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6162816 |
Crystalline form of the S-enantiomer of omeprazole
The invention provides S-omeprazole in a neutral form characterised in that it is in a solid state, preferably in a partly crystalline or substantially crystalline state, such as form A or form B....
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6159968 |
Activation of chloride channels for correction of defective chloride transport
This invention provides a method for increasing the permeability of epithelial cells to a chloride ion in a subject comprising administering a permeability enhancing amount of a composition...
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6150380 |
Crystalline form of omeprazole
The present invention relates to a novel crystalline form of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sul
finyl]-1H-benz imidazole, known under the generic name omeprazole. Further,...
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6150379 |
Compounds and compositions as anticoagulants
The present invention relates to novel biheterocyclic derivatives which are factor Xa inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and...
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6127389 |
Benzimidazole derivatives as bradykinin agonists
This invention relates to compounds of formula: ##STR1## wherein R 6 , R 7 , R 2 , R 2 , R 3 and A 1 are as defined in the disclosure; and pharmaceutically acceptable salts thereof, to processes...
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6110935 |
Benzofurazan compounds for enhancing glutamatergic synaptic responses
Compounds of the general structural formula ##STR1## are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of...
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6107312 |
Thiopyridines for use in the control of helicobacter bacteria
Thiopyridines of formula (I) ##STR1## in which the substituents and symbols are as defined in the specification are suitable for use in controlling Helicobacter bacteria. They are compounded into...
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6103734 |
Drug combination as a medicament to suppress the dependence of individuals to opiates
Combination of chemical compounds used as a medicament intended to suppress the dependence of individuals to opioids, the combination comprising a laxative or enema of irrigation, repeated doses of...
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6093735 |
Selective β-3 adrenergic agonists
The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective β3 adrenergic...
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6093738 |
Proton pump inhibitors
Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H + /K + -ATPase. The compounds...
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6090828 |
5-aryleheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders
A class of 5-arylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds is described for use in treatment of circulatory disorders such as hypertension. Compounds of particular interest are...
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6090827 |
Pharmaceutical formulation of omeprazole
An enteric coated oral pharmaceutical formulation comprising as active ingredient a compound selected from the group of omeprazole, an alkaline salt of omeprazole, the (-)-enantiomer of omeprazole...
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6087380 |
Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions
New disubstituted bicyclic heterocycles of general formula R a --A--Het--B--Ar--E (I) Compounds of the above general formula I, wherein E denotes an R b ...
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6083960 |
Constrained somatostatin agonists and antagonists
The present invention relates to a compound of general formula I ##STR1## for treating medical disorders related to binding to human somatostatin receptor subtypes.
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6060487 |
Indanol compounds
A compound of formula (I): ##STR1## wherein R 1 , R 2 , R 3 , R 4 , X--Y, A, Z and Z' are as defined in the description, in the form of the cis or trans isomers each in racemic or optically active...
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6051570 |
Benzimidazole derivatives as antiulcer agents, process for their preparation and pharmaceutical compositions containing them
This invention particularly relates to novel pyridylmethylsulfinyl benzimidazole represented by the general formula (I), its tautomers, its derivatives, its analogs, its stereoisomers, its...
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6043257 |
Amidinoindoles, amidinoazoles, and analogs thereof
The present application describes amidinoindoles, amidinoazoles, and analogs thereof of formula I: ##STR1## wherein W, W 1 , W 2 , and W 3 are selected from CH and N, provided that one of W 1 and...
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6043240 |
3-heteroaryl-1-pyrrolidinealkylamines and derivatives thereof and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents the compounds are especially useful for treating psychoses by administering to a mammal a...
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6040327 |
Benzimidazole, benzoxazole and benzothiazole compounds
A compound of formula (I): ##STR1## wherein: R 1 represents halogen or a different group as defined in the description, Ra and Rb, which mnay be identical or different, represent hydrogen,...
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6017916 |
Nonpeptide endothelin antagonists I
Novel nonpeptide antagonists of endothelin I are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of...
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6011039 |
Aminopyridine derivatives
A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for hyperphagia, obesity or diabetes, which comprises such a compound or...
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6004997 |
Trioxane dimer compounds having antiproliferative and antitumor activities
Novel trioxane dimers of structure ##STR1## which possess antiproliferative and antitumor activities.
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5997884 |
Compositions and method for treating migraine
An aqueous solution of droperidol suitable for injection having a concentration from about 0.1 to about 10.0 mg/ml, and a sufficient amount of tonicity adjusting agent to render the solution...
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5998445 |
Pyridine derivatives having anti-ulcerative activity
Pyridine derivatives useful for preventing or treating peptic ulcers, pharmaceutical preparations and methods of treating peptic ulcers are described.
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5990134 |
Oral droperidol compositions and method for treating migraine
Oral dosage form of droperidol are provided and a method for treating migraine using such oral formulations. The dosage forms include tablets, capsules, powders, effervescent formulations and syrups.
