Patents in Class 514/338

Matches 1 - 50 out of 813

Match	Document	Document Title
1	7622497	Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis The present invention is directed to novel derivatives of gambogic acid and analogs thereof. The present invention also relates to the discovery that novel derivatives of gambogic acid are...
2	7615570	Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof Compounds having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein L, A, G, R 1 , R 2 and R 3 are as defined herein. These compounds are...
3	7612098	Amorphous hydrous esomeprazole magnesium A hydrate of esomeprazole magnesium in the form of an amorphous solid is provided. Methods of preparation and use of, as well as formulation containing the hydrate of esomeprazole magnesium in the...
4	7612094	Tri-substituted heteroaryls and methods of making and using the same Compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic...
5	7598273	Inhibitors of the gastric H⁺, K⁺-ATPase with enhanced therapeutic properties Chemical syntheses and medical uses of novel inhibitors of the gastric H + , K + -ATPase for the treatment and/or management of duodenal ulcers, heartburn, acid reflux, other conditions mediated by...
6	7598236	Diazabicyclic central nervous system active agents Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
7	7592357	Compounds Novel Inhibitors of Rho-kinases are disclosed.
8	7569688	Propane-1, 3-dione derivative Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione...
9	7569591	Gyrase inhibitors and uses thereof The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions...
10	7563812	Amorphous esomeprazole hydrate The present invention relates to a novel amorphous form of esomeprazole hydrate, to a process for its preparation and to a pharmaceutical composition containing it. Thus, tetrahydrofuran and water...
11	7560472	Salts of omeprazole and esomeprazole II The present invention relates to new salts of the single enantiomers of omeprazole, i.e. salts of (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methy l]sulfinyl]-1H-benzimidazole...
12	7557138	5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated Kv1.3 potassium channel Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects,...
13	7557129	Cyanopyridine derivatives useful in the treatment of cancer and other disorders This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis...
14	7553857	S-omeprazole magnesium The present invention discloses a process for preparing a magnesium salt of S-omeprazole. The S-omeprazole salt preferably has a water content below about 4.8% by weight, a magnesium content of...
15	7553856	Crystalline form of omeprazole A novel crystalline form of the substrate known under the chemical name 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sul finy]-1H-benzimidazole, and having the generic name omeprazole,...
16	7553854	6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of...
17	7553848	Vanilloid receptor ligands and their use in treatments bis-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster...
18	7547722	Chemical compounds The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, which are useful as...
19	7531558	Carboxamide derivatives Compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein P, W, X, Y, R 2 , R 3 , r and s are as defined in the specification, processes for preparing...
20	7528158	Indazolone derivatives useful as 11b-HSD1 inhibitors Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 7 have the significances given in the description and claims can be used in the form...
21	7524862	Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds Alkyne compounds of formula I wherein A, B, W, X, Y, Z, R 1 , and R 2 have the meanings given herein, which have MCH-receptor antagonistic activity and are useful for preparing pharmaceutical...
22	7517897	Derivatives of 6,7-dihydro-5h -imidazo[1,2-a] imidazole-3-sulfonic acid Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of...
23	7517894	VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridinamides, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis, as well as...
24	7511065	Mixed lineage kinase modulators The present invention provides a compound of the formula: (Formula I); or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of...
25	7511056	TGF-β inhibitors The present invention is directed to inhibitors of TGF-β of Formula I:
26	7498349	Biaryl compounds having anti-infective activity Aromatic compounds exemplified by exhibit antimicrobial activity.
27	7495015	Indazole derivatives and methods for using the same Compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein m, k, B, R 1 , R 2 and R 3 are those defined herein, and compositions comprising the...
