|
Match
|
Document |
Document Title |
|
|
6894059 |
Compounds and methods for treatment of asthma, allergy and inflammatory disorders
The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting...
|
|
|
6881736 |
Vitronectin receptor antagonists
Compounds of the formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis:
wherein
R 1 is Het or Ar R 2 is
or a...
|
|
|
6881742 |
Benzyl amidoxime derivatives, intermediate products and method for their production and use as fungicides
Novel benzamidoxime derivatives, processes and intermediates for their preparation and their use as fungicides are described. In the context of the present invention, benzamidoxime derivatives are...
|
|
|
6875779 |
Sulfonyl heteroaryl triazoles as anti-inflammatory/analgesic agents
The present invention relates to compounds of the formula
wherein R 1 , R 3 , R 5 and A are defined as in the specification, to pharmaceutical compositions containing them and to their...
|
|
|
6867225 |
Thiazole or oxazole derivatives which are useful in the treatment of cardiovascular and related diseases
A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof
Wherein
R 1 and R 2 are independently H or C 1-3 alkyl or R 1 and R 2 which are...
|
|
|
6864268 |
β3 adrenergic receptor agonists
The present invention provides β 3 -adrenergic receptor agonists of structural Formula (I) as well as pharmaceutical formulations thereof and methods for treating β 3 -adrenergic...
|
|
|
6852496 |
Methods of screening for agents that promote nerve cell growth
Analogs of FK506 that do not bind FKBP-12 have been found to effectively promote nerve cell growth and regeneration, thereby speeding functional recovery of damaged nervous tissue and axonal...
|
|
|
6852720 |
Thiazol-2-yl-imine compounds as PDE-7 inhibitors
A compound selected from those of formula (I):
wherein:
R 1 , R 2 , R 3 are as defined in the description, and optionally, its optical isomers, N-oxide, and addition salts thereof with...
|
|
|
6852745 |
Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
Novel biphenyl sulfonamide compounds which are combined angiotensin and endothelin receptor antagonists are claimed along with methods of using such compounds in the treatment of conditions such as...
|
|
|
6852719 |
Glucocorticoid receptor modulators
The present invention provides non-steroidal compounds of Formula I, including prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e.g., agonists, partial...
|
|
|
6849636 |
Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1
Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as...
|
|
|
6849622 |
Aliphatic nitrogenous five-membered ring compounds
The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]:
wherein
A represents —CH 2 — or —S—, R 1 ...
|
|
|
6846838 |
Ureido-substituted aniline compounds useful as serine protease inhibitors
Compounds having the formula (I),
or pharmaceutically-acceptable salts, hydrates or prodrugs thereof, are effective as inhibitors of Factor VIIa.
|
|
|
6838479 |
Amidine inhibitors of serine proteases
Inhibitors of serine proteases are provided having formula (I)
wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. In particular, the compounds bind to factor VIIa, tissue...
|
|
|
6835743 |
Pesticidal pyrazoles and derivatives
Process for the protection of a building that has already been built or is going to be built, whereby an effective amount of an insecticidally active compound is spread around or under the said...
|
|
|
6831088 |
3-heterocyclypropanohydroxamic acid PCP inhibitors
Compounds of formula (1): and their salts, solvates, prodrugs, etc., wherein the substituents have the values mentioned herein, are Procollagen C-Proteinase (PCP) inhibitors and have utility in...
|
|
|
6825220 |
3-Substituted oxindole β 3 agonists
The present invention relates to a β;3 adrenergic receptor agonist of formula I: (1); or a pharmaceutical salt thereof; which is useful for treating Type II diabetes and/or obesity.
|
|
|
6821972 |
3-heterocyclylpropanohydroxamic acid PCP inhibitors
Compounds of formula (I): and their salts, solvates, hydrates and prodrugs are useful PCP inhibitors, processes for making the same, compositions comprising the same, and methods of treating a...
|
|
|
6787552 |
PPAR delta activators
Compounds of the general formula (I) or salts thereof and activators of PPARδ (peroxisome proliferator activated receptor δ) containing the compounds or the salts as the active ingredient:...
|
|
|
6787556 |
Benzoic acid derivatives for the treatment of diabetes mellitus
The present invention relates to the use of certain benzoic acid derivatives of formula (I), as disclosed in the specification, which act as peroxisome proliferator activated receptor (PPAR)...
|
|
|
6784199 |
Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, and atherosclerosis in mammals
The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug...
|
|
|
6759414 |
Aromatic amides
This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa,...
|
|
|
6759419 |
Pyrrolidinone derivatives, their preparation and pharmaceutical composition comprising the same
The present invention relates to substituted pyrrolidinone compounds of formula 1, wherein n is 0 or 1; Aza is a heterocycle optionally substituted with C 1-4 alkyl, or C 1-4 alkyl substituted...
|
|
|
6756391 |
Antiviral compounds
The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have...
|
|
|
6749870 |
Compositions and methods for the control of smoking
A composition for the control of smoking which comprises: (a) a flavonoid in the form of an extract from Eupatorium cannibium or Eupatorium Fortunei , preferably euparin; (b) a cytochrome P450...
|
|
|
6743811 |
Oxazalidinone compounds and methods of preparation and use thereof
Oxazolidinones and methods for their synthesis are provided. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising...
|
|
|
6737426 |
Sulfonyloxazoleamines
The invention relates to compounds of the general formula (I) where R 1 and R 2 independently of one another are H, —R 6 , C 3 -C 8 -cycloalkyl, —(CH 2 ) n —R 7 , —(CH 2 ) n —O—R 6...
