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4767769 |
Antiulcer benzimidazole derivatives
Compounds of formula I ##STR1## in which R 1 and R 2 , which may be the same or different, are hydrogen, a C 1 to C 3 alkyl group or R 1 and R 2 together with the nitrogen to which they are...
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4766133 |
(Bezimidazol-2-yl)-pyridinium compounds
(Benzimidazol-2-yl)-pyridinium compounds of the formula ##STR1## wherein A is --SR 9 , --SO 3 - or --S--SO 3 - ; R 1 and R 3 each is hydrogen or (C 1 -C 7 )-alkyl; R 2 is hydrogen, (C 1 -C...
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4760068 |
Certain pyridyl alkenoic acid derivatives which inhibit the action of thromboxane A.sub.2 synthetase
Novel compound of the formula: ##STR1## wherein R 1 is pyridyl group, R 2 is a phenyl group, a thienyl group, a furyl group, a naphthyl group, a benzothienyl group or pyridyl group, which may...
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4760057 |
(Acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs
This invention relates to novel (acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs having a primary or secondary amine function...
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4758579 |
Fluoroalkoxy substituted benzimidazoles useful as gastric acid secretion inhibitors
Dialkoxypyridines of formula I ##STR1## wherein R1 is 1-3C-alkyl which is completely or predominantly substituted by fluorine, or a chlorodifluoromethyl radical and R1' is hydrogen, halo,...
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4758576 |
Pyridine derivatives and use as histamine H.sub.2 antagonists
This invention relates to 2-pyridine derivatives substituted in the 4-position with a dialkylamino- or piperidinyl- or pyrrolidinylallyl group. The compounds have histamine H 2 -antagonist activity.
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4757081 |
1,2,6-triphenyl-4(1H)-pyridinone derivatives, and uses as fungicidal agents
New substituted derivatives of 1,2,6-triphenyl-4(1H)-pyridinone are now provided, which are useful as fungicidal agent having practically valuable and improved fungicidal activities against a...
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4757080 |
1,4-dihydropyridine derivatives
New compounds which act on the cardiac circulation and correspond to the general formula ##STR1## and may be used for the treatment of cardiac diseases, in certain forms of hypertension and in...
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4753955 |
Benzimidazole derivatives
Benzimidazole derivatives of the general formula [I] are provided: ##STR1## wherein R 1 is hydrogen, methyl or methoxy, and R 2 and R 3 each is hydrogen or methyl, at least one of R 1 , R 2 and...
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4749698 |
Antihypertensive derivatives
Compounds having the general structure ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are defined herein, which exhibit antihypertensive activity.
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4746669 |
Substituted thiazoles as immunoregulants
Thiazole derivatives have been made, for example, by reacting a 2-aryl-2,2-dialkoxyethylamine with an appropriately substituted aryl acetyl halide followed by treating the resulting amide with...
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4746667 |
Pharmaceutical composition containing 2-(2-benzimidazolyl thiomethyl) pyridine
A pharmaceutical preparation containing as active ingredient a compound of the formula ##STR1## or a therapeutically acceptable salt thereof in which formula R 1 and R 2 are the same or different...
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4745125 |
Antiulcer benzimidazoles
Antiulcer amino-benzimidazole compounds substituted on the nitrogen; these compounds correspond to the following general formula: ##STR1## in which the various substituents are defined hereinbelow.
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4738974 |
Base addition salts of omeprazole
Novel salts of omeprazole with Li + , Na + , K + , Mg 2 +, Ca 2 +, Ti 4 +, N + (R 1 ) 4 or ##STR1## as cation; processes for their preparation thereof, pharmaceutical compositions containing such...
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4738975 |
Pyridine derivatives, and use as anti-ulcer agents
The compound of the formula ##STR1## wherein R 1 is hydrogen, fluorine, methoxy or trifluoromethyl, R 2 is a C 1 -8 alkyl, R 3 is a C 1 -8 alkyl which may be fluorinated, and n is 0 or 1, or a...
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4735956 |
Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers
Novel substituted 4-heteroaryl-1,4-dihydropyridine compounds useful as calcium channel blockers, pharmaceutical compositions therof, and methods of treatment are disclosed.
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4735955 |
2-substituted cycloheptoimidazole derivatives and anti-ulcerative agents containing the same
Derivatives of 2-substituted-cycloheptoimidazole are disclosed, which are represented by the following formula: ##STR1## wherein R is a hydrogen atom, a lower-alkyl, acetyl, lower-alkylaminoalkyl...
