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7414064 |
4-(3,3-dihalo-allyloxy) phenoxy alkyl derivatives
Compounds of formula
wherein A 1 , A 2 and A 3 are each independently of the others a bond or a C 1 -C 6 alkylene bridge; A 4 is a C 1 -C 6 alkylene bridge; D is CH or N; W is, for...
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7414060 |
Pyridine-2-carboxyamide derivatives
The invention relates to compounds of formula I:
wherein R 1 to R 3 are as defined in the specification, to processes for their preparation, to pharmaceutical compositions containing them,...
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7399775 |
β-amyloid protein production/secretion inhibitor
Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1):
and capable of...
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7396936 |
Modulators of calcitonin and amylin receptor activity
In various aspects, the present invention relates to non-peptidic compounds, which modulate calcitonin and amylin receptor activity; to processes for the preparation of some such compounds; and to...
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7396840 |
Chemokine receptor binding heterocyclic compounds
Tertiary amine compounds that bind chemokine receptors such as CXCR4 and CCR5 are disclosed.
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7393865 |
Sleep inducing compounds and methods relating thereto
Compounds having the following structure (I):
including stereoisomers, prodrugs, and pharmaceutically acceptable salts, esters and solvates thereof, wherein R 1 , R 2 , R 3a , R 3b , L 1 , L 2 ...
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7384961 |
Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants
Saturated and unsaturated heteroarylcycloalkylmethyl-amine compounds corresponding to formula I,
processes for their preparation, pharmaceutical formulations comprising these compounds and the...
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7375122 |
Compounds useful as pesticides
Compounds useful to control pests are provided.
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7375118 |
Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation
The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic....
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7365068 |
Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
The invention provides compounds and pharmaceutically acceptable salts of Formula I
wherein the variables A 1 , A 2 , R 1 , R 2 , V, W, X, Y, and Z are defined herein. Certain compounds of...
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7361658 |
2-acylaminothiazole derivative or salt thereof
2-Acylaminothiazole derivatives or salts thereof which have a platelet increasing activity based on an excellent human c-mpl-Ba/F3 cell growth function and a function of accelerating formation of...
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7354936 |
2-phenylpyran-4-one derivatives
The present invention relates to 2-(4-sulphonylphenyl)pyran-4-one derivatives of general formula
processes for their preparation, pharmaceutical compositions containing them, and their medical...
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7351825 |
Cyclopropane compounds and pharmaceutical use thereof
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the...
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RE40155 |
Methods for treatment of benign and malignant tumors, including lymphomas, leukemias, and leiomyomas
In a preferred embodiment, drugs having chemotherapeutic properties which are useful against certain neoplastic disorders with wide safety margins as evidenced by their low toxicity, and molecular...
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7332509 |
Heterocyclic amides, a process for their preparation, compositions comprising them and their use
What is described are amides of the formula (I) and salts thereof,
where the symbols and indices are as defined below:
X is CH or N; Y is O or S; n is 0 or 1; R 1 is (C 1 -C 4...
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7332504 |
Heterocyclic substituted aminoazacycles useful as central nervous system agents
Heterocyclic substituted aminoazacyclic compounds of formula I
Z-R 3 I,
...
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7317010 |
Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone
The invention relates to a group of novel thieno-pyrrole compounds of Formula (I), wherein: R 1 , R 2 , R 4 , R 5 , R 6 , R 6a , R 7 , R 8 , A and B are as defined in the specification, which are...
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RE39991 |
Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
A compound having the following formula:
wherein R 3 and M are defined herein, and processes therewith.
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7312236 |
Substituted (4-aminocyclohexen-1-yl)phenyl and (4-aminocyclohexen-1-yl)pyridinyl compounds as 5-HT1F agonists
The present invention relates to compounds of formula I:
or a pharmaceutically acceptable acid addition salt thereof, where;
X is —C(R 4 )═ or —N═; Ar is phenyl, substituted...
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7312235 |
Benzamide inhibitors of factor Xa
Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or...
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7297694 |
Pyridylfurans and pyrroles as Raf kinase inhibitors
Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac...
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7297693 |
Nitrogen-containing heterocyclic compounds and their use as Raf inhibitors
Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac...