|
|
|
6734143 |
2-methoxyimino-2(pyridinyloxymethyl)phenyl acetamides useful as fungicides
The present invention provides 2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamides according to formula (I) as well as their use as fungicidal compounds.
|
|
|
6734197 |
Combination therapy for type II diabetes or Syndrome X
This invention provides methods of using a pharmacological combination of a biguanide agents, such as metformin, and one or more PTPase inhibiting agents and, optionally, one or more sulfonlylurea...
|
|
|
6723742 |
Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
The use is described of 3,5-diphenyl-1,2,4-triazoles of the formula I in which R 1 -R 5 are as defined in the description. The compounds have useful pharmaceutical properties and are...
|
|
|
6716871 |
Cyclic AMP-specific phosphodie sterase inhibitors
Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases...
|
|
|
6706738 |
Substituted bicyclic heteroaryl compounds and their use as integrin antagonists
The invention is directed to physiologically active compounds of general formula (I): R 1 Z 1 —Het—L 1 —Ar 1 —L 2 —Y (I) wherein Het is an optionally substituted, saturated, partially...
|
|
|
6706743 |
β3 adrenergic receptor agonists and uses thereof
The instant invention provides β 3 adrenergic receptor agonists of structural Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds,...
|
|
|
6699853 |
4-HALOALKYL-3-HETEROCYCLYLPYRIDINES, 4-HALOALKYL-5-HETEROCYCLYL-PYRIMIDINES AND 4-TRIFLUOROMETHYL-3-OXADIAZOLYLPYRIDINES, PROCESSES FOR THEIR PREPARATION, COMPOSITIONS COMPRISING THEM, AND THEIR USE AS PESTICIDES
The present invention relates to 4-Haloalkyl-3-heterocyclylpyridines, 4-haloalkyl-5-heterocyclyl-pyrimidines and 4-trifluoromethyl-3-oxadiazolylpyridines, Processes for Their Preparation,...
|
|
|
6689800 |
β3-adrenergic receptor agonist crystal forms, processes for the production thereof, and uses thereof
The present invention provides the tosylate salt of (R)-2-(2-(4-oxazol-4-yl-phenoxy)-ethylamino)-1-pyridin-3-yl-
ethanol, the monohydrate of such salt, processes useful in the preparation of such...
|
|
|
6680311 |
Cryptophycin compounds
The present invention provides cryptophycin compounds of Formula I that are useful in the treatment of neoplasms.
|
|
|
6677341 |
(R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma...
|
|
|
6670380 |
Pyridone inhibitors of fatty acid binding protein and method
Compounds are provided having the formula: wherein A, Q, and X are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes,...
|
|
|
6660753 |
Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and...
|
|
|
6653330 |
Amide-type triazole compounds
A compound of formula (I) or a pharmacologically acceptable prodrug or salt thereof which exhibits excellent antifungal activity: wherein Ar 1 represents a phenyl group or the like; Ar 2 ...
|
|
|
6649635 |
Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders
The present invention relates to novel heteroaryl-carboxamides which modulate the activity of protein tyrosine kinases and therefore are expected to be useful in the treatment of abnormal protein...
|
|
|
6638954 |
&Dgr 2-1,2,3-TRIAZOLINE ANTICONVULSANTS AND THEIR ACTIVE METABOLITE ANALOGUES, THE AMINOALKYLPYRIDINES, ARE EXCITATORY AMINO ACID ANTAGONISTS AND ANTIISCHEMIC AGENTS, USEFUL IN THE TREATMENT OF CEREBRAL ISCHEMIA RESULTING FROM STROKE
Pharmaceutical compositions comprise as the active ingredient, nonneurotixic antiischemic compounds that are highly effective by the intraperitoneal route, and that are excitatory amino acid and...
|
|
|
6638955 |
Antibiotic oxazolidinone derivatives
The present application discloses a class of antibiotic compounds containing an oxazolidinone ring. These compounds have useful activity against Gram-positive pathogens including MRSA and MRCNS...
|
|
|
6632803 |
Pharmaceutical formulations containing voriconazole
The invention provides pharmaceutical formulation comprising voriconazole, or a pharmaceutically acceptable derivative thereof, and a sulfobutylether β-cyclodextrin.
|
|
|
6624176 |
Heteroaromatic substituted amides with antagonistic activity to neurokinin 1 receptors
The present invention is a heteroaromatic substituted amide showing antagonist activity to neurokinin 1 (NK-1, substance P) receptors.
|
|
|
6620825 |
Adenosine A3 receptor antagonists
A pharmaceutical composition for antagonizing adenosine at adenosine A 3 receptors which comprises a 1,3-azole compound substituted on the 4- or 5-position, or both, by a pyridyl which may be...
|
|
|
6617323 |
Amino-substituted compounds useful as inhibitors of IMPDH enzyme
The present invention discloses compounds useful in treating or preventing IMPDH-associated disorders, such as transplant rejection and autoimmune diseases, having the formula (I), wherein X is...
|
|
|
6617339 |
Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
Compounds of formula (I) as defined herein, or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, are useful as antibacterial agents. Processes for their manufacture and...
|
|
|
6610717 |
Dihydropyridine derivatives
Dihydropyridine derivatives represented by the following formula: analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type...
|
|
|
6602896 |
p38MAPK inhibitor and uses thereof
The present invention demonstrates that p38 MAPK inhibitor induces low density lipoprotein receptor expression 6-8 fold, and further provides the application of such inhibitor in the treatment of...
|