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7618988 |
Use of substituted aminomethyl chromans
Compounds of formula I in which R has a meaning as indicated in claim 1 , or one of their optical isomers or pharmaceutically acceptable salts, used for the treatment of extrapyramidal movement...
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7615570 |
Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
Compounds having formula (I)
or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein L, A, G, R 1 , R 2 and R 3 are as defined herein. These compounds are...
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7605158 |
Carbamoyl-type benzofuran derivatives
The present invention provides a carbamoyl-type benzofuran derivative of the formula [1]:
wherein Ring Z is a group of the formula:
etc.; A is a single bond, and the like; Y is a...
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7589111 |
C10 cyclopentyl ester substituted taxanes
A taxane having a cyclopentyl ester substituent at C10, a keto substituent at C9, a hydroxy substituent at C2, a 2-thienyl substituent at C3′ and an isopropoxycarbamate substituent at C3′.
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7531695 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to compounds having the structure (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic...
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7531537 |
Benzofuran derivative
The present invention provides a benzofuran derivative of the formula [1]:
wherein x is a group of the formula: —N═ or —CH═; Y is an optionally substituted amino group, an optionally...
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7524870 |
Biaryloxymethylarenecarboxylic acids as glycogen synthase activators
The present invention relates to compounds of formula (I)
wherein Ar, Ar 2 , R 2 , R 3 , R 4 , m, p and s are as defined in the description and claims, and pharmaceutically acceptable salts...
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7524869 |
Taxanes having a C10 ester substituent
Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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7524864 |
Methods of treating sleep disorders
The invention relates to novel antihistamines and methods of modulating sleep by administering a doxepin analog or a pharmaceutically effective salt thereof.
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7524862 |
Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
Alkyne compounds of formula I
wherein A, B, W, X, Y, Z, R 1 , and R 2 have the meanings given herein, which have MCH-receptor antagonistic activity and are useful for preparing pharmaceutical...
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7507761 |
Benzopyran derivatives, method of production and use thereof
The invention relates to novel benzopyran derivatives of formula I, to their method of production, to composition comprising the derivatives and use thereof.
wherein:
R 1 , R 2 , R 3 and R 4...
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7504409 |
Mucin synthesis inhibitors
The claimed invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds in controlling mucin over-production associated with diseases such as chronic...
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7501443 |
Flavaxate derivatives as muscarinic receptor antagonists
This invention generally relates to the derivatives of 3.6-disubstituted azabicyclo [3.1.0] hexanes of the following formula [IA]. The compounds of this invention can function as muscarinic...
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7498349 |
Biaryl compounds having anti-infective activity
Aromatic compounds exemplified by exhibit antimicrobial activity.
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7473701 |
Substituted indazoles, compositions containing them, method of production and use
Substituted indazoles, compositions containing them, method of production and use. The present invention relates in particular to novel specific substituted indazoles exhibiting kinase-inhibiting...
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7449459 |
Inhibitors of soluble adenylate cyclase
The invention relates to compounds of general formula I as well as the production and use thereof as a medication.
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7442712 |
Constrained himbacine analogs as thrombin receptor antagonists
A compound represented by the structural formula
and pharmaceutically acceptable salts and solvents thereof is disclosed, wherein:
the single-dashed line
...
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7442702 |
Prostaglandin agonists
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
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7442701 |
Amino-heterocycles as VR-1 antagonists for treating pain
The present invention provides a compound of formula (I): wherein V represents NR 5 , O, S, SO or S(O) 2 ; W and X each independently represent CH or N; Y represents N, CH or C—Ar 2 , with the...
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7432282 |
Pyridinalkyl-aminoalkyl-IH-indole derivatives having an inhibitory action on 5-HT and serotonin reuptake as antidepressants and anxiolytics
Novel indole derivatives of the formula (I), in which X, Y, R 1 , R 1′ , m and n have the meanings indicated in Patent Claim 1, have a strong affinity to the 5-HT 1A and in some cases to the...
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7425568 |
Compounds, which are potent inhibitors of Na+ /Ca2+ exchange mechanism and are useful in the treatment of arrhythmias
Therapeutically active compounds of formula (I):
wherein the variables shown in formula (I) are defined in the disclosure; and pharmaceutically acceptable salts and esters thereof. The...
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7393865 |
Sleep inducing compounds and methods relating thereto
Compounds having the following structure (I):
including stereoisomers, prodrugs, and pharmaceutically acceptable salts, esters and solvates thereof, wherein R 1 , R 2 , R 3a , R 3b , L 1 , L 2 ...
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7384947 |
Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
This invention relates to a novel fused tricyclic heterocycle of the formula
and its use for the treatment of hyper-proliferative disorders.
