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5356911 |
Substituted biphenylpyridones
Substituted biphenylpyridones can be prepared by alkylating pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active substances in medicaments, in particular in...
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5342941 |
Naphthalene derivatives, processes for preparing the same, and synthetic intermediates therefor
Naphthalene derivative of the formula [I]: ##STR1## wherein R 1 and R 2 are the same or different and are hydrogen atom, hydroxy group, cyclo-lower alkyloxy group, substituted or unsubstituted...
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5338737 |
Biphenyl oxadiazoles and thiadiazoles as angiotensin II antagonists
Novel heterocyclic methyl derivatives of biphenyl oxadiazoles and thiadiazoles are described, as well as methods for the preparation of said derivatives and pharmaceutical compositions of the same,...
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5334614 |
Hydroxylamine derivatives
The invention concerns hydroxylamine derivatives of the formula I ##STR1## wherein R 4 is hydrogen, carbamoyl, (1-4C)alkyl, cyclopentyl, cyclohexyl, tetrahydrofuran-3-yl, tetrahydropyran-4-yl,...
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5332750 |
1,2-dihydro-2-oxopyridines
New 1,2-dihydro-2-oxopyridines of formula I ##STR1## in which R is the radical ##STR2## and R 1 to R 6 and X are as defined herein, and their salts, have antagonistic properties towards...
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5330994 |
Tetrahydropyridine isoxazoline derivatives
A novel compound of the following formulas useful in treating immune-related diseases, inflammation, stoke, epilepsy, dystonias, psychoses, anxiety, and depression: ##STR1##
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5324723 |
Oxazoles and thiazoles for the treatment of senile dementia
1,3-Oxazole and 1,3-thiazole compounds of formula I, and their pharmaceutically acceptable salts and prodrugs: ##STR1## wherein X represents oxygen or sulphur; R 1 represents a non-aromatic...
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5322845 |
Acrylic acid derivatives, a fungicide containing them as an active ingredient, and intermediate compounds thereof
An acrylic acid compound useful for fungicides is provided. The compound has the following formula (I) ##STR1## wherein X represents a phenyl group which may be substituted, or a methylene group, n...
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5304565 |
Nitrogen containing heterocyclic compounds, their production and use
Nitrogen-containing heterocyclic compounds of the formula (I): ##STR1## wherein Y is N or CH; R 1 , which may be optionally bound through a hetero atom, is a hydrocarbon residue which may be...
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5294632 |
Phosphono/biaryl substituted dipetide derivatives
The invention relates to the N-phosphonomethyl-biaryl substituted dipeptide derivatives of formula I ##STR1## and tetrazole derivatives of the formula Ia ##STR2## wherein A represents a direct...
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5292737 |
N,N'-bis(sulfonamido)-2-amino-4-iminonaphthalen-1-ones and N,N'-bis(amido)-2-amino-4-iminonaphthalen-1-ones
N,N'-Bis(sulfonamido)-2-amino-4-iminonaphthalen-1-ones and N,N'-Bis(amido)-2-amino-4-iminonaphthalen-1-ones are disclosed. Methods of inhibiting protein kinase C activity which comprises contacting...
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5286738 |
Triazole compound and insecticide
A triazole compound of the formula (I): ##STR1## and an insecticide comprising the same as the active ingredient.
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5284860 |
Triazole derivatives and insecticides
A novel triazole derivative for use in an insecticide has a general formula [I]: ##STR1## (wherein R 1 is a lower alkyl group, R 2 and R 3 are same or different halogen atoms and X is a chlorine...
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5281614 |
Substituted 1,2,4-triazoles bearing acidic functional groups as angiotensin II antagonists
Novel substituted triazolinone, triazolinethione, and triazolinimine compounds of the formula I are useful as angiotensin II antagonists. ##STR1##
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5276045 |
Thioformamide derivative, process for its preparation, pharmaceutical composition thereof and treatment method
A thioformamide derivative of the formula: ##STR1## wherein R represents alkyl, A represents optionally substituted pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin-3-yl, quinolin-3-yl,...
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5273984 |
Salts formed between basic histamine H.sub.2 -receptor antagonists and bismuth complexes
The invention relates to salts formed between basic H 2 -receptor antagonists and a complex of bismuth with a carboxylic acid, and solvates of such salts, excluding salts in which the basic H 2 ...
