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4482558 Antifungal amide and urea derivatives of (3-amino-2-aryl-2-hydroxyprop-1-yl)-1H-1,2,4-triazoles  
Compounds of the general formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R is naphthyl, biphenylyl, phenyl or substituted phenyl; and R 1 is ##STR2## where X...
4482549 Aminocyclopentane esters and pharmaceutical formulation  
Compounds are described of the formula ##STR1## in which --COR 1 is a complex ester or thioester group, W is alkylene, X is cis or trans --CHCH or --CH 2 CH 2 --, n is 1 or 2, Y...
4482563 Nitro pyrrols and their pharmaceutical use  
3-Nitro-2-substituted aminopyrroles are histamine H 2 - receptor antagonists. The 2- position substituent is a fully-unsaturated heterocyclyl alkyl group preferably with alkyl group interrupted by...
4481199 1,2,4-Triazole-3-amine and 1,2,4 triazole-3,5-diamine compounds and their pharmaceutical use  
The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which the substituents are defined later. The...
4476126 1,2,4 Triazoze amines and their pharmaceutical use  
This invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof in which the substituents are defined later. The...
4465681 Bis-(aminoalkoxy)-phenyl, pyridyl ketones, and use as immunological agents  
Pyridine derivatives of the formula: ##STR1## or pharmaceutically acceptable acid addition salts thereof, wherein R 1 , R 2 , R 3 and R 4 are the same or different and each represents hydrogen...
4442110 1H-1,2,4-Triazole-3,5-diamine derivatives and use as selective histamine H.sub.2 -antagonists  
The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which R 1 and R 2 , which may be the same or...
4428953 Pleuromutilin derivatives, their production and use  
Novel pleuromutilin derivatives of formula I, ##STR1## in which R 1 is ethyl or vinyl, m is 0 or 1, and R 2 is a heterocyclic radical, in which a 5- or 6-membered, unsaturated or saturated...
4427672 Combating fungi with substituted triazolylalkyl pyridyl ethers  
Substituted triazolylalkyl pyridyl ethers of the formula ##STR1## in which R 1 is a halogen atom, R 2 is a hydrogen or halogen atom, X is a keto group or a CH(OH) group, Y each...
4414213 Dihydropyridyl cyclic imidate esters and their pharmaceutical use  
A series of 1,4-dihydropyrid-5-yl cyclic imidate esters have been prepared possessing the general formula ##STR1## wherein R and R 1 are independently selected from hydrogen, lower alkyl or...
4410532 N-Substituted aziridine-2-carboxylic acid derivatives and their immuno-stimulation compositions and methods  
A 2-cyanaziridine derivative of the formula ##STR1## wherein R' is a straight-chained or branched, saturated or mono- or polyunsaturated aliphatic hydrocarbon radical with up to 8 carbon atoms,...
4410523 Heterocyclic derivatives  
The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which R 1 and R 2 , which may be the same or...
4405624 Nitro-substituted dihydropyrroles and tetrahydropyridines, compositions, compounds, and medicinal use  
2,3-Unsaturated nitrogen-containing heterocyclic compounds with a 3-nitro group and a 2-heterocyclyl alkylamino group. The alkyl group of 2-position substituents is preferably interrupted by sulfur...
4404214 2-Pyridinecarboxamide derivatives compositions containing same and method of using same  
A 2-pyridinecarboxamide derivative of the formula: ##STR1## wherein R 1 is hydrogen, lower alkyl, lower alkoxy, halogen, lower alkyl-thio or nitro and is in the 3rd-, 4th- or 5th-position of the...
4401670 Method for treating gonorrhea infections with 2-acetyl- and 2-propionylpyridine thiosemicarbazones  
This invention relates to various 2-acetyl- and 2-propionylpyridine thioscarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in...
4399143 Phenoxybutyltriazole compound, agricultural and horticultural fungicidal composition containing the same, and process for producing the same  
A phenoxybutyltriazole compound represented by the following formula (I): ##STR1## wherein X is a halogen atom, a phenyl group or a 5-trifluoromethylpyridine-2-yloxy group; Y is a halogen atom or a...
