Matches 351 - 400 out of 469 < 1 2 3 4 5 6 7 8 9 10 >
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4886806 Flavone-3-carboxylic acids compounds and pharmaceutical compositions containing them  
Falvone-3-carboxylic acid compounds corresponding to the Formula I: ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 represent hydrogen, lower alkyl, halogen, hydroxy, or etherified or esterified...
4883793 Hydrazinocarbonyloxylabdanes for treating cardiac failure  
Novel hydrazinocarbonyloxylabdanes, intermediates and processes for the preparation thereof, and a method for treating cardiac failure utilizing compounds or compositions thereof are disclosed.
4877441 Fungicidal substituted carboxylic acid derivatives  
A substituted carboxylic acid derivative which is fungicidally active is provided. The compound has the formula: ##STR1## wherein R 1 stands for a methyl or ethyl group, A stands for ##STR2## R 2 ...
4873255 Thiazolidinone derivatives, their preparation and their use  
Thiazolidinone derivatives of formula (I): ##STR1## in which R 1 , R 2 , R 3 , R 4 and R 5 are various atoms or organic groups, Ar is an aromatic group and n is an integer have valuable...
4868190 N-pyridinyl-9H-carbazol-9-amines  
There are described compounds of the formula: ##STR1## where, X is hydrogen, loweralkyl, loweralkoxy or halogen; Y is hydrogen, loweralkyl or halogen; Z is hydrogen, loweralkyl or halogen; ...
4847254 CNS affecting 5-oxy-3-aminomethyl-dihydro-benzofurans and benzothiophenes  
The present invention relates to 3-aminomethyl derivatives of indane, dihydrobenzofurane, dihydrobenzothiophene, and indoline, acid addition salts thereof, isomers thereof, methods of preparation,...
4847272 Thianaphthene derivatives  
Compounds of formula (I): ##STR1## (wherein n is 0 or 1, R 1 and R 2 are hydrogen or alkyl, one of A 1 and A 2 is --Z--Y and the other is --W--COOH, where W and Z are alkenylene or alkylene and...
4845094 2-phenylbenzoxepin derivative  
2-phenylbenzoxepin derivatives having a hypoglycemic activity, hypotensive activity, and platelet coagulation inhibiting activity, a process for production of the derivatives, and pharmaceutical...
4839367 Antihypertensive amide compounds  
Provided are antihypertensive compounds of the formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl, and may be the...
4822804 5,6,7,-trinor-4,8-inter-m-phenylene 2-nor PGI.sub.2 derivatives and anti-ulcer, anti-thrombotic and anti-hypertensive pharmaceutical compositions containing them  
Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI 2 derivatives such as 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-16,16-dimethyl PGI 2 , ...
4808762 Insecticidal cyclopropyl-substituted di(aryl) compounds  
Compounds of the formula ##STR1## in which Ar is substituted or unsubstituted phenyl, naphthyl, or thienyl; Z is oxygen, sulfur, or methylene; and Ar' is 2-methyl[1,1'-biphenyl]-3-yl,...
4806534 Therapeutically active flavonyl-1,4-dihydrophyridines  
The novel flavonyl-1,4-dihydropyridines having the general formula (I): ##STR1## are therapeutically effective calcium antagonists and smooth muscle relaxant.
4786641 Dihydropyridine compounds and their use in reducing blood sugar  
Blood-sugar-lowering dihydropyridines of the formula ##STR1## in which R 1 represents phenyl, naphthyl, thienyl, pyridyl, chromenyl or thiochromenyl, it being possible for the radicals mentioned...
4786639 Method for the treatment of reversible airways obstruction and asthma  
A method for the treatment and/or prophylaxis of reversible airways obstruction and asthma in mammals, which method comprises administering to the mammal in need of said treatment an effective...
4782083 3,4-dihydro-2H-1-benzopyrans useful as anti-hypertensive agents  
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: one of R 1 and R 2 is hydrogen or C 1 -4 alkyl and the other is C 1 -4 alkyl or R 1 and R 2 together...
4772603 Method for treating congestive heart failure, angina, occlusive peripheral vascular disease or cerebral vascular disease in mammals  
A method for the treatment and/or prophylaxis of congestive heart failure, angina, occlusive peripheral vascular disease or cerebral vascular disease in mammals, such as humans, which method...
4769387 Dibenzofuran lipoxygenase inhibiting compounds, compositions and use  
Compounds of the formula: ##STR1## wherein R 1 is (1) hydrogen, (2) C 1 to C 4 alkyl, (3) C 2 to C 4 alkenyl, or (4) NR 2 R 3 , wherein R 2 and R 3 are independently selected from hydrogen,...
