Matches 251 - 300 out of 469 < 1 2 3 4 5 6 7 8 9 10 >
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5510370 Parathyroid hormone and raloxifene for increasing bone mass  
The present invention includes a method for increasing bone mass in a subject by administration of PTH and raloxifene. Another aspect of the invention is a method for treating bone loss in a...
5500425 Chroman derivatives and a method of treating 5-HT mediated disorders  
Compounds of the formula I ##STR1## processes for their preparation, pharmaceutical preparations, use of and method of treatment of disorders in CNS by using compounds of formula I.
5496853 Benzoxa condensed ring compounds, process for producing the same and pharmaceutical composition comprising the same  
Pharmaceutical compositions containing a benzoxazole compound and a 2,3-dihydrobenzofuran compound represented by the following formula (I) and its pharmaceutically acceptable salt: ##STR1## In the...
5494910 Benzofuran derivatives as 5-HT.sub.1 -like receptor antagonists  
This invention relates to benzofuran derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their medical use, in particular to compounds and...
5492908 Diaminotrifluoromethylpyridine derivatives, process for their production and phospholipase A.sub.2 inhibitor containing them  
A method of treating rheumatoid arthritis using a diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW 1 R 1 , --COCOR 2 , --CW 1 NHCOR 2 ,...
5489601 Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them  
Taxane derivatives having a 3' pyridyl substituted C13 side chain.
5482942 (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants  
This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to...
5480645 Hydroxyamines N-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with peroxidation and inflammation phenomena  
Hydroxyamines N-acyl derivatives with benzochroman or 2,3-dihydrobenzofuran carboxy acids and relative pharmaceutical composition for the therapeutic treatment of those CNS, vascular,...
5470861 Method of promoting hair growth  
The use of the compound 2-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)pyr idine-1-oxide represented by the formula ##STR1## as well as pharmaceutically acceptable salts, as topical...
5468746 Compounds active on the cardiovascular system  
Compounds of the formula ##STR1## (wherein Ar, R, R 1 , R 2 , R 3 , R 4 , R 5 , m and n have the meanings given in the description), their preparation and pharmaceutical compositions containing...
5457118 Pyridine derived agents for cardiovascular diseases  
5457117 Method for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[B][2-(piperidin-1-yl)ethoxyphenylime thanone hydrochloride  
The current invention provides a method useful for inhibiting the loss of bone using 6-hydroxy-2-(4-hydroxyphenyl)-benzo(B)thien-3-yl-4[2-(piperi din-1-ethoxyph enol]methanone hydrochloride.
5451591 Method of using 5-arylheteroarylalkyl-1,3 5-trisubstituted-1,24-triazole compounds for treatment of circulatory disorders  
A class of 5-arylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds is described for use in treatment of circulatory disorders such as hypertension. Compounds of particular interest are...
5447943 Novel benzopyran derivatives  
Compounds of the Formula: ##STR1## wherein: R 1 -7 are as defined in the specification. The compounds and salts exhibit useful pharmacological properties, including potassium channel activating...
5446055 Polyether naphthalenic lignan lactones as inhibitors of 5-lipoxygenase  
Compounds of formula ##STR1## Ar is optionally substituted phenyl, furyl, pyridyl, or thienyl; Y is selected from hydrogen, halogen, cyano, alkyl, haloalkyl, alkoxy, and alkoxycarbonyl; L is...
5434153 2-amino-4-heteroaryl-1,4-dihydropyridines and their use in medicaments  
The present invention relates to new 2-amino-4-hetero-aryl-1,4-dihydropyridines of the general formula (I) ##STR1## in which R 1 to R 4 have the meaning given in the description, processes for...
5428039 Method for electively achieving reversible hyperpolarized cardiac arrest  
While performing cardiopulmonary bypass, the aorta is cross-clamped and the beating heart is stopped by introducing of an ATP-dependent potassium channel opening agent. The infusion into the...
