Matches 101 - 150 out of 297 < 1 2 3 4 5 6 >
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6187758 Anthracycline glycosides  
An anthracycline glycoside of formula I ##STR1## wherein R is one of the two following residues: ##STR2## or a pharmaceutically acceptable salt thereof.
6180095 Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents  
The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric prodrugs are preferably of the formula: ##STR1## wherein: L 1 is a bifunctional...
6177404 Conjugates useful in the treatment of benign prostatic hyperplasia  
Novel pharmaceutical compositions useful for the treatment of benign prostatic hyperplasia which comprises novel oligopeptides, which are selectively cleaved by enzymatically active PSA, in...
6149913 Compositions and methods for controlling insects  
Compositions and methods for controlling the population of insects are disclosed. The compositions include a feeding stimulant for a particular insect, an effective amount of a 1-arylpyrazole or...
6147094 Reduction of cardiotoxicity of an antitumor agent using manganese compound  
The invention relates to the use of certain chelating agents and their metal chelates and to the use of certain manganese containing compounds, in particular manganese chelates, in the manufacture...
6130248 Tricarboxylic acid-containing oxyalkyl esters and uses thereof  
This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating...
6124311 Methods for treating resistant tumors  
The present invention provides methods for reversing multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted indole, benzofuran,...
6121244 Antitumoral method by administration of partricin derivatives  
The use of some semisynthetic derivatives of the antifungal polyene partricin to selectively hinder the growth of tumor cells is here described. Their use can be associated with the use of other...
6121245 Method of treating cancer using alkylglycerols in conjunction with chemotherapy  
Tumor cell kill is increased and the sensitivity of tumors to chemotherapeutic agents is increased by the administration of an alkylglycerol together with the chemotherapeutic agent.
6103700 Fluoro labelled anthracyclinone and anthracycline derivatives  
Compounds of formula (A), wherein R 1 , R 2 , R 3 , Y and Z are organic substituents, are useful in the diagnosis of amyloidosis; some of the compounds of formula (A) are novel. Processes for their...
6080396 Anthracycline compound derivative and pharmaceutical preparation containing the same  
A dimer, trimer or tetramer of an anthracycline compound which can be obtained by directly, chemically bonding anthracycline compounds having anticancer activities to each other by an alkali...
6054437 Method for inducing death of neoplastic cells using piperazine derivatives  
A method for inducing cell death in neoplastic cells, includes the step of administering a compound of formula I or a pharmaceutically acceptable salt thereof, as a primary chemotherapeutic agent...
6022545 Usage of pathogen-killing foams  
This invention describes the effect of a means to prevent the sexual transmission of infectious pathogens of the vaginal and uterine wall in women, farm animals and pets. This discovery concerns a...
6020316 Glutaraldehyde modified chemotherapeutic agents and methods of use thereof  
Clinical utility of chemotherapy agents is limited by dose-dependent systemic toxicity and emergence of resistant tumor cell lines. The present invention provides derivatives of chemotherapeutic...
6020315 Preparation having increased in vivo tolerability  
A preparation having increased in vivo tolerability comprising a glycosyl-Y[--C(Y)--X--] p --W(R) n --X--C(Y)-active compound, sugar or sugar alcohol and, optionally divalent ions, and a...
5965407 Anthracycline compound 0624  
The present invention relates to compound 0624 having excellent antitumor activity and antimicrobial activity, which is represented by the general formula (1), and a pharmaceutically acceptable...
5958889 Anthracycline derivatives having 4-amino-2,4,6-trideoxy-2-fluoro-mannopyranosyl group  
7-O-(4-Amino-2,4,6-trideoxy-2-fluoro-α-L-mannopyranosyl)dau nomycinone or -adriamycinone is now synthesized as a daunomycinone or adriamycinone derivative having the general formula ##STR1##...
5948815 Methods for inhibiting bacterial cytotoxicity  
The invention provides methods and compositions for reducing microbial cytotoxicity to a cell, by contacting a cell subject to extracellular microbial cytotoxicity with an effective amount of at...