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4732898 |
2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
The present invention are 2-(2-aryl-2-oxo-alkylidene) analogs of 1,2,3,4-tetrahydropyridine-3,5-pyridinecarboxylic acids and particularly esters thereof having valuable calcium antagonist and...
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4730003 |
Tricyclic compounds for treating heart and circulatory diseases
The present invention provides compounds of the general formula: ##STR1## wherein the various substituents are defined hereinbelow. The compounds are used for the treatment and/or prophylaxis of...
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4728662 |
1,2-benzisoxazoloxyacetic acids and related compounds
Novel 1,2-benzisoxazoloxyacetic acids and related compounds, methods for preparing same and methods of treatment by administering compositions containing such a compound are described. These...
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4727072 |
3-alkoxy-2-aminopropylamines compositions and use as cardiovascular agents
Propylamines of the formula (I): ##STR1## and isomers thereof, particularly those enantiomers and racemates relative to the chiral carbon indicated by an asterisk (*). The propylamines can be used...
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4725602 |
Acetylene amines and their use as vasodilators and antihypertensives
Acetylenes of the following formula (I): ##STR1## wherein Y, m, R 1 , R 2 , R 3 , n and R 4 are defined herein and R 5 is hydrogen, alkyl, cycloalkyl or substituted alkyl are useful vasodilators...
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4722930 |
3-benzoyl-1-[(oxo or thioheteroaryl-ylalkyl)-piperid-4-yl]ureas and derivatives
The invention concerns the preparation of compounds of formula ##STR1## and acid addition and quaternary ammonium salts thereof, wherein the dotted line represents an optional bond, Ar represents a...
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4722931 |
Calcium antagonist
The invention concerns a compound of the formula ##STR1## and salts thereof resulting from addition with pharmaceutically acceptable mineral or organic acid, wherein R is an alkylenedioxy group...
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4721712 |
1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also on the carboxamide nitrogen atom, are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO)...
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4708952 |
Method of treatment of the infectious and viral diseases by one time interference
A composition adapted to prolong the residence time of sulfa and cinchona alkaloid drugs in the circulating plasma of mammals including humans comprising hexanoic acid, potassium hydrogen tartrate,...
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4705797 |
N-(3,3-diphenylpropyl) aminoethyl esters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid, compositions and use
Novel antihypertensive and coronary dilating asymmetric diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid (or the stereoisomers or pharmaceutically acceptable acid addition salts...
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4704390 |
Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
Novel phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy benzheterocyclic compounds are described which have valuable neuroleptic properties by virtue of their dopamine autoreceptor...
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4703044 |
Imidazoquinolines containing other heterocyclic groups, useful as anti-ulcer or anti-secretory agents
The invention provides novel imidazoquinolines, processes for their preparation and pharmaceutical compositions containing them. The compounds have Formula I ##STR1## wherein A is a C 1 -C 4 ...
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4698351 |
Tetrahydrocarbazole derivatives and pharmaceutical compositions
Tetrahydrocarbazole derivatives of the general formula I ##STR1## in which Thc is a 1,2,3,4-tetrahydro-3-carbazolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl,...
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4696939 |
Benzothiadiazole compounds for treating hypertension
Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.
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4696938 |
Insecticidal 6-aryl-pyridine thiosemicarbazones
This invention relates to novel insecticidal 6-aryl-pyridine-thiosemicarbazones, compositions containing those compounds, methods of using said compounds and compositions.
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4695571 |
Tricyclic oxindole antiinflammatory agents
Tricyclic oxindole carboxamides, prepared by (a) reaction of an isocyanate with the basic ring system or (b) ammonolysis of a corresponding alkyl ester, are non-steroidal antiinflammatory agents...
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4694004 |
Semicarbazide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
A compound of the formula: ##STR1## wherein R 1 is hydrogen, R 2 is hydrogen, lower alkyl, ar(lower)alkyl, lower alkenyl or aryl, R 3 is lower alkyl, ar(lower)alkyl, lower alkenyl or aryl,...
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4694013 |
Insecticidal and acaricidal phenoxypyrdinyl esters and intermediates
Insecticidal and acaricidal organic esters formed from pyrethroid carboxylic acids and phenoxypyridinyltrifluoroethanols, agricultural compositions containing said esters and their use against...
