Matches 151 - 200 out of 297 < 1 2 3 4 5 6 >
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5614502 High-pressure impulse transient drug delivery for the treatment of proliferative diseases  
A method of treating diseases of cell proliferation in a patient such as neoplasms and rheumatoid arthritis including administering sub-toxic doses of a compound in combination with high pressure...
5602108 Semisynthetic diastereomerically pure N-glycidylanthracyclines, a process for the stereoselective preparation thereof as the use thereof as cytostatics  
Semisynthetic diastereomerically pure N-glycidylanthracyclines, a process for the stereoselective preparation thereof and the use thereof as cytostatics. The invention relates to anthracyclines...
5597809 Treatment of optic neuritis  
Methods of treating optic neuritis comprising administering a protective agent which inhibits glutamate-mediated retinal cell damage to a mammal at risk of developing optic neuritis.
5593970 Heterocyclic anthracycline analogs  
Novel pyrano heterocyclic anthracycline derivatives are described, which are useful in the treatment of cancer and tumors, such as breast cancer, leukemia, lung cancer, colon cancer, ovarian...
5580857 Use of gibberellins for the treatment of prostatitis  
The use of active gibberellins for the preparation of a pharmaceutical composition for the treatment of prostatitis. The method results in a decrease in prostate mass.
5571785 Biologically active compounds  
The present invention provides polymer-bound anthracyclines of formula A which consists essentially of three units represented by formulae 1, 2 and 3: ##STR1## wherein: Gly represents glycine; n...
5569471 Medicine for the treatment of tumor  
A medicine for the treatment of tumor. The medicine contains 4-piperidino-piperidine or a physiologically acceptable salt thereof as the effective component. Although 4-piperidino-piperidine or a...
5561119 Glycosylated prodrugs, their method of preparation and their uses  
Glycosylated prodrugs, a preparation method therefor, and their use with tumor-specific immunoenzymatic conjugates for the treatment of cancer, are described. These anthracycline prodrugs have...
5534499 Lipophilic drug derivatives for use in liposomes  
The present invention provides novel lipophilic drug derivatives which are capable of being formulated in liposomes or micelles. These drug derivatives are known therapeutic agents which are...
5532218 3'-aziridino-anthracycline derivatives  
Anthracycline glycosides of general formula 1 and 2: ##STR1## wherein R 1 is hydrogen or a methoxy group; R 2 is hydrogen, a hydroxy group or represents an acyloxy residue of formula 3 --O--COR 5...
5514664 1,4-dihydropyridines for application in combatting resistance to drugs  
Optically pure diaryl compounds of formula (I), in which the substituents and symbols have the meanings indicated in the description are proposed as active ingredients in medicinal preparations for...
5496808 Mono and bis alkylamino-anthracyclines  
An anthracycline glycoside of general formula 1: ##STR1## wherein R 1 is hydrogen or methoxy group; R 2 is hydrogen or hydroxy group, A and B both represent hydrogen or one of A and B is hydrogen...
5433955 Site specific in vivo activation of therapeutic drugs  
A method for site-specific in-vivo activation of a prodrug in an animal using an activator-targeting moiety conjugate to localize an activator at a predetermined site of use and a prodrug compound...
5409690 Treatment of multidrug resistant diseases in cancer cell by potentiating with masoprocol  
Disclosed are: a method for reversing multidrug resistance in a mammal; and a composition to reverse multidrug resistance comprising: ##STR1## wherein R 1 and R 2 are independently H, lower alkyl...
5348946 Heteroanthracycline antitumor analogs  
Heterocyclic antitumor compounds are described, which are useful in the treatment of cancer and tumors in vitro, such as breast cancer, leukemia, lung cancer, colon cancer, ovarian cancer, renal...
5312813 Biofilm reduction method  
A method of killing microorganisms which form a biofilm on a tissue or implant surfaces in a patient, and which are refractory to a biocide at a dose which is effective to kill the microorganism in...
5229371 Chemical modification of elsamicin A at the 3' and/or 4' OH groups  
This invention relates to novel elsamicin A derivatives having an alkylidene group on the 3' and 4'-OH group or a tetrahydropyranyl group on the 4'-OH group, a process for producing said elsamicin...
