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7635694 |
Cyclobutenedione-containing compounds as inhibitors of hepatitis C virus NS3 serine protease
The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
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7615567 |
Compounds and methods for promoting smoking cessation
Compounds and methods for promoting smoking cessation. The compounds may be used to treat a variety of other conditions and disease states.
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7612099 |
Vinylogous acid derivatives
The invention is concerned with vinylogous acids derivatives of formula (I)
wherein A and R 1 to R 6 are as defined in the description and in the claims, as well as physiologically acceptable...
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7605156 |
Methods for the use of inhibitors of cytosolic phospholipase A2
This invention provides methods for the use of substituted indole compounds of the general formula:
and pharmaceutically acceptable salt forms thereof. The invention provides methods for the...
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7592332 |
Cytokine inhibitors
Disclosed are compounds of formula (I)
which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving...
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7582658 |
Bicyclic compound
A novel compound represented by the following formula (1) or a salt thereof:
wherein symbol “A” represents a saturated heterocyclic group, a 5-membered heteroaromatic group having two...
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7579362 |
Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonists
The present invention relates to 1-aza-bicycloalkyl derivatives of formula I,
wherein X is CH 2 or a single bond; Y is a group of formula
and wherein R has the meanings as defined in the...
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7579365 |
Indolyl-3-glyoxylic acid derivatives having antitumor action
The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents
and to a pharmaceutical composition having antitumor action, characterized...
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7576079 |
Viral polymerase inhibitors
An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I:
wherein:
A is O, S, NR 1 , or CR 1 , wherein R 1 is defined herein; represents either a single...
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7572806 |
PPAR active compounds
Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
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7560480 |
Alkyl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
The present invention relates to alkyl-containing 5-acylindolinones of general formula
wherein R 1 to R 3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures...
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7557130 |
Bicyclic heteroaromatic alanines
Compounds of formula (1) are described: in which X is an —O— or —S— atom or —N(R 2 )— group and R 1 is a group Ar 1 L 2 Ar 2 Alk- in which Ar 1 is an optionally substituted aromatic...
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7544685 |
2,3-dihydroindole compounds
The invention relates to compounds of the formula I
wherein the variables are as defined in the claims. The compounds are useful in the treatment of a disease where a D4 receptor and/or a 5-HT...
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7534803 |
Method of treating demyelinating diseases or conditions
N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of...
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7531535 |
Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
The present application describes lactam-containing compounds and derivatives thereof of Formula I:
or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7...
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7524862 |
Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
Alkyne compounds of formula I
wherein A, B, W, X, Y, Z, R 1 , and R 2 have the meanings given herein, which have MCH-receptor antagonistic activity and are useful for preparing pharmaceutical...
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7524871 |
Thrombin inhibitors
Novel thrombin inhibitors of the formula I (I)and pharmaceutically acceptable salts thereof are described wherein the substituents in the description have the specific meanings. The compounds are...
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7504401 |
Anti-cancer agents and uses thereof
The present invention is in the area of novel compounds and salts thereof, their syntheses, and their use as anti-cancer agents. The compounds include compounds of Formula I:
and solvates,...
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7498349 |
Biaryl compounds having anti-infective activity
Aromatic compounds exemplified by exhibit antimicrobial activity.
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7488743 |
Indolin-2-one pyridine derivatives, preparation and therapeutic use thereof
The disclosure concerns indolin-2-one pyridine compounds of general formula (I):
wherein R 0 , R 1 , R 2 , R 3 , R 4 , Z and B have the meanings given in the description, and pharmaceutically...
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7482368 |
Triamide-substituted heterobicyclic compounds
The invention relates to triamide MTP/ApoB inhibitors of the formula 1
wherein R 1 -R 8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and...
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7468380 |
Nitrogen-containing aromatic derivatives
A compound represented by the general formula:
wherein X 1 represents a nitrogen atom or a group represented by the formula —CR 10 ═; X 2 represents a nitrogen atom or a group represented...
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7465718 |
Ansamycins having improved pharmacological and biological properties
Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and...
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7452910 |
Indolyl-3-glyoxylic acid derivatives having therapeutically valuable properties
The invention relates to the use of N-substituted indole-3-glyoxylamides of the general Formula I:
and to pharmaceutical compositions having antitumor action.
