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7612045 |
Compounds, compositions and methods for controlling biofilms and bacterial infections
The present invention provides compounds and compositions useful for controlling bacterial biofilms as well as for controlling and/or preventing bacterial infections. The compounds of the invention...
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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7557091 |
HKI10311129, novel antibiotic, method for producing the same and the use thereof
The invention relates to the novel antibiotic HKI10311129 which has a molecular weight of 1113 and the summation formula C 56 H 75 NO 22 . The invention also relates to a method for producing said...
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7557090 |
Anthracycline antibiotics and methods of treating cancer using the same
The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3′ of the sugar moiety or modified or unmodified alkyl-aromatic...
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7547673 |
Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of ATP production
The present invention relates to methods of treating a cancerous tumor using selective inhibitors of ATP production. The present invention also relates to pharmaceutical preparations comprising...
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7541342 |
Use of PKC-activating compounds as cardioprotectants and as apoptosis-inducing anti-tumor agents
Compounds for the inducing apoptosis in cancer cells are described. The described compounds induce the translocation of protein kinase C-δ to the mitochondria and the phosphorylation of...
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7534768 |
Treatment of DNA viral infections
The synergistic combination of a loop diuretic and a cardiac glycoside is useful in the treatment of DNA viral infections.
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7514413 |
In-vivo energy depleting strategies for killing drug-resistant cancer cells
This invention also provides a method for treating a cancer subject comprising administering to the subject a combination of ATP-depleting agents at concentrations which deplete the ATP level to,...
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7511023 |
Anticancer drug-chitosan complex forming self-aggregates and preparation method thereof
The present invention relates to an anticancer drug-chitosan complex forming self-aggregates and the preparation method thereof. More precisely, the present invention relates to the anticancer...
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7470714 |
GM-95-containing antitumor effect potentiator, combined antitumor preparation and antitumor agent
An antitumor effect enhancer for enhancing the antitumor effects of an antitumor substance, which comprises a compound represented by the following formula (1):
wherein each R independently...
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7470672 |
Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
This invention is in the field of chemical restructuring of pharmaceutical agents known to cause tissue toxicity as a side effect, by producing their orotate derivatives. More particularly, it...
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7465716 |
Targeted drug delivery with a hyaluronan ligand
The invention is a drug delivery system of a delivery vehicle having a low molecular weight hyaluronan ligand with an affinity for CD44 receptors. Preferably, the delivery vehicle is a liposome but...
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7462601 |
Ameliorant for chemical treatment of cancer
An ameliorating agent for cancer chemotherapy is disclosed, which comprises a chromanol glycoside represented by the following general formula (1)
(wherein R 1 , R 2 , R 3 , and R 4 , which are...
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7449315 |
Bifunctional energy-reversible acyl-compositions
Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include:
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7445764 |
Carrier-drug conjugate
The invention relates to a carrier-drug conjugate comprising a carrier containing a polypeptide sequence having one or several cysteine radicals and a pharmacon containing a pharmaceutical and/or...
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7368102 |
Pulmonary delivery of aminoglycosides
The present invention is directed to the administration of aminoglycosides. In particular, the present invention is directed to compositions and methods for the pulmonary administration of...
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7345023 |
Treatment of hyperproliferative conditions of body surfaces
The present invention relates to pharmaceutical formulations comprising an anthracycline and the uses thereof for treatment of clinical conditions of body surfaces such as skin and mucosal...
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7288534 |
Sphingomyelin enhancement of tumor therapy
Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing...
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7229973 |
pH-sensitive polymeric micelles for drug delivery
Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug...
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7217770 |
Stable polymeric micelle-type drug composition and method for the preparation thereof
A biocompatible stable composition containing a hydrophobic drug, such as paclitaxel. The composition, which forms a syringeable polymeric micellar solution in aqueous or body fluids, is a...
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7204996 |
Method of cancer treatment
This invention comprises a method of treating a subject having relapsed or refractory cancer such as leukemia with liposomal annamycin including the steps of
(a) evaluating the subject to...
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7163930 |
Pharmaceutical compositions and methods relating to fucans
Compositions, methods and the like comprising fucans such as fucoidan to treat surgical adhesions, arthritis, and psoriasis.
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7163703 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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7163702 |
Process for isolating sea cucumber saponin Frondoside A, and immunomodulatory methods of use
This present invention discloses use of a chloroform/solvent mixture extraction at different solvent-to-feed ratios, followed by evaporation and extraction with ethyl acetate/water; followed by...
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7160865 |
Cancer treatment including glycolytic inhibitors
Glycolytic inhibitors are useful in the treatment of solid tumors by attacking anaerobic cells at the center on the tumor. 2-deoxyglucose, oxamate and various analogs thereof are identified as...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7135177 |
Immunoliposomes that optimize internalization into target cells
The present invention provides for immunoliposomes that optimizes internalization of a drug into target cells bearing a characteristic cell surface marker. The immunoliposomes comprise an Fab'...