4396624 Combating fungi with 1-(azol-1-yl)-2-hydroxy-or-keto-1-pyridinyloxy-alkanes  
1-(Azol-1-yl)-2-hydroxy-or-keto-pyridinyloxy-alkanes of the formula ##STR1## in which A is CH or N, R is alkyl X is --CO--or --CH(OH)-- Y is halogen, alkyl, halogenoalkyl, alkenyl,...
4391827 3-(2-Hydroxy-4-(substituted)phenyl)-cycloalkanone and cycloalkanol analgesic agents and intermediates therefor  
Cycloalkanones, cycloalkanols and unsaturated analogs thereof, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have...
4385055 2-Acetyl-and 2-propionylpyridine thiosemicarbazones as antimalarials  
This invention relates to various 2-acetyl- and 2-propionylpyridine thioscarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in...
4379158 Antisecretory imidazole amidine compounds, composition and method of use  
Novel heterocyclic compounds shown by the formula ##STR1## wherein Het represents a 5-membered or 6-membered heterocyclic group which may have substituent(s); Z represents a sulfur atom or oxygen...
4370323 2-Cyanoaziridinyl-(1)-2-substituted-aziridinyl-(1)-methanes  
A 2-cyanoaziridinyl-(1)-2-substituted-aziridinyl-(1)-methane ##STR1## wherein R is a nitrile or carbamoyl group, and R 1 and R 2 each independently is a hydrogen atom, an aliphatic hydrocarbon...
4362728 Haloguanidine compounds, pharmaceutical compositions and methods of use  
Compounds useful for inhibiting gastric acid secretion and for the treatment of peptic ulcers caused or exacerbated by gastric acidity having the following formula (I): ##STR1## in which R 1 and R...
4358449 1-(1,3-Dioxolan-2-ylmethyl)-1H-1,2,4-triazoles and compositions  
1-(1,3,-Dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles useful as antifungal and antibacterial agents.
4342765 Guanidine derivatives and pharmaceutical compositions containing them  
Guanidine derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. These derivatives have the formula: ##STR1## in which X is oxygen or sulphur; Y is nitrogen or...
4338316 9-Aryloxy prostane derivatives  
The disclosure relates to 9β-aryloxy prostane derivatives, for example 16-(3-chlorophenoxy)-11α,15α-dihydroxy-16-methyl-9β-pheno xy-18,19,20-trinor-5-cis,13-trans-prostadienoic acid, which...
4332809 Pyridinecarboxamide derivatives and process for the preparation thereof  
N-(5-Tetrazolyl)-6-phenyl-2-pyridinecarboxamide derivatives of the formula: ##STR1## wherein R is hydrogen, a halogen, a lower alkyl or a lower alkoxy, and the phenyl ring A is a phenyl having a...
4330547 Combatting fungi with triazolylphenacyl pyridyl ether derivatives  
Triazolylphenacyl pyridyl ether derivatives of the formula ##STR1## in which R is optionally substituted phenyl, X is --CO-- or CH(OH)--, Y each independently is halogen, alkyl, alkoxy or...
4318913 1,2,4-Triazole-3,5-diamine derivatives  
The invention relates to compounds of the formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which R 1 and R 2 represent hydrogen, an aliphatic...
4307112 9-Deoxy-9A-methylene isosteres of PGI.sub.2 and process for their preparation  
9-deoxy-9A-methylene-isosteres of PGI 2 , including processes for their preparation and pharmaceutical and veterinary compositions containing same, are disclosed. The compounds are useful as...
4288440 Pyridinones  
The present invention relates to certain 6-alkyl-1,2-dihydro-2-oxo-3-substituted pyridine derivatives, their preparation and antihyperglycemic use.
4283403 Substituted isoxazolines for control of plant phytopathogens  
A class of 2-isoxazolines bearing an aryl substituent at the 3-position and a substituted methyl or ethyl group at the 5-position effectively control microorganisms, particularly fungal foliar...
4276297 Pyridylaminotriazole therapeutic agents  
A series of novel 3-amino-5-(4-pyridyl)-1,2,4-triazole derivatives has been prepared, including their pharmaceutically acceptable acid addition salts. These particular compounds are useful in...
RE30633 3-Lower alkylcarbamylsulfonamido-4-phenylaminopyridines, n-oxides, derivatives thereof and pharmaceutical compositions containing same  
This invention relates to new derivatives of pyridine having anti-inflammatory and diuretic properties. The new derivatives of pyridine may be represented by the following general formula: ##STR1##...
