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6335325 |
Acylated 4-aminopyridine derivatives as pesticides and fungicides
The present application relates to novel acylated 4-amino-pyridine derivatives in which R 1 , R 2 , R 3 , R 4 , A, X 1 , X 2 , m and n are as defined in the description, to process for their...
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6331551 |
Methods of treating microbial infection and therapeutic formulations therefor
Active compounds including sclareol-like and sclareolide-like compounds are usefull in methods of treating a wide variety of conditions and disorders, including those disorders caused by microbial...
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6329371 |
α-substrates benzyl heterocyclic derivatives, intermediates for producing the same and agrochemical composition containing the same as active ingredient
A compound represented by the formula (I): ##STR1## wherein R 1 is an optionally substituted heterocyclic group; R 2 is optionally substituted aryl or heterocyclic group; R 3 is hydrogen, alkyl,...
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6326385 |
Methods for treating or preventing pain
The present invention relates to a novel method of treating of pain, using compounds that modulate KCNQ potassium channels and currents.
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6316467 |
Elevation of HDL cholesterol by 4-[(Aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides
Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the "good" cholesterol and as such may be useful for treating diseases such as atherosclerosis. These...
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6313127 |
Heterocyclic compounds useful as pharmaceutical agents
Compounds of formula (I) ##STR1## in which all variables are defined in the description and their salts inhibit the enzyme oxido squalene cyclase and are useful in treating hypercholesterolemia and...
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6313148 |
Aromatic amine compounds that antagnoize the pain enhancing effects of prostaglandins
Compounds antagonistic of the pain enhancing effects of prostaglandins are disclosed. The compounds comprise an optionally-substituted A ring with a --CH(R 3 )N(R 2 )B--R 1 and --OD groups...
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6313147 |
Heterocyclic substituted isoxazolidines and their use as fungicides
Compounds with fungicidal properties having formula ##STR1## X is CH or nitrogen; R is (C 1 -C 12 )alkyl, halo(C 1 -C 12 )alkyl, (C 2 -C 8 )alkenyl, halo(C 2 -C 8 )alkenyl, (C 2 -C 8...
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6310050 |
Therapeutic use of compounds with β3-agonist activity
The invention relates to the method of use of compounds with B 3 -agonist activity for inhibiting uterine contractions, preventing or slowing down premature labor, or for the treatment and/or...
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6306873 |
Substituted β-thiocarboxylic acids
This invention relates to compounds of general formula (I): ##STR1## in which Ar is a group selected from: ##STR2## A1, A2, B, C, D, E, Q1-Q3, R1-R9, Z1 and Z2 are as defined in the disclosure, and...
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6303638 |
Substituted pyridines as modulators of the mammalian neuronal nicotinic acetylcholine receptor
Novel compounds are provided that modulate the neuronal nicotinic acetylcholine receptor (nAChR), particularly the mammalian nAChR (m-nAChR). The compounds are substituted pyridine derivatives such...
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6303639 |
Propanolamine derivatives substituted by heterocyclic radicals, processes for their preparation, pharmaceuticals comprising these compounds and their use
Substituted propanolamine derivatives and pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula (I), ##STR1## in...
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6300346 |
Indenyl hydroxamic acids, (hydroxy) ureas and urethanes for treating patients with precancerous lesions
Indenyl hydroxamic acids, (hydroxy) ureas and urethanes are useful in the treatment of precancerous lesions and neoplasms.
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6297256 |
Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands
Disclosed are aryl and heteroaryl substitated pyridino compounds. These compounds are highly selective agonists, antagonists or inverse agonists for GABA A brain receptors or prodrugs of agonists,...
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6297261 |
Substituted phenyl derivatives, their preparation and use
A compound having the formula (I) or a pharmaceutically acceptable salt thereof where the variables are defined in the specification are useful in the treatment of sickle-cell anemia. ##STR1##
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6297262 |
Treatment of schizophrenia and psychosis
The compound 5-(2-ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyri
dine has shown effects on models of psychosis, schizophrenia and schizophreniform diseases and is useful for the...
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6294549 |
Method for eliciting an αvβ5 or dual αvβ3/αvβ5 antagonizing effect
A method for eliciting an α v β 5 or dual α v β 3 /α v β 5 antagonizing effect in a mammal which comprises administering to the mammal a therapeutically effective amount of a compound of...
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6288091 |
Antiherpes virus compounds and methods for their preparation and use
This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also...
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6288088 |
Oxadiazoline derivative and their use as insecticides
The present invention relates to a compound of the formula [I]: ##STR1## wherein R 1 is C 1 -6 alkyl or C 1 -6 haloalkyl; n is 0, 1 or 2; X is (1) group of --NR 2 R 3 wherein R 2 and R 3 ...
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6284779 |
Heteroaromatic compounds
The invention relates to the compounds of Formula I ##STR1## as well as the process for their production and their use as pharmaceutical agents.
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6281233 |
Method of treating gastrointestinal motility disorders
The present invention relates to a novel method for treating a mammal suffering from gastrointestinal motility disorders.
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6274617 |
Heterocyclic ester and amide hair growth compositions and uses
This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using heterocyclic esters or amides.
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6271236 |
Diaminopyridine-containing thiourea inhibitors of herpes virus
Compounds of the formula ##STR1## wherein R 1 -R 5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms,...
