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4668675 |
2-[(amino-pyridinyl)amine]phenyl]aryl methanones, their thioxomethyl, ketal or thioketal analogs
Pyrido[1,4]benzodiazepines having antidepressant activity of the formula ##STR1## wherein Ar is 2, 3 and 4-pyridinyl, 2 or 3-thienyl, phenyl or a substituted phenyl; R is hydrogen, loweralkyl or an...
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4663332 |
5-substituted N-alkylated tetrazoles
Compounds of the formula ##STR1## wherein R 1 , R 2 , R 3 , and A are as described herein, are set forth. These compounds are useful as anti-allergic agents and agents for the treatment of...
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4663319 |
3-(1,3-dithiol-2-ylidene)-2,4-dioxopyrrolidines, -piperidines, and -hexahydroazepines and use thereof against hepatic diseases
Novel thioketene derivatives of the formula: ##STR1## wherein R 1 is hydrogen atom, an alkyl group, a lower alkenyl group, a phenyl group or a group of the formula: --B--Y; Y is a...
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4663323 |
Tetrazole derivatives, anti-ulcer composition containing the same and method for treating ulcers
Tetrazole derivatives of the formula: ##STR1## wherein R 1 is an optional defined substituent; A is sulfur or a lower alkylene-thio, l is 0 or 1; B is a lower alkylene; R 2 is hydroxy, a lower...
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4657908 |
Carbonyl derivatives
The invention relates to carbonyl derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention where is provided a guanidine derivative of...
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4656176 |
2-thiazolyl, oxazolyl, triazolyl and thiadiazolyl alkylamino-3-nitro-heterocyclic compounds
2,3-Unsaturated nitrogen-containing heterocyclic compounds with a 3-nitro group and a 2-heterocyclyl alkylamino group. The alkyl group of 2-position substituents is preferably interrupted by sulfur...
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4652572 |
2-(furanyl alkylamino or thienyl alkylamino or phenylalkylamino)-3-carboxy (or hydroxy)-pyridines
This invention relates to 2-amino-3-hydroxy, and 3-carboxy pyridine derivatives, in which the amino group is substituted by a methylthioethyl, butyl or oxypropyl group bearing a terminal...
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4647569 |
Antiarthritic pyridylaminoethene disulfonyl compounds and use
Pyridylaminoethene derivatives of the formula: ##STR1## wherein R 1 is pyridyl, unsubstituted or substituted by one or more substituents R 4 selected from halogen, amino, carboxy, cyano nitro,...
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4643995 |
Analgesic pyridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring
There are disclosed pyridine-2-ethers and pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring corresponding to the formula ##STR1## the pyridine-N-oxides and/or amine oxides...
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4634716 |
Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
Compounds of the formula: ##STR1## where R 3 is ##STR2## where n is 1-3 and the R a 's and R b 's are independently hydrogen or loweralkyl; and pharmaceutically acceptable salts thereof; are...
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4631288 |
Triazolylmethyl-pyridyloxymethyl-carbinol fungicides
Novel triazolylmethyl-pyridyloxymethyl-carbinols of the formula ##STR1## in which R is optionally substituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl, Y is...
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4624963 |
Use of oxindole compounds for the treatment of epilepsy
Oxindole compounds of the formula I ##STR1## in which R 1 , R 2 , R 3 , R 1 ', R 2 ', R 3 ', R 4 , R 5 and R 6 have the meanings given, and physiologically acceptable salts thereof, for the...
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4618616 |
Cyclopropylidene antifungal agents
1-substituted-1-haloaryl-1-('-[1H-1,2,4-triazol-1-yl]-cyclop
ropyl)-2-(1H-1, 2,4-triazol-1-yl)ethane compounds and pharmaceutical compositions thereof are useful in treating fungal infections in...
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4616024 |
Dihydropyridine anti-ischaemic and antihypertensive agents
1,4-Dihydropyridine derivatives of the formula: ##STR1## wherein R is aryl or heteroaryl: R 1 and R 2 are each independently C 1 -C 4 alkyl or 2-methoxyethyl; Y is --(CH 2 ) n --, --CH 2 ...
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4616002 |
Dihydro pyridine compounds, compositions and use
Compounds of the formula I ##STR1## in which n represents 1, 2 or 3, Ar represents a carbocyclic or heterocyclic aryl radical, Ac represents the acyl radical of an acid, Z represents a radical --OR...