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5273990 |
Phosphono substituted tetrazole derivatives
The present invention relates to the N-phosphonomethyl substituted tetrazole derivatives of formula I ##STR1## and tautomers thereof wherein R 1 is aryl or biaryl; n is zero, 1 or 2...
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5273989 |
3,5-disubstituted 2-isoxazolines and isoxazoles, agents containing them and their use
Novel 3,5-disubstituted 2-isoxazolines and isoxazoles and novel pharmaceuticals are described which are suitable, in particular, for the prophylaxis and/or treatment of pathological,...
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5268374 |
Non-peptide renin inhibitors
The present invention relates to renin inhibiting compounds of the formula: ##STR1##
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5264443 |
3-aryl oxazolidinone compounds and therapeutic use thereof
Derivatives having the formula: ##STR1## where R 1 denotes C 1 -C 4 alkyl; X denotes oxygen or methylene; R 2 denotes C 1 -C 4 alkyl or CF 3 ; R 3 denotes a CH 2 R 4 group in which R 4 ...
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5262427 |
3-substituted and optionally 1-substituted azacyclic or azabicyclic compounds, pharmaceutical compositions, thereof and their use as stimulants of cognitive functions
Azacyclic compounds selected from the group consisting of ##STR1## wherein R 1 is H or C 1 -6 -alkyl R 3 is ##STR2## wherein R' is C 3 -8 -alkyl, cyclopropyl, C 4 -8 -cycloalkyl, benzyl which...
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5260320 |
Diaminotrifluoromethylpyridine compounds and phospholipase A.sub.2 inhibitor containing them
A diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW 1 R 1 , --COCOR 2 , --CW 1 NHCOR 2 , --C(W 1 )W 2 R 3 or --CW 1 N(R 4 )R 5 , and Y is...
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5256666 |
3-Isoxazolylphenyl compounds, their preparation and their use
3-Isoxazolylphenyl compounds Ia and Ib ##STR1## where R is halogen; alkyl; haloalkyl; alkoxy; haloalkoxy; alkenyl; haloalkenyl; unsubstituted or substituted phenylethenyl; alkynyl; cycloalkyl;...
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5254571 |
Chemical compounds
This invention relates to phenylpyridone derivatives which have bronchodilator and anti-allergic activities. A compound of the invention is...
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5244906 |
Insect control with substituted oxadiazole and thiadiazole compounds
Insects, especially sucking insects, such as brown planthoppers, and phytophageous mites, such as two-spotted spider mites, are controlled by applying an oxadiazole or thiadiazole compound...
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5242927 |
Prodrugs for oxadiazole muscarinic agonists
A class of novel oxadiazoles, substituted on one of the ring carbon atoms with a non-aromatic azacyclic or azabicyclic ring and on the other ring carbon atom with a substituent which is convertible...
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5240921 |
Cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides, processes for their preparation and their use
The invention relates to cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides of the formula I ##STR1## in which n and X have the meanings given. The compounds according to the invention...
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5236937 |
Pyridinyl compounds which are useful as angiotensin II antagonists
The invention concerns pharmaceutically useful compounds of the formula I, in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , Rz, X and Z have the various meanings defined herein, and their...
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5236936 |
Pyridine compounds which are useful as angiotensin II receptor antagonists
The invention concerns pharmaceutically useful compounds of the formula I, in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X and Z have the various meanings defined herein, and their non-toxic...
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5234946 |
Substituted alkylamine derivatives
The substituted alkylamine derivatives represented by formula (I) ##STR1## wherein R 1 represents (a) substituted or unsubstituted C 2 -6 alkenyl group, (b) substituted or unsubstituted C 3 -6...
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5231106 |
Azacyclic carboxylic acid derivatives and their preparation and use
Novel O-alkylated oximes of the general formula I ##STR1## or ##STR2## wherein R 1 and R 2 are optionally substituted aromatic or heteroaromatic rings, R 3 is hydrogen or lower alkyl, R 4 is a...
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5223516 |
3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same
Compounds of the formula ##STR1## wherein Y can be tetrazolyl are disclosed. These compounds are useful as cardiovascular agents.
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5223523 |
Fungicidal oxazolidinones
Compounds for an methods of controlling plant diseases using thiooxazolidinones, oxazolidindiones and agriculturally suitable compositions containing them are disclosed.