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7378399 |
Avermectins substituted in the 4″ and 4′-positions having pesticidal properties
What is described are a compound of the formula (I) Wherein A-B is —CH═CH— or —CH 2 —CH 2 —; n is 0 or 1; R 1 , is C 1 -C 12 alkyl, C 3 -C 8 cycloalkyl or C 2 -C 12 alkenyl; R 2 and R...
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7368477 |
Benzofuranyl alkanamine derivatives and uses thereof
Compounds of formula I or pharmaceutically acceptable salts thereof are provided:
wherein each of R 1 , R 1′ , R 2 , R 3 , R 4 , n, and Ar are as defined, and described in classes and...
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7368476 |
Hydroxamates as therapeutic agents
The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone...
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7365095 |
Chromane and chromene derivatives and uses thereof
Compounds of formula I or pharmaceutically acceptable salts thereof are provided:
wherein each of R 1 , R 2 , R 3 , R 4 , y, m, n, and Ar are as defined, and described in classes and subclasses...
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7304079 |
Substituted indolealkanoic acids
Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the...
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7256213 |
Taxanes having a C10 carbonate substituent
Taxanes having a methylcarbonate or ethylcarbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(13) side chain substituents.
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7241758 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological...
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7235568 |
3-(cyclopenten-1-yl)-benzyl-or 3-(cyclopenten-1-yl)-heteroarylmethyl-amine derivatives and use thereof as medicines for treating schizophrenia
The invention provides compounds of the formula:
wherein (a) is a single or double bond; W is CH, CH 2 , CHCH 3 , C(CH 3 ) 2 , C(CH 2 ) 2 or C(CH 2 ) 3 ; X is N; and Y is H or F, and salts,...
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7235567 |
Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
A crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist compound, which exhibits a powder x-ray diffraction profile substantially the same as that shown in FIG. 1 , or which...
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7230013 |
C10 carbamoyloxy substituted taxane compositions
Compositions comprising a taxane having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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7226944 |
Taxanes having a C7 carbonate substituent
Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
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7217723 |
Heterocyclic compound having oxime group
The present invention provides a compound that has an excellent inhibitory activity on STAT6 activation and is effective against allergic diseases, and a medicinal composition thereof. According to...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7208491 |
N-monoacylated o-phenylenediamines
Mono-acylated o-phenylendiamines derivatives of formula I
wherein X and R are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone...
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7189758 |
Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof
A compound of Formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such...
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7186719 |
Antibacterial agents
Compounds of formula (II) are antibacterial agents wherein Q represents a radical of the formula: —N(OH)CH(═O) or the formula: —C(═O)NH(OH); R 1 represents hydrogen, C 1 –C 6 alkyl or C...
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7157474 |
C10 heterosubstituted acetate taxane compositions
Compositions comprising a taxane having a heterosubstituted acetate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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7153871 |
Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
PDE4 inhibition is achieved by novel compounds, e.g., aminoindazole and aminobenzofuran analogs. The compounds of the present invention are of Formulas I and II:
wherein R 1 , R 2 , R 3 , R 4 ,...
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7144885 |
Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders
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7129234 |
Phenyl heterocyclyl ethers
The invention relates to compounds of formula I
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7105513 |
Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
The present invention relates to acylated, heteroaryl-condensed cycloalkenylamines, to pharmaceutical compositions comprising such compounds, to methods for the stimulation of the expression of...
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7087625 |
Phosphodiesterase 4 inhibitors
PDE4 inhibition is achieved by novel nitroxide compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formulas I–III:
wherein A, B, D,...
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7081468 |
Ortho-substituted anthranilic acid amides and their use as medicaments
Ortho-substituted anthranilic acid amides and use thereof as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described.
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7056946 |
C10 carbonate taxane compositions
Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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7045545 |
Aminoalkylbenzofurans as serotonin (5-HT(2c)) agonists
The present invention provides serotonergic aminoalkylbenzofurans of Formula (I): where R, R 1 , R 2 , R 3 , R 4 , R 4 ′, R 5 , R 5 ′, and R 12 are as described in the specification.
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7034044 |
Conjugated aromatic compounds with a pyridine substituent
The present invention relates to compounds of formulae
The compounds of the present invention are NMDA (N-methyl-D-aspartate)-receptor subtype blockers and are used in the treatment of diseases...
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7034035 |
Fungicidal mono-, bi-, and tri-cycloheteroalkyl amides and their compositions, methods of use and preparation
The present invention relates to compounds of Formula I:
wherein:
a)
represents a 6-membered heterocyclic aromatic ring in which X 1 is N and X 2 , X 3 and X 4 are each...
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