5182267 Anti-cancer activity potentiator  
A pharmaceutical oil-in-water type microemulsion having an action of potentiating the activities of anti-cancer agents, said micro-emulsion comprises fine particles of a vegetable oil or a...
5160727 Tumor cell sensitization method using quinazolinedione derivatives  
A method for sensitizing cancer cells which have become resistant to treatment with one or more anticancer agents which comprises treating said cells with a quinazolinedione compound.
5153179 Medicament with improved penetration of the tissue membrane  
A composition useful as a medicament with improved penetration of cell membranes comprising an active material and a compound of general formula: ##STR1## wherein either residue R 1 or R 2 is an...
5147860 TAN-1120, its derivatives, production and use thereof  
The present invention relates to a compound of the formula: ##STR1## wherein X is hydroxyl group or hydrogenatom, or a salt thereof. The compound (I) has an acitivity to inhibit angiogenesis, which...
5132290 Esters of 3'-deaminodoxorubicin and liposomal compositions thereof  
Three'-deaminodoxorubicin esters have been found to have excellent encapsulization efficiency in liposomes and to display high antineoplastic activity. The liposomal formulations have also been...
5130126 Polymer-drug conjugate and a method of producing it  
The present invention provides a polymer-combined drug having directional characteristics to digestive organs, wherein it comprises a medicine combined with a polymer which has an alkyleneoxy group...
5122368 Anthracycline conjugates having a novel linker and methods for their production  
The invention relates to anthracycline conjugates comprising at least one anthracycline molecule linked to a molecule that is reactive with a cell population to be eliminated such as antibody,...
5120717 Pharmaceutical composition for inhibiting infection with virus causative of acquired human immunodeficiency syndrome  
Pharmaceutical compositions containing at least one of benanomicins A and B and their salts are now provided, which are useful to inhibit the infection of human T-cells with HIV, namely a virus...
5110801 Treatment of acne  
Acne is treated by administering to the subject a substance which is effective in blocking glucose entry into sebaceous cells, thereby inhibiting the production of sebum by these cells. Typically,...
5104858 Sensitizing multidrug resistant cells to antitumor agents  
A method for sensitizing multidrug resistant cells to antitumor agents comprosing contacting multidrug resistant cells, with an effective amount of a compound of the formula ##STR1## wherein n is...
5093323 Antibiotic N-acetylbenanomicin B, and the production and uses thereof  
As a new compound is now provided N-acetylbenanomicin B which is useful as an antifungal agent and also as antiviral agent for inhibiting infection of human T-cell with HIV, namely a virus...
5091373 Method of treating tumors with a pharmaceutical composition containing anthracycline glycosides  
Stable, rapidly soluble, lyophilized injectable preparations comprising an anthracycline glycoside, or a pharmaceutically acceptable salt thereof, as the active drug substance, and use of said...
5066585 Method of inhibiting fungus using novel antifungal compounds  
A new species of Micromonospora, in particular Micromonospora spartanea ATCC 53803, is described. The species produces antifungal compounds spartanamicins A and B. Methods for the production,...
5049549 Rhodomycins with a modified carbohydrate unit  
7-O-Glycosyl-rhodomycins which correspond to the general formula I below ##STR1## in which the radicals have the following meaning: R 1 is a hydrogen atom or a hydroxyl group, R 2 is a...
5045534 4-demethoxy-4'-amino-4'-deoxy-anthracycline derivatives  
Antitumour anthracycline glycosides of formula I: ##STR1## wherein R 1 is hydrogen or a hydroxyl group, and pharmaceutically acceptable acid addition salts thereof.
5004593 Hexamethylmelamine formulation exhibiting reduced neurotoxicity  
A method is provided for reducing the side effects of chemotherapy with hexamethylmelamine (HMM) comprising intravelously administering a stabilized solution of HMM in an aqueous lipid dispersion,...
5001115 Prodrugs of biologically active hydroxyaromatic compounds  
Prodrugs of bio-active hydroxyaromatic drugs having the structural formula: A pharmaceutically acceptable prodrug of a biologically active, therapeutically effective hydroxyaromatic drug, said...