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5217974 |
Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
Administration of a folate binding protein binding agent in conjunction with use of an antitumor agent which is an inhibitor of glycinamide ribonucleotide transformylase or other antifolate reduces...
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RE34242 |
Amino-oxazole compounds having dopaminergic activity
The present invention relates to new amino-thiazole and amino-oxazole derivatives of the general formula: ##STR1## wherein: R represents hydrogen, a lower alkyl group with 1 to 4 carbon atoms, a...
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5204357 |
Renin-inhibiting amino acid derivatives
The invention relates to compounds of the formula I ##STR1## in which A represents a substituted thio-, sulfinyl- or sulfonyl-alkanoyl radical or a four- to eleven-membered heterocycle, B is an...
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5198439 |
Angiotension II antagonizing pyridine derivatives
The invention concerns pharmaceutically useful novel compounds of the formula I, in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X and Z have the various meanings defined herein, and their...
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5196537 |
5-apylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders
A class of 5-arylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds is described for use in treatment of circulatory disorders such as hypertension. Compounds of particular interest are...
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5177096 |
Substituted 5-((tetrazolyl)alkenyl)imidazoles and pharmaceutical methods of use thereof
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
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5177095 |
Triazole angiotensin II antagonists incorporating a substituted benzyl element
Substituted triazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists. ##STR1##
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5175182 |
Acryloyl substituted pyrrole derivatives
The invention relates to acryloyl substituted pyrrole derivatives of formula (I) ##STR1## wherein n is an integer of 1 to 5; each of R 1 and R 2 , which may be the same or different, is...
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5156669 |
5-(1,2,4-triazol-1-ylmethyl)-isoxazolines
5-(1,2,4-Triazol-1-yl-methyl)-isoxazolines I ##STR1## where R 1 and R 2 are each H, alkoxyalkyl, haloalkyl, alkyl, cycloalkylalkyl, phenylalkyl, naphthylalkyl, cycloalkyl, phenyl, naphthyl or...
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5155117 |
1-arylheteroarylalkyl substituted-1H-1,2,4-triazole compounds for treatment of circulatory disorders
A class of 1-arylheteroarylalkyl substituted-1H-1,2,4-triazole compounds is described for use in treatment of circulatory disorders such as hypertension. Compounds of particular interest are...
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5137889 |
Dihydropyridine derivatives and process for preparing the same
Dihydropyridine derivatives and salts thereof represented by the general formula, ##STR1## which possess excellent calcium antagonist effect, hypotensive effect, platelets aggregation inhibitory...
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5134146 |
Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma
The use of compounds for formula (I): ##STR1## or a salt or prodrug thereof; wherein one of X, Y, or Z is an oxygen or sulphur atom and the other two are nitrogen atoms, and the dotted circle...
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5126338 |
Fungicides which are N-pyridyl-cyclopropane carboxamides or derivatives thereof
Compounds of having the general formula (I): ##STR1## and stereoisomers thereof, wherein R 1 is hydrogen, halogen, C 1 -4 alkoxy, C 1 -4 alkyl, C 2 -4 alkenyl, C 2 -4 alkynyl, C 1 -4 haloalkyl, C...
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5124341 |
Oxadiazolinone derivative and its production and use
The present invention relates to an oxadiazolinone derivative represented by the following general formula, a process for producing the same and insecticides containing the same as an active...
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5122529 |
Pyridyl cyclopropane carboxamidine fungicides
A compound of general formula (II): ##STR1## and stereoisomers thereof, wherein R 1 is hydrogen, halogen, C 1 -4 alkoxy C 1 -4 alkyl, C 2 -4 alkenyl, C 2 -4 alkynyl, C 1 -4 haloalkyl, C 1 -4...
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5120750 |
Generation of 1,4-dihydropyridine derivatives
A 1,4-dihydropyridine derivative of the formula I: ##STR1## is provided in which: A is an azole moiety; R is a C 1 -C 4 alkyl group; X is --CH 2 --, --S--, --SO-- or --SO 2 --; n is 5,...
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5120734 |
Fungicidal pyrid-2-yl-amino acetic acid esters
Fungicidal acetic acid esters of the formula ##STR1## in which A 1 is an optionally substituted phenyl, naphthyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, thienyl, furanyl, pyrrolyl,...
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