Matches 201 - 250 out of 297 < 1 2 3 4 5 6 >
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4863739 Liposome compositions of anthracycline derivatives  
Disclosed are liposomal antitumor compositions having improved pharmacological characteristics. Liposomes described herein are formed through the incorporation of a particular class of...
4859655 Urdamycin G and derivatives thereof, a process for their preparation and their use  
A new substance, urdamycin G, has been found which, like its O-acyl derivatives, exhibits an antibiotic or antitumoral activity.
4853221 Method for treating non-small cell lung cancer, head and neck cancers and breast cancer  
5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]-methyl]-2,4-quin azolinediamine (trimetrexate) has been shown to possess clinical activity against non-small cell lung cancer, head and neck squamous...
4840938 Pharmaceutical compositions containing anthracycline glycosides  
Stable, rapidly soluble, lyophilized injectable preparations comprising an anthracycline glycoside, or a pharmaceutically acceptable salt thereof, as the active drug substance, and use of said...
4839346 Antitumor anthracycline glycosides, intermediates thereof, and composition and use thereof  
New anthracycline glycosides having formula: ##STR1## wherein R 1 is hydrogen or hydroxy and either R 2 or R 3 is hydrogen with the other amino-methyl are described. The new compounds and their...
4831019 Pharmaceutical preparations of 4-demethoxy-n-trifluoroacetyl anthracyclines  
Antineoplastic pharmaceutical preparations and a method for treating neoplastic conditions using 4-demethoxy-N-trifluoroacetyldaunomycin and 4-demethoxy-N-trifluoroacetyldoxorubicin.
4789665 Anthracyclines and drugs containing them  
The present invention relates to new anthracyclines corresponding to the general formula I below: ##STR1## in which R' and R", which may be identical or different, denote a hydrogen atom (and in...
4781676 Interstitial administration of perfluorochemical emulsions for reoxygenation of hypoxic tumor cells  
A method is set forth for treatment of hypoxic tumors by interstitial injection of oxygen bearing fluorocarbon emulsions directly into the hypoxic zone of the tumor followed by radiation treatment.
4772590 Oily composition of aclarubicin or hydrochloride thereof  
An oily composition of aclarubicin or aclarubicin hydrochloride comprising aclarubicin or aclarubicin hydrochloride; at least one fatty acid selected from saturated medium chain fatty acids,...
4749693 Nitro anthracyclines, process for their preparation and use thereof  
Anthracycline glycosides of the general formula (A'): ##STR1## wherein R 1 represents a hydrogen atom, a hydroxy group or a methoxy group; one of R 2 and R 3 represents a hydroxy group and the...
4746516 Pharmaceutical compositions consisting or consisting essentially of freeze-dried drug-carrying liposomes  
A method is disclosed for purifying non-homogeneous systems, known as liposomic suspensions, from non-entrapped drugs wherein said suspensions are treated with liquid or solid polymers of synthetic...
4743591 Composition for animals  
Disclosed is a composition for treatment or prevention of diseases of animals or for addition to feeds for acceleration of growth which contains a mycinamicin antibiotic and at least one compound...
4742050 Sensitization of hypoxic tumor cells and control of growth thereof  
Method of sensitizing hypoxic tumor cells to radiotherapy and chemotherapy by contacting the cells or the vasculature thereof with an aqueous dispersion of an oxygen carrying perfluoro compound and...
4737323 Liposome extrusion method  
A suspension of liposomes whose sizes are predominantly greater than about 1 micron is passed through an asymmetric ceramic filter whose inner-surface pore size is about 1 micron. The processed...
4713371 Anthracycline derivatives and their use as cytostatics  
The present invention relates to the micro-organism Streptomyces purpurascens (DSM 2658), its mutants and variants, a process for the preparation of anthracycline derivatives by fermentation of...
4713370 Carnitine and its use in reducing cardiac toxicity and as a synergist with cytostats  
Carnitine may be administered for the purpose of reducing cardiac toxicity resulting from administration of a cytostat. Carnitine may also be administered in combination with cytostats to produce...
4687762 Water soluble drug complex and method for production of same  
The invention provides a method of producing a water-soluble complex comprising a water-insoluble drug and a phospholipid, comprising the steps of (1) dissolving a water-insoluble drug and a...
