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8173610 |
Derivatives of epirubicin, their medicinal application and pharmaceuticaly acceptable forms of drugs
The present invention relates to novel derivatives of epirubicin, pharmaceutical composition comprising these derivatives, and uses of epirubicin and its derivative for treating HCV.
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8158591 |
Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines
A 13-deoxy anthracycline and a taxane can be administered to a patient simultaneously, separately, sequentially, or consecutively to produce a therapeutic anticancer effect with reduced toxicity...
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8148339 |
Method of reducing cardiac levels of doxorubicin when given as orotate salt
This invention is in the field of chemical restructuring of pharmaceutical agents known to cause tissue toxicity as a side effect, by producing their orotate salts. More particularly, it concerns...
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8148338 |
Doxorubicin formulations for anti-cancer use
Doxorubicin block copolymer formulations for use in preparing injectable compositions for treating cancer patients which contain lactose for solubilizing the doxorubicin and block copolymers in...
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8075916 |
Poly(organophosphazene) hydrogels for drug delivery, preparation method thereof and use thereof
A biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances are provided.
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8076373 |
Method for treating mammalian diseases and injuries caused by the over-expression of peroxynitrite
The present invention provides a method for treating wounds and diseases in mammals, caused by mammalian cells involved in an inflammatory response, by altering indigenous in vivo levels of...
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8066971 |
Targeting pulmonary epithelium using ADRP
This invention provides novel compositions and methods for the specific and/or preferential delivery of an effector (e.g. a drug or label) to an epithelial cell (e.g. a pulmonary epithelium). The...
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8057816 |
Compositions and methods of administering paclitaxel with other drugs using medical devices
Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs...
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8043631 |
Tumor targeting drug-loaded particles
A composition for delivering a tumor therapeutic agent to a patient includes a fast-release formulation of a tumor apoptosis inducing agent, a slow-release formulation of a tumor therapeutic agent,...
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8034375 |
Combinations and modes of administration of therapeutic agents and combination therapy
The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective...
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8030283 |
Stabilization of amrubicin hydrochloride
A stabilized amrubicin hydrochloride composition which comprises 3 to 8 wt. % water and 92 to 97 wt. % amrubicin hydrochloride; and a method of storing amrubicin hydrochloride.
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8026230 |
Methods and compositions for treating cancer using proteasome inhibitors
The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to...
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8022279 |
Liposomal formulations of anthracycline agents and cytidine analogs
Compositions which comprise an anthracycline agent, and a cytidine analog are encapsulated in liposomal carriers. The preferred anthracycline agent is selected from the group of daunorubicin,...
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8003630 |
Combinatorial therapies for the treatment of neoplasias using the opioid growth factor receptor
The present invention relates to pharmaceutical compositions for treating neoplasias in an animal or human comprised of a carrier and therapeutically effective amounts of at least one...
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7994141 |
Compositions comprising compounds of natural origin for damaged skin
The present invention relates to a skin-protecting composition for the damaged skin, comprising glycyrrhizin, quercetin, rosmarinic acid, madecassic acid, chamazulene, bicalein and emodin. The...
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7968085 |
Hydrogel formulations
A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active...
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7947308 |
Effervescent powders for inhalation
Effervescent powders comprising inhalable particles are disclosed, as are methods for preparing these powders. The inhalable carrier particles comprise an inorganic or organic carbonate, and an...
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7923435 |
Hoodia plant extract with improved flavor
Extracts of Hoodia plant containing steroidal glycosides which have improved flavor, by virtue of reduced levels of discovered negative flavor compounds. Food compositions containing steroidal...
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7915227 |
Pharmaceutical formulations employing short-chain sphingolipids and their use
Pharmaceutical formulations containing (i) an amphiphilic drug and (ii) a short-chain sphingolipid are described and provided herein along with methods of making and using same.
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7902144 |
Therapeutic and diagnostic ligand systems comprising transport molecule binding properties and medicaments containing the same
The invention relates to transport molecule binding ligand compounds which comprise a therapeutically and/or diagnostically active substance and a carrier molecule-affine substance with a high...
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7863321 |
Anti-cancer combinations
The present invention relates to synergistic combinations of the compound 5, 6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from anthracyclines and topisomerase II inhibitors,...
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7781412 |
Biphenyl inhibitors of carbonyl reductase
Compositions of matter and methods of treating cancer patients may prevent or limit cardiotoxicity during or after chemotherapy, and/or may prevent or lower resistance to anthracycline drugs, both...
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7776832 |
Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines
A 13-deoxy anthracycline and a taxane can be administered to a patient simultaneously, separately, sequentially, or consecutively to produce a therapeutic anticancer effect with reduced toxicity...
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7772192 |
Compositions and methods for treatment of disease with acetylated disaccharides
Compositions and methods for treatment of disease with acetylated disaccharides and analogs thereof are provided.