5948750 Conjugates useful in the treatment of prostate cancer  
Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are...
5929104 Method for inducing apoptosis of cancer cell  
Disclosed herein are a method for inducing apoptosis of cancer cells, which comprises administering an effective amount of a 2-nitroimidazole derivative represented by the general formula (1):...
5925669 Carrier compositions for anti-neoplastic drugs  
The invention provides new carrier compositions containing a triglyceridic oil rich in DHA and anti-neoplastic drugs and a DHA-containing phospholipid.
5908835 Anti-tumor compositions containing taxane derivatives  
Disclosed are antitumor compositions comprising taxol, taxotere or their derivatives in combination with an anthracycline antibiotic, the combination having a pharmacologic activity greater than...
5877158 Pro-prodrugs, their production and use  
Substrate-spacer-prodrug compounds (pro-prodrugs) suited for site specific delivery of drugs, a process of preparing them and their use are described.
5874412 Bis-anthracyclines with high activity against doxorubicin resistant tumors  
The present invention discloses new and novel bisanthracyclines linked through the saccharide portions. These compounds show high activity against two clinically relevant mechanisms of resistance....
5874423 Digitalis-like compounds  
A human cataractous lens nuclei methanolic extract characterized in that it comprises substances having a molecular weight lower than 3000 daltons, inhibiting ATP hydrolysis by Na + ,K + -ATPase...
5863912 Method of treatment of hormone-unresponsive metastiatic prostate cancer  
Prostate cancer particularly hormone-unresponsive metastatic prostate cancer, is treated by cyclophosphamide or other normally substantially inactive agent. Potentiation of the anti-cancer activity...
5852018 Pharmaceutical piperazine compounds  
Piperazine derivatives of formula (A): ##STR1## wherein - ------- denotes an optional bond, provided that either - --- a - --- and - --- c - --- are both bonds and - --- b - --- and - --- d -...
5840721 Imidazole derivatives as MDR modulators  
The present invention relates to polysubsituted imidazole having formula 1 ##STR1## These compounds are useful for restoring the sensitivity of multidrug resistant cells to cancer chemotherapeutic...
5814608 S-fluoro-anthracyclines, processes for their preparation and pharmaceutical compositions containing them  
8-fluoro-anthracyclines of formula (I) have anti-tumor activity. ##STR1## wherein: R is chosen in the group consisting of H, OH, OR 4 wherein R 4 is chosen in the group consisting of CHO, COCH 3...
5807835 3'-Deamino-4'-deoxy-4'-amino-8-fluoroanthracyclines  
New 8-fluoroanthracycline derivatives of formula I possessing antitumoral properties are described, together with their preparation and pharmaceutical compositions containing them.
5801152 Antracycline disaccharides, process for their preparation, and pharmaceutical compositions containing them  
The present invention is referred to compounds of general formula (I) and (II), respectively ##STR1## their pharmaceutically acceptable salts, the process for their preparation, and the...
5789386 Fluorine-containing anthracycline derivatives having hydroxyl groups(s) mono- or di-o-aminoalkanoylated in the sugar moiety thereof  
To provide novel fluorine-containing anthracycline derivatives having high antitumor activities and a solubility in water, there have now been synthesized a 7-O-(2,6-dideoxy-2-fluoro-3-O- or -4-O-...
5780446 Formulations of vesicant drugs and methods of use thereof  
The present invention relates to methods of treating, as well as preventing extravasation injury. In particular, the present invention pertains to photochemotherapeutic methods of prophylaxis...
5776891 Compositions for reducing multidrug resistance  
The present invention comprises methods and compositions for reducing or eliminating multidrug resistance in cancers or certain infections by drug resistant microorganisms in patients. According to...
5773435 Prodrugs for β-lactamase and uses thereof  
The instant invention relates to a novel method for the delivery of antitumor drugs to tumor cells by the administration of a tumor-selective antibody-β-lactamase conjugate that binds to tumor...