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4689331 |
Substituted 2-pyridinyl benzimidazoles, and their use for inhibiting gastric acid secretion
Novel compounds of the formula I ##STR1## and its salts; process for the preparation thereof, pharmaceutical compositions containing such compounds and their use in medicine to affect gastric acid...
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4686217 |
Calcium antagonist 2-fluoroalkyl-1,4-dihydropyridines
There are described compounds of formula I, ##STR1## in which R 1 represents benzofurazanyl, pyridyl or phenyl, the pyridyl or phenyl being substituted, --COOR 2 and --COOR 3 are various...
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4686230 |
Picoline derivative useful as gastric acid secretion inhibitors
Picoline derivatives of the formula I ##STR1## wherein the substituents have the meanings given in the description, and their salts are new compounds having a pronounced protective action on the...
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4684664 |
Derivatives of β-(4-isocyano-1,2,3,4-diepoxycyclopentyl) acrylic acid
Disclosed herein are derivatives of β-(4-isocyano-1,2,3,4-diepoxycyclopentyl)acrylic acid, the derivatives showing an antibacterial activity, an antifungal activity and an antimycoplasmal activity.
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4684658 |
Anti-thrombotic ortho-condensed pyrrole derivatives, compositions, and method of use therefor
The invention provides novel pyrrole derivatives of formula: ##STR1## in which R'=H, alkyl or phenyl optionally substituted by halogen, alkyl, alkyloxy or alkylthio, Z=0 or S, p=0 or 1, and ...
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4680305 |
Use of sulphonyldihydropyridines as medicaments for the treatment of asthma
A method of treating a patient suffering from asthma which comprises administering to such patient an asthma-relieving amount of a 5-sulphonyl-1,4-dihydropyridine of the formula ##STR1## in which R...
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4668799 |
Anti-hepatitis and anti-cirrhotic 1,3-dithiol-2-ylidene derivatives, and pharmaceutical compositions therefor
A 1,3-dithiol-2-ylidene derivative of the formula: ##STR1## wherein each of R and R 1 which may be the same or different, is a lower alkyl group, a lower alkenyl group, a cycloalkyl group, a lower...
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4666923 |
Pyrrolobenzimidazoles for treating heart or circulatory diseases
Pyrrolobenzimidazoles, processes for the preparation thereof and pharmaceutical compositions thereof for the treatment of coronary insufficiencies, cardiac failure, blood circulatory disturbances...
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4659737 |
Substituted aminomethyl benzopyrans having anti-hypertensive activities
Substituted benzopyrans of the formula ##STR1## in which --A-- is a single or double bond, X is a direct bond, optionally substituted methylene, oxygen or optionally substituted --NH--, and the...
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4657905 |
Novel hypotensive imidazothiadiazolealkanecarboxamides
Imidazothiadiazolealkenecarboxamides of the formula ##STR1## in which R 1 is hydrogen, aryl, substituted aryl or a cyclic or aliphatic hydrocarbon radical which is optionally interrupted by O, S,...
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4657908 |
Carbonyl derivatives
The invention relates to carbonyl derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention where is provided a guanidine derivative of...
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4652573 |
Calcium antagonist N-hetero ester 1,4-dihydropyridines
Compounds having calcium channel antagonist activity of the formula: ##STR1## wherein R 1 and R 2 are each independently amino, trifluoromethyl, pentafluoroethyl, alkoxy, lower alkenyl, or lower...
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4647563 |
Heterocyclic compounds
Compounds of the formula ##STR1## wherein Het is ##STR2## n is an integer from 1 to 4, inclusive, preferably 2 or 3, R 1 is H or acyl, R 2 is H, R 1 O, --NHSO 2 R 7 , --NHCOR 8 , --NHCONHR 8...
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4645775 |
Positive inotropic 3-nitro-5-substituted ester and thioester-1,4-dihydropyridines
Novel 3-nitro-dihydropyridine derivatives of the formula ##STR1## in which R 1 and R 2 each independently is hydrogen, C 1 -C 4 -alkyl, C 1 -C 12 -alkoxy, C 1 -C 4 -halogenoalkoxy, halogen,...
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4636518 |
Imidazole derivatives and pharmaceutical compositions
Compounds of the general formula: ##STR1## and acid addition salts thereof; in which Ar and Ar 1 which may be the same or different, each represent an aromatic radical which may be substituted one...
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