4271169 N-Heterocyclic alkyl-N'-pyridyl alkylthioureas, ureas and guanidines  
The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. A compound of this invention is...
4269844 Alkoxypyridyl N-cyano or N-carbamoylguanidino alkanes, compositions containing same and uses thereof  
The compounds are C 2 -C 8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted...
4263306 3-N-Pyridinium nocardicin and antibiotic composition thereof  
This invention relates to a new class of antibiotics (I): ##STR1## wherein the stylized radical (hereafter referred to as R'): ##STR2## attached to the 3-amino nitrogen of nocardicin represents a...
4261994 1,2,4-Oxadiazole derivatives, their preparation and pharmaceutical use  
1,2,4-Oxadiazole derivatives of the formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 =H, halogen or alkyl, or two of them represent the --CHCH--CHCH-- group required to form a fused...
4250183 N-(Substituted amino)alkanoyl-aminoalkanoic acids and salts, their use and their compositions  
N-substituted ω-aminoalkanoyl-ω-aminoalkanoic acids and their pharmacologically-acceptable salts (with a base) are useful, e.g., in pharmaceutical-composition form for the treatment or...
4241068 2-(Pyridyl-amino)-benzoic acids and salts thereof  
Compounds of the formula ##STR1## wherein A is CH-- or N--; R 1 is (a) hydrogen, lower alkyl, lower alkoxy or a fused benzene ring, or (b) --CO--R 4 , tetrazol-5-yl or cyano in the 4- or...
4212867 2-Cyano-5-substituted 1,3,4-oxadiazoles and fungicidal compositions containing them  
1,3,4-Oxadiazole derivatives, are disclosed which correspond to the formula ##STR1## in which R represents the phenyl radical; a phenyl radical which is substituted by 1 to 5 identical or different...
4212869 Substituted 1-pyridinyloxy-1-(imidazolyl)-2-butanone compounds and their use as fungicides  
Substituted 1-pyridinyloxy-1-(triazolyl or imidazolyl)-2-butanone compounds which correspond to the formula: ##STR1## wherein each X independently represents halogen, methyl, trichloromethyl,...
4210652 Pharmacologically active 1,3-bis[1-(2-heteroalkylthio)ethylamino)-2-nitrovinyl-1-amino]propane derivatives  
The compounds are C 2 -C 8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted...
4160030 N-oxy and N-amino guanidines  
The compounds are N-oxy and N-amino guanidines which are histamine H 2 -antagonists. A compound of this invention is N-hydroxy-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio )ethyl]guanidi ne.
4153701 2-Substituted-N-(3-substituted phenyl)-oxazolidine-3-carbothioamides  
2-Substituted-N-(3-substituted phenyl)oxazolidine-3-carbothioamides, useful as insecticides.
4144343 Heterocycle substituted (3-loweralkylamino-2-R.sub.1 O-propoxy)pyridines  
Heterocycle substituted (3-loweralkylamino-2-R 1 O-propoxy)pyridines, their pharmaceutically acceptable salts and their preparation are disclosed. These pyridines have pharmaceutical properties...
4139625 5-(Substituted triphenylmethyl)picolinamides and their use as anti-acne agents  
Disclosed herein are novel 5-tritylpicolinic acids, amides, esters and pharmaceutically acceptable salts thereof. Also disclosed are methods for the use of said novel compounds as anti-acne agents.
4139624 Alkoxypyridyl substituted alkanes  
The compounds are C 2 -C 8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted...
4137319 Guanidino, thioureido, isothioureido and nitrovinylamino derivatives of pyridine  
The compounds are C 2 -C 8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted...
4112101 N-(Pyridyl)-1H-(or 2H) tetrazole-5-carboxamide derivatives for the prevention of immediate type hypersensitivity reactions  
Anti-allergic agents of N-(pyridyl)-1H-(or 2H) Tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which R is --H or lower alkyl; R 2 is --H, lower alkoxy, --CN,...
4105768 Hypotensive substituted 1,2,4-triazoles  
Compounds having the general formula ##STR1## pharmaceutical preparations containing the compounds and use in the treatment of hypertension.
Matches 701 - 750 out of 770 < 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 >