5426111 [Alkoxy-, alkenyloxy-, alkynyloxy-, and phenylmethyloxyalkoxycycloalkyl or alkoxycycloheteroalkyl]naphtho[2,3-c]furan-1(3H)-one inhibitors of 5-lipoxygenase  
Compounds of formula ##STR1## Ar is selected from (a) phenyl, (b) phenyl substituted with one or more groups selected from halogen, cyano, alkyl, haloalkyl, alkoxy, and alkoxycarbonyl, (c) furyl,...
5424320 Heteroaryl coumarins as inhibitors of leukotriene biosynthesis  
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5424315 Benzothiophen analogs as antiviral agents  
Benzothiophene analogs useful to treat herpes viral infections, particularly cytomegalovirus, are provided. These antiviral agents have the structural formula (I) ##STR1## wherein R and R 1 are as...
5418252 Method for inhibiting cartilage degradation  
A method of inhibiting cartilage degradation comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR1## wherein R 1 and...
5416097 Potassium channel activators/openers  
This invention relates to novel potassium channel activators and their acid addition salts. The compounds of the invention as potassium channel activators/openers have therapeutic value in a number...
5409940 3,4-dehydropiperidine derivatives  
The invention relates to a group of new 3,4-dehydropiperidine derivatives of the formula ##STR1## wherein R 1 is a hydrogen atom or an alkyl group having 1-3 carbon atoms; Y is a group of the...
5407947 Methods for inhibiting bone loss using pyrolidine and piperidine substituted benzopyrans  
A method of inhibiting bone loss comprising administering to an animal an effective amount of a compound having the formula ##STR1## wherein: R 1 and R 2 are, independently, --H, --OH, halo, --OC...
5399561 Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-oxochromanyl, 2-oxothiochromanyl or 2-oxo-1,2,3,4-tetrahydro-quinolinyl group having retinoid-like biological activity  
Compounds of the formula ##STR1## where R 1 and R 2 are hydrogen, lower alkyl of 1-6 carbons, or halogen; R 3 is hydrogen, lower alkyl of 1-6 carbons, halogen, OR 11 , SR 11 , OCOR 11 , SCOR 11...
5391751 2,2-dimethylchromene derivatives, process for their preparation and pharmaceutical compositions in which they are present  
The present invention relates to 2,2-dimethylchromene derivatives of the formula: ##STR1## in which Z represents a halogen atom or a cyano, nitro, acetyl, phosphono or dialkoxyphosohoryl group, the...
5389650 (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis  
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5378699 Methods of using dihydropyrans  
Methods of treating an immune disease, cell proliferation, restenosis and vascular smooth muscle cells using the pharmaceutical compounds of the formula ##STR1## in which R 2 is phenyl, naphthyl...
5378717 Therapy for diabetic complications  
This invention provides a method of treating diabetic complications in mammals which comprises the administration of a compound of the Formula I: ##STR1## in which n, R 1 , R 2 , R 3 , and R 4 are...
5376677 Benzo[b]thiophene derivatives  
The invention relates to novel compounds of the formula ##STR1## in which R is as defined in the description, to their preparation, to fungicidal compositions which contain such compounds as active...
5364878 Use of substituted 3,4-dihydro-2H-benzopyrans as remedies for obstructive functional disorders of the lungs  
The use of substituted 3,4-dihydro-2H-benzopyrans as remedies for obstructive functional disorders of the lungs and/or disorders of the efferent urinary passages The use of...
5364869 Heterocycle-substituted benzyaminopyridine angiotensin II receptor antagonists  
Compounds are disclosed having the formula: ##STR1## wherein D is a substituted heterocycle, especially substituted pyridyl, E-G is a linking group, especially --N(R 5 )--CH 2 --, and Q is a...
5350744 Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis  
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5346895 Chromans and thiochromans with heteroarylethynyl substituents at the 7-position having retinoid-like biological activity  
Novel compounds of the formula ##STR1## where X is S, O; R 1 -R 5 are hydrogen or lower alkyl; R 6 is lower alkyl, lower alkenyl, lower cycloalkyl having 1 to 6 carbons, or halogen; A is lower...
