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4900750 |
1.4-Dihydropyridines
This invention concerns compounds of formula ##STR1## or salts thereof, wherein: Ar is an optionally substituted aryl radical; R represents hydrogen or an optionally substituted alkyl, aralkyl,...
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H000734 |
Method for inhibiting onset of or treating migraine headaches employing an ACE inhibitor
A method is provided for inhibiting onset of or treating migraine headache by administering an ACE inhibitor, such as captopril, alone or in combination with a calcium channel blocker such as...
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4892875 |
Substituted heterocyclylalkyl esters of 1,4-dihydropyridine-3,5-dicarboxylic acids
Dihydropyridine derivatives and acid addition salts thereof which are of use as prophylactic or/and therapeutic drugs for cardiovascular diseases, said dihydropyridine derivatives having the...
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4892879 |
1-substituted-4-(thiazolyl-2-)-piperazines, -piperidines and tetrahydro-pyridines useful as anxioltic, psychogeriatric, antisepressant and antischiziphrenic agents
Thiazoles or pharmaceutically acceptable acid addition salts thereof are useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents.
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4886803 |
Benzimidazole derivatives
Compounds are described of formula (I) ##STR1## wherein R 1 is a hydrogen atom, an alkyl group, an alkoxy group, a dialkylamino group or a halogen atom; n is 1 to 4; R 2 is a hydrogen atom, an...
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4886820 |
Dihydropyridine combination product comprising a dihydropyridine compound and a cardioactive nitrate
A solid medicament formulation which can be administered orally, comprising 1 to 40 mg of a dihydropyridine of the formula ##STR1## in which R 1 and R 3 are always different from one another and...
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4885304 |
Mitomycin analogs
Compounds of the formula, I, ##STR1## wherein: Y is hydrogen or lower alkyl; and X is a thiazolamino radical, a furfurylamino radical or a radical of the formula, ##STR2## in which R, R 1 , and R 2...
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4882342 |
5-alkylbenzimidazoles, method of use and pharmaceutical compositions
The present invention concerns new 5-alkylbenzimidazoles of the formula: ##STR1## wherein R 1 is a phenyl ring of the formula: ##STR2## or R 1 is naphthyl, heterocycle or a bicyclic heterocycle...
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4876263 |
Pesticidal nitro-substituted heterocyclic compounds
Nitro-subsliluted heterocyclic compounds of the formula (I) ##STR1## wherein R is hydrogen or alkyl, Z is an optionally substituted aryl or optionally subtituted heterocyclic groun containing at...
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4874759 |
5-Hydroxyindole-3-carboxylic acid amide compounds, pharmaceutical compositions and use
Hydroxyindole-3-carboxylic acid amide compounds of the general formula: ##STR1## wherein R 1 , R 2 , R 3 and R 4 are, the same or different, respectively a hydrogen atom, an alkyl group, an aryl...
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4873237 |
2,3-dihydro- thiazolo- and thiazino- benzimidazoles as atni-hyper secretion agents
The invention relates to a method of treatment of ulcers or hypersecretion in a mammal which comprises administering a compound of formula ##STR1## or a pharmaceutically acceptable salt thereof...
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4873254 |
1,4-Dihydropyridines substituted by 3-aryloxy-2-hydroxypropyl amino moiety in the 4-phenyl group
A dihydropyridine of the formula: ##STR1## wherein R 1 and R 2 each is alkyl, alkenyl or alkoxyalkyl, wherein R 3 and R 4 each is alkyl, wherein benzene ring A is unsubstituted or bears one or...
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4871751 |
1,2,6-Triphenyl-4(1H)-pyridinone derivatives, and their use as fungicides
New substituted derivatives of 1,2,6-triphenyl-4(1H)-pyridone are now provided, which are useful as fungicidal agent having practically valuable and improved fungicidal activities against a variety...
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4871734 |
Substituted thienoimidazole-toluidine derivatives as inhibitors of gastric acid secretion
Thienoimidazole-toluidines of the formula I ##STR1## in which A represents ##STR2## T denotes --S--, --SO-- or --SO 2 --, and R 1 to R 9 have the meanings stated in the description, and a...
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4863936 |
3,5-Substituted-2-pyridyl-alkylaminocyclobutenediones having histamine h.sub.1 -antagonist activity
Various substituted aminoalkylamino-2-pyridine derivatives are disclosed which are useful as histamine H 1 -antagonists.
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4859687 |
Substituted 1,3-dioxolane compounds and their use as fungicides
The described novel pyridine derivatives are those of the general formula I ##STR1## wherein R is hydrogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, phenyl, benzyl, phenyl substituted by C 1 -C...