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6248759 |
Method for treatment of light-injured retinal degeneration disease
A method for treatment of light-injured retinal degeneration disease comprising, administering an effective amount of a dihydropyridine calcium antagonist other than nimodipine is provided. The...
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6239175 |
Carbamoyloxy derivatives of mutiline and their use as antibacterials
Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R 1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is...
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6232329 |
Tetrahydropyridine-(or 4-hydroxypiperidine) alkylazoles
The present invention relates to the compounds of general formula ##STR1## used as medicaments possessing therapeutic activity for the treatment of anxiety, psychosis, epilepsy, convulsion,...
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6231894 |
Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase
Paraquat has been found to accept electrons from nitric oxide synthase (NOS) whereupon the reduced paraquat generates toxic O 2 - and prevents NOS from giving electrons to arginine and thereby...
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6228868 |
Oxazoline antiproliferative agents
Compounds having Formula I ##STR1## are useful for treating cancer. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of treating cancer in a mammal.
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6211214 |
Biphenyl ether oxazolines and their use as pest-control agents
The present invention relates to novel biphenyl ether-oxazolines of the formula (I) ##STR1## in which X, Y, Z, R 1 , R 2 , A, m and n have the meaning given in the description, to processes...
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6211216 |
Isoxazolyl- and isoxazolinyl-substituted benzoylcyclohexanediones, process for their preparation and their use as herbicides and plant growth regulators
Isoxazolyl- and isoxazolinyl-substituted benzoylcyclohexanediones, process for their preparation and their use as herbicides and plant growth regulators. Benzoylcyclohexanediones of the formula...
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6207671 |
Cycloalkano-pyridines
The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the...
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6194440 |
Small molecule carbamate or urea hair growth compositions and uses
This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using small molecule carbamates and ureas.
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6194441 |
Oxazolidinone derivatives and their use as antibacterial agents
The invention concerns a compound of formula (I) wherein for example R 1 is of the formula --NHC(O)R a wherein R a is hydrogen, or (1-4C)alkyl; R 2 and R 3 are independently hydrogen or...
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6191147 |
Pyrazole compounds and uses thereof
The present invention is directed to compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting...
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6187797 |
Phenyl-isoxazoles as factor XA Inhibitors
The present application describes oxygen and sulfur containing heteroaromatics and derivatives thereof of formula ##STR1## or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is...
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6187796 |
Sulfone hair growth compositions and uses
This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using small molecule sulfonamides.
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6174886 |
Antipsychotic use of triazolo-pyridazine derivatives
A class of substituted or 7,8-ring fused 1,2,4-triazolo[4,3-b]pyridazine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and a...
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6174910 |
AT1 receptor antagonist for the stimulation of apoptosis
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6174901 |
Substituted pyridine and pyridazine compounds and methods of use
Selected novel substituted pyridine and pyridazine compounds are effective for prophylaxis and treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies,...
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6172088 |
Testosterone compounds and use for the protection of neurons
Androgens and their derivates and analogs, such as anabolic agents, are characterized by at least one substituent or substituent grouping with radical trapping properties. These compounds are used...
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6156765 |
Method of treating and preventing vasospasm
The present invention is drawn to a method of preventing or treating vasospasm by administering to a patient an effective amount of an iron chelator which preferentially chelates ferrous iron over...
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6153628 |
1,3,4-thiadiazoles and 1,3,4-Oxadiazoles as α.sub.v β.sub.3 antagonists
This invention relates to 1,3,4-thiadiazoles and 1,3,4-Oxadiazoles of Formula (I) which are useful as antagonists of α v β 3 and related integrin receptors, to pharmaceutical compositions...
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6150387 |
Heterocyclic carboxamide compounds effective in the treatment of drug abuse
This invention relates to the use of heterocyclic carboxamide compounds for preventing or reducing self-administration, by a human or animal patient, of a drug or a substance capable of giving rise...
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6150371 |
Method for preventing and for treating autoimmune disease
A method for preventing or treating autoimmune diseases (excluding type I diabetes) by administering an insulin resistance improving substance as an active ingredient.
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6136844 |
5-aroylpyrrol-2-ylmethylarene derivatives
Compounds selected from the group of compounds represented by formula I: ##STR1## where: R 10 is represented by the formula (A), (B), or (C): ##STR2## R 20 is represented by the formula (U), (V),...
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6133294 |
2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamides with 5 membered heterocyclic rings on the pyridine ring
The present invention provides novel 2-methoxyimino-2-(pyridinyloxymethyl)phenyl acetamide compounds with 5 membered heterocyclic rings on the pyridine ring, their use as fungicidal compounds, and...
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6114328 |
Isoxazoline and isoxazole fibrogen receptor antagonists
This invention relates to novel isoxazolines and isoxazoles which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex or the vitronectin receptor, to...
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6114361 |
5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives
The present invention relates to a compound of the formula ##STR1## wherein R 1 , R 2 , R 3 are as defined above, to pharmaceutical compositions and methods of treatment.
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6110947 |
Pyrrolidinyl hydroxamic acid compounds and their production process
A compound of the formula: ##STR1## and it pharmaceutically acceptable salt, wherein A is hydrogen, hydroxy or OY, where Y is a hydroxy protecting group; Ar is phenyl optionally substituted with...
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6107313 |
Dopamine receptor antagonists
This invention provides a novel class of oxadiazolyl piperidines which exhibit a high binding affinity for dopamine ligands. The compounds of the invention display selectivity for the dopamine D 4 ...
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