5344843 Cat-1 inhibitors, pharmaceutical compositions and methods of use  
The invention relates to compounds of the formula ##STR1## wherein R 1 , R 2 , R 2 ' X, Y, Z, A, B, Q and n are as described herein. Their pharmaceutically acceptable salts, and when appropriate,...
5342941 Naphthalene derivatives, processes for preparing the same, and synthetic intermediates therefor  
Naphthalene derivative of the formula [I]: ##STR1## wherein R 1 and R 2 are the same or different and are hydrogen atom, hydroxy group, cyclo-lower alkyloxy group, substituted or unsubstituted...
5340833 Urokinase inhibitors  
Disclosed are benzothiophene and thienothiophene derivatives useful for inhibiting urokinase activity.
5317029 Pharmaceutical composition of benzopyranes for the inhibition of bone resorption  
Pharmaceutical compositions for the inhibition of bone resorption comprising a pharmaceutical carrier and a therapeutically effective amount of a benzopyran derivative represented by the general...
5298512 Substituted chromans and their use in the treatment of asthma, arthritis and related diseases  
Substituted chromans which by inhibiting 5-lipoxygenase enzyme are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction, stroke and related disease...
5296492 Certain chroman derivatives useful for treating symptoms caused by contraction of smooth muscles, circulatory diseases or epilepsy  
A chroman derivative represented by the following general formula [1]: ##STR1## wherein R 1 represents cyano group, nitro group, halogenomethyl group or --SO 2 --X group (X represents lower alkyl...
5296495 Thiazolylbenzofuran derivatives and pharmaceutical composition comprising the same  
Compounds of the formula: ##STR1## wherein R 1 , R 2 , R 3 , R 4 , A, X and Y are as defined and pharmaceutically acceptable salts thereof; which have activities as leukotriene and Slow Reacting...
5284868 Pharmaceutical compounds  
A pharmaceutical compound of the formula ##STR1## in which n is 0, 1 or 2 and R 1 is attached at any of the positions 5, 6, 7, 8, 9 or 10, and each R 1 is halo, trifluoromethyl, C 1 -4 alkoxy,...
5284838 Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma  
The invention relates to 2,2-dimethylchroman-3-ol derivatives of the formula: ##STR1## in which: A, between N and CO, represents the group --CHCH--ECH-- or the group ##STR2## Z represents a...
5278174 Sigma binding site agents  
Sigma binding site agents having the formula ##STR1## which are useful to inhibit sigma binding site-induced activity, pharmaceutical compositions including these agents, and methods of using these...
5278169 Method of treating or prevention of fibrillation of the heart  
A method for the treatment and prevention of fibrillation using one or more potassium channel activators. Also, disclosed is a process for the preparation of compounds of the formula ##STR1## and...
5262430 Substituted 2-imidazolines and use thereof  
The invention relates to novel substituted 2-imidazolines (I) having a lowering effect on blood glucose in mammals, to their preparation, to pharmaceutical compostions containing them and to their...
5260320 Diaminotrifluoromethylpyridine compounds and phospholipase A.sub.2 inhibitor containing them  
A diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW 1 R 1 , --COCOR 2 , --CW 1 NHCOR 2 , --C(W 1 )W 2 R 3 or --CW 1 N(R 4 )R 5 , and Y is...
5260444 Dihydropyridine derivative  
The present invention provides dihydropyridine derivatives represented by the following formula (I) ##STR1## and salts thereof. They have extremely strong, slow and long-acting vasodilating action...
5260294 Chromanes and their pharmaceutical compositions and methods  
Racemic Compounds of the formula ##STR1## A is --C.tbd.C--R 6 , --CH 2 --CH 2 --R 7 or ##STR2## and the remainder of the variables are as defined in the specification, and their enantiomers and...
5254570 Acyl derivative of dianhydrohexitols  
The present invention relates to a pharmaceutical composition comprising: (a) a compound of the formula ##STR1## wherein R 1 and R 2 are as defined below; and (b) isosorbide 5-mononitrate or...
Matches 251 - 300 out of 469 < 1 2 3 4 5 6 7 8 9 10 >