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7442702 |
Prostaglandin agonists
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
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7435729 |
Compounds and methods for modulation of estrogen receptors
Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective modulators for...
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RE40525 |
Hepatitis C inhibitor tri-peptides
A racemate diastereoisomer and optical isomer of a compound of formula (I):
wherein B is H, a C 6 or C 10 aryl, C 7-16 aralkyl; Het or (lower alkyl)-Het, all of which may be optionally...
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7425553 |
Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases
The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder...
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7423054 |
Therapeutic pyrazolo[3,4-b]pyridines and indazoles
The present invention provides for compounds of Formula I:
wherein R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X, and L have any of the values defined in the specification, and pharmaceutically...
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7410961 |
2,6-disubstituted piperiddines as modulators
The present invention is further directed to compounds of formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 16 , R 17 , R 18 , R 19 , R 20 , R 21 and R 22 are as...
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7399762 |
Opioid receptor agonist compounds and their use in treatment of pain
Structurally novel opioid receptor agonists are provided, and the use of these agonists in treatment of chronic and/or acute pain.
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7399765 |
Substituted diazabicycloalkane derivatives
Compounds of formula (I)
Z-Ar 1 —Ar 2 (I)
wherein Z is a diazabicyclic...
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7384946 |
M3 muscarinic acetylcholine receptor antagonists
Novel dimeric benzoazabicyclohepatane compounds, pharmaceutical compositions, processes for their preparation and use thereof in treating M 3 muscarinic acetylcholine receptor mediated diseases...
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7375118 |
Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation
The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic....
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7365061 |
2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor...
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7351733 |
Tetrahydrocarbazole derivatives and their pharmaceutical use
The present invention relates to novel compounds that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds.
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7345062 |
Substituted acylhydroxamic acids and method of reducing TNFαlevels
Imido and amido substituted acylhydroxamidic acids which reduce the levels of TNFα and inhibit phosphodiesterase in a mammal. A typical embodiment is...
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7342029 |
Substituted indoles
Compounds of the formula I
are suitable for preparing pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NFκB is involved.
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7338966 |
Substituted oxindole derivatives as tyrosine kinase inhibitors
The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful...
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7329675 |
Substituted azabicyclic compounds
This invention is directed to physiologically active compounds of formula (I)
wherein
represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring
is an...
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7323470 |
Viral polymerase inhibitors
An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I:
wherein wherein A, B, R 2 , R 3 , M 1 , M 2 , M 3 , M 4 , Y 1 and Z are as defined in claim 1 , or...
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7320992 |
Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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7319100 |
Substituted pyrazinones, pyridines and pyrimidines as corticotropin releasing factor ligands
Compounds provided herein are novel substituted pyrazinones, pyridines and pyrimidines of Formula (I) and (II):
Such compounds are particularly useful as CRF receptor ligands, and hence, in the...
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7317027 |
Azaindole-derivatives as factor Xa inhibitors
The present invention relates to compounds of the formula I
wherein R 0 , R 1 , R 2 , R 3 , Q, V, G and M are as defined herein. The compounds of the formula I are valuable pharmacologically...
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7294638 |
Treatment of ADHD
The use of 3-[1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-1,2,3,6-t
etrahydropyridin-4-yl]-6-chloro-1H-indole, any of its enantiomers and pharmaceutically acceptable salts thereof for the...
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7288553 |
Indole derivatives as selective androgen receptor modulator (SARMS)
The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen...
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7285560 |
Indole derivatives or benzimidazole derivatives for modulating IκB kinase
The present invention relates to indole derivatives or benzimidazole derivatives, to processes for preparing such compounds, to pharmaceutical compositions comprising such compounds, and methods...
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7285551 |
Fused-ring compounds and use thereof as drugs
The present invention provides a fused ring compound of the following formula [I]
wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a...
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7256188 |
3-aminoalkyl-2-aryl-indole derivatives and their use as GnRH antagonists
The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use...
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7256187 |
Rifamycin C-11 oxime derivatives effective against drug-resistant microbes
The invention relates to rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms, specifically, the rifamycin derivatives having an oxime...
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