4684629 3'-deamino-3'-hydroxy-4'-deoxy-4'-amino doxorubicin and related daunorubicin  
Anthracycline glycosides of general formula (I) ##STR1## wherein R is hydrogen or hydroxy, and pharmaceutically acceptable salts thereof, are anti-tumor agents.
4673668 Aminonaphthacene derivatives  
9-Aminonaphthacene derivative having the formula: ##STR1## wherein R 1 and R 2 are both hydrogen atoms or either one of them is a hydrogen atom and the other is hydroxy group or methoxy group; R...
4671954 Microspheres for incorporation of therapeutic substances and methods of preparation thereof  
Novel hydrophilic protein or polypeptide microspheres prepared by dispersing an aqueous solution or dispersion of protein or polypeptide in an organic solvent solution of a high molecular weight...
4672057 Morpholino derivatives of daunorubicin and doxorubicin  
Anthracycline glycosides of the general formula (A): ##STR1## wherein X is hydrogen or hydroxy and R is hydrogen or a methyl or a hydroxymethyl group; and their pharmaceutically acceptable salts;...
4628047 Agent for enhancing antitumor activity of antitumor agent  
An agent for enhancing antitumor activity of antitumor agents comprising as the active ingredient diltiazem or a pharmaceutically acceptable acid addition salt thereof, an antitumor composition...
4620973 Use of nootropics  
The invention relates to the use of nootropics, particularly Piracetam®, in connection with the treatment of cancer with cytostatically effective preparations, for the prevention or mitigation of...
4613591 Adminiculum for antitumor agents  
Adminiculum increasing the antitumor activities of mitomycin C and doxorubicin hydrochloride and decreasing the side effects associated with their use comprising an aqueous or aqueous organic...
4610977 N-alkyl and N-benzyl adriamycin derivatives  
Compounds having the structure ##STR1## in which A is alkanoate having from 4 to 10 carbon atoms, hemiadipate, or hemiglutarate, and R 1 and R 2 are n-propyl, or n-butyl, or R 1 is hydrogen,...
4604381 4-demethoxy-13-dihydrodaunorubicin and use thereof  
A new antitumor anthracycline glycoside, 4-demethoxy-13-dihydrodaunorubicin, is disclosed. The new compound is prepared by reduction of the side-chain ketone function of the known...
4585760 Dimethylfurano heterocyclic analogs of daunomycin  
Dimethyfurano analogs of daunomycin are described, including (±)-8α-acetyl-6,7,8,9-tetrahydro-5,6β,8β,10-tetrahydrox y-1,3-dimethyl-anthra[2,3-c]-furan-4,11-dione-6-(3-amino-2,3 -6-trideoxy-.al...
4563444 Anthracycline glycosides, use and compositions containing same  
Anthracycline glycosides of the formula (I) ##STR1## wherein one of R 1 and R 2 is hydrogen and the other of R 1 and R 2 is hydroxy, each of R 3 , R 4 and R 5 is independently selected from...
4562177 3'-Amino-2' halo-anthracycline antibiotics  
Compounds of the formula ##STR1## wherein R 1 is a hydrogen atom or a hydroxyl group; R 2 is a hydrogen atom or a hydroxyl or methoxyl group; X is a fluorine, chlorine, bromine or iodine atom;...
4550159 Anthracycline compounds  
An anthracycline compound, ditrisarubicin, of the formula: ##STR1## wherein R represents one of the following substituents (A), (B), and (C): ##STR2## is produced by a process which comprises...
4548927 Method and agents for raising animal tolerance to oxidant stress-inducing antibiotics  
A method and agents are disclosed for raising the tolerance of animal tissue to antibiotic compounds that induce oxidant stress. The method comprises administering one or more nontoxic redox...
4537882 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same  
Compounds of the formula (I), acid addition salts thereof, and pharmaceutical preparations containing the same are disclosed ##STR1## wherein R 1 is hydroxy; one of X and X' is hydrogen and the...
4522815 Anthracycline glycosides  
Disclosed is a process for preparing the glycoside antitumor anthracyclines 7-0-(2,6-dideoxy-α-L-arabino-hexopyranosyl)-daunomycinone (Ia);...
4489065 Chondroitin drug Complexes  
A chondroitin or a chondroitin sulfate covalently or ionically bonded to a drug substance of the group consisting of chloramphenicol, methotrexate, adriamycin, vinblastine, vincristine, vindesine,...