4766144 3-carbamoyl-4-hydroxy-coumarins for combating parasitic heiminths  
3-carbamoyl-4-hydroxy-couramins for combating parasitic helminths of the formula ##STR1## in which R 1 represents hydrogen, halogen, alkyl, NO 2 , CN or alkoxy, X represents O, S, SO or SO 2 ...
4762853 1-oxo-1,3,4,7-tetrahydrobenzo[C]furans  
1-Oxo-1,3,4,7-tetrahydrobenzofuranes of the formula ##STR1## in which X is O or S, R is optionally substituted phenyl or heteroaryl, R 1 is OH, monoalkylamino or dialkylamino, and R 2 is...
4760068 Certain pyridyl alkenoic acid derivatives which inhibit the action of thromboxane A.sub.2 synthetase  
Novel compound of the formula: ##STR1## wherein R 1 is pyridyl group, R 2 is a phenyl group, a thienyl group, a furyl group, a naphthyl group, a benzothienyl group or pyridyl group, which may...
4746669 Substituted thiazoles as immunoregulants  
Thiazole derivatives have been made, for example, by reacting a 2-aryl-2,2-dialkoxyethylamine with an appropriately substituted aryl acetyl halide followed by treating the resulting amide with...
4742067 Acylalkylaminocarbonyl substituted amino and imino acid compounds  
Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of...
4738963 Method for the treatment of incontinence in mammals  
A method for the treatment and/or prophylaxis of incontinence in mammals, which method comprises administering to the mammal in need of said treatment an effective amount of a compound of formula...
4732898 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders  
The present invention are 2-(2-aryl-2-oxo-alkylidene) analogs of 1,2,3,4-tetrahydropyridine-3,5-pyridinecarboxylic acids and particularly esters thereof having valuable calcium antagonist and...
4731364 Dihydrobenzo(B)thiophenes and pharmaceutical compositions thereof useful as antifungals  
2-Alkyl-, 2-alkenyl- and 2-alkynyl-2,3-dihydro-2-(1H-azolyl(C 1 -C 2 )alkyl)benzo[b]thiophenes especially 2-alkyl-, 2-alkenyl- and...
4719220 15(R)-5-fluoroprostacyclins, pharmaceutical compositions and anti-thrombotic methods of use thereof  
The present invention provides novel compounds of Formula I ##STR1## which are pharmacologically selectively useful as anti-thrombotic agents with minimal blood pressure lowering activity.
4713393 Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents  
Phenylalkyl-2,3-dihydrobenzofurans and analogs were prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a...
4704390 Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents  
Novel phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy benzheterocyclic compounds are described which have valuable neuroleptic properties by virtue of their dopamine autoreceptor...
4701456 Aminoalkoxybenzopyranones as antipsychotic and anxiolytic agents  
Aminoalkyoxybenzopyranones of the formula ##STR1## wherein R 1 is of the formula ##STR2## are described as well as methods of preparation, pharmaceutical compositions and methods for treating...
4698352 4-oxo-1,4-dihydronicotinic acid derivatives, salts thereof, and antibacterial agents containing the same  
This invention relates to a novel 4-oxo-1,4-dihydronicotinic acid derivative ##STR1## or a salt thereof, wherein R 1 is hydrogen or carboxyl-protecting group; R 2 is substituted phenyl and...
4690932 Coumarins with imidazolyl group or pyridyloxy group having plateletes aggregation inhibiting activity  
Novel coumarin compounds of the formula ##STR1## wherein R 1 represents an imidazolyl group or a pyridyloxy group which may be substituted by lower alkyl group(s); R 2 represents a hydrogen atom...
4684658 Anti-thrombotic ortho-condensed pyrrole derivatives, compositions, and method of use therefor  
The invention provides novel pyrrole derivatives of formula: ##STR1## in which R'=H, alkyl or phenyl optionally substituted by halogen, alkyl, alkyloxy or alkylthio, Z=0 or S, p=0 or 1, and ...
4684661 Anti-fungal homopropargylamines, compositions, and method of use therefor  
The invention relates to novel homopropargylamines of formula I ##STR1## wherein n is 2 or 3, R 1 is a group of formula IIa, IIb or IIc ##STR2## in which R 6 and R 7 independently are H,...
4681890 3,4-dihydrobenzopyran compounds and pharmaceutical composition containing the same  
Novel 3,4-dihydrobenzopyran compounds of the formula: ##STR1## wherein R 1 , R 2 and R 3 are each hydrogen or nicotinoyl group and at least one of them is nicotinoyl group, m is an integer of 0,...