28	7494983	Ophthalmic compositions for treating ocular hypertension This invention relates to potent potassium channel blocker compounds of structural Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated...
29	7491738	Pest control agents There is provided a pest control agent comprising a compound represented by formula (I) as active ingredient.
30	7482367	Substituted benzimidazoles and methods of their use New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments,...
31	7482344	Tricyclic steroid hormone nuclear receptor modulators The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula I in...
32	7482342	Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors Compound corresponding to general formula (I): in which, R 1 represents a hydrogen or halogen atom, an NH 2 , NHR 2 , NHCOR 2 , NO 2 , CN, CH 2 NH 2 and CH 2 NHR 2 ; or alternatively R 1 ...
33	7479500	Antidepressant piperidine derivatives of heterocyclefused benzodioxans Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder,...
34	7470712	Amino-benzazoles as P2Y₁receptor inhibitors The present invention provides novel amino-benzazoles and analogues thereof, which are selective inhibitors of the human P2Y 1 receptor. The invention also provides for various pharmaceutical...
35	7446122	Substituted indole derivatives Provided herein are indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
36	7442702	Prostaglandin agonists This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
37	7439258	Viral polymerase inhibitors A compound of the formula I: wherein: X is CH or N; Y is O or S; Z is OH, NH 2 , NMeR 3 , NHR 3 ; OR 3 or 5- or 6-membered heterocycle, having 1 to 4 heteroatoms selected from O, N and S, said...
38	7427414	Modified release oral dosage form using co-polymer of polyvinyl acetate Once a day modified release oral dosage form comprising of granules or pellets which are either compressed into tablet or filled inside the capsule, wherein the pellet has a core of active...
39	7423054	Therapeutic pyrazolo[3,4-b]pyridines and indazoles The present invention provides for compounds of Formula I: wherein R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X, and L have any of the values defined in the specification, and pharmaceutically...
40	7411070	Form of S-omeprazole The present invention relates to a novel form of the (−)-enantiomer of 5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sul finyl]-1H-benzimidazole, i.e. S-omeprazole. More specifically,...
41	7410982	Propanamine derivatives as serotonin and norepinephrine reuptake inhibitors There is provided a heretoaryloxy/thio 3-substituted propanamine compound of formula (I) wherein A is selected from —O— and —S—; X is selected from phenyl optionally substituted with up to...
42	7410981	Prodrugs of imidazole derivatives, for use as proton pump inhibitors in the treatment of e.g. peptic ulcers An imidazole compound represented by the formula (I), a salt thereof and a compound of the formula (V), which is one of the intermediates thereof. wherein each symbol is as defined in the present...
43	7410980	Crystals of taxane derivative and process for their production A crystal of (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-9,10-[ (1S)-2-(dimethylamino)ethylidenedioxy]-5,20-epoxy-1-hydroxyt ax-11-en-13-yl...
44	7402597	Activator of peroxisome proliferator-activated receptor δ A compound represented by the formula (I) or a salt of the compound, and a PPAR-δ activator which contains the compound or salt as the active ingredient: (wherein A represents O or S; B 1 ...
45	7399772	Substituted benzimidazole dosage forms and method of using same The present invention relates to pharmaceutical preparations comprising substituted benzimidazole proton pump inhibitors. There is provided a liquid or solid pharmaceutical composition consisting...
46	7399765	Substituted diazabicycloalkane derivatives Compounds of formula (I) Z-Ar 1 —Ar 2 (I) wherein Z is a diazabicyclic...
47	7396841	Injections An injectable composition comprises a benzimidazole compound having an antiulcer action and a strong alkali (e.g., an alkali metal hydroxide such as sodium hydroxide) in a proportion of about 1...
48	7393867	Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase I The present invention discloses and claims compounds of formula (I) and formula (II), as inhibitors of human casein kinase Iε and methods for using said compounds for treating central nervous...
49	7393866	Amide compounds and medications containing the same The present invention provides to a novel compound having an ACAT inhibiting activity. The present invention relates to compounds represented by formula (I) wherein represents an...
50	7381734	Serine protease inhibitors Compounds of formula (I) where R 5 , R 6a , each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents.

Matches 1 - 50 out of 813

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