4477444 Antracycline glycosides, pharmaceutical compositions and method of use  
Disclosed is a process for preparing the new antitumor glycosides: 4'-deoxy-3'-epi-daunorubicin and 4'-deoxy-3'-epi-doxorubicin starting from the known...
4452786 Condurango glycoside compounds, processes for their preparation, antitumor agents comprising them and compositions  
Novel condurango glycoside compounds, antitumor agents comprising them and processes for their preparation, compositions containing them and methods of treating tumor with them are disclosed herein...
4438105 4'-Iododerivatives of anthracycline glycosides  
Starting from the known 4'-deoxy-4'-iodo-N-trifluoroacetyldaunorubicin, two new anthracycline glycosidic antibiotics, the 4'-deoxy-4'-iodo-daunorubicin and 4'-deoxy-4'-iodo-doxorubicin, have been...
4427664 2'Halo derivatives of daunomycin, desmethoxy daunomycin, adriamycin and carminomycin  
The compounds are derived from aglycons which may be daunomycin, desmethoxy daunomycin, adriamycin and carminomycin. A preferred compound is ##STR1## (1) R'=H; R 2 =OMe; X; Y (2) R'=OH; R 2 =OMe;...
4421851 Antitumor antibiotics  
Anthracycline glycosides W, X, Y and Z which are prepared by the fermentation of mutant F.I. 416 of Streptomyces peucetius var. caesius. The new compounds are useful against both gram positive and...
4419348 Anthracycline glycoside compositions, their use and preparation  
Anthracycline glycoside antibiotics are complexed with cardiolipin and then encapsulated in liposomes to reduce mammalian cardiac tissue uptake of the anthracycline glycoside and to thereby reduce...
4400375 Tobramycin-double stranded RNA complex suitable for inducing interferon  
A complex is described which is useful in inducing interferon production, in activating peritoneal macrophages, and in inhibiting the proliferation and migration of tumor cells, which complex...
4393052 Antitumor anthracycline glycosides, their preparation, intermediates therefor, and compositions and use thereof  
Novel antitumor anthracycline glycosides are prepared by condensing daunomycinone with 2,3,4,6-tetradeoxy-4-C-methylene-3-trifluoroacetamido-L-thre o-hexopyranosy l chloride;...
4374980 3'-Deamino-3'-morpholino carminomycin  
Disclosed is 3'-deamino-3'-morpholino-carminomycin, a new anthracycline glycoside having both antimicrobial and antitumor activity. Also disclosed is a new N-alkylation procedure for preparing the...
4373094 Anthracycline derivatives  
New anthracycline compounds, 2-hydroxy-aclacinomycins M, N, S and T having potent antitumor activity and low toxicity, and the processes for the preparation thereof from 2-hydroxy-aclacinomycin A...
4370474 11-Deoxy-carminomycin compounds  
Anthracycline glycosides W, X, Y and Z which are prepared by the fermentation of mutant F.I. 416 of Streptomyces peucetius var. caesius. The new compounds are useful against both gram positive and...
4355026 4-Demethoxy,11-deoxy anthracycline derivatives  
New 4-demethoxy-11-deoxydaunomycin and 4-demethoxy-11-deoxyadriamycin anthracycline derivatives have been prepared and found to be useful antimicrobial and antitumor agents.
4353894 5-Iminodoxorubicin  
5-Iminodoxorubicin and its pharmaceutically acceptable acid addition salts having good antitumor activity.
4353889 Rebaudioside analogs  
Analogs of the glycoside rebaudioside A are disclosed. These materials have the formula ##STR1## wherein R is a simple physiologically acceptable noncarbohydrate polar organic group. The analogs...
4348388 11-Amino-11-deoxydaunorubicin and analogs  
11-Amino-11-deoxydaunorubicin and analogs represented by the formula: ##STR1## wherein: R is hydrogen, hydroxy or methoxy; R 1 is hydrogen or hydroxy; and the pharmaceutically acceptable salts...
4331648 N-Acetyl-cysteine protects against cardiac damage from subsequently-administered cardio-toxic anthra-cycline in cancer therapy  
The cardiac damage, occurring after treatment with an anthracycline, such as adriamycin, is prevented when N-acetyl-cysteine is orally administered about one hour prior to the treatment with the...
Matches 201 - 250 out of 297 < 1 2 3 4 5 6 >