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5985877 |
Combination of tyrosine kinase inhibitor and chemical castration to treat prostate cancer
A method of treating prostate cancer by co-administering a tyrosine kinase inhibitor such as an indolocarbazole and a chemical castration agent is disclosed. A composition containing a tyrosine...
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5981552 |
Sublingual and buccal compositions of droperidol and method for treating migraine
Sublingual and buccal dosage forms of droperidol are provided in a method for treating migraine using such formulations.
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5981551 |
2,5-diimino-3a,6a-diaryl-1,2,3,3a,4,5,6,6a-octahydroim idazo[4,5-d]imidazoles which are effective as G-CSF mimetics
Described herein are substituted 2,5-Diimino-3a,6a-diaryl-1,2,3,3a,4,5,6,6a-octahydroimidazo[
4,5-d]imidazol es of formula (I), wherein R 1 , R 2 , R 3 and R 4 are defined therein, pharmaceutical...
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5977110 |
Substituted cyclohexylamines as central nervous systems agents
Substituted cyclohexylamines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents...
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5977145 |
Method of treating migraine
Intravenous or intramuscular injection of droperidol is disclosed to treat migraine episodes.
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5972969 |
Methods of combatting infectious disease using dicationic bis-benzimidazoles
The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a...
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5965582 |
N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect
The N-benzylindole- and benzopyrazole derivatives of the general formula 1 ##STR1## possess anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effect and are suitable for the...
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5958953 |
Substituted indazole derivatives
The invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof, wherein the broken line in formula I indicates a single or double bond, and wherein R, R...
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5948789 |
Process for synthesis of substituted sulphoxides
A novel process for enantioselective synthesis of single enantiomers of omeprazole or its alkaline salts, of other optically pure substituted 2-(2-pyridinylmethyl-sulphinyl) -1H-benzimidazoles as...
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5948797 |
Trisbenzimidazoles useful as topoisomerase I inhibitors
The present invention provides anti-neoplastic topoisomerase I inhibitors of the formula: ##STR1## wherein Ar is (C 6 -C 12)aryl or (6- to 12-membered) heteroaryl comprising 1-3 N, S or...
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5948798 |
Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles
Novel pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing...
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5942535 |
a!-Annelated pyrrole derivatives and pharmaceutical use thereof
The present invention relates to heterocyclic compounds of the formula ##STR1## in which R 1 -R 7 , B, a and X have the meanings recited in the specification. These compounds are usable in the...
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5932520 |
Use of pyrrole compounds as antifouling agents
There is provided a method for controlling or combatting the attachment of a fouling organism to an underwater surface which comprises contacting said organism with an antifouling-effective amount...
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5929097 |
Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-α...
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5922725 |
Benzimidazole compounds and their use as modulators of the GABA.sub.A receptor complex
The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R 3 is ##STR2## wherein A, B and D each is...
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5919799 |
Imidazothiazole compound
An imidazothiazole compound having the formula (A): ##STR1## wherein R 1 is a phenyl or napthyl which may have a substituent, R 2 is an acyl, and the two bonds at dotted line portions may or may...
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5900424 |
Omeprazole magnesium salt form
A novel compound form of magnesium omeprazole useful in the manufacture of pharmaceutical formulations, the use of the product and the process for its production are described.
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5895649 |
Method for treating neurogenic red skin blotches with compositions containing TNF-alpha antagonists
Topically applicable pharmaceutical/dermatological/cosmetic compositions, well suited for the therapeutic treatment of neurogenic red skin blotches and rosacea afflicting the skin, scalp and/or...
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5889035 |
1-(Arylthioalkyl, arylaminoalkyl or arylmethylenealkyl)-3-(heteroaryl) pyrrolidines and related compounds useful as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5888535 |
Methods and compositions for treating gastric disorders using optically pure (-) pantoprazole
Methods and compositions are disclosed utilizing optically pure (-) pantoprazole for the treatment of ulcers in humans while substantially reducing the concomitant liability of adverse effects...
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5877192 |
Method for the treatment of gastric acid-related diseases and production of medication using (-) enantiomer of omeprazole
A method for treatment of gastric acid related diseases by inhibition of gastric acid secretion comprising administering to a mammal in need of treatment a therapeutically effective amount of the...
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5869490 |
Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one
The compounds of formula I: ##STR1## wherein X is H 2 or O; R 1 is hydrogen, hydroxy, halo, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy, aralkoxy, alkanoyloxy, amino, mono- or...
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5861424 |
Composition and method for treating cancer
A pharmaceutical composition for treatment of cancer in a mammal comprising: (A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds...
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5861420 |
N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders
A class of N-arylheteroarylalkyl imidazol-2-one compounds is described for use in treatment of circulatory disorders such as hypertension and congestive heart failure. Compounds of particular...
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5861407 |
Tetrahydropyridine derivatives as dopamine receptor subtype ligands
A class of substituted 1,2,3,6-tetrahydropyridine derivatives are disclosed that are ligands for dopamine receptor subtypes within the body. These compounds are therefore useful in the treatment...
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