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7115576 |
Water-soluble antibiotic comprising an amino sugar, in the form of a polysaccharide conjugate
The invention relates to novel pharmaceutical forms for antibiotics containing amino sugar, amphotericin B, daunorubicin and doxorubicin, in which the known side effects are reduced and which can...
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7109177 |
Methods and compositions for the manufacture of C-3′ and C-4′ anthracycline antibiotics
The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3′ of the sugar moiety or modified or unmodified alkyl-aromatic...
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7101842 |
Targeted delivery of drugs for the treatment of parasitic infections
Targeting agents such as transferrin and transcobalamin can be conjugated with anti-protozoan drugs for the treatment of protozoan infections. Any suitable anti-protozoan drug can be used,...
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7094775 |
Method of treating breast cancer using a combination of vitamin D analogues and other agents
The invention provides therapeutic methods for inhibiting, ameliorating or alleviating the hyperproliferative cellular activity of diseases of the breast, e.g., breast cancer, which includes...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7091189 |
Medicament for treating lung cancer
By using a combination of amrubicin or a pharmaceutically acceptable salt thereof with another medicament for treating lung cancer (irinotecan, vinorelbine, gemcitabine, etc.), it is intended to...
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7091188 |
Stabilization of amrubicin hydrochloride
A stabilized amrubicin hydrochloride composition which comprises 3 to 8 wt. % water and 92 to 97 wt. % amrubicin hydrochloride; and a method of storing amrubicin hydrochloride.
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7071158 |
Antioxidant enhancement of therapy for hyperproliferative conditions
A method to enhance the cytotoxic activity of an antineoplastic drug comprising administering an effective amount of the antineoplastic drug to a host exhibiting abnormal cell proliferation in...
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7026301 |
Method of orally treating inflammatory skin conditions with prodrugs of 5-fluorouracil
The present invention relates to the treatment of inflammatory skin conditions, including psoriasis, with a prodrug of 5-fluorouracil. The invention relates to methods for treatment of psoriasis...
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7012068 |
Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer
Methods and compositions for treating cancer with a formulation are provided in which a polysaccharide, galactomannan, is co-administered with a therapeutic agent to a subject to reduce toxicity...
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7005421 |
Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
According to the invention there is provided a sterile, pyrogen-free, ready-to-use solution of an anthracycline glycoside, especially doxorubicin, which consists essentially of a physiologically...
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6982255 |
Delivery of a therapeutic agent in a formulation for reduced toxicity
Methods and compositions for reducing toxicity of a toxic agent are provided in which a polysaccharide, galactomannan is coadministered with a therapeutic agent in a liquid formulation to a subject...
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6977247 |
Sequential therapy comprising a 20(S)-camptothecin and a pyrimidine base analog
A method is provided for treating a patient having a disease associated with undesirable or uncontrolled cell proliferation, the method comprising: administering to the patient a 20(S)-camptothecin...
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6974798 |
Treatment of balance impairments
Compositions and methods are provided for prophylactic or therapeutic treatment of balance impairments involving neuronal damage, loss, or degeneration, preferably of vestibular ganglion neurons,...
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6933320 |
Combination comprising combretastatin and anticancer agents
An antitumor combination comprising a stilbene derivative and an anticancer compound selected from the group consisting of taxanes, alkylating agents, antimetabolites, vinca alkaloids, platinum...
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6927211 |
Method for reducing toxicity of combined chemotherapies
Compositions and methods are provided for use in the treatment of cancer.
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6914046 |
NF-κB activation inhibitors, and their pharmaceutical uses
Compounds inhibiting the activation of the nuclear factor κB (NF-κB) are used for the preparation of medications adapted for the treatment of malignant hemopathies and solid tumors, and for the...
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6906059 |
Pharmaceutical composition with protective action against oxidative/toxic substances, especially cardiotoxic substances
The use of benzazepin-N-acetic acid derivatives which contain an oxo group in the a position to the nitrogen atom and are substituted in the 3 position by a...
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6875745 |
Method and composition for the treatment of cancer
We have discovered that the administration of a G1 and/or S phase drug such as β-lapachone in combination with a G2/M drug such as a taxane derivative such as paclitaxel resulted in a greater than...
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6844318 |
Peptidase-cleavable, targeted antineoplastic drugs and their therapeutic use
This invention is directed to antineoplastic agents conjugated to enzyme-cleavable peptides comprising the amino acid recognition sequence of a membrane-bound and/or cell-secreted peptidase, and to...
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6822001 |
Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent such as gemcitabine or paclitaxel.
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6809120 |
Composition containing propargylamine for enhancing cancer therapy
Antineoplastic drug modulators are described. The specific modulators referred to are propargylamines which can enhance the cytotoxic effects of antineoplastic drugs on cancer cells while...
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6794370 |
Method for treating cancer using camptothecin derivatives and 5-fluorouracil
A combination therapy for treating cancer including administering at least one camptothecin derivative in conjunction with another anticancer agent. The combination therapy is preferably used as a...
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