|
Match
|
Document |
Document Title |
|
|
5861429 |
13-substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests
Compounds of formula (I): ##STR1## wherein: R 1 is methyl, ethyl, isopropyl or sec-butyl; X is carbonyl or methylene; Z is īCī(R 2 ) 2 or īCī(CH 2 ) m , in which R 2 is alkyl, and m is...
|
|
|
5861421 |
4,4-(disubstituted) cyclohexan-1-one monomers and related compounds
This invention relates to derivatives of 4,4-(disubstituted)cyclohexan-1-ones and related compounds which are useful for treating allergic and inflammatory diseases.
|
|
|
5859030 |
Substituted arylalkylthioalkylthiopyridines for use in the control of helicobacter bacteria
A compound of the formula I ##STR1## Wherein all the variables are defined in the specification. The compounds are used for controlling Helicobacter bacteria.
|
|
|
5852011 |
Benzimidazole derivatives
Disclosed are compounds represented by the following chemical formula (I) and pharmacologically acceptable salts thereof which are novel compounds useful as anticancer agents, antiviral agents or...
|
|
|
5843968 |
Symmetrical bis-heteroarylmethoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis
Compounds having the formula: ##STR1## wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted...
|
|
|
5840737 |
Omeprazole solution and method for using same
A pharmaceutical composition includes an aqueous solution/suspension of omeprazole or other substituted benzimidazoles and derivatives thereof in a pharmaceutically acceptable carrier comprising a...
|
|
|
5830895 |
Methods for the determination and adjustment of prolactin daily rhythms
Methods for detecting abnormalities in prolactin daily rhythms of a subject are provided. Prolactin levels of a subject are compared to levels of healthy subjects and based on the comparison a...
|
|
|
5811426 |
Urea and thiourea derivatives of azolones
The invention is concerned with the compounds having the formula ##STR1## the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X is O or S; Y is...
|
|
|
5780493 |
AMPA antagonists and method of treatment therewith
The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R 1 is hydrogen, alkyl or benzyl; X is O or NOR 2 , wherein R 2 is...
|
|
|
5776932 |
1,3,5-tribsubstituted indazole derivatives, processes for preparing, and for pharmacological treatment therewith
1,3,5-trisubstituted indazole derivatives of the formula ##STR1## wherein R1 is H, (b) a C 1 -6 straight or branched, substituted or unsubstituted alkyl residue, (c) a C 3 -7 cycloalkyl residue,...
|
|
|
5773451 |
Substituted arylthioalkylthiopyridines
Described are compounds of formula (I) in which R1,R2,R3,R4,R5,R6,R7, m,n,p, and q are as defined in the description. Such compounds are suitable for use against Helicobacter bacteria. ##STR1##
|
|
|
5773434 |
Facilitation of AMPA receptor-mediated synaptic transmission in brain as a treatment for schizophrenia
Psychotic symptoms are treated by the administration of drugs which amplify the ability of natural stimulators of AMPA receptors to enhance the mediation of excitatory synaptic response. What is...
|
|
|
5770598 |
Heterocyclic compounds
The present invention relates to heterocyclic compounds which have been found to have anti-tumour activity. More specifically, the invention concerns Pyrrolo 3,2-b! carbazoles, 1H-Benzofuro ...
|
|
|
5767121 |
Pyridine derivatives, their production and use
There is disclosed a pharmaceutical composition for providing antiinflammatory, antipyretic, analgesic, antiallergic, immunosuppressing or immunomodulating activity which comprises a pyridine...
|
|
|
5767118 |
4-Heterocyclic peperidines promote release of growth hormone
The present invention is directed to certain novel compounds identified as 4-heterocycle substituted piperidines of the general structural formula: ##STR1## wherein R 1 , R 4 , R 5 , A, R 3 and...
|
|
|
5756532 |
Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives
The compounds of formula I: ##STR1## wherein R 1 and R 2 are, independently, hydrogen, alkyl, phenyl or benzyl; or R 1 and R 2 , taken together, are benzylidene optionally substituted with R 3 ...