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4610991 |
Antihypertensive pyridylaminobenzamide compounds
A series of 4-pyridinylaminobenzamides, useful as antihypertensive agents, was prepared from the corresponding 4-pyridinylaminobenzoic acids by reacting the acid chloride of the latter with ammonia...
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4610994 |
1,2,3-triazole anticonvulsant drugs
Anticonvulsant compositions comprise as the active ingredient a compound selected from the group consisting of those of the formulae: ##STR1## wherein R 1 is phenyl, 4-pyridyl, 3-pyridyl, or...
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4608380 |
Substituted aminopyridones having histamine H.sub.2 -receptor blocking activity
This invention relates to 2-substituted aminopyridone compounds which have histamine H 2 -antagonist activity.
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4607041 |
Antihypertensive 2-phenyl Hantzsch dihydropyridines
There are described compounds of formula I, ##STR1## in which R 1 represents benzofurazanyl, pyridyl or phenyl, the pyridyl or phenyl being substituted by one or more of the groups halogen, nitro,...
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4594341 |
Perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives as antihypertensives
There are disclosed perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives and related compounds which are useful as angiotensin converting enzyme inhibitors and as...
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4587238 |
Substituted caprylolactam derivatives as anti-hypertensives
The invention in its broad aspects relates to caprylolactam derivatives which are useful as angiotensin converting enzyme inhibitors and as antihypertensives.
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4584307 |
Antifungal 2-aryl-2-hydroxy perfluoro-1-(1H-1,2,4-triazol-1-yl) alkanones and alkanols
A fungicidal agent of the formula: ##STR1## or a pharmaceutically or agriculturally acceptable salt thereof, wherein R is 5-chloropyrid-2-yl or a phenyl group optionally substituted by 1 to 3...
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4571394 |
Heterocyclic derivatives
The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which Q represents a benzene ring in which...
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4563446 |
Thromboxane synthetase inhibiting 3-(1-alkenyl) pyridines
Novel compounds of the formula: ##STR1## wherein R 2 is an aromatic or heterocyclic group, which may optionally be substituted, R 2 is a methyl group, a hydroxymethyl group, a nitroxymethyl...
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4558058 |
Substituted 1,4-dihydropyridines and their use as medicaments
1,4-dihydropyridines of the formula I ##STR1## in which R denotes, for example, --CO 2 R 3 or cyano, R 1 denotes, for example, an optionally substituted phenyl, pyridyl or thienyl, R 2 denotes...
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4555519 |
Thromboxane synthetase enzyme inhibiting N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]pyridinecarboxamides
This invention concerns novel N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]pyridinecarboxamides which are useful as inhibitors of thromboxane synthetase and/or as hypotensive agents in...
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4552886 |
Fungicidal pyridylmethyl-amines
N-Thiazolyl heterocyclic amines, useful as fungicides and aquatic plant growth regulators.
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4551466 |
Pyridyl-2-oxy-propyl-1H-1,2,4-triazole-3,5-diamines
This invention relates to diaminotriazole derivatives in which one amino group is substituted by a 4-dialkylamino- or piperidinyl- or pyrolidinylmethyl pyrid-2-yloxypropyl group. The compounds have...
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4539316 |
Pyridine derivatives of 1,2-diaminocyclobutene-3,4-diones
Compounds of the formula ##STR1## wherein R 12 is a leaving group, Z is S, O or CH 2 and A is a phenyl, furyl, thienyl or pyridyl ring substituted by a ##STR2## moiety, in which R 8 and R 9 are...
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4536508 |
Triazoleamine derivatives having histamine H.sub.2 -antagonist properties
The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, which show pharmacological activity as selective...
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4525360 |
Anti-psychotic phenylindene derivatives and acid addition salts thereof
The present invention relates to novel phenylindene derivatives having interesting pharmacodynamic properties which make them useful as psychopharmacologicals in the treatment especially of...
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4525477 |
2-Thiazolyl, isothiazolyl, oxazolyl and isoxazolyl alkylamino-3-nitro-heterocyclic compounds
2,3-Unsaturated nitrogen-containing heterocyclic compounds with a 3-nitro group and a 2-heterocyclyl alkylamino group. The alkyl group of 2-position substituents is preferably interrupted by sulfur...
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4518601 |
2-(3-Pyridyl)-1,3,4-oxadiazoles and use thereof in pest control
The invention relates to 2-(3-pyridyl)-1,3,4-oxadiazoles of the formula ##STR1## wherein R 1 is hydrogen, C 1 -C 6 alkyl, --COOR 2 or ##STR2## wherein R 2 is C 1 -C 6 alkyl R 3 and R 4 ,...