4677210 1-arylalkoxy- and 1-arylalkylthioaryl-2-pyrazolines as anti-inflammatory or anti-allergic agents  
4675320 Aminoalkyl and aminoalkoxy derivatives of 2-nitro-3-phenylbenzofuran  
Antimicrobial 2-nitro-3-phenylbenzofurans wherein the benzo or the 3-phenyl portion of the molecule is bonded to an alkylene or an oxyalkylene group which is in turn bonded to a basic nitrogen atom...
4673685 Hydroximic acids of 7-oxabicycloheptane substituted ethers and thioethers useful in the treatment of thrombotic disease  
Hydroximic acids of 7-oxabicycloheptane substituted ether and thioether prostaglandin analogs are provided having the structural formula ##STR1## wherein Y is O or ##STR2## and including all...
4670422 α-acyloxy phosphonate angiotensin converting enzyme inhibitors  
Compounds of the formula ##STR1## wherein X is various amino or imino acids and esters are disclosed. These compounds are useful as anti-hypertensive agents due to their angiotensin converting...
4668691 Circulation-active novel 7-aryl-or pyridyl-1-oxo-1,c,4,7-tetrahydrobenzofurans  
1-Oxo-1,3,4,7-tetrahydrobenzofuranes of the formula ##STR1## in which X is O or S, R is optionally substituted phenyl or heteroaryl, R 1 is OH, monoalkylamino or dialkylamino, and R 2 is...
4668690 1,2,3,4,4a,9b-hexahydro-4a-aminoalkyldibenzofurans useful as analgesics, anticonvulsants or antidepressants  
This invention relates to 1,2,3,4,4a,9b-hexahydro-4a-aminoalkyldibenzofurans of the formula ##STR1## where X is hydrogen, loweralkyl, F and Cl; R 1 is hydrogen, loweralkyl, arylloweralkyl,...
4668799 Anti-hepatitis and anti-cirrhotic 1,3-dithiol-2-ylidene derivatives, and pharmaceutical compositions therefor  
A 1,3-dithiol-2-ylidene derivative of the formula: ##STR1## wherein each of R and R 1 which may be the same or different, is a lower alkyl group, a lower alkenyl group, a cycloalkyl group, a lower...
4663347 Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis  
Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit the mammalian 5-lipoxygenase enzyme, thus...
4663344 Anti-inflammatory and analgesic 3-hydroxybenzo[b]thiophene derivatives, compositions, and method of use therefor  
3-Hydroxybenzo[b]thiophene derivatives, such as 2-aralkyl, 2-alkyl and 2-alkenyl-3-hydroxybenzo[b]-thiophenes, were prepared by, among other methods, ring closure of...
4659737 Substituted aminomethyl benzopyrans having anti-hypertensive activities  
Substituted benzopyrans of the formula ##STR1## in which --A-- is a single or double bond, X is a direct bond, optionally substituted methylene, oxygen or optionally substituted --NH--, and the...
4659717 Dihydropyridines useful in the treatment of angina and stroke  
This invention provides certain substituted dihydropyridines, their pharmaceutical formulations, and their use for causing vasodilation in mammals.
4657908 Carbonyl derivatives  
The invention relates to carbonyl derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention where is provided a guanidine derivative of...
4634716 Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents  
Compounds of the formula: ##STR1## where R 3 is ##STR2## where n is 1-3 and the R a 's and R b 's are independently hydrogen or loweralkyl; and pharmaceutically acceptable salts thereof; are...
4629734 Benzopyrans  
Compounds of formula (I): ##STR1## wherein: R 1 -R 6 are as defined in the specification; X is oxygen or sulphur; and the R 6 NCXR 5 and OCOH moieties are trans and, when one or the other of...
4621091 3-hydroxybenzo[b]thiophene-2-sulfide derivatives compositions, and method of use therefor  
3-hydroxybenzo[b]thiophene-2-sulfide derivatives have been prepared by ring closure of an appropriately substituted 2--R 1 SCH 2 S-- benzoic acid ester in the presence of a strong base. These...
4617296 3-O-acylated derivatives of (+)-cyanidan-3-ol  
The subject of the present invention is new O-substituted derivatives of (+)-cyanidan-3-ol corresponding to the general formula I ##STR1## in which R represents an optionally substituted...
Matches 351 - 400 out of 469 < 1 2 3 4 5 6 7 8 9 10 >