|
|
|
5753660 |
Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
Selected sulfonylalkanoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention...
|
|
|
5731002 |
Veterinary composition
A stable, oral pharmaceutical composition comprising a proton pump inhibitor and a gelling agent designed for the treatment of gastric acid related diseases in animals, the process for preparation...
|
|
|
5728709 |
Alkyl and aralkyl-substituted pyrrolocarbazole derivatives that stimulate platelet production
Described herein is a pyrrolocarbazole derivative and a pharmaceutically acceptable salt thereof having the following formula (I): ##STR1## wherein R 1 is lower alkyl or aralkyl; R 2 is hydrogen,...
|
|
|
5728717 |
Pyridiniminyl-1,2-benzisothiazoles
Novel pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing...
|
|
|
5726195 |
Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents
Certain novel aminoacyl adenylate mimics are described. An exemplary compound of this invention is S-(R*,R*)!-3,6-anhydro-1,2-dideoxy-1- 5- 4- (5-nitro-2-thienyl)ethynyl!ph...
|
|
|
5723484 |
Benzopyran compounds as 5-HT.sub.2C receptor antagonists
Compounds of formula (I): ##STR1## in which: n represents 1 or 2, R 1 represents hydrogen or alkyl, benzyl, acetyl, benzoyl, allyl, pyridinecarbonyl, pyridinemethyl, acylaminoalkyl (optionally...
|
|
|
5719182 |
Endothelin receptor anatagonists
Novel indane and indene derivatives are described which are endothelin receptor antagonists.
|
|
|
5714498 |
Benzimidazole derivatives
The invention is directed to substituted benzimidazole compounds which are ligands for dopamine receptor subtypes used in the treatment of the dopamine system.
|
|
|
5714504 |
Compositions
The novel optically pure compounds Na + , Mg 2 +, Li + , K + , Ca 2 + and N + (R) 4 salts of (+)-5-methoxy-2- (4-methoxy-3,5-dimethyl-2-pyridinyl)methyl!sulfinyl!-1H- benzimidazole or...
|
|
|
5714505 |
Method for treatment of psoriasis, by omeprazole or related compounds
A method for treatment of psoriasis is disclosed comprising administration of a therapeutically effective dosage of omeprazole.
|
|
|
5712295 |
Agonists and antagonists of the nicotinic acetylcholine receptors of insects to control endoparasites
Use of agonists and antagonists of the nicotinergic acetylcholine receptors of insects for combating endoparasites is disclosed.
|
|
|
5710164 |
Diheterocyclic styryl nitriles
Disclosed herein are compounds of the formula: ##STR1## where Ar 1 and Ar 2 are, independently, pyridinyl, quinolinyl, 1,4-benzodioxanyl, dihydro-1,4-benzodioxanyl, pyrrolyl, azaindolyl or...
|
|
|
5708013 |
Pyridine derivative and therapeutic agent for ulcer comprising the same
A pyridine compound having the formula is disclosed and useful to treat the peptic ulcer. ##STR1## wherein R 1 and R 2 which may be the same or different are each a hydrogen atom, a lower alkyl...
|
|
|
5706829 |
Method for treating neurocardiogenic syncope
The present invention relates to methods for treating neurocardiogenic syncope. The method involves administering to a patient an effective amount of a compound having the formula: ##STR1## wherein...
|
|
|
5703097 |
5-pyrrolyl-2-pyridylmethylsulfinyl benzimidazole derivatives
The present invention relates to a novel compound 5-pyrrolyl-2-pyridylmethylsulfinylbenzimidazole derivative having general formula (I) and its salt, ##STR1## wherein all variables are as defined...
|
|
|
5696136 |
Method of treating psychosis using azaheterocyclylmethyl
A method of treating psychosis by administering to a patient an azaheterocyclylmethyl-chroman of the formula: ##STR1## in which E represents an azaheterocyclyl group selected from the group...
|
|
|
5696137 |
Azaheterocyclymethyl-chromans
Azaheterocyclylmethyl-chromans of the formula: ##STR1## in which E represents an azaheterocyclyl group selected from the group consisting of: ##STR2## wherein R 6 represents hydrogen, hydroxyl,...