5756475 Isoprene derivatives  
Isoprene derivatives of formula (I) ##STR1## wherein m is an integer of 0 to 3, n is an integer of 5 to 12, A is cyclo(C 3 -C 6 )alkylene, phenylene, fluorenylene, pyrrolidinylene,...
5744455 Reduction of anthracycline-induced cardiotoxicity  
Disclosed is a method for preventing cardiotoxicity in a human in need of such preventive treatment, the method including administering an effective amount of a bisdioxopiperazine. Also disclosed...
5744454 Anthracycline derivatives  
The present invention provides the new use in the manufacture of a medicament for use in the treatment of amyloidosis of an anthracycline of formula A: wherein R1, R2, R3 and X are appropriate...
5744460 Combination for treatment of proliferative diseases  
The invention relates to combinations of PKC-targeted (especially PKC-α-targeted) deoxyribo- and ribo-oligonucleotides and derivatives thereof with other chemotherapeutic compounds, as well as to...
5736523 Antineoplastic heteronapthoquinones  
This invention relates to a naphthoquinone derivatives, to processes and to intermediates for preparing these derivatives, to pharmaceutical composition and to the use of these derivatives as...
5733891 Compound for medicinal ingredient and hyaluronic acid and process for producing the same  
A compound of hyaluronic acid and a medicinal ingredient produced by the convalent bonding (preferably amide bonding) of hyaluronic acid and the medicinal ingredient, and a process for preparing...
5723149 Use of medicago saponins for the preparation of cosmetic or pharmaceutical compositions, especially dermatological compositions, promoting renewal of the epidermis, stimulating hair regrowth or delaying hair loss  
The invention relates to the use of Medicago saponins for the preparation of cosmetic or pharmaceutical compositions. The invention provides for the incorporation of 0.01% to 5% by weight of a...
5710134 Combination of necrosis-inducing substances with substances which are activated by necroses for the selective therapy of tumors and inflammatory disorders  
The invention relates to a combination of substances (component I) inducing necrosis in tumors or inflamed tissue with other nontoxic substances ("prodrugs", component II). The enzymes set free by...
5710135 Anthracycline prodrugs, method for preparation as well as their use in selective chemotherapy  
Anthracycline derivatives are disclosed which are coupled to an enzymatically cleavable N-phenyl-O-glycosyl carbamate spacer group, which derivatives are represented by the formula ##STR1## as well...
5698529 Chemotherapeutic compositions  
Compositions of anti-neoplastic agents incorporate the agent in micelles of at least one block copolymer of poly(oxyethylene)-poly(oxypropylene) in which the ratio of (oxypropylene) blocks to the...
5698528 Substance IT-62-B and medicinal composition containing the same  
A substance IT-62-B represented by the following formula (1): ##STR1## a production process thereof, a medicinal composition comprising the compound as an active component, and methods of treating...
5681812 Methods and compositions for reducing multidrug resistance  
The present invention comprises methods and compositions for reducing or eliminating multidrug resistance in cancers or certain infections by drug resistant microorganisms in patients. According to...
5639735 Antitumor antibiotic compounds: hayumicins and analogs thereof  
Hayumicin compounds, obtainable by cultivation of a strain of Actinomadura sp. designated ATCC 55432, and analogs of these compounds. The novel compounds have antitumor as well as antibiotic,...
5637572 Use of 4'-iodo-4'-deoxydoxorubicin for the treatment of amyloidosis  
The use of 4'-iodo-4'-deoxydoxorubicin and its pharmaceutically acceptable salts in the treatment of amyloidosis is described.
5614557 Method of controlling tumor growth rate  
α-Fluoromethyl- or α-difluoromethylornithine, and certain derivatives thereof, can be used alone or in combination with cytotoxic agents for the treatment of neoplastic diseases.
Matches 101 - 150 out of 297 < 1 2 3 4 5 6 >