Pharmaceutical compounds  
This invention relates to novel substituted nitrocatechol derivatives, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing...
8536165 Azabiphenylaminobenzoic acid derivatives as DHODH inhibitors  
The present disclosure relates to new azabiphenylaminobenzoic acid derivatives of formula (I); as well as processes for their preparation, pharmaceutical compositions comprising them, and their use...
8536185 Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases  
Multiheteroaryl compounds, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical use in the prevention and treatment of prostaglandin D2 mediated...
8524699 Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors  
The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the...
8524746 Dosage regimen for COMT inhibitors  
The invention relates to the use of an oxodiazolyl compound (I) for the preparation of a medicament for the prevention or treatment of central and peripheral nervous system associated disorders,...
8518974 Isoxazolo-pyridine derivatives  
The present invention is concerned with isoxazole-pyridine derivatives of formula I wherein X, R1 to R6 are as described herein. The compounds are active on the GABA A α5 receptor binding site and ...
8518938 c-MET protein kinase inhibitors  
The present invention relates to compounds of formula I useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the...
8513273 Arylethynyl derivatives  
The present invention relates to ethynyl compounds of formula I wherein R1, R2, R2′, R3, R3′, R4, R4′, U, V, W, Y, m, and n are as defined herein and to a pharmaceutically acceptable acid addit...
8507535 Methyl-pyrrolidine ether derivatives  
The invention relates to a compound of formula wherein A is defined herein or to pharmaceutically active salts, stereoisomeric forms, including individual diastereoisomers and enantiomers of the...