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7744854 |
Method for optimizing cancer therapy by monitoring maturation of tumor associated vasculature by selenium
This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an...
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7737123 |
Multidrug resistant anticancer anthracyclines
Daunorubicin (“DNR”) compounds synthesized with uncommon sugars exhibit enhanced effectiveness in treating various drug-resistant cancers.
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7727968 |
Combination therapy for the treatment of acute leukemia and myelodysplastic syndrome
Methods of treatment and pharmaceutical combinations are provided for the treatment of acute leukemia, such as acute myelogenous leukemia, and myelodysplastic syndrome. The methods of treatment and...
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7727967 |
Cyanooxime inhibitors of carbonyl reductase and methods of using said inhibitors in treatments involving anthracyclines
Compositions of matter for treating cancer patients are used to prevent or limit cardiotoxicity during or after treatment with anthracycline drugs, and to prevent or lower resistance to...
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7704954 |
Method and carrier complexes for delivering molecules to cells
The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the...
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7682630 |
Antitumor agent and process for producing the same
The present invention relates to polymeric antitumor agent which is formed in polymeric micelle complex by intermolecular bonding or mutual interaction between styrene maleic acid copolymer (SMA)...
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7612045 |
Compounds, compositions and methods for controlling biofilms and bacterial infections
The present invention provides compounds and compositions useful for controlling bacterial biofilms as well as for controlling and/or preventing bacterial infections. The compounds of the invention...
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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7557090 |
Anthracycline antibiotics and methods of treating cancer using the same
The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3′ of the sugar moiety or modified or unmodified alkyl-aromatic r...
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7557091 |
HKI10311129, novel antibiotic, method for producing the same and the use thereof
The invention relates to the novel antibiotic HKI10311129 which has a molecular weight of 1113 and the summation formula C56H75NO22. The invention also relates to a method for producing said...
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7547673 |
Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of ATP production
The present invention relates to methods of treating a cancerous tumor using selective inhibitors of ATP production. The present invention also relates to pharmaceutical preparations comprising...
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7541342 |
Use of PKC-activating compounds as cardioprotectants and as apoptosis-inducing anti-tumor agents
Compounds for the inducing apoptosis in cancer cells are described. The described compounds induce the translocation of protein kinase C-δ to the mitochondria and the phosphorylation of ...
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7534768 |
Treatment of DNA viral infections
The synergistic combination of a loop diuretic and a cardiac glycoside is useful in the treatment of DNA viral infections.
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7514413 |
In-vivo energy depleting strategies for killing drug-resistant cancer cells
This invention also provides a method for treating a cancer subject comprising administering to the subject a combination of ATP-depleting agents at concentrations which deplete the ATP level to,...
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7511023 |
Anticancer drug-chitosan complex forming self-aggregates and preparation method thereof
The present invention relates to an anticancer drug-chitosan complex forming self-aggregates and the preparation method thereof. More precisely, the present invention relates to the anticancer...
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7470672 |
Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
This invention is in the field of chemical restructuring of pharmaceutical agents known to cause tissue toxicity as a side effect, by producing their orotate derivatives. More particularly, it...
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7470714 |
GM-95-containing antitumor effect potentiator, combined antitumor preparation and antitumor agent
An antitumor effect enhancer for enhancing the antitumor effects of an antitumor substance, which comprises a compound represented by the following formula (1): wherein each R independently...
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7465716 |
Targeted drug delivery with a hyaluronan ligand
The invention is a drug delivery system of a delivery vehicle having a low molecular weight hyaluronan ligand with an affinity for CD44 receptors. Preferably, the delivery vehicle is a liposome but...
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7462601 |
Ameliorant for chemical treatment of cancer
An ameliorating agent for cancer chemotherapy is disclosed, which comprises a chromanol glycoside represented by the following general formula (1) (wherein R1, R2, R3, and R4, which are identical...
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7449315 |
Bifunctional energy-reversible acyl-compositions
Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include:
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7445764 |
Carrier-drug conjugate
The invention relates to a carrier-drug conjugate comprising a carrier containing a polypeptide sequence having one or several cysteine radicals and a pharmacon containing a pharmaceutical and/or...
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7368102 |
Pulmonary delivery of aminoglycosides
The present invention is directed to the administration of aminoglycosides. In particular, the present invention is directed to compositions and methods for the pulmonary administration of...
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7345023 |
Treatment of hyperproliferative conditions of body surfaces
The present invention relates to pharmaceutical formulations comprising an anthracycline and the uses thereof for treatment of clinical conditions of body surfaces such as skin and mucosal...
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7288534 |
Sphingomyelin enhancement of tumor therapy
Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing...
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7229973 |
pH-sensitive polymeric micelles for drug delivery
Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug...
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7217770 |
Stable polymeric micelle-type drug composition and method for the preparation thereof
A biocompatible stable composition containing a hydrophobic drug, such as paclitaxel. The composition, which forms a syringeable polymeric micellar solution in aqueous or body fluids, is a...
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