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7291631 |
CXCR4 chemokine receptor binding compounds
The present invention relates to compounds that bind to chemokine receptors, and having the formula
wherein each A, X, Y, R 1 , R 2 and R 3 are substituents. The present invention also...
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7282514 |
Reactive probes for two-photon fluorescent imaging and sensing
Fluorescent dyes and probes are key components in multiphoton based fluorescence microscopy imaging of biological samples. In order to address the demand for better performing dyes for two-photon...
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7282502 |
CCR9 inhibitors and methods of use thereof
The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates...
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7279476 |
Pyrazole-derived kinase inhibitors and uses thereof
Described herein are compounds that are useful as protein kinase inhibitors having the formula:
where B, R 1 , n, R 3 , Q, and R 4 are described in the specification. The compounds are useful...
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7271181 |
Inhibitors of p38
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods...
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7259166 |
Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators
2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being...
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7259157 |
N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
Compounds represented by Formula (I):
or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
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7256203 |
Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents
A compound of Formula (I):
wherein:
X is selected from the group consisting of O, S, and NR 17 , where R 17 is hydrogen or lower alkyl; A and Y are CH, N, NR 17 , O, or S; C 1 and C 2 ...
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7253191 |
2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry
The invention relates to 2-thio-substituted imidazole derivatives of the formula I
in which the radicals R 1 , R 2 , R 3 and R 4 are as defined in the description. The compounds according to...
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7253188 |
Aminobenzamide derivative
This invention relates to a novel compound represented by the formula (I):
or a pharmaceutically acceptable salt thereof,
wherein R 1 is —S(O)p-A, —S—(O)q-B or —O-D, wherein p...
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7253187 |
Heterocyclic inhibitors of ERK2 and uses thereof
Described herein are compounds that are useful as protein kinase inhibitors having the formula:
wherein Z 1 and Z 2 are each independently nitrogen or CH and Ring A, T m R 1 , QR 2 , U n R 3...
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7244763 |
Compounds that modulate PPAR activity and methods of preparation
This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising...
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7244752 |
Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors
The present invention concerns the compounds having the formula
N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R 1 and R 8 each are...
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7241758 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological...
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7238717 |
CCR9 inhibitors and methods of use thereof
The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates...
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7230015 |
Method of treating of demyelinating diseases or conditions
N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of...
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7217714 |
CCR5 modulators
Compounds of Formula 1
[R egion α]−[R egion β]−[R egion γ]−[R egion δ] (I)
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7211595 |
Farnesyltransferase inhibitors
Substituted imidazoles and thiazoles having the formula
are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting...
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7205305 |
Inhibitors of p38
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods...
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7196106 |
Cyanothiophene derivatives, compositions containing such compounds and methods of use
The present invention addresses substituted cyanothiophene derivatives of the formula I:
as well as compositions containing such compounds and methods of treatment. The compounds in the present...
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7196102 |
Calcium receptor modulating agents
The compounds of the invention are represented by the following general structure
or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are...
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7196100 |
Opioid receptor antagonists
A compound of the formula (I) wherein the variables X 1 to X 5 , R 1 to R 7 including R 3′ , E, q, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate,...
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7196089 |
EP4 receptor antagonists
Compounds of formula (I):
wherein: R 2 is H or an optionally substituted C 1-4 alkyl group; Y is either —(CH 2 ) n —X—, where n is 1 or 2 and X is O, S, S(═O), S(═O) 2 , or NR N1 ,...
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7192967 |
Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents
The invention relates to new pyridylalkane, alkene, and alkine carboxamides substituted with an imide with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid...
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7189755 |
Pyrrolidine melanocortin-specific compounds
Melanocortin receptor-specific pyrrolidine compounds having the structure:
and stereoisomer and pharmaceutically acceptable salts thereof, where R 1 , R 2 , and R 3 are as described in the...
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7186719 |
Antibacterial agents
Compounds of formula (II) are antibacterial agents wherein Q represents a radical of the formula: —N(OH)CH(═O) or the formula: —C(═O)NH(OH); R 1 represents hydrogen, C 1 –C 6 alkyl or C...
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7186709 |
Dihydropyrancarboxamides and uses thereof
The present invention provides novel dihydropyrancarboxamide compounds of formula (I):
and collections of these compounds, and provides methods for the synthesis of these compounds; wherein R 1...
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