|
|
|
5693633 |
Angiotensin II antagonists
This invention provides novel heterocyclic derivatives, their pharmaceutical formulations, and their use for antagonizing angiotensin II receptors in mammals.
|
|
|
5693653 |
Method of treating depression using azaheterocyclylmethyl-chromans
Azaheterocyclylmethyl-chromans are prepared by reaction of corresponding methylchromans with corresponding azaheterocyclic compounds, optionally with subsequent variation of the substituents. The...
|
|
|
5691360 |
Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents
Compounds having both calcium antagonist and antioxidant activity are disclosed. The compounds are useful in preventing or alleviating damage to tissues at the cellular level. Methods of treatment...
|
|
|
5691361 |
1,4-dihydropyridine derivatives, a process for their preparation and their use for influencing the blood flow
The invention relates to new 1,4-dihydropyridine derivatives of the general formula I ##STR1## in which R 1 , R 2 , R 3 and n have the meaning stated in the patent claims. The compounds of the...
|
|
|
5688809 |
5-heteroarylindole derivatives
The present invention relates to compounds of the formula ##STR1## The present invention also relates to intermediates for the preparation of compounds of the formula I, pharmaceutical compositions...
|
|
|
5686470 |
2, 3-substituted pyridines for the treatment of inflammation
A class of substituted pyridyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II ##STR1##...
|
|
|
5686484 |
Milbemycin derivatives, their preparation and their use
Compounds of formula (I): ##STR1## and of formula (I) w : ##STR2## in which: A represents group having one of the following formulae: ##STR3## wherein R 2 , R 3 and R 4 are independently...
|
|
|
5681836 |
Methanesulfonate salts of antipsychotic benzofuran derivatives
The methanesulfonate salt of a class of antipsychotic compounds comprising a benzo b!furan moiety and a substituted heterocyclic moiety, linked via the 3-position of the benzo b!furan moiety by a...
|
|
|
5679670 |
Sulfonamides useful as carbonic anhydrase inhibitors
Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration...
|
|
|
5677302 |
Thiadiazole compounds useful as proton pump inhibitors
Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H + /K + -ATPase. The compounds...
|
|
|
5670530 |
Anti-cancer composition comprising rhodacyanine compound and cyclodextrin
An anti-cancer composition comprising a rhodacyanine compound and cyclodextrin or derivative thereof, wherein said rhodacyanine compound is selected from the group consisting of compounds...
|
|
|
5668131 |
Substituted aminoalkylaminopyridines
Compounds of formula I ##STR1## wherein R1, R2, R3, R4, R5, R6, X, n and A have the meanings as given in the description, can be used for combatting Helicobacter bacteria.
|
|
|
5665722 |
Benzofuran derivatives as D.sub.4 receptor antagonists
A class of chemical compounds comprising a benzo [b] furan moiety and a substituted heterocyclic moiety, linked via the 3-position of the benzo [b] furan moiety by a methylene group, are...
|
|
|
5665737 |
Substituted benzoxazoles
Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improved PDE IV inhibition as compared to theophylline or rolipram, with improved selectivity with regard...
|
|
|
5663191 |
Benzopyran compounds as 5HT.sub.2C receptor antagonists
Compounds of formula (I): ##STR1## in which: n represents 1 or 2, R 1 represents hydrogen or alkyl, benzyl, acetyl, benzoyl, allyl, pyridinecarbonyl, pyridinemethyl, acylaminoalkyl (optionally...
|
|
|
5643926 |
Pyrazolidinone CCK and gastrin antagonists and pharmaceutical formulations thereof
Novel substituted pyrazolidinones have been found to exhibit significant binding to cholecystokinin (CCK) receptors and gastrin receptors in the brain and/or peripheral sites such as the pancreas,...
|
|
|
5635520 |
Anti-ulcer compositions suitable for rectal administration
The present invention relates to a composition for rectal administration which comprises a benzimidazole compound having antiulcer activity and a salt of C 6 -20 fatty acid, both of which are...
|