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4859684 |
(1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders
Novel (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives, compositions containing the same, and methods of treating androgen dependent disorders in mammals.
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4857312 |
Dihydropyridine spray, process for its preparation and its pharmaceutical use
A sprayable liquid formulation comprising, per 100 ml of the formulation, (a) 0.2 to 5 grams of a dihydropyridine of the formula ##STR1## in which R 1 and R 2 each independently is alkyl with...
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4857516 |
Coumaran derivatives and their pharmaceutical use
A compound of the formula ##STR1## wherein R is a lower alkyl group, R 0 is hydrogen or an acyl group, R 1 and R 2 are lower alkyl groups which may optionally be substituted or wherein R 1 and...
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4853405 |
Condensed pyrazole derivatives, pharmaceutical compositions and use
The invention relates to compounds having the general formula (I) ##STR1## and the pharmaceutically acceptable salts thereof, which possess immunomodulating activity and are useful e.g. in the...
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4851419 |
Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding benzothiazoles or benzimidazoles having anti-inflammatory or gastric acid secretion inhibition activity
There are described compounds of formula I, ##STR1## in which A is a benzene or heterocyclic ring, y is 0 or 1, L is a group containing 1 or 2 carbon atoms, or is a single bond, R 9 and R 10...
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4845113 |
2-substituted -1,4-dihydropyridines and pharmaceutical compositions containing them
Compounds of formula I ##STR1## wherein R is hydrogen or lower alkyl; R 1 is acetyl, benzoyl, cyano, nitro, carboxy, alkoxycarbonyl or aminocarbonyl groups; R 2 is an optionally substituted aryl...
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4845118 |
Substituted thienoimidazole derivatives, pharmaceutical compositions containing them, and their use as inhibitors of gastric acid secretion
The invention relates to compounds of the formula ##STR1## in which A represents ##STR2## T denotes --S--, --SO-- or --SO 2 --, and R 1 to R 9 have the meanings given in the description, to a...
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4831032 |
Cardiotonic benzimidazoles
The present invention provides benzimidazoles of the general formula: ##STR1## wherein R 1 , X, A, and R 2 are as defined in the specification. The present invention also provides processes for...
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4829077 |
Benzopyran[4,3-d]-thiazole-derivatives with anti-allergic, anti-anaphylactic and anti-arithritic activity and compositions containing them
Compounds of formula ##STR1## (wherein R and R 1 have the meanings reported in the specification) and their preparation are described. The compounds of formula I have anti-allergic,...
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4818766 |
Novel phenoxyaliphatylphenyleneoxyalkyl esters and amides
The invention relates to novel 1,4-dihydropyridine-3-carboxylic acid phenoxyaliphatylphenyleneoxyalkyl esters of the formula ##STR1## in which Ac represents an acyl group, X represents oxy or...
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4818760 |
Derivatives of pyridylsulfinyl(benz-or thieno-)imidazoles and their use as gastric secretion inhibiting substances
The invention relates to novel derivatives of 4,5-dihydrooxazoles of the formula ##STR1## in which A denotes --CHCH-- or --S--, R 1 , R 3 and R 4 , independently of one another, denote...
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4816467 |
Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions and use
The invention relates to compounds having the general formula (I) ##STR1## and the pharmaceutically acceptable salts thereof, which possess immunomodulating activity and are useful e.g. in the...
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4808605 |
Tetrahydronaphthalene derivatives as calcium antagonists
Compounds of the formula ##STR1## wherein R is lower-alkyl, R 1 is halogen, R 2 is C 1 -C 12 -alkyl, R 3 is hydroxy, lower-alkoxy, lower-alkyl-carbonyloxy,...
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4808762 |
Insecticidal cyclopropyl-substituted di(aryl) compounds
Compounds of the formula ##STR1## in which Ar is substituted or unsubstituted phenyl, naphthyl, or thienyl; Z is oxygen, sulfur, or methylene; and Ar' is 2-methyl[1,1'-biphenyl]-3-yl,...
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4808622 |
Circulation active methionine-substituted 1,4-dihydropyridines
Circulation active, e.g. antihypertensive novel methionine-substituted dihydropyridines of the formula ##STR1## in which R 1 is phenyl or a heterocyclic radical, or a physiologically acceptable...
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4806554 |
Pyrazol and indazolpyridinamines
There are described compounds of the formula ##STR1## where n is 0 or 1; R 1 is independently hydrogen, loweralkyl, loweralkenyl, loweralkynyl, loweralkoxycarbonylloweralkyl,...