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4518598 |
1,2,4-Triazole-3-amines, their pharmaceutical compositions and method of use
The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, and hydrates thereof. The substituents are defined in the specification. The compounds...
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4518604 |
Antifungal 1-aryl-2-(1H-1,2,4-triazol-1yl)-1-perfluoroalkylethyl halides
Compounds of the formula ##STR1## or a pharmaceutically or agriculturally acceptable acid addition salt thereof wherein R is 5-chloro-2-pyridyl, phenyl or phenyl substituted by from 1 to 3...
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4517183 |
N-Substituted aziridine-2-carboxylic acid derivatives
The present invention provides pharmaceutical compositions containing N-substituted aziridine-2-carboxylic acid derivatives of the general formula: ##STR1## wherein X is a carboxyl, a cyano, an...
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4511572 |
Triazoline anticonvulsant drugs
Anticonvulsant compositions comprise as the active ingredient a compound selected from the group consisting of those of the formulae: ##STR1## wherein R 1 is o-chlorophenyl, o-nitrophenyl, 2,4- or...
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4510148 |
2-Heterocyclic-1,3-bis(1H-1,2,4-triazol-1-yl)-propan-2-ols as antifungal agents
Compounds of the formula ##STR1## wherein R is thienyl, mono-, di- and trihalothienyl, furyl, 2-benzothiazolyl, pyridyl or chloropyridyl and their pharmaceutically acceptable salts are useful...
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4508719 |
Hydroxyimino and alkoxyimino derivatives of 1,4-dihydropyridine and anti-hypertensive compositions
Compounds of formula I: ##STR1## are described in which R 1 is a linear or branched alkyl radical containing between 1 and 5 carbon atoms, the alkyl radical being unsubstituted or substituted by...
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4507296 |
Tetrazoles, pharmaceutical use and compositions
The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts or hydrates thereof, in which the substituents are defined later in the specification....
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4505919 |
Antifungal S-arylmethyl- and S-heterocyclylmethyl ethers of 2-aryl-3-mercapto-1-(1H-1,2,4-triazol-1-yl) propan-2-ols
Compounds of the formula: ##STR1## wherein Ar is phenyl substituted by from 1 to 3 substituents, each substituent being independently halo or CF 3 ; n is 0 or 1; and R is a phenyl or a...
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4503061 |
Substituted phenyl-pyridinones as cardiotonic agents
Certain 2(1H)-pyridinones are cardiotonic agents. Methods for their preparation and use are disclosed.
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4503063 |
N-Acyl 3-aryl-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)-butyramide antifungal agents
Compounds of the formula ##STR1## a pharmaceutically or agriculturally acceptable salt thereof, wherein R is 5-chloro-2-pyridyl or phenyl optionally substituted by one to three substituents, each...
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4500532 |
1-(Substituted aminoalkyl)-1,4-dihydropyridines
Compounds of the formula ##STR1## wherein Z is alkylene containing 1 to 5 carbon atoms; R 3 is aminoalkyl containing 2 to 4 carbon atoms; R 4 is H, alkyl, cycloalkyl, aminoalkyl, hydroxyalkyl or...
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4499090 |
N-(5-aminomethyl-2-oxazolin-2-yl)-N'-phenylureas, compositions and use
This invention relates to new N-(5-aminomethyl-2-oxazoline-2-yl)-N'-phenylureas, the method for producing them and their application in therapy, particularly in treating convulsions, rhythm...
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4497812 |
2-Amino-5-aminomethyl-2-oxazolines, compositions and use
This invention relates to new 2-amino-5-aminomethyl-2-oxazolines, the method of preparing them, and their pharmacological properties making possible their application in cardiovascular,...
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4497821 |
Medicaments having antihypoxic and ischaemia-protective activity
A method of controlling damage to the central nervous system of a patient which comprises administering to such patient a central nervous system-controlling effective amount of a pyridine...
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4496571 |
Histamine H2-antagonists
The invention relates to carbonyl derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention where is provided a guanidine derivative of...
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4496564 |
Amide derivatives
The invention relates to amide derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of the...
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4485104 |
1,2,4-Triazole-3-amines and their pharmaceutical use
Compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof have been found to show pharmacological activity as selective histamine H 2 ...
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