4987126 3'-deamino-4'-deoxy-4'-amino anthracyclines  
Anthracycline glycoside compounds of general formula I or II: ##STR1## wherein R 1 is hydrogen or a hydroxy group and R 2 is hydrogen or a methoxy group, and their pharmaceutically acceptable...
4983397 Pharmaceutical compositions consisting of acylated phospholipids  
Liposome dispersions are prepared from (a) a synthetic phospholipid of the cephaline type in which the amino group is monoacylated with a dicarboxylic acid; (b) a synthetic phospholipid of the...
4980149 Reduction of the toxic effects caused by anthraquinone drugs  
The toxic effects caused by anthraquinone drugs, particularly by antitumor anthraquinone drugs, are inhibited or reduced by administering Orgotein in a quantity sufficient to inhibit or reduce the...
4975278 Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells  
This invention relates to a novel method for the delivery of cytotoxic drugs to tumor cells by the administration of a tumor-specific antibody-enzyme conjugate that binds to the tumor cells, and...
4975531 Sakyomicin E and the derivatives thereof, a process for the preparation thereof and the use thereof  
The compounds of the formula I ##STR1## in which R 1 to R 3 denote, independently of one another, hydrogen or a (C 1 -C 18 )-acyl group, and a process for the preparation thereof are described....
4963585 Compound, WF11605 and derivative thereof  
The invention relates to a compound of antimicrobial activity of the formula ##STR1## wherein R 1 is hydrogen or lower alkanoyl, R 2 is hydrogen or ##STR2## in which R 4 , R 5 , R 6 and R 7 ...
4954438 Process for preparing antibiotics D788-7  
This invention relates to a process for preparing an antibiotic D788-7 wherein, after culturing carborubicin-producing bacteria, the obtained culture liquid is extracted in acidic conditions while...
4952566 Stabilized anthracycline preparation containing L-cysteine  
A stabilized preparation, particularly, freeze-drying injection, of anthracycline, for example, (7S, 9S)-9-acetyl-9-amino-7-[(2-deoxy-β-D-erythropentopyranosyl) oxy]-7,8,9...
4942155 Biosynthetic anthracyclines related to daunorubicin  
The novel compounds are provided with good antibacterial and antitumour activity.
4938949 Treatment of damaged bone marrow and dosage units therefor  
Various types of biological treatments, including antineoplastic treatments with antineoplastic drugs, can result in damage to the blood-forming function of the bone marrow. This damage can be...
4939125 Acyl derivatives of urdamycin A, their preparation and their use  
The O-acyl derivatives of urdamycin A exhibit an antibiotic or antitumoral activity.
4933169 Antiviral inhalation therapy  
Methods and compositions for treating infectious diseases comprising introducing such compositions, which consist essentially of one or more glycyrrhizie triterpenoid compounds, such as, for...
4900538 Composition for increasing potency of adriamycin or daunomycin and reducing toxicities thereof  
The pressent invention provides a composition comprising adriamycin or daunomycin in mixture with one or more compounds selected from sulfite, acid sulfite, pyrosulfite, diothionite and sulfurous...
4891360 6-amino anthracyclines, process for their preparation and use thereof  
Anthracycline glycosides having the general formula (A): ##STR1## wherein R 1 is hydrogen, hydroxy or methoxy; R 2 is amino, R 3 is hydrogen or hydroxy and X is hydrogen; and their...
4879376 Triterpene saponins having anti-inflammatory, mucolytic and antiedemic activities, process for the preparation thereof and pharmaceutical compositions containing them  
Triterpene saponins of formula ##STR1## wherein R 1 is H or OH and R 2 is a tetrasaccharide, or alternatly pentasaccharide, chain have antiinflammatory, mucolytic and antiedemic activities. Said...
4870058 14-Acyloxy-2'-halo-anthracycline anti-cancer antibiotics  
Compounds of the formula (I) and pharmaceutical preparations containing the same are disclosed ##STR1## wherein R 1 is --OOCR 3 or --OOC(CH 2 ) n COOR 4 ; R 2 is hydrogen, hydroxy or methoxy;...
Matches 151 - 200 out of 297 < 1 2 3 4 5 6 >