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4804668 |
Thiazole derivatives and medical compositions thereof
A thiazole derivative represented by the formula I, pharmaceutically acceptable acid addition salt thereof, and a process for preparation thereof ##STR1## wherein R 1 represents --COOR 4 ,...
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4803212 |
Amino disulfides
The present invention refers to mitomycin analogs containing a disulfide group. These compounds are mitromycin C derivatives in which the 7-amino group bears an organic substituent incorporating a...
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4798831 |
Substituted thieno[2,3-B]furan-2-sulfonamides as antiglaucoma agents
Thieno[2,3-b]furan-2-sulfonamides are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure and glaucoma.
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4798840 |
Coronary-active fluorine-containing 1,4-dihydropyridines
Hypotensive long-acting 1,4-dihydropyridines of the formula ##STR1## in which R 1 is phenyl or heterocyclic, R 2 , R 3 , R 4 and R 5 have the usual definitions in such compounds, R 6 ...
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4797413 |
Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
Aromatic sulfonamides with a saturated heterocycle fused thereto are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure.
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4794123 |
Thiazolo- and thiazino- benzimidazoles and their use as anti-ulcer agents
This invention relates to a method of treating ulcers or hypersecretion in a mammal which comprises administering a compound of formula ##STR1## or a pharmaceutically acceptable salt thereof...
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4794111 |
Dihydropyridine preparations containing β-blockers
An antihypertensive and antianginal combination comprising (A) 0.1 to 10 parts by weight of an asymmetrical dihydropyridine of the formula ##STR1## in which R 1 and R 5 each independently is...
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4791114 |
2-Benzimidazolylalkylthio (or -sulfinyl or -sulfonyl) derivatives, their preparation and their application as medicinal products
The present invention relates to new benzimidazole derivatives, to the process for preparing them and also to their application as medicinal products. The 2-alkylbenzimidazole derivatives according...
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4791139 |
Diphenyl ether derivatives and their use as insecticides
A compound of formula: ##STR1## wherein W represents one or more substituents selected from halo, alkyl, alkoxy, alkoxyalkyl, haloalkyl and haloalkoxy or W represents a bidentate group linking...
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4788205 |
Dihydropyridine anti-allergic and antiinflammatory agents
Certain 4-aryl-5-carbamoyl-1,4-dihydropyridines useful in the treatment of allergic and inflammatory conditions in mammals.
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4786645 |
1H, 3H-pyrrolo (1,2-C) thiazole derivatives and pharmaceutical compositions
A compound of the general formula I: ##STR1## in which Ar is a pyridyl, quinolinyl, isoquinolinyl, naphthyridinyl, pyrimidyl, quinazolinyl, thiazolyl, benzothiazolyl, imidazolyl, benzimidazolyl,...
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4783472 |
1H,3H-pyrrol[1,2-c]thiazole derivatives and pharmaceutical compositions containing them
A compound of the general formula I; ##STR1## in which R is hydrogen or a halogen or an alkyl, alkyloxy, alkylthio, trifluoromethyl, amino, alkylamino, dialkylamino, hydroxy, cyano, carboxy,...
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4782069 |
1,4-Dihydropiridines and their use as antithrombotic drugs
The present invention refers to new 1,4-dihydropyridines, to their obtention processes and to their use as antithrombotic drugs. Said new 1,4-dihdyropyridines have the following general formula (I)...
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4772633 |
6-pyridyl- and 6-phenyl-3-phenyl-1-hexenes and -1-hexynes, composition containing them, and insecticidal and acaricidal method of using them
This invention relates to a novel compound represented by the following general formula (I), its production, and an insecticidal and acaricidal composition containing it as an active ingredient:...
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4772619 |
[(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines
This invention relates to [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines that are useful in the treatment and prevention of ulcers.
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4771058 |
3,4-diamino-1,2,5-thiadiazole-1-oxides having histamine H.sub.1 -antagonist activity
The invention relates to a class of 3,4-diamino-1,2,5-thiadiazole-1-oxides which have histamine H 1 -antagonist activity. A preferred compound of the invention is...
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4767757 |
Acyloxythiophene-carboxamide fungicides, compositions and use
Novel fungicidally active acyloxythiophene-carboxamides of the formula ##STR1##
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4767769 |
Antiulcer benzimidazole derivatives
Compounds of formula I ##STR1## in which R 1 and R 2 , which may be the same or different, are hydrogen, a C 1 to C 3 alkyl group or R 1 and R 2